Journal
POLYMER CHEMISTRY
Volume 9, Issue 4, Pages 499-505Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7py01942d
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Funding
- German Research council (DFG)
- Karlsruhe Institute of Technology (KIT)
- Queensland University of Technology (QUT)
- Australian Research Council (ARC)
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We pioneer an approach for the visualization of pH-controlled molecular release of a fluorescent drug from a nitroxide polymer which combined yields a profluorescent system. A methacrylate-based terpolymer, bearing water-solubilizing triethylene-glycol chains, unpaired spins in the form of nitroxide and hydrazone-bound doxorubicin was synthesized to explore the possibilities of release quantification from profluorescent assemblies. Critically, we establish the fluorescence-silencing effect of polymer-bound nitroxides on covalently attached fluorophores and the overall accessibility of such constructs. The facile approach towards a functional assembly shown here provides an easy-to-assemble construct for complex delivery architectures towards applications in theranostics.
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