Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian
Summary: This study revealed that MRSA-derived MVs are capable of reducing the pathogen's susceptibility to VAN, thereby increasing its resistance to treatment, particularly in interactions with human neutrophils. Additionally, the elevated expression of proteins associated with antibiotic resistance in MVs may further impact MRSA's resistance.
Article
Infectious Diseases
Cheng-En Tsai, Chia-Jui Yang, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study aimed to determine the synergistic effects of combining CPT with DAP, VAN, or LNZ against different MRSA strains. The results showed that the CPT-DAP combination exhibited significant synergistic bactericidal effects, while the CPT-VAN and CPT-LNZ combinations did not show synergistic activity. Therefore, DAP may be a better choice for combination therapy with CPT in the treatment of MRSA infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biotechnology & Applied Microbiology
Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie, Rong Gui
Summary: A novel nano-drug delivery system, PLT@Ag-MOF-Vanc, was constructed for the treatment of MRSA infections, showing good antibacterial activity, biocompatibility, and targeting capabilities. It killed MRSA through multiple approaches and demonstrated superior anti-infective effects in a mouse MRSA pneumonia model compared to free vancomycin.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pathology
Jill Parkes-smith, Haakon Bergh, Patrick N. A. Harris
Summary: Staphylococcus aureus bacteraemia has high morbidity and mortality, and timely use of effective antibiotics is crucial. Molecular diagnostics can shorten the time from blood culture positivity to identification of MRSA or MSSA.
Article
Immunology
Yifei Lu, Yingran Wang, Jing Wang, Yan Zhao, Qiu Zhong, Gang Li, Zhifeng Fu, Shuguang Lu
Summary: Endolysin LysP108 demonstrates promising antibacterial potential as it can lyse bacterial cell walls, inhibit bacterial biofilms, and work synergistically with vancomycin to reduce abscess size in MRSA-infected mice. The results indicate strong bactericidal effects against MRSA and the ability to significantly reduce subcutaneous abscess size when used in combination with vancomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nur Najihah Izzati Mat Rani, Xiang Yi Chen, Zahraa M. Al-Zubaidi, Hanisah Azhari, Tzar Mohd Nizam Khaitir, Pei Yuen Ng, Fhataheya Buang, Geok Chin Tan, Yin Ping Wong, Mazlina Mohd Said, Adeel Masood Butt, Azmy A. Hamid, Mohd Cairul Iqbal Mohd Amin
Summary: This study focused on the encapsulation of vancomycin into liposomes coated with a red blood cell membrane with a targeting ligand, and successfully achieved targeted drug delivery to bacterial cells. The conjugation of the targeting ligand was confirmed through various analyses, and the formulation exhibited controlled drug release. In vitro and in vivo experiments demonstrated the high antibacterial efficacy of the formulation against MRSA, with low toxicity to mammalian cells and human erythrocytes.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Immunology
Marin L. Schweizer, Kelly Richardson, Mary S. Vaughan Sarrazin, Michihiko Goto, Daniel J. Livorsi, Rajeshwari Nair, Bruce Alexander, Brice F. Beck, Michael P. Jones, Mireia Puig-Asensio, Daniel Suh, Madeline Ohl, Eli N. Perencevich
Summary: Among patients with methicillin-resistant Staphylococcus aureus bloodstream infections, switching to daptomycin is associated with lower 30-day mortality, especially when done within 3 days of initial vancomycin receipt. However, switching to daptomycin at any time during the first hospitalization did not significantly affect 30-day mortality.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Mengli Jin, Shuyue Zhu, Yating Tang, Xiangri Kong, Xingye Wang, Yufen Li, Shuang Jiang, Lin Wei, Chunjie Hu, Bingmei Wang, Wu Song
Summary: Antimicrobial resistance (AMR) is a global health threat, and there is a need for new anti-infective agents. Ayanin, a flavonoid extracted from Callicarpa nudiflora, was found to be an inhibitor of MRSA ClpP, suggesting its potential therapeutic effect against MRSA infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Pooi Yin Chung, Pey Lin Narissa Loh, Hui-min Neoh, Ramliza Ramli
Summary: Staphylococcus aureus is a significant threat to human health and has developed resistance to conventional antimicrobials. The presence of biofilms complicates treatment for infections caused by multi-drug resistant S. aureus. Alpha-amyrin has been shown to reduce biomass and inhibit metabolic activity of S. aureus. This study demonstrates that alpha-amyrin can reduce biofilm biomass of MSSA, MRSA, and VISA isolates, suggesting its potential as a therapeutic agent for chronic S. aureus infections.
Article
Emergency Medicine
Anthony J. Renzoni, Gary D. Peksa, Joshua M. DeMott
Summary: A study of 116 emergency department patients found that conducting MRSA nasal screening for pneumonia patients did not decrease the duration of anti-MRSA antibiotics. Secondary outcomes showed no significant differences either. Therefore, there is currently no need for ED providers to consider MRSA nasal screening for patients admitted to general medicine.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Polymer Science
Haseena, Muddaser Shah, Khadija Rehman, Adnan Khan, Arshad Farid, Carlotta Marini, Alessandro Di Cerbo, Muhammad Raza Shah
Summary: The emergence of bacterial resistance has increased the economic burden of infectious diseases. This study focused on the synthesis of mannose-coated metal-organic frameworks (MOFs) to enhance the antibacterial activity of therapeutic drugs against resistant Staphylococcus aureus.
