Article
Immunology
Hong-Wei Sun, Wen-Chao Wu, Hai-Tian Chen, Yi-Tuo Xu, Yan-Yan Yang, Jing Chen, Xing-Juan Yu, Zilian Wang, Ze-Yu Shuang, Limin Zheng
Summary: The study demonstrates that glutamine deprivation can enhance the expression of G-CSF and GM-CSF in breast cancer cells, leading to generation of immunosuppressive myeloid-derived suppressor cells (MDSCs) due to impaired HPC-maintaining capacity in the bone marrow.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Hyunju In, Ji Soo Park, Hyun Soo Shin, Seul Hye Ryu, Moah Sohn, Wanho Choi, Sejung Park, Soomin Hwang, Jeyun Park, Lihua Che, Tae-Gyun Kim, Min Kyung Chu, Hye Young Na, Chae Gyu Park
Summary: DCs can be generated from mouse bone marrow with GM-CSF or FLT3L treatment, and can be classified into different subsets based on marker expression and antibody staining. In FLT3L-treated cultures, a majority of cDC2-gated CD11c(+)MHCII(hi) cells exhibited a specific phenotype, suggesting a new cDC precursor population.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qianyue Zhang, Qiaoling Song, Shan Liu, Yuting Xu, Danling Gao, Peizhe Lu, Yuantao Liu, Guanghui Zhao, Lihong Wu, Chenyang Zhao, Jinbo Yang
Summary: This study investigated the metabolic differences between GM-BMDMs and M-BMDMs and their consistency with protein levels through transcriptome and metabolome analysis. The core metabolic pathways of macrophages were found to be closely associated with canonical macrophage functions such as inflammatory response and phagocytosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Erika Bertozzi de Aquino Mattos, Patricia Ribeiro Pereira, Lyris Anunciata Demetrio Merida, Anna Carolina Nitzsche Teixeira Fernandes Correa, Maria Paula Vigna Freire, Vania Margaret Flosi Paschoalin, Gerlinde Agate Platais Brasil Teixeira, Maria de Fatima Brandao Pinho, Mauricio Afonso Vericimo
Summary: The study found that tarin in taro corms can affect bone marrow hematopoietic populations, promoting the proliferation of specific cell lineages and exhibiting cytokine-mimetic effects.
Review
Biochemistry & Molecular Biology
Marc Charabati, Michael A. Wheeler, Howard L. Weiner, Francisco J. Quintana
Summary: Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system. Neuroimmune interactions play a key role in MS pathology and offer potential targets for therapy. This review explores risk factors, pathogenesis mechanisms, current therapies, and emerging technologies for addressing clinical needs.
Article
Oncology
Zhengzheng Zhang, Zhiyan Yao, Zimeng Zhang, Ling Cui, Ling Zhang, Gang Qiu, Xiaotian Song, Shuxia Song
Summary: This study investigates the mechanism by which radiotherapy promotes the recruitment of M-MDSCs in the lung and increases the risk of lung metastasis in breast cancer. The findings show that radiotherapy increases the number of M-MDSCs in the lung, inhibits T cell function, and promotes MDSCs migration through the CXCL1/CXCR2 and CCL2/CCR2 signaling pathways. This study reveals a detrimental effect of radiotherapy in promoting immunosuppressive premetastatic niches formation in the lung.
