Article
Cell Biology
Zegui Tu, Xiancheng Chen, Tian Tian, Guo Chen, Meijuan Huang
Summary: This study found that high expression of epigenetic regulatory genes UHRF1, EZH2, WHSC1 and RAD54L in NSCLC patients is associated with tumor stage and poor survival, suggesting their potential as prognostic biomarkers for distinguishing high-risk from low-risk NSCLC patients.
Article
Cell Biology
Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo, Jie Jiang
Summary: This study identified a regulatory circuit linking NF-kappa B signaling and OVOL2 in the modulation of glucose metabolism in non-small cell lung cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Medicine, General & Internal
Dailong Li, Wanqiang Li, Cheng Tian, Yaqi Pang, Lu Xu, Yuke Wang, Xinhua Xu
Summary: This meta-analysis shows that the expression of Nm23-H1 is associated with tumor differentiation, TNM stage, and lymph node status in NSCLC patients, but not associated with sex, age, pathological type, and T stage. Additionally, low Nm23-H1 expression is correlated with lower 3-year and 5-year survival rates.
Article
Pathology
Daniel J. Shepherd, Elisabeth S. Tabb, Keiko Kunitoki, M. Lisa Zhang, Marina Kem, Jaimie Barth, David A. Qualls, Meghan J. Mooradian, Justin F. Gainor, Mari Mino-Kenudson, Yin P. Hung
Summary: LAG-3 expression in non-small-cell lung carcinoma is associated with CD8(+) T-cell count and PD-L1 expression, with high LAG-3 expression linked to smoking history, high T stage, aggressive pathologic features, and lack of EGFR mutation in adenocarcinomas. High LAG-3 and LAG-3/CD8 index are associated with worse overall survival in the entire resected tumor cohort and in adenocarcinomas. High CD8 is linked to better overall survival in squamous-cell carcinomas. The predictive impact of LAG-3 in non-small-cell lung carcinoma varies by histotype.
Article
Oncology
Min-Kyung Yeo, Yoonjoo Kim, Da Hye Lee, Chaeuk Chung, Go Eun Bae
Summary: This study found that the expression of NF-kappa B and AICDA increased in EGFR-TKI-resistant LAC, and the suppression of NF-kappa B and AICDA had a significant therapeutic effect in overcoming EGFR-TKI resistance.
Review
Medicine, General & Internal
Zhiqiang Li, Yunfei Huang, Rongsheng Zhou, Zhicheng Li, Qitao Yan
Summary: This study investigated the association between SMAD4 expression and clinicopathological parameters and prognosis of non-small cell lung cancer (NSCLC) patients. The results showed that SMAD4 expression was negatively correlated with tumor differentiation, lymph node metastasis, tumor node metastasis stage, and good overall survival (OS) in NSCLC. The study suggests that SMAD4 is expressed at lower levels in NSCLC and is associated with favorable prognosis.
Article
Cell Biology
Jinlin Zhao, Xin Wang, Zeyun Mi, Xiangli Jiang, Lin Sun, Boyu Zheng, Jing Wang, Maobin Meng, Lu Zhang, Zhongqiu Wang, Junwei Song, Zhiyong Yuan, Zhiqiang Wu
Summary: The study identified miR-135b as a tumor-promoting miRNA significantly upregulated in NSCLC and associated with poor prognosis. Overexpression of miR-135b enhanced aggressiveness of NSCLC by targeting CYLD and modulating NF-kappa B signaling, while IL-6/STAT3 could elevate miR-135b levels and form a positive feedback loop in NSCLC.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Ying Su, Ru Chen, Zhongcheng Han, Rong Xu, Lili Ma, Reyina Wufuli, Hongbo Liu, Fang Wang, Lei Ma, Rui Chen, Jiang Liu
Summary: CD117 expression in NSCLC patients is not correlated with gender, clinical stage, tumor grade, T-stage, distal metastasis, and disease-free survival, but is associated with lymph node metastasis, histological type, and worse overall survival.