Article
Infectious Diseases
Samantha D. Yeager, Justin E. Oliver, Mahmoud A. Shorman, Laurence R. Wright, Michael P. Veve
Summary: This study compared the effectiveness and safety of oral step-down linezolid with standard parenteral therapy in MRSA bloodstream infection. The results showed that linezolid had similar clinical outcomes and safety profiles compared to parenteral therapy, with fewer adverse events requiring re-hospitalization. Additional research is needed to explore the use of step-down linezolid in MRSA bloodstream infection.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Oncology
Qinde Yang, Jing Wang, Yufang Yang, Suting Li, Yujun Dong, Yan Sun
Summary: The study demonstrates that vancomycin hydrogel has a similar antibacterial effect to vancomycin, providing a reference for the development of novel sustained-release vancomycin formulations in the treatment of MRSA.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Motoyasu Miyazaki, Akio Nakashima, Yoshihiko Nakamura, Yuya Sakamoto, Koichi Matsuo, Miwa Goto, Masanobu Uchiyama, Keisuke Okamura, Ryoko Mitsutake, Hidenori Urata, Hidetoshi Kamimura, Osamu Imakyure
Article
Multidisciplinary Sciences
Yutaka Ueda, Kota Mashima, Motoyasu Miyazaki, Shuuji Hara, Tohru Takata, Hidetoshi Kamimura, Satoshi Takagi, Shiro Jimi
SCIENTIFIC REPORTS
(2019)
Article
Medicine, General & Internal
Shiro Jimi, Satoshi Takagi, Francesco De Francesco, Motoyasu Miyazaki, Arman Saparov
MEDICINA-LITHUANIA
(2020)
Article
Environmental Sciences
Motoyasu Miyazaki, Masanobu Uchiyama, Yoshihiko Nakamura, Koichi Matsuo, Chika Ono, Miwa Goto, Ayako Unoki, Akio Nakashima, Osamu Imakyure
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Microbiology
Yutaka Ueda, Motoyasu Miyazaki, Kota Mashima, Satoshi Takagi, Shuuji Hara, Hidetoshi Kamimura, Shiro Jimi
Article
Multidisciplinary Sciences
Shiro Jimi, Seiko Koizumi, Kenji Sato, Motoyasu Miyazaki, Arman Saparov
Summary: The study showed that Pro-Hyp can accelerate muscle tissue regeneration and reduce scars formation. Experimental results indicated that Pro-Hyp is beneficial for wound healing, reducing fibrosis, and promoting muscle regeneration.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Shiro Jimi, Michinobu Yoshimura, Kota Mashima, Yutaka Ueda, Motoyasu Miyazaki, Arman Saparov
Summary: Investigation of drug-resistant mechanisms of intracellular survival in methicillin-resistant S. aureus (MRSA) revealed that biofilm-forming MRSA can escape lysosomes and autophagosomes to survive for more than ten days in host cells.
Article
Infectious Diseases
Yota Yamada, Motoyasu Miyazaki, Hisako Kushima, Yukie Komiya, Koichi Matsuo, Masanobu Uchiyama, Akio Nakashima, Mitsuhiro Kamata, Hiroshi Ishii, Osamu Imakyure
Summary: The study found that the mortality rate of CDI patients classified according to MN criteria is higher than that of non-severely ill patients, which is particularly useful in predicting patient prognosis.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Hisako Kushima, Hiroshi Ishii, Yoshiaki Kinoshita, Yohei Koide, Yukie Komiya, Junko Kato, Mayumi Umehara, Miho Sakata, Motoyasu Miyazaki, Mikihiro Ikuta
Summary: This study aimed to investigate the antibody levels and adverse reactions after COVID-19 vaccination among medical staff with or without a history of COVID-19. The study found that previously infected individuals showed a significant increase in antibody titers after the first and second vaccinations, but the titers started to decrease after a certain period of time. Previously infected individuals had a higher incidence of adverse reactions after the first vaccination compared to non-infected individuals, but the incidence of adverse reactions after the second and third vaccinations was similar.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Motoyasu Miyazaki, Ryoko Yanagida, Akio Nakashima, Koichi Matsuo, Norihiro Moriwaki, Masanobu Uchiyama, Yota Yamada, Hitomi Hirata, Hisako Kushima, Yoshiaki Kinoshita, Hiroshi Ishii, Osamu Imakyure
Summary: This study assessed the efficacy and safety of Remdesivir (RDV) treatment in mildly to moderately ill patients with COVID-19. The results showed that RDV may be highly effective and safe in patients with COVID-19 requiring oxygen therapy.
MEDICINA-LITHUANIA
(2022)
Article
Veterinary Sciences
Shiro Jimi, Arman Saparov, Seiko Koizumi, Motoyasu Miyazaki, Satoshi Takagi
Summary: The study established a novel experimental model of scar-forming wound, which showed lesions similar to human scar lesions. This model has unique value in studying the pathogenesis and preclinical treatment of scar lesions.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Health Care Sciences & Services
Koichi Matsuo, Hisanaga Nomura, Masanobu Uchiyama, Motoyasu Miyazaki, Osamu Imakyure
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Motoyasu Miyazaki, Koichi Matsuo, Masanobu Uchiyama, Yoshihiko Nakamura, Yuya Sakamoto, Momoko Misaki, Kaoko Tokura, Shiro Jimi, Keisuke Okamura, Sen Adachi, Tomohiko Yamamoto, Kazuyuki Shirai, Hidenori Urata, Osamu Imakyure
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
(2020)
Article
Microbiology
Yuki Katayama, Takuya Azechi, Motoyasu Miyazaki, Tohru Takata, Miwa Sekine, Hidehito Matsui, Hideaki Hanaki, Koji Yahara, Hiroshi Sasano, Kota Asakura, Tomoiku Takaku, Tomonori Ochiai, Norio Komatsu, Henry F. Chambers
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)