Article
Rheumatology
Avishai M. Tsur, Abdulla Watad, Omer Gendelman, Daniel Nissan, Arnon D. Cohen, Howard Amital
Summary: The study found a positive association between FMF and asthma through a cross-sectional study. Further research is needed to validate and explore possible explanations for this association. These findings challenge previous studies that suggested FMF as a protective factor against asthma.
Review
Biochemistry & Molecular Biology
Maddalena Lancieri, Marta Bustaffa, Serena Palmeri, Ignazia Prigione, Federica Penco, Riccardo Papa, Stefano Volpi, Roberta Caorsi, Marco Gattorno
Summary: This study provides an updated overview on the main aspects of pathophysiology, genetics, diagnosis, and treatment resistance of Familial Mediterranean Fever (FMF), a prototypal autoinflammatory disease. It also emphasizes the importance of FMF in understanding the functioning of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Seza Ozen
Summary: Recent studies have revealed new insights into the pathogenesis of familial Mediterranean fever, including genetic mutations conferring resistance to ancient microbial pathogens and recommendations for genetic analysis of FMF. We now have recommendations for assessing genetic analysis of the MEFV gene and how to reliably classify a patient as FMF.
CURRENT OPINION IN RHEUMATOLOGY
(2021)
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Article
Medicine, General & Internal
Zehra Serap Arici, Micol Romano, David Piskin, Ferhat Guzel, Sezgin Sahin, Roberta A. Berard, Mahmut Yilmaz, Erkan Demirkaya
Summary: This study aimed to compare the clinical phenotype of patients with FMF-related AA amyloidosis based on age of FMF diagnosis and E148Q genotype. The most common clinical manifestations were fever, abdominal pain, and arthritis. The study found M694V and E148Q to be the most common genetic mutations, with higher mortality rate among patients with homozygous M694V genotype and the need for close monitoring of patients with homozygous E148Q genotype. The relationship between E148Q and AA amyloidosis warrants further confirmation in other ethnicities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Vasiliki Sgouropoulou, Evangelia Farmaki, Theophanis Papadopoulos, Vasiliki Tzimouli, Jenny Pratsidou-Gertsi, Maria Trachana
Summary: NGS technology elucidates the genetic characteristics of patients with atypical phenotypes, supports therapeutic management decisions, and reveals the frequent involvement of R202Q in the pathogenesis of FMF patients.
RHEUMATOLOGY INTERNATIONAL
(2022)
Review
Rheumatology
Cengiz Korkmaz, Dondu Uskudar Cansu, Sibel Canbaz Kabay
Summary: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterized by fever and serositis attacks caused by mutations in the MEditerranean FeVer (MEFV) gene encoding the pyrin gene. FMF patients are more likely to develop inflammatory diseases such as Behcet's disease, psoriasis, and vasculitis, as well as multiple sclerosis. The coexistence of FMF and demyelinating disorders in multiple family members is rare, with only a few reported cases.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Hematology
Serap Kirkiz, Zuhre Kaya, Sevim Gonen, Munci Yagci, Ulker Kocak
Summary: This study investigated the simultaneous occurrences of Familial Mediterranean Fever (FMF) in patients with haemophilia, identifying 8 out of 30 severe haemophilic patients with FMF. The study found that FMF patients had fewer target joints and a positive family history, indicating the importance of screening for FMF in haemophilia patients with arthritis and a family history of FMF in Mediterranean countries.
Article
Immunology
Maeva Veyssiere, Sara Sadat Aghamiri, Arturo Hernandez Cervantes, Thomas Henry, Vassili Soumelis
Summary: This study aimed to provide a computational model capturing the mechanistic details of biological pathways involved in FMF physiopathology and studying the dynamics of the patient's immune cells. By building a molecular map and a mathematical model of FMF, the researchers were able to identify key players in the disease inflammation phenotype. The results of the study showed that NF-kappa B and JAK1/TYK2 play critical roles in modulating the inflammatory response.
CLINICAL IMMUNOLOGY
(2023)
Article
Pediatrics
Burcu Bozkaya Yucel, Ozlem Aydog, Hulya Nalcacioglu, Aysegul Yilmaz
Summary: The study retrospectively analyzed 65 FMF patients who received canakinumab treatment due to colchicine resistance or intolerance. The results showed that canakinumab treatment was highly effective, well-tolerated in pediatric FMF patients, and controlled extension of the canakinumab dose interval was safe, with no severe adverse effects observed.
