Article
Immunology
Grace A. Snyder, Shir Eliachar, Michael T. Connelly, Shani Talice, Uzi Hadad, Orly Gershoni-Yahalom, William E. Browne, Caroline V. Palmer, Benyamin Rosental, Nikki Traylor-Knowles
Summary: This study identified and characterized phagocytes from coral and sea anemones, demonstrating their role in engulfing bacteria, fungi, beads, as well as self and damaged cells. The findings also showed that phagocytic cells target antigens localize to low pH phagolysosomes, and the inhibition of actin filament rearrangement interferes with efficient particle phagocytosis. Additionally, cellular markers for lysolitic vesicles and reactive oxygen species were found to correlate with hexacorallian phagocytes, laying a foundation for better understanding of their immune cell biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Liting Wu, Yanjian Yang, Along Gao, Jun Li, Jianmin Ye
Summary: The study found that tilapia anterior kidney (AK) leukocytes can be divided into two subsets of IgM(+) B cells: lymphoid (L) gate and granulocyte-monocyte/macrophage (G-M) subsets. The G-M gate IgM(+) cells resemble plasma-like cells, with high antibody-secreting, phagocytic, and antigen-presenting capacities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Simona Granata, Maurizio Bruschi, Alberto Verlato, Paola Pontrelli, Loreto Gesualdo, Giovanni Stallone, Gianluigi Zaza
Summary: This study revealed for the first time the activation of the autophagy pathway in immune cells of patients on peritoneal dialysis (PD), which may serve as a novel therapeutic target.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Soraya Jativa, Selene Torrico, Priscila Calle, Angeles Munoz, Miriam Garcia, Ana Belen Larque, Esteban Poch, Georgina Hotter
Summary: This study proposes the use of peripheral blood mononuclear cell therapy based on cell NGAL release for the treatment of acute kidney injury (AKI) and associated fibrosis. The results show that PBMC(A/R) can reduce BUN and creatinine levels, lower inflammation, promote proliferation of tubular epithelial cells, and reduce AKI-induced fibrosis. Moreover, the release of NGAL from PBMC(A/R) plays a crucial role in the beneficial effects of this therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Martina Butori, Bjorn Eriksson, Nikola Nikolic, Carina Lagergren, Goran Lindbergh, Rakel Wreland Lindstrom
Summary: This work investigates the effect of temperature in the range of 80-120 degrees C on a commercial membrane electrode assembly (MEA) in proton exchange membrane fuel cells (PEMFCs). The results show that adequate operation at intermediate temperature is achievable if there is sufficient oxygen partial pressure. However, the ionic conductivity in the polymer can become limiting at high currents. Overall, a higher operating temperature does not necessarily cause a decrease in obtained current density.
