Article
Physiology
Ann Monaghan, Glenn Jennings, Feng Xue, Lisa Byrne, Eoin Duggan, Roman Romero-Ortuno
Summary: In this observational cross-sectional study, predictors of orthostatic intolerance (OI) in adults with long COVID symptoms were investigated. OI was found to be associated with female sex, fatigue, depressive symptoms, inability to perform daily activities, and higher heart rate at the lowest systolic blood pressure point. However, initial orthostatic hypotension and classical orthostatic hypotension were not correlated with OI.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
C. (Linda) M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt, Frans C. Visser
Summary: Muscle pain, fatigue, and concentration problems are common symptoms among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study found that orthostatic stress is an important determinant of postexertional malaise (PEM) in ME/CFS patients, as indicated by significantly increased numeric rating scales (NRS) for pain, fatigue, and concentration even at 7 days post head-up tilt testing (HUT).
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Charles C. Edwards III, Charles C. Edwards II, Scott Heinlein, Peter C. Rowe
Summary: This study reviewed the outcomes of surgical management of cervical stenosis, providing further evidence that cervical stenosis can exacerbate or cause orthostatic intolerance and ME/CFS. Surgical interventions may offer relief for selected patients with refractory symptoms and neurological signs in this complex condition.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Kunihisa Miwa
Summary: Oral minocycline therapy may be an effective treatment option for patients with ME, especially in the initial stage of the disease. Favorable effects were observed after treatment, but a considerable number of patients discontinued treatment due to acute adverse effects.
Article
Cardiac & Cardiovascular Systems
Kate M. Bourne, Robert S. Sheldon, Juliette Hall, Matthew Lloyd, Karolina Kogut, Nasia Sheikh, Juliana Jorge, Jessica Ng, Derek V. Exner, John V. Tyberg, Satish R. Raj
Summary: Compression garments reduced heart rate and improved symptoms in adult patients with POTS during HUT, with the effects being driven by improved stroke volume. Abdominal compression alone may also provide a clinical benefit if full lower body compression is not well tolerated.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser
Summary: The study found that orthostatic intolerance in ME/CFS patients is not caused by deconditioning as defined in cardiopulmonary exercise testing. An abnormally high decline in cerebral blood flow during orthostatic stress was present in all ME/CFS patients regardless of their %peak VO2 results on cardiopulmonary exercise testing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Elena M. Christopoulos, Esmee M. Reijnierse, Peter W. Lange, Carel G. M. Meskers, Andrea B. Maier
Summary: Orthostatic hypotension (OH) and orthostatic intolerance symptoms are prevalent in one-fifth of geriatric rehabilitation inpatients, with different determinants for each. OH is associated with the number of comorbidities and geriatric conditions, while symptoms are related to factors such as gender, comorbidities, functional independence, depression risk, and physical performance.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Medicine, General & Internal
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser
Summary: There is overlap in symptoms and responses to tilt testing between patients with long-haul COVID-19 and ME/CFS, but the impairment of cerebral blood flow and cardiac index appears to be more severe in long-haul COVID-19 patients.
MEDICINA-LITHUANIA
(2022)
Article
Cardiac & Cardiovascular Systems
Yuanyuan Wang, Yan Sun, Qingyou Zhang, Chunyu Zhang, Ping Liu, Yuli Wang, Chaoshu Tang, Hongfang Jin, Junbao Du
Summary: This study found that baseline-corrected QT interval dispersion (QTcd) plays a role in predicting the effectiveness of metoprolol on pediatric postural tachycardia syndrome (POTS), and can be used as a predictive indicator.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
M. Nadir Haider, Kush S. Patel, Barry S. Willer, Victoria Videira, Charles G. Wilber, Andrew R. Mayer, Christina L. Master, Brandon L. Mariotti, Christopher Wertz, Eileen P. Storey, Kristy B. Arbogast, Grace Park, Scott J. Oglesbee, Itai Bezherano, Kenneth Aguirre, Jesse G. Fodero, Blair D. Johnson, Rebekah Mannix, Jeffrey C. Miecznikowski, John J. Leddy
Summary: This study found that adolescents commonly experience orthostatic intolerance after concussion, even if they do not meet the standard criteria for Orthostatic Hypotension. Symptoms of lightheadedness/dizziness were reported more frequently in the Concussion Group compared to controls.
