Article
Multidisciplinary Sciences
Yanfei Li, Zhenpeng Liao, Rong Wang, Zibin Liang, Zhihe Lin, Shiqi Deng, Lei Chen, Zhigang Liu, Shaoyan Feng
Summary: This study reveals that SPRY4-IT1 is significantly up-regulated in nasopharyngeal carcinoma (NPC) cells and its knockdown inhibits cell proliferation, migration, and metastasis. Furthermore, knockdown of SPRY4-IT1 leads to cell cycle arrest and increased apoptosis. These findings suggest that SPRY4-IT1 could be a potential therapeutic target for the treatment of NPC.
Article
Medicine, Research & Experimental
Guodong Liu, Xiwu Ouyang, Liansheng Gong, Lei Yao, Shiqing Liu, Jiarong Li, Qi Zhang, Yao Xiao
Summary: The study reveals the crucial role of circ-PRKAR1B in liver cancer progression, promoting cancer advancement through the miR-432-5p/E2F3 pathway. Clinical data and animal experiments further confirm the significance of this newly identified signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Weicong Sang, Rujian Zhu, Dong Liu, Min Gong
Summary: The expression of SPRY4-IT1 is upregulated in prostate cancer tissues and cell lines, and is further increased under hypoxic conditions. Knockdown of SPRY4-IT1 expression leads to S-phase arrest, decreased expression of cell cycle-associated proteins, and reduced AKT phosphorylation. These findings indicate that SPRY4-IT1 promotes prostate cancer cell proliferation through regulation of the cell cycle and the PI3K/AKT signaling pathway, providing a basis for targeted therapy development.
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lin Zhao, Longyang Jiang, Ming Zhang, Qiang Zhang, Qiutong Guan, Yalun Li, Miao He, Jingdong Zhang, Minjie Wei
Summary: SPRY4-IT1 promotes colorectal, breast, and ovarian cancer metastasis through STAU1-mediated mRNA decay, affecting TCEB1 mRNA stability and expression. The study reveals a novel mechanism of SPRY4-IT1 in cancer metastasis.
Article
Biochemistry & Molecular Biology
Yulu Zhang, Hongling Chen, Renjie Yuan, Yange Wang, Dian Zhang, Qian Zeng, Weiqian Jiang, Ruiming Zhang, Tingmei Chen, Chengsen Chai, Bianqin Guo
Summary: In this study, it was found that PDK1 regulated the lncRNA SPRY4-IT1 in breast cancer cells, leading to enhanced stability and promoting tumor progression. SPRY4-IT1 was highly expressed in breast cancer and played a crucial role in cell proliferation and inhibition of apoptosis. The PDK1/SPRY4-IT1/NFKBIA axis was identified as a potential therapeutic target in breast cancer.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, Research & Experimental
Zhibo Tan, Peitao Zhou, Zhenru Zhu, Ying Wang, Zeqin Guo, Mengying Shen, Yazhi Xiao, Weixi Shen, Dehua Wu
Summary: The study reveals that in esophageal squamous cell carcinoma (ESCC), long non-coding RNA LincIN is significantly overexpressed and exerts an oncogenic role through the regulation of the NF90/miR-7/HOXB13 axis. This suggests that LincIN may serve as a potential prognostic biomarker and therapeutic target for ESCC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yan Liu, Hejia Zhang, Hui Wang, Jiarui Du, Peng Dong, Meihan Liu, Yuanqiang Lin
Summary: The study investigated the role of lncRNA DUXAP8 in papillary thyroid carcinoma (PTC) and found that DUXAP8 promoted the proliferation, migration, and invasion of PTC cells. This effect was partly dependent on the miR-223-3p/CXCR4 axis.
Article
Oncology
Yanping Liu, Chengguang Hu, Xiaoyong Qu, Honghui Chen, Logen Liu, Linlin Zhou, Side Liu, Guoqing Li, Yuanping Zhou
Summary: ASAP1-IT1 is significantly upregulated in hepatocellular carcinoma (HCC), and higher levels are associated with poorer prognosis. It is mainly localized in the nucleus of hepatoma cells and plays a critical role in cell proliferation and migration, potentially promoting proliferation and migration of HCC cells by interacting with miR-221-3p.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qiuyan Zhao, Zhonglin Zhu, Wenqin Xiao, Guanzhao Zong, Chuanyang Wang, Weiliang Jiang, Kai Li, Jie Shen, Xingya Guo, Jianhua Cui, Lihong Guo, Rong Wan
Summary: This research reveals that the hypoxic conditions within pancreatic tumors promote the production of a circular RNA molecule called circRNF13, which is associated with aggressive tumor growth. High levels of circRNF13 are linked to a poor prognosis and it modulates downstream targets that contribute to tumor progression, providing new targets for drug development.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Ji Huang, Qiu-Ming He, Qi Wu, Wei-Min Zhou, Chao Hao, Gong-Xian Wang, Xin-Hua Tu
Summary: The long non-coding RNA 00858 (LINC00858) is found to be upregulated in bladder cancer tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion of bladder cancer cells by regulating the miR-3064-5p/CTGF axis.
Article
Oncology
Ji Wang, Yanming Chen, Qing Wang, Hui Xu, Qianqian Jiang, Man Wang, Shenggang Li, Ying Chen, Chunwang Wu, Pei Yu, Zongyu Xiao, Wenjin Chen, Qing Lan
Summary: SPRY4-IT1 is overexpressed in glioma and correlates with poor prognosis. It promotes glioma cell proliferation and angiogenesis by upregulating EZH2 through sponging miR-101-3p to induce VEGFA expression.
Article
Oncology
Yu Wen, Bin Li, Ming He, Songling Teng, Yuxiu Sun, Guangbin Wang
Summary: The study revealed that circHIPK3 was upregulated in osteosarcoma and promoted cell proliferation, migration, and invasion by sponging miR-637 to increase HDAC4 expression. This circHIPK3/miR-637/HDAC4 axis plays a crucial role in the progression of osteosarcoma.
Article
Oncology
Christian Cedric Bongolo, Erick Thokerunga, Nyimi Bushabu Fidele, Tapara Dramani Maman Souraka, Peter Kisembo, Simon Peter Rugera, Paul F. Worley, Jian-Cheng Tu
Summary: The study demonstrated that the lncRNA, LIPCAR is significantly upregulated in hepatocellular carcinoma patients and that its upregulation promotes HCC proliferation, migration, and metastases.
Article
Oncology
Yingying Chen, Ying Zhang
Summary: This study reveals the crucial role of circDLG1 in the malignant progression of NSCLC. It interacts with miR-630 and CENPF to regulate the behavior of NSCLC cells. This finding provides a promising molecular target for the treatment of NSCLC.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
