Article
Critical Care Medicine
Cheleka A. M. Mpande, Munyaradzi Musvosvi, Virginie Rozot, Boitumelo Mosito, Timothy D. Reid, Constance Schreuder, Tessa Lloyd, Nicole Bilek, Huang Huang, Gerlinde Obermoser, Mark M. Davis, Morten Ruhwald, Mark Hatherill, Thomas J. Scriba, Elisa Nemes
Summary: The Delta HLA-DR biomarker can accurately identify individuals with recent QuantiFERON-TB conversion and disease progression, enabling targeted preventive treatment for those at highest risk of tuberculosis. Further validation studies in various settings and at-risk populations are necessary.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jessica Handke, Laura Kummer, Markus A. Weigand, Jan Larmann
Summary: The study found that preoperative expansion of Tregs can mitigate the destabilization of atherosclerotic plaques induced by surgical stress. This suggests that therapeutic expansion of Tregs prior to major surgery may help prevent cardiovascular events associated with non-cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Cong He, Huan Wang, Chen Yu, Chao Peng, Xu Shu, Wangdi Liao, Zhenhua Zhu
Summary: Intestinal tuberculosis (ITB) and Crohn's disease (CD) have distinct gut microbiota profiles, with ITB showing a dominance of Proteobacteria and reduction of Firmicutes, as well as altered functional modules associated with inflammation. In contrast, CD is characterized by lower alpha diversity and increased abundance of specific bacteria, allowing for clear differentiation from ITB.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Zhang, Shuang Song, Haitao Li, Xinyan Wang, Lianlian Song, Jianfei Xue
Summary: Ganoderma lucidum polysaccharide-1 (GLP-1) has been found to alleviate cognitive impairment in mice with chronic cerebral hypoperfusion (CCH) by increasing regulatory T cell levels and regulating cytokine levels as well as abnormal energy metabolism.
Review
Immunology
Mahshid Zohouri, Fereshteh Mehdipour, Mahboobeh Razmkhah, Zahra Faghih, Abbas Ghaderi
Summary: The immune system not only fights infectious diseases, but also helps to combat noninfectious diseases while maintaining the balance between self and non-self discrimination. Understanding the cellular and molecular basis of immune regulation provides better insights into the immune pathology of diseases. One particular subset of CD4(+)T cells, positive for FoxP3 and negative for CD25, has been reported to have a range of functional activities in cancer and autoimmune diseases, but its exact role and functions are still under investigation.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2021)
Article
Immunology
Qiang Liang, Weidong Jin, Zhigang Huang, Huquan Yin, Shengchun Liu, Liehua Liu, Xiangwei Song, Zili Wang, Jun Fei
Summary: This study identified a 3-plasma miRNA combination (hsa-miR-506-3p, hsa-miR-543, hsa-miR-195-5p) that can be used to effectively diagnose spinal tuberculosis and distinguish it from other spinal diseases and pulmonary tuberculosis. The results showed that this miRNA combination can accurately discriminate spinal tuberculosis from other diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ritika Rampal, Saurabh Kedia, Mohamad Nahidul Wari, Deepak Madhu, Amit Kumar Singh, Veena Tiwari, V. Pratap Mouli, Srikant Mohta, Govind Makharia, Vineet Ahuja
Summary: The study validated that the increased frequency of CD4(+)CD25(+)FOXP3(+) Treg in the peripheral blood can be used as a biomarker with high diagnostic accuracy to differentiate ITB from CD.
INTESTINAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Shengjie Tang, Xiangcheng Xie, Ming Wang, Wei Wei
Summary: Interferon intravenous infusion has a good effect on the prevention and treatment of stroke patients, but due to its high price, it should be used with caution. This study demonstrates that treatment with interferon can significantly reduce the mortality and disability rate of stroke patients, providing a new treatment option for clinical practice.
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Food Science & Technology
Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo, Jinhong Hu, Lina Zhu, Xiaole Cui, Bing Chen, Lingling Li, Congli Cai, Haobo Cui, Tianli Yue
Summary: This study found that obesity induced by a high-fat diet leads to osteoporosis, but it is unclear whether the high-fat diet itself promotes osteoclastogenesis and bone loss. The results showed that non-obese mice are protected from bone loss induced by a high-fat diet through gut microbiome regulation.