Article
Medicine, General & Internal
Varvara A. A. Ryabkova, Natalia Y. Y. Gavrilova, Tamara V. V. Fedotkina, Leonid P. P. Churilov, Yehuda Shoenfeld
Summary: This study conducted the first cross-sectional study of ME/CFS in a community population in Russia, finding that ME/CFS shares similar clinical presentation and pathophysiological characteristics with post-COVID syndrome. The severity of fatigue in ME/CFS and post-COVID ME/CFS was not correlated with anxiety/depressive symptoms, but was positively correlated with other symptoms of ME/CFS. Immunological abnormalities were identified in all ME/CFS patients tested. Microcirculation function was significantly altered in both ME/CFS and post-COVID ME/CFS patients, resembling the hyperemic form of microcirculation disorders observed in acute inflammatory response or systemic vasoconstriction failure.
Article
Cardiac & Cardiovascular Systems
Sameer M. Jamal, David B. Landers, Steven M. Hollenberg, Zoltan G. Turi, Taya Glotzer, Jana Tancredi, Joseph E. Parrillo
Summary: This study performed head-up tilt table (HUTT) testing in symptomatic patients with post-acute sequela of COVID-19 (PASC), revealing orthostatic intolerance suggestive of autonomic dysfunction in nearly all subjects. Patients with provoked orthostatic intolerance (POI) showed earlier improvement of symptoms compared to those with postural orthostatic tachycardia syndrome (POTS).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Suzanne D. Vernon, Sherlyn Funk, Lucinda Bateman, Gregory J. Stoddard, Sarah Hammer, Karen Sullivan, Jennifer Bell, Saeed Abbaszadeh, W. Ian Lipkin, Anthony L. Komaroff
Summary: This study found that an orthostatic stress test performed in an office setting can reveal different symptomatic, hemodynamic, and cognitive abnormalities in individuals with Long COVID and ME/CFS compared to healthy control subjects.
FRONTIERS IN MEDICINE
(2022)
Review
Pediatrics
Natacha Baurens, Clemence Briand, Lisa Giovannini-Chami, Jean-Marie De Guillebon De Resnes, Thomas Hubiche, Christine Chiaverini, Pascal Giordana, Georges Leftheriotis, Julie Bernardor
Summary: BASCULE syndrome is an underreported pediatric vascular disorder associated with virus infections. A survey in France showed that BASCULE syndrome is underdiagnosed and under recognized in pediatric practice. Tilt-test is suggested for physicians to diagnose BASCULE syndrome when postural orthostatic tachycardia syndrome is suspected.
FRONTIERS IN PEDIATRICS
(2022)
Article
Neurosciences
Bridget R. Mueller, Carly Ray, Alyha Benitez, Jessica Robinson-Papp
Summary: Abnormal autonomic reflexes may be associated with the development of POTS and chronic headache in patients with headache, according to a retrospective analysis of autonomic function testing data from 2018 to 2022.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Gracjan Rozanski, Derek Pheby, Julia L. Newton, Modra Murovska, Pawel Zalewski, Joanna Slomko
Summary: Metabolic-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a common chronic liver disease worldwide. Currently, there is no effective pharmacological therapy for this disease. Intermittent fasting shows potential as a non-pharmacological alternative, but further studies are needed to determine its effectiveness for MAFLD.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Andrew M. Blamire, Linda Heskamp, Julie Hall, Roger Whittaker
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Lukasz Rzepinski, Monika Zawadka-Kunikowska, Julia L. Newton, Pawel Zalewski, Joanna Slomko
Summary: This study evaluates cardiovascular autonomic dysfunction in multiple sclerosis and explores its relationship with disease variant, disability level, fatigue severity, and patients' demographics.
NEUROLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Agnieszka Kujawska, Slawomir Kujawski, Mariusz Kozakiewicz, Weronika Hajec, Malgorzata Kwiatkowska, Natalia Skierkowska, Jakub Husejko, Julia L. Newton, Pawel Zalewski, Kornelia Kedziora-Kornatowska
Summary: This study explored the network relationship between cognitive function, depressive symptom intensity, body composition, proxies of cognitive reserve, trophic factor, adipokines and myokines, physical performance and blood pressure in a group of older individuals with poorly managed hypertension. The results showed that there was dysregulation in the network of individuals with poorly managed hypertension compared to normotensive individuals.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Harmen Reyngoudt, Fiona E. Smith, Ericky Caldas de Almeida Araujo, Ian Wilson, Roberto Fernandez-Torron, Meredith K. James, Ursula R. Moore, Jordi Diaz-Manera, Benjamin Marty, Noura Azzabou, Heather Gordish, Laura Rufibach, Tim Hodgson, Dorothy Wallace, Louise Ward, Jean-Marc Boisserie, Julien Le Louer, Heather Hilsden, Helen Sutherland, Aurelie Canal, Jean-Yves Hogrel, Marni Jacobs, Tanya Stojkovic, Kate Bushby, Anna Mayhew, Volker Straub, Pierre G. Carlier, Andrew M. Blamire
Summary: This multi-center study demonstrated that quantitative MRI/P-31 MRS measurements can detect significant changes in lower limb skeletal muscles of dysferlinopathy patients over a 3-year period. These findings can serve as reference values for future clinical trials and comparisons with other limb-girdle muscular dystrophy subtypes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Clinical Neurology
Linda Heskamp, Alexis R. Miller, Matthew G. Birkbeck, Julie Hall, Ian S. Schofield, Andrew M. Blamire, Roger G. Whittaker
Summary: This study used MRI to assess the in-vivo cross-sectional and 3D morphology of human motor units in hand, forearm, and lower leg muscles. The results showed no significant differences in the size and morphology of motor units among these muscles, and the 3D imaging revealed a more complex structure of human motor units than previously thought.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Chris Patrick Pflanz, Marco S. Egle, John T. O'Brien, Robin G. Morris, Thomas R. Barrick, Andrew M. Blamire, Gary A. Ford, Daniel Tozer, Hugh S. Markus
Summary: In cerebral small vessel disease, brain network analysis may serve as a sensitive surrogate marker in clinical trials. Measures of brain network efficiency may be more sensitive to the effects of blood pressure control treatment than conventional DTI metrics.
Article
Medicine, Research & Experimental
Jessica Tarn, Evelyn Evans, Emmanuella Traianos, Alexis Collins, Mryto Stylianou, Jehill Parikh, Yang Bai, Yu Guan, James Frith, Dennis Lendrem, Victoria Macrae, Iain McKinnon, Bruce S. Simon, Justyna Blake, Mark R. Baker, John Paul Taylor, Stuart Watson, Peter Gallagher, Andrew Blamire, Julia Newton, Wan-Fai Ng
Summary: This experimental medicine study investigates the relationship between noninvasive stimulation of the vagus nerve (nVNS) and fatigue in Primary Sjogren's syndrome (PSS). The results show that nVNS significantly improves fatigue symptoms in PSS patients.