JOURNAL OF POWER SOURCES
(2023)
Article
Veterinary Sciences
Joan Martorell-Ribera, Dirk Koczan, Marzia Tindara Venuto, Torsten Viergutz, Ronald M. Brunner, Tom Goldammer, Ulrike Gimsa, Alexander Rebl
Summary: Aquaculture management involves regular handling procedures, which can cause stress responses in farmed fish. A study on maraena whitefish revealed that handling may compromise their health and welfare.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Marith I. Francke, Dennis A. Hesselink, Yi Li, Birgit C. P. Koch, Lucia E. A. de Wit, Ron H. N. van Schaik, Lin Yang, Carla C. Baan, Teun van Gelder, Brenda C. M. de Winter
Summary: The study found poor correlation between [Tac](blood) and [Tac](cells), with age, albumin, and haematocrit correlating with the [Tac](cells)/[Tac](blood) ratio, while genetic variations in ABCB1, CYP3A4, and CYP3A5 did not. Neither [Tac](blood) nor [Tac](cells) were correlated with clinical outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Angela Duong, Alesya Evstratova, Adam Sivitilli, J. Javier Hernandez, Jessica Gosio, Azizia Wahedi, Neal Sondheimer, Jeff L. Wrana, Jean-Martin Beaulieu, Liliana Attisano, Ana C. Andreazza
Summary: The study developed cerebral organoids (COs) from induced pluripotent stem cells (iPSCs) derived from human peripheral blood mononuclear cells (PBMCs) and monitored mitochondrial health from the primary, reprogrammed and differentiated stages. Results show preserved mitochondrial genetics, function and treatment responses throughout the process, with measurable neuronal activity in the COs.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard
Summary: This study successfully derived podocytes from human-induced pluripotent stem cells using a accelerated 12-day protocol. The derived podocytes showed comparable marker expression and morphology to longer cultured podocytes. These podocytes can be used for modeling diabetic kidney disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Materials Science, Ceramics
Dongliang Liao, Gurong Lin, Feng Chen, Xian Pan, Kaiping Peng
Summary: Ba3MoNb1-xGaxO8.5-delta (BMNG, 0 < x < 0.2) powders were prepared by sol-gel autoignition method and the effects of Ga3+ doping on BMN were characterized. Doping a small amount of gallium effectively improved BMN's conductivity and sintering density, with the highest ionic conductivity observed in BMNG10. Furthermore, the successful assembly and evaluation of a single cell supported by BMNG10 electrolyte demonstrated its feasibility for intermediate temperature-solid oxide fuel cells (IT-SOFCs).
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Guangyu Xue, Xiaojiao Zhang, Lu Wang, Yunjie Hao, Jiao Li, Haibin Sun, Xue Guo, Hua Zhang
Summary: The effects of different Cu doping amounts on the crystal structure, fiber morphology, and electrochemical performance of intermediate-temperature solid oxide fuel cell cathode materials were investigated. LSFCu2 fiber cathode displayed the optimal electrochemical performance.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
K. P. Padmasree, Ke-Yu Lai, Arumugam Manthiram
Summary: The calcium cobaltite Ca(3-x)La(x)Co(4-y)CuyO(9+delta) doped with x and y = 0 and 0.1 showed slightly affected electrical and thermal properties, with the undoped sample exhibiting improved symmetrical cell performance in intermediate-temperature solid oxide fuel cells.
CERAMICS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Jaehee Lee, Leejin Park, Hyeyoung Kim, Bong-il Rho, Rafael Taeho Han, Sewon Kim, Hee Jin Kim, Heung Sik Na, Seung Keun Back
Summary: This study investigated the therapeutic effects of adipose-derived stem cells (ASCs) on atopic dermatitis (AD) rats. The results showed that systemic administration of ASCs can alleviate AD-like symptoms, restore the phagocytic activity of peripheral blood mononuclear cells (PBMCs), decolonize cutaneous Staphylococcus aureus, and improve the skin condition of AD rats.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Arya Zarinsefat, George Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio Vincenti, Chun J. Yee, Minnie M. Sarwal
Summary: COVID-19 poses a significant threat to global health, with IL-6 playing a key role in the cytokine storm. Tocilizumab shows promise in treating COVID-19 by reducing expression of inflammatory genes and pathways, particularly in monocytes, as observed in single-cell RNA sequencing.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Yapei Yuan, Huan Chen, Sihua Ou, Baomei Cai, Ruifang Zhang, Yue Qin, Mengjie Pan, Shangtao Cao, Duanqing Pei, Fan Fan Hou
Summary: This study successfully generated mitochondria-rich kidney organoids via partial reprogramming of human urine cells, which recapitulated the structural and functional characteristics of the kidneys, providing a promising model to study mitochondria-related kidney physiology and disease in a personalized manner.