NPJ SCIENCE OF FOOD
(2023)
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Wafaa Mohamed Abd El-Magid, Sheren F. M. Ahmed, Hanan Assaf, Reham Ebraheem Abd Elkhalek, Marwa Mohamed
Summary: This study evaluated the expression of regulatory T cell markers in pemphigus patients and found a significant reduction of these cells in the lesional skin, indicating their importance in the pathogenesis of pemphigus.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Immunology
Muthya Pragun Acharya, Sai Pallavi Pradeep, Venkataramappa Srinivasa Murthy, Panduranga Chikkannaiah, Vivekanand Kambar, Satyanarayana Narayanashetty, Sharath Burugina Nagaraja, Dr Niveditha, Raksha Yoganand, Vijaya Satchidanandam
Summary: The study found that the Mtb-specific CD38(+)CD27(-)TNF-α(+)CD4(+) T-cell subset can serve as a robust biomarker for diagnosing and assessing cure of tuberculosis. Experiments with this biomarker showed significant efficacy in distinguishing infected individuals with active tuberculosis from those without disease.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Computer Science, Artificial Intelligence
Yinghao Chen, Ying Li, Minfeng Wu, Fanggen Lu, Muzhou Hou, Yani Yin
Summary: Crohn's disease and intestinal tuberculosis have similarities in clinical manifestations and imaging features, making differentiation challenging. A fusion correlation neural network is proposed to diagnose these conditions, with an average accuracy exceeding 91%.
KNOWLEDGE-BASED SYSTEMS
(2022)
Review
Gastroenterology & Hepatology
Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W. Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ajuja, Nicola Panaccione, Abdel-Azi Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabian Juliao-Banos, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao, Maojuan Li
Summary: This study investigates the hospitalization rates of inflammatory bowel disease (IBD) in different regions of the world and finds that while the rates are stabilizing in developed countries, they are rapidly increasing in newly industrialized countries, leading to a growing burden on global healthcare systems.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P. Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen G. C. McGregor, Tim Ambrose, Bruce D. George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P. L. Travis, Jack Satsangi
Summary: The changes in acute severe colitis (ASC) management have resulted in improved outcomes. A simple predictive model can be used to identify patients who will not respond to steroids upon admission.
Article
Gastroenterology & Hepatology
Arshdeep Singh, Vandana Midha, Vikram Narang, Saurabh Kedia, Ramit Mahajan, Pavan Dhoble, Bhavjeet Kaur Kahlon, Ashvin Singh Dhaliwal, Ashish Tripathi, Shivam Kalra, Narender Pal Jain, Namita Bansal, Rupa Banerjee, Devendra Desai, Usha Dutta, Vineet Ahuja, Ajit Sood
Summary: The prevalence of concomitant PSC in IBD patients is low in India, and it is associated with a lower rate of development of malignancies. Male sex, pancolitis (UC) or colonic CD are more commonly associated with PSC-IBD.