Article
Geriatrics & Gerontology
Ursula Moore, Ericky Caldas de Almeida Araujo, Harmen Reyngoudt, Heather Gordish-Dressman, Fiona E. Smith, Ian Wilson, Meredith James, Anna Mayhew, Laura Rufibach, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Madoka Mori-Yoshimura, Elena Bravver, Elena Pegoraro, Jerry R. Mendell, Kate Bushby, Andrew M. Blamire, Volker Straub, Pierre G. Carlier, Jordi Diaz-Manera
Summary: In limb girdle muscular dystrophies, T2H2O mapping can be used as a prognostic tool to identify changes in muscle function over time. A higher T2H2O at baseline is associated with a greater decline on functional tests, suggesting that inter-patient differences in functional decline may be explained by differences in the severity of muscle damage.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Immunology
Fiona Cooke, Mary Neal, Matthew J. Wood, I. Jolanda M. de Vries, Amy E. E. Anderson, Julie Diboll, Arthur . G. G. Pratt, James Stanway, Ioana Nicorescu, Nicholas Moyse, Dawn Hiles, David Caulfield, Anne. M. M. Dickinson, Andrew. M. M. Blamire, Pete Thelwall, John . D. D. Isaacs, Catharien M. U. Hilkens
Summary: Tolerogenic dendritic cell (tolDC) therapies aim to restore self-tolerance in patients with autoimmune diseases. This study tested the suitability of using nanoparticles containing F-19 for labeling therapeutic human tolDC for detection through F-19-MRI. The results showed that F-19-NP is a suitable imaging agent for tolDC and does not affect their function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Ursula Moore, Esther Fernandez-Simon, Marianela Schiava, Dan Cox, Heather Gordish-Dressman, Meredith K. James, Anna Mayhew, Ian Wilson, Michela Guglieri, Laura Rufibach, Andrew Blamire, Pierre G. Carlier, Madoka Mori-Yoshimura, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Elena Bravver, Elena Pegoraro, Jerry R. Mendell, Kate Bushby, Jordi Diaz-Manera, Volker Straub
Summary: This study assessed the roles of serum myostatin and follistatin concentrations in dysferlinopathy as monitoring or prognostic biomarkers. The results showed that myostatin correlated with muscle function and MRI measurements, while its changes over three years did not correlate with functional or MRI changes. Linear modeling demonstrated that function, serum creatine kinase, and C-reactive protein were independently related to myostatin concentration. Baseline myostatin concentration predicted loss of ambulation, but not the rate of change in functional or MRI measures. Overall, myostatin does not appear to be a promising treatment target in dysferlinopathy.
NEUROMUSCULAR DISORDERS
(2023)
Article
Clinical Neurology
Laura Llanso, Ursula Moore, Carla Bolano-Diaz, Meredith James, Andrew M. Blamire, Pierre G. Carlier, Laura Rufibach, Heather Gordish-Dressman, Georgina Boyle, Heather Hilsden, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Alan Pestronk, Maggie C. Walter, Carmen Paradas, Tanya Stojkovic, Madoka Mori-Yoshimura, Elena Bravver, Elena Pegoraro, Jerry R. Mendell, Volker Straub, Jordi Diaz-Manera
Summary: In this study, the muscle imaging and clinical features of a subgroup of Dysferlinopathy patients were analyzed. It was found that approximately 63% of the patients did not meet the established imaging criteria, and 13% of them were considered as outliers with distinct clinical characteristics.
NEUROMUSCULAR DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew G. Birkbeck, Linda Heskamp, Ian S. Schofield, Julie Hall, Avan A. Sayer, Roger G. Whittaker, Andrew M. Blamire
Summary: This study used phase contrast MU MRI to measure the contraction and relaxation times of the anterior compartment in a group of healthy adults. The results showed that age and sex have a significant effect on the contraction and relaxation times. Females had significantly longer contraction times than males.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jose G. Raya, Alejandra Duarte, Nian Wang, Valentina Mazzoli, Diego Jaramillo, Andrew M. M. Blamire, Olaf Dietrich
Summary: Diffusion-weighted imaging (DWI) is a well-established MRI technique for investigating tissue microstructure. Musculoskeletal tissues, with their highly ordered structure, are an ideal application for DWI. However, there are specific challenges in acquiring DWI data for musculoskeletal applications. This review provides an overview of the technical aspects of DWI acquisition and discusses its applications in various musculoskeletal tissues.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Wilby Williamson, Adam James Lewandowski, Odaro John Huckstep, Winok Lapidaire, Alexander Ooms, Cheryl Tan, Afifah Mohamed, Maryam Alsharqi, Mariane Bertagnolli, William Woodward, Cameron Dockerill, Annabelle McCourt, Yvonne Kenworthy, Holger Burchert, Aiden Doherty, Julia Newton, Henner Hanssen, John Kennedy Cruickshank, Richard McManus, Jane Holmes, Chen Ji, Sharon Love, Elena Frangou, Colin Everett, Melvyn Hillsdon, Helen Dawes, Charlie Foster, Paul Leeson
Summary: This study investigated the effects of aerobic exercise, self-monitoring, and motivational coaching on blood pressure in young adults. The results showed that moderate to high intensity aerobic exercise training did not effectively reduce blood pressure in this group.