Article
Oncology
Hitomi Jo, Tatsuya Yoshida, Hidehito Horinouchi, Shigehiro Yagishita, Yuji Matsumoto, Yuki Shinno, Yusuke Okuma, Yasushi Goto, Noboru Yamamoto, Kazuhisa Takahashi, Noriko Motoi, Yuichiro Ohe
Summary: Cancer cachexia significantly impacts the prognosis of patients with advanced NSCLC receiving pembrolizumab, but is not associated with the response to pembrolizumab. Serum levels of pro-inflammatory cytokines and appetite-related hormones are related to the pathogenesis of cancer cachexia.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Meng Jin, Guangcai Li, Wei Liu, Xiaofeng Wu, Jing Zhu, Dong Zhao, Zhaofu Zeng, Mengqing Xiong, Yan Song, Xin He, Qingfeng Zhang, Ke Hu
Summary: This study reveals that cigarette smoking induces aberrant N6-methyladenosine modification of DAPK2, promoting the progression of NSCLC. DAPK2 acts as a tumor suppressor, and downregulation enhances proliferation and migration abilities of NSCLC cells. Selective inhibition of NF-kappa B signaling pathway effectively suppresses DAPK2-induced oncogenic phenotypes in NSCLC cells.
Article
Oncology
Guan-Ying Ma, Shuai Shi, Yu-Rui Zhang, Zhi-Bin Guo, Wen-Wu Bai, Zhi-Gang Zhang
Summary: The study aimed to explore the significance of SPARC expression in NSCLC in terms of clinicopathology, immune-cell infiltration, and survival prognosis. The results of meta-analysis and bioinformatics analysis indicated that SPARC expression was elevated in NSCLC tissues compared to normal tissues. SPARC expression was not significantly associated with TNM stage and lymph-node metastasis, but was positively associated with patient gender. Low expression of SPARC mRNA was negatively correlated with overall survival, first progression survival, and post-progression survival of NSCLC patients. Further analysis showed that SPARC expression levels and TNM stage were significant risk factors affecting prognosis. The study suggests that SPARC expression can serve as a valuable indicator of prognosis in NSCLC patients.
Article
Oncology
Justyna Durslewicz, Anna Klimaszewska-Wisniewska, Jakub Jozwicki, Paulina Antosik, Kamil Kozerawski, Dariusz Grzanka, Marcin Braun
Summary: MATR3 is a nuclear matrix protein involved in mRNA stabilization, nuclear retention of hyper-edited RNAs, and RNA splicing. This study investigates the expression levels and prognostic significance of MATR3 in early-stage non-small cell lung cancer (NSCLC) patients. The study found that the expression of MATR3 protein was significantly higher in tumor-adjacent tissue compared to cancer tissue, while MATR3 mRNA levels were significantly higher in tumor tissue compared to control lung tissues. High levels of MATR3 mRNA were associated with worse overall survival of NSCLC patients. Further investigation is needed to understand the biological and prognostic value of MATR3 as a potential prognostic marker in early-stage NSCLC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Kosuke Ichikawa, Satoshi Watanabe, Satoru Miura, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Tomohiro Tanaka, Yu Saida, Rie Kondo, Satoshi Hokari, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi
Summary: This study found a significant negative correlation between elevated procalcitonin levels and prognosis in small cell lung cancer (SCLC) patients. Procalcitonin levels were higher in SCLC patients compared to non-small cell lung cancer patients. Although procalcitonin elevation was significantly associated with prognosis, it may be challenging to differentiate bacterial infections in SCLC patients using procalcitonin.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Plant Sciences
Zihan Lin, Lijuan Liao, Shengchao Zhao, Wei Gu, Guanzhen Wang, Ziyi Shen, Yuanhui Wang, Kun Chen, Wei Liu, Yi Cai, Chunpeng Wan, Tingdong Yan
Summary: The study found that corylin is a substance that inhibits the progression of non-small cell lung cancer cells, and it inhibits the NF-kappa B signaling pathway by blocking p65 nuclear translocation. The study provides a novel strategy for improving the prognosis and treatment of non-small cell lung cancer patients.
Article
Health Care Sciences & Services
Eva Obermayr, Nina Koppensteiner, Nicole Heinzl, Eva Schuster, Barbara Holzer, Hannah Fabikan, Christoph Weinlinger, Oliver Illini, Maximilian Hochmair, Robert Zeillinger
Summary: This study highlighted the importance of molecular characterization of circulating tumor cells (CTCs) in NSCLC patients. The analysis found that cancer stem cell-related transcripts were significantly associated with overall survival at both primary diagnosis and disease progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)