INTESTINAL RESEARCH
(2023)
Letter
Gastroenterology & Hepatology
Akshita Gupta, Saurabh Kedia, Vineet Ahuja
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Infectious Diseases
U. B. Singh, Y. Ray, S. Kanswal, H. P. Sharma, A. K. Aayilliath, N. Wig, V. Ahuja, A. Biswas, T. Velpandian
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Gastroenterology & Hepatology
Sophie Vieujean, James O. Lindsay, Ferdinando D'Amico, Vineet Ahuja, Mark S. Silverberg, Ajit Sood, Jesus K. Yamamoto-Furusho, Masakazu Nagahori, Mamoru Watanabe, Ioannis E. Koutroubakis, Kalliopi Foteinogiannopoulou, Irit Avni Biron, Alissa Walsh, An Outtier, Rie Louise Moller Nordestgaard, Maria T. Abreu, Marla Dubinsky, Corey Siegel, Edouard Louis, Iris Dotan, Walter Reinisch, Silvio Danese, David T. Rubin, Laurent Peyrin-Biroulet
Summary: This study analyzes the reasons for non-enrollment of IBD patients in RCTs and finds that patients are lost at each step, with eligibility criteria, the risk of placebo assignment, and insufficient disease activity being the main barriers.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Arti Gupta, Sudheer K. Vuyyuru, Bhaskar Kante, Peeyush Kumar, Mariyam Farooqui, Mukesh K. Ranjan, Neha Singh, Sandeep K. Mundhra, Divya Madan, Rithvik Golla, Namrata Singh, Govind Makharia, Saurabh Kedia, Vineet Ahuja
Summary: This observational study found that the prevalence of NAFLD in patients with UC is approximately a quarter and is associated with metabolic parameters rather than disease activity.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2024)
Editorial Material
Gastroenterology & Hepatology
Karan Sachdeva, Saurabh Kedia, Vineet Ahuja
INDIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Aditya Vikram Pachisia, Alka Kumari, Shubham Mehta, Anam Ahmed, Ashish Chauhan, Ankit Agarwal, Vignesh Dwarkanathan, Sachin Rajpoot, Shubham Prasad, Sanjay Kumar, Saroj Kant Sinha, Divya Sharma, Mahender Rajput, Prasenjit Das, Sushil Falodia, Rakesh Kochhar, Bs Ramakrishna, Vineet Ahuja, Govind Makharia
Summary: The study validates whether the titers of anti-tTG antibodies can predict villous abnormalities in Asian adult patients with CeD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Sasi, V. Ahuja, U. Arora, A. Razik, S. Kedia, P. Das, R. Singh Jadon, M. Soneja, N. Wig
Summary: This study aimed to explore the possibility of using CT perfusion imaging to monitor the response to anti-tubercular therapy in patients with intestinal tuberculosis. The results showed significant alterations in CT perfusion parameters following treatment, consistent with a decline in inflammation and vascularity.
CLINICAL RADIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Maia Kayal, Jean Frederic Colombel
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Aditya Bajaj, Manasvini Markandey, Mukesh Singh, Pabitra Sahu, Sudheer K. Vuyyuru, Bhaskar Kante, Peeyush Kumar, Mahak Verma, Govind Makharia, Saurabh Kedia, Simon P. L. Travis, Vineet Ahuja
Summary: The study found that exclusive enteral nutrition (EEN) supplementation with corticosteroid therapy can alter gut microbial composition in patients with acute severe ulcerative colitis (ASUC), increasing the abundance of beneficial bacteria and correlating with clinical parameters and disease activity scores.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Shubham Mehta, Ankit Agarwal, Aditya Vikram Pachisia, Alka Singh, Sana Dang, Dwarakanathan Vignesh, Anam Ahmed, Bodhisattya Roy Chaudhari, Shubham Prasad, Ritik Mahaveer Goyal, Amitkumar Chavan, Aagamjit Singh, Sanjay Kumar, Divya Sharma, Ashish Chauhan, Mahendra Singh Rajput, Sachin Rajput, Prasenjit Das, Sushil Falodia, Saroj Kant Sinha, Rakesh Kochhar, Vineet Ahuja, Govind K. Makharia
Summary: Delayed diagnosis of celiac disease leads to increased severity of symptoms, highlighting the need for increased sensitivity in diagnosing celiac disease in appropriate clinical settings.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Surgery
Vitish Singla, Sukhda Monga, Arun Kumar, Bhanu Yadav, Tamoghna Ghosh, Sandeep Aggarwal
Meeting Abstract
Gastroenterology & Hepatology
Aditya Vikram Pachisia, Ankit Agarwal, Shubham Mehta, Alka Kumari, Anam Ahmed, Shubham Prasad, Vignesh Dwarkanathan, Sonu Sharma, Sambuddha Kumar, Prasenjit Das, Rimlee Dutta, Shalimar Shalimar, Vineet Ahuja, Govind Makharia
JOURNAL OF HEPATOLOGY
(2023)