CELL AND BIOSCIENCE
(2022)
Review
Urology & Nephrology
Andrew T. Gabrielson, Marisa M. Clifton, Christian P. Pavlovich, Michael J. Biles, Mitchell Huang, Jacqueline Agnew, Phillip M. Pierorazio, Brian R. Matlaga, Petar Bajic, Zeyad R. Schwen
Summary: Poor ergonomics in the operating room can have detrimental effects on a surgeon's physical, psychological and economic well-being. Most urologists have experienced work-related musculoskeletal pain or injury at some point in their career. Despite limited research in this area, practical recommendations can help surgeons reduce the risk of injury.
NATURE REVIEWS UROLOGY
(2021)
Article
Urology & Nephrology
Jillian Egan, Joseph G. Cheaib, Michael J. Biles, Mitchell M. Huang, Meredith Metcalf, Andres Matoso, Phillip Pierorazio
Summary: The study demonstrates that testis-sparing surgery is safe and effective for small, benign masses as well as in cases of bilateral disease or tumors in a solitary testis. The sensitivity and specificity of intraoperative frozen section analysis were high, and most patients had no evidence of disease at a median follow-up of 12.2 months.
Article
Urology & Nephrology
Joan C. Delto, Aaron Fleishman, Peter Chang, Da David Jiang, Sara Hyde, Kyle McAnally, Catrina Crociani, Marcus Jamil, Hiten D. Patel, Jonathan Pavlinec, Jeffrey Budzyn, Adri Durant, Benjamin Eilender, Ashley O. Gordon, Mitchell M. Huang, Phillip M. Pierorazio, Jay D. Raman, Craig Rogers, Li-Ming Su, Andrew A. Wagner
Summary: The study evaluated the outcomes of perioperative aspirin use during robotic partial nephrectomy (RPN) in a multicenter setting. It found that the use of perioperative aspirin (81 mg) was reasonable and safe, but it was associated with a higher risk of blood transfusions and major complications.
JOURNAL OF UROLOGY
(2022)
Article
Oncology
Ridwan Alam, Hiten D. Patel, Zhuo T. Su, Joseph G. Cheaib, Yasser Ged, Nirmish Singla, Mohamad E. Allaf, Phillip M. Pierorazio
Summary: This study found that self-reported quality of life metrics can predict all-cause mortality in patients with renal cell carcinoma with higher accuracy and parsimony. Physical health is a stronger predictor of mortality than mental health.
Meeting Abstract
Oncology
Ridwan Alam, Joseph G. Cheaib, Michael J. Biles, Jared S. Winoker, Nirmish Singla, Trinity Bivalacqua, Phillip M. Pierorazio, Max R. Kates, Sunil H. Patel
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Hiren Patel, Arnav Srivastava, Sinae Kim, Hiten D. Patel, Phillip M. Pierorazio, Aditya Bagrodia, Timothy A. Masterson, Saum B. Ghodoussipour, Isaac Y. Kim, Eric A. Singer, Thomas L. Jang
Summary: The study aimed to investigate the impact of lymph node count on the outcome of primary retroperitoneal lymph node dissection (RPLND) in men with clinical stage I or II testicular nonseminomatous germ cell tumor (NSGCT). The results showed that higher lymph node count significantly increased the likelihood of identifying lymph node-positive disease (pN+) and improved overall survival.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Surena F. Matin, Phillip M. Pierorazio, Nir Kleinmann, John L. Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott G. Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D. Raman, John J. Knoedler, Douglas Scherr, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B. Smith, Jennifer Linehan, Jonathan Coleman, Mitchell R. Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Elyse Seltzer, Mark Schoenberg, Seth P. Lerner
Summary: The study aimed to evaluate the long-term safety and durability of UGN-101 as a primary chemoablative treatment for low-grade upper tract urothelial carcinoma. The results showed that UGN-101 has a clinically meaningful durability of response, providing a kidney-sparing therapeutic alternative for patients with low-grade disease.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Meredith R. Metcalf, Vanessa N. Pena, Joseph G. Cheaib, Arnav Srivastava, Phillip M. Pierorazio, Hiten D. Patel
Summary: This study evaluates the racial, gender, and socioeconomic differences in the treatment of metastatic renal cell carcinoma (mRCC) and their impact on survival. The study finds that there are disparities in the treatment of mRCC based on race, gender, and socioeconomic factors, which are associated with differences in overall survival. Dismantling systemic barriers and improving access to care may reduce these disparities and improve outcomes for mRCC.