FRONTIERS IN PEDIATRICS
(2021)
Review
Rheumatology
Berkay Kilic, Yelin Guler, Feyza N. Azman, Ece Bostanci, Serdal Ugurlu
Summary: This study aimed to evaluate the efficacy and safety of anti-IL-1 agents in FMF patients. The results showed that anti-IL-1 agents significantly decreased levels of inflammatory markers and demonstrated good efficacy and low adverse events in adult and pediatric FMF patients.
Article
Medicine, General & Internal
Bahri Oztas, Hatice Eren, Ali Yagiz Ayla, Ali Koc, Kemal Erol, Adile Irfan, Erkan Caglar, Serdal Ugurlu
Summary: This study investigated the relationship between portal hypertension and familial Mediterranean fever (FMF). The results showed that FMF patients had significantly lower peak portal blood flow velocity compared to the control group, indicating the presence of portal hypertension. However, the differences in other findings related to portal hypertension were not significant.
Article
Rheumatology
Sevtap Acer Kasman, Mehmet Tuncay Duruoz
Summary: This study evaluated the frequency and manifestations of spondyloarthritis (SpA) in patients with familial Mediterranean fever (FMF), as well as the impact of SpA on FMF and the associations of non-episodic findings with FMF features. The results showed that a significant number of FMF patients also had SpA, indicating that SpA and its shared manifestations with FMF may have an impact on FMF.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Clinical Neurology
Inbar Lidor, Shmuel Tiosano, Kassem Sharif, Howard Amital, Arnon D. Cohen, Daniela Amital
Summary: Through big data analysis, the study found a significant association between FMF and higher prevalence of depression and anxiety compared to age- and sex-matched controls. After controlling for confounding variables, this association remained significant, highlighting the importance of raising awareness for these comorbidities.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pediatrics
Selen Duygu Arik, Gulsah Kavrul Kayaalp, Vafa Guliyeva, Fatma Gul Demirkan, Ayse Tanatar, Ozlem Akgun, Sengul Caglayan, Kadir Ulu, Taner Coskuner, Serife Gul Karadag, Betul Sozeri, Nuray Aktay Ayaz
Summary: This study compared the characteristics of FMF patients with and without fever during their attacks and highlighted the different clinical presentations of FMF in children.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Itay Lotan, Esther Ganelin-Cohen, Evgeny Tartakovsky, Vadim Khasminsky, Mark A. Hellmann, Israel Steiner, Ilan Ben-Zvi, Avi Livneh, Sizilia Golderman, Batia Kaplan
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Rheumatology
Olga L. Kukuy, Pazit Beckerman, Dganit Dinour, Ilan Ben-Zvi, Avi Livneh
Summary: This study compared FMF amyloidosis patients who experienced an episode of amyloid storm with those who did not. It found that patients with amyloid storm were more likely to progress to ESRD or death in a shorter time period, with infections being the major triggers.