CANCER CELL INTERNATIONAL
(2023)
Article
Immunology
Takao Sudo, Yasutaka Motomura, Daisuke Okuzaki, Tetsuo Hasegawa, Takafumi Yokota, Junichi Kikuta, Tomoka Ao, Hiroki Mizuno, Takahiro Matsui, Daisuke Motooka, Ryosuke Yoshizawa, Takashi Nagasawa, Yuzuru Kanakura, Kazuyo Moro, Masaru Ishii
Summary: This study reveals that BM-resident ILC2s support the recovery of HSPCs by secreting GM-CSF and interact with B cells to maintain hematopoietic homeostasis. ILC2s function by "sensing" damaged BM spaces and supporting hematopoietic recovery under stress conditions.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Haisam Alattar, Huaming Xu, Martin Zenke, Manfred B. B. Lutz
Summary: In this study, it was demonstrated that HoxB8 cells can be used as an alternative to bone marrow cells in generating monocytic MDSC, with comparable quantity and quality.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Remi Vernet, Emily Charrier, Erika Cosset, Sabine Fievre, Ugo Tomasello, Julien Grogg, Nicolas Mach
Summary: The study investigated the use of secreted adjuvant GM-CSF to enhance the efficacy of a SARS-CoV-2 vaccine, showing improved cellular and humoral immune responses. The results also underscored the importance of delivery strategies in inducing cellular and humoral-mediated immune responses.
Article
Physiology
Kenjiro Shima, Paritha Arumugam, Anthony Sallese, Yuko Horio, Yan Ma, Cole Trapnell, Matthew Wessendarp, Claudia Chalk, Cormac McCarthy, Brenna C. Carey, Bruce C. Trapnell, Takuji Suzuki
Summary: Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by mutations in GM-CSF receptor subunit alpha/beta genes, resulting in impaired surfactant clearance and respiratory failure. Through mouse models, it was found that homozygous Csf2ra gene disruption caused lung disease similar to hPAP in children with CSF2RA mutations, while heterozygous gene had no effect. Pulmonary macrophage transplantation restored GM-CSF responsiveness and showed potential as a therapy for hPAP.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Immunology
Lucia Minarrieta, Gloria J. Godoy, Lis N. Velazquez, Peyman Ghorbani, Tim Sparwasser, Luciana Berod
Summary: The CD11c(+)MHCII(+) compartment in GM-CSF cultures contains two populations with different metabolic profiles: MHCII(low)CD11b(high) cells (GM-Macs) and MHCII(high)CD11b(int) cells (GM-DCs). GM-Macs upregulate iNOS and produce nitric oxide (NO) to inhibit mitochondrial respiration (OXPHOS), while promoting glycolytic metabolism in GM-DCs, which do not express iNOS naturally.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nicole E. Mihalik, Sijin Wen, Benoit Driesschaert, Timothy D. Eubank
Summary: GM-CSF-loaded PLGA/PLGA-PEG NPs were successfully developed and evaluated in vitro as a potential candidate for in vivo administration, showing promising results for future tumor immunotherapy applications.
Article
Medicine, Research & Experimental
Shuguang Zhao, Shaohua Li, Jingci Yang, Weinian Gao, Ziying Chen
Summary: This study examined the effect of HDAC inhibitor, trichostatin A (TSA), on the differentiation of bone marrow cells to myeloid-derived suppressor cells (MDSCs). The results showed that TSA enhanced the differentiation of bone marrow cells to MDSCs. Transplantation of MDSCs effectively suppressed T cell proliferation and increased the recruitment of Treg to the grafts, leading to prolonged graft survival.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Cell Biology
Lena Batoon, Amy J. Koh, Rahasudha Kannan, Laurie K. McCauley, Hernan Roca
Summary: This study introduced a novel inducible caspase-9 (iCasp9) mouse model that allowed targeted cell apoptosis and further investigation of efferocytosis. The unique feature of this model, controlled by any Cre-expressing mouse lines, holds extensive potential applications and provides more insights into the diversity of mechanisms and cellular effects induced by apoptosis.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Elias D. Buhrer, Michael A. Amrein, Stefan Forster, Stephan Isringhausen, Christian M. Schuerch, Salil S. Bhate, Tess Brodie, Joel Zindel, Deborah Stroka, Mohamad Al Sayed, Cesar Nombela-Arrieta, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
Summary: The study demonstrated that in CML, LSCs preferentially accumulate in the spleen, where red pulp macrophages form a niche for maintaining LSCs, leading to disease progression and resistance to therapy.