Article
Urology & Nephrology
Michael J. Biles, Michael C. Haffner, Brian Hanratty, Phillip M. Pierorazio
Summary: The pathophysiology of bilateral testicular germ cell tumors (TGCT) is poorly understood. This study identified independent genomic alterations in bilateral TGCTs, suggesting distinct biological behavior and the need for independent staging and prognostic evaluation.
Editorial Material
Urology & Nephrology
Kiran Sury, Phillip M. Pierorazio
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2022)
Article
Medicine, Research & Experimental
Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Summary: T cells in acute kidney injury (AKI) undergo metabolic reprogramming, and targeting the T cell glutamine pathway could be a promising therapeutic approach. Ischemic AKI in mice showed the presence of a distinct T cell subset with altered expression of certain metabolic proteins. Similarly, human nonischemic and ischemic kidney tissue exhibited similar findings. Inhibition of glutamine with JHU083 attenuated renal injury and reduced T cell activation and proliferation in AKI.
Article
Oncology
Michael A. Gorin, Hiten D. Patel, Steven P. Rowe, Noah M. Hahn, Hans J. Hammers, Alice Pons, Bruce J. Trock, Phillip M. Pierorazio, Thomas R. Nirschl, Daniela C. Salles, Julie E. Stein, Tamara L. Lotan, Janis M. Taube, Charles G. Drake, Mohamad E. Allaf
Summary: In this study, the safety and tolerability of preoperative administration of three doses of the immune checkpoint inhibitor nivolumab in patients with clinically localized high-risk renal cell carcinoma were evaluated. The study demonstrated the safety of this approach and found that a subset of patients may have features of an immune-related pathologic response.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Urology & Nephrology
Christian D. Fankhauser, Luca Afferi, Sean P. Stroup, Nicholas R. Rocco, Kathleen Olson, Aditya Bagrodia, Fady Baky, Walter Cazzaniga, Erik Mayer, David Nicol, Ekrem Islamoglu, Stephane de Vergie, Ragheed Saoud, Scott E. Eggener, Sebastiano Nazzani, Nicola Nicolai, Lee Hugar, Wade J. Sexton, Deliu-Victor Matei, Ottavio De Cobelli, Joseph Cheaib, Phillip M. Pierorazio, James Porter, Thomas Hermanns, Robert J. Hamilton, Andreas Hiester, Peter Albers, Noel Clarke, Agostino Mattei
Summary: The study aims to describe the perioperative safety, functional, and immediate post-operative oncological outcomes of minimally invasive RPLND (miRPLND) for testis cancer. The results show that miRPLND has a positive impact on postoperative ejaculatory function and a low proportion of complications and peritoneal recurrences, supporting further studies on miRPLND.
WORLD JOURNAL OF UROLOGY
(2022)
Meeting Abstract
Urology & Nephrology
Nir Kleinmann, Phillip Pierorazio, Jay Raman, Scott Hubosky, Ahmad Shabsigh, Brian Hu, Hristos Kaimakliotis, Marcelino Rivera, Douglas Scherr, Alon Weizer, Raymond Pak, Mark Schoenberg, Elyse Seltzer, Karim Chamie
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Sadichhya Lohani, Mohanraj Sadasivam, Hamid Rabb, Mohamed G. Atta
Summary: Collapsing glomerulopathy can be associated with various factors, including viral infections, medications, autoimmune diseases, and genetic predisposition. Studies suggest that the activation and elevated production of interferon gamma by double negative T cells may play a role in the progression of collapsing glomerulopathy.