Article
Medicine, General & Internal
Ariel Israel, Gil Bornstein, Lee Gilad, Liran Shechtman, Nadav Furie, Ilan Ben-Zvi, Chagai Grossman
Summary: The study aimed to investigate the prognostic value of markedly elevated ferritin levels in hospitalized patients. It found that high ferritin levels were mainly associated with infectious and malignant diseases, but did not predict mortality rates.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Obstetrics & Gynecology
Liron Yoffe, Amir A. Kuperman, Ofer Isakov, Danielle Haguel, Avital L. Polsky, Luba Farberov, Nir Pillar, Vyacheslav Gurevich, Izhak Haviv, Noam Shomron
Summary: This study examined the association between preeclampsia and the microbiome composition in the placenta and found that bacterial and viral abundance may have limited involvement in the pathogenesis of preeclampsia. The research also discovered significant differences in bacterial RNA composition between various areas of the placenta, indicating a need for further investigation into the true nature of the placental microbiome.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Psychiatry
Ifat Israel-Elgali, Libi Hertzberg, Guy Shapira, Aviv Segev, Israel Krieger, Uri Nitzan, Yuval Bloch, Nir Pillar, Ori Mayer, Abraham Weizman, David Gurwitz, Noam Shomron
Summary: This study aimed to elucidate the transcriptional differences in peripheral blood mononuclear cells (PBMC) between individuals with treatment-resistant depression (TRD) and a control group. The findings suggest that the expression levels of FKBP5, ITGA2B, and miR-24-3p in PBMC could be further explored as potential biomarkers for ECT response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Rafael Y. Brzezinski, Neta Rabin, Nir Lewis, Racheli Peled, Ariel Kerpel, Avishai M. Tsur, Omer Gendelman, Nili Naftali-Shani, Irina Gringauz, Howard Amital, Avshalom Leibowitz, Haim Mayan, Ilan Ben-Zvi, Eyal Heler, Liran Shechtman, Ori Rogovski, Shani Shenhar-Tsarfaty, Eli Konen, Edith M. Marom, Avinoah Ironi, Galia Rahav, Yair Zimmer, Ehud Grossman, Zehava Ovadia-Blechman, Jonathan Leor, Oshrit Hoffer
Summary: The newly developed non-contact thermal imaging tool showed high sensitivity and area under the curve in detecting COVID-19 infection. This technology could be used for non-invasive screening of COVID-19 in low-income regions with limited medical resources.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Orit Kaidar-Person, Rakefet Yoeli-Ullman, Nir Pillar, Shani Paluch-Shimon, Philip Poortmans, Yaacov R. Lawrence
Summary: The study found that breast cancer survivors are at increased risk of obstetric and maternal complications at the time of delivery, with differences in socioeconomic status, age, chronic diseases, and multiple gestations.
Article
Rheumatology
Soad Haj-Yahia, Ilan Ben-Zvi, Merav Lidar, Avi Livneh
Summary: This study evaluated the role of TNF in the treatment of FMF, showing that a small proportion of patients with colchicine-resistant FMF may benefit from TNF blockers, with no predictable factors for response.
Review
Biochemistry & Molecular Biology
Eitan Giat, Ilan Ben-Zvi, Merav Lidar, Avi Livneh
Summary: This article reviews the clinical manifestations of Familial Mediterranean Fever (FMF) and the utility of anakinra, a recombinant IL-1 receptor antagonist, in FMF. Anakinra, due to its short half-life, is often the preferred IL-1 blocker in certain clinical scenarios of FMF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Areej Abu Rmaileh, Balakrishnan Solaimuthu, Anees Khatib, Shirel Lavi, Mayur Tanna, Arata Hayashi, Michal Ben Yosef, Michal Lichtenstein, Nir Pillar, Yoav D. Shaul
Summary: Metastatic breast cancer cells exploit axon guidance proteins, with DPYSL2 playing a crucial role in regulating cell migration. The interaction between DPYSL2 and JAK1 is essential for cell migration and the expression of vimentin.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Health Care Sciences & Services
Karney Lahad, Elad Maor, Robert Klempfner, Chagai Grossman, Amit Druyan, Ilan Ben-Zvi
Summary: The CHA2DS2-VASC score is a predictor for the risk of cerebrovascular accident (CVA) in patients without known atrial fibrillation (AF) during the first year after hospitalization. Higher scores are associated with an increased risk of CVA/TIA.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Pediatrics
Rakefet Sidlik Muskatel, Nir Pillar, Jeremy Godefroy, Michal Lotem, Gal Goldstein
Summary: This article reports a case of aggressive clear cell sarcoma in a 9-year-old patient, highlighting the critical role of molecular analysis in the diagnosis and treatment of rare cancer variants in the era of personalized medicine. The study suggests that cabozantinib can be an effective treatment for clear cell sarcoma.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Pathology
Nir Pillar, Aydogan Ozcan
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Review
Optics
Bijie Bai, Xilin Yang, Yuzhu Li, Yijie Zhang, Nir Pillar, Aydogan Ozcan
Summary: Histological staining is an important technique in clinical pathology and research, but it is expensive, time-consuming, and limited in resource-limited settings. Deep learning techniques have provided a solution by digitally generating histological stains, which are rapid, cost-effective, and accurate alternatives to chemical staining methods. This review provides an overview of recent advances in deep learning-enabled virtual histological staining and discusses its future potential.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Medicine, General & Internal
Liran Shechtman, Karney Lahad, Ilan Ben-Zvi
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2021)
