The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes

(2017) Maria Petrosino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

(2017) Xu Qian et al.   MOLECULAR CELL

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

(2016) S.-O. Lim et al.   CANCER RESEARCH

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Non-metabolic functions of glycolytic enzymes in tumorigenesis

(2016) X Yu et al.   ONCOGENE

Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents

(2016) Huaming Sheng et al.   Recent Patents on Anti-Cancer Drug Discovery

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

(2016) Aristeidis E. Boukouris et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability

(2016) Laura Lori et al.   PLoS One

Defining “mutation” and “polymorphism” in the era of personal genomics

(2015) Roshan Karki et al.   BMC Medical Genomics

Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer

(2015) S Sun et al.   BRITISH JOURNAL OF CANCER

Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins

(2015) Tugba G Kucukkal et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

On Human Disease-Causing Amino Acid Variants: Statistical Study of Sequence and Structural Patterns

(2015) Marharyta Petukh et al.   HUMAN MUTATION

Canonical and new generation anticancer drugs also target energy metabolism

(2014) Sara Rodríguez-Enríquez et al.   ARCHIVES OF TOXICOLOGY

Terazosin activates Pgk1 and Hsp90 to promote stress resistance

(2014) Xinping Chen et al.   Nature Chemical Biology

Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer

(2013) SUFIAN S. AHMAD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Characterization of a Reduced Form of Plasma Plasminogen as the Precursor for Angiostatin Formation

(2013) Diego Butera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and Structure

(2013) Clorinda Lori et al.   PLoS One

Molecular Insights on Pathogenic Effects of Mutations Causing Phosphoglycerate Kinase Deficiency

(2012) Laurent R. Chiarelli et al.   PLoS One

Structural Stability of Human Protein Tyrosine Phosphatase ρ Catalytic Domain: Effect of Point Mutations

(2012) Alessandra Pasquo et al.   PLoS One

FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma

(2011) Jianzhong Ai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Correlating disease-related mutations to their effect on protein stability: A large-scale analysis of the human proteome

(2011) Rita Casadio et al.   HUMAN MUTATION

A Spring-loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase

(2011) Louiza Zerrad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Insight into the Mechanism of Domain Movements and their Role in Enzyme Function: Example of 3-Phosphoglycerate Kinase

(2010) M. Vas et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis

(2010) Matthew J. Cliff et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase

(2008) C. Gondeau et al.   NUCLEIC ACIDS RESEARCH