Article
Oncology
Shu Jiang, Debbie L. Bennett, Bernard A. Rosner, Graham A. Colditz
Summary: This study found that the rate of change in breast density was associated with the risk of subsequent breast cancer. Incorporation of longitudinal changes into existing models could optimize risk stratification and guide more personalized risk management.
Review
Radiology, Nuclear Medicine & Medical Imaging
Tone Hovda, Kaitlyn Tsuruda, Solveig Roth Hoff, Kristine Kleivi Sahlberg, Solveig Hofvind
Summary: The study reviewed mammograms for 1225 women with screen-detected breast cancer. Results showed that visible findings on prior screening mammograms were not necessarily indicative of screening failure. Some cases were classified as missed, aiming to improve the quality of breast cancer screening.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristin Johnson, Kristina Lang, Debra M. Ikeda, Anna Akesson, Ingvar Andersson, Sophia Zackrisson
Summary: Interval cancer rates were lower in DBT screening compared to DM screening, potentially indicating screening benefits. Interval cancers in the trial generally exhibited nonfavorable characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierpaolo Pattacini, Andrea Nitrosi, Paolo Giorgi Rossi, Stephen W. Duffy, Valentina Iotti, Vladimiro Ginocchi, Sara Ravaioli, Rita Vacondio, Pamela Mancuso, Moira Ragazzi, Cinzia Campari
Summary: The baseline cancer detection was higher in the DBT plus DM arm compared to the DM arm, but the interval cancer incidence was similar between the two groups. Cumulative incidence remained higher in women over 50 in the DBT plus DM arm, while it was similar in women aged 45-49.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jose Luis Raya-Povedano, Sara Romero-Martin, Esperanza Elias-Cabot, Albert Gubern-Merida, Alejandro Rodriguez-Ruiz, Marina Alvarez-Benito
Summary: Using artificial intelligence systems in breast cancer screening can significantly reduce workload without compromising cancer detection rates, according to the study.
Review
Radiology, Nuclear Medicine & Medical Imaging
Raymond J. Acciavatti, Su Hyun Lee, Beatriu Reig, Linda Moy, Emily F. Conant, Despina Kontos, Woo Kyung Moon
Summary: Breast density is an independent risk factor for breast cancer and can be assessed visually using digital mammography and tomosynthesis. In addition to density, textural complexity is also a measure of breast cancer risk. Other screening modalities like breast US and MRI offer independent risk measures as well.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rossano Girometti, Anna Linda, Paola Conte, Michele Lorenzon, Isabella De Serio, Katerina Jerman, Viviana Londero, Chiara Zuiani
Summary: The study found that preoperative contrast-enhanced spectral mammography (CEM) had better ability to detect additional cancer lesions in breast cancer patients compared to digital mammography plus digital breast tomosynthesis (DM + DBT), especially in dense breasts. CEM and DM + DBT showed similar performance in cancer size assessment.
Article
Oncology
Kanako Ban, Hiroko Tsunoda, Seiko Togashi, Yuko Kawaguchi, Takanobu Sato, Yoko Takahashi, Yoshitaka Nagatsuka
Summary: This study confirmed that using digital breast tomosynthesis (DBT) for breast cancer screening in Japanese women can improve the recall rate, decrease positive predictive value, and reduce the detection of focal asymmetric density (FAD). There was no significant difference in cancer detection rates between the DBT group and digital mammography group, only confirming the non-inferiority of DBT.
Article
Genetics & Heredity
Ji Li, Jiayue Qiu, Junwei Han, Xiangmei Li, Ying Jiang
Summary: This study found a significant association between tumor microenvironment (TME) infiltration and survival rates and treatment outcomes in breast cancer patients. By developing a nine-pathway-based TME-related risk model to predict the prognosis of breast cancer patients, it was discovered that patients in the IPRS-low group had significantly better overall survival rates compared to the IPRS-high group. Furthermore, IPRS-low patients exhibited a strong immune response and were enriched in multiple immune-associated signaling pathways.
Article
Medicine, General & Internal
Ya-Chen Tina Shih, Wenli Dong, Ying Xu, Ruth Etzioni, Yu Shen
Summary: The study evaluated the cost-effectiveness of breast cancer screening strategies stratified by breast density, concluding that baseline mammography at age 40 is effective and cost-effective.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sahand Hooshmand, Warren M. Reed, Mo'ayyad E. Suleiman, Patrick C. Brennan
Summary: The prototype of a new innovative risk model, Breast-iRRISC, is designed to evaluate the total risk involved with screening mammography for each individual female using information gathered from a single mammographic examination. This novel tool demonstrates the applicability of personalized risk assessment in informing clinical decision-making and health policy regarding breast cancer screening.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Natalia Siminiak, Anna Pasiuk-Czepczynska, Antonina Godlewska, Piotr Wojtys, Magdalena Olejnik, Joanna Michalak, Piotr Nowaczyk, Pawel Gajdzis, Dariusz Godlewski, Marek Ruchala, Rafal Czepczynski
Summary: This study evaluated the diagnostic performance of CEM and DBT in women recalled from a breast cancer screening program. The results showed that CEM and DBT had similar diagnostic accuracy and outperformed FFDM. CEM had a sensitivity of 97% and DBT had a sensitivity of 100%.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Marcel Opitz, Sebastian Zensen, Katharina Breuckmann, Denise Bos, Michael Forsting, Oliver Hoffmann, Martin Stuschke, Axel Wetter, Nika Guberina
Summary: This study compared the radiation dose delivered by digital breast tomosynthesis (DBT) and digital mammography (FFDM) in a clinical follow-up setting. The results showed that the radiation dose was significantly higher for DBT in the mediolateral oblique (MLO) views compared to FFDM, but still below the national diagnostic reference level.
Article
Cell Biology
Mikael Eriksson, Stamatia Destounis, Kamila Czene, Andrew Zeiberg, Robert Day, Emily F. Conant, Kathy Schilling, Per Hall
Summary: Screening with digital breast tomosynthesis (DBT) improves breast cancer detection and reduces false positives. A DBT-based risk model was developed and validated, which can predict the occurrence of breast cancer. By using imaging features and age for risk assessment, our model can assist radiologists in selecting women for clinical care, leading to earlier detection and improved prognoses.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulia Bicchierai, Simone Busoni, Paolo Tortoli, Silvia Bettarini, Federica Di Naro, Diego De Benedetto, Elena Savi, Chiara Bellini, Vittorio Miele, Jacopo Nori
Summary: This retrospective study compares the radiation dose received during CEDM, short and long protocol (CEDM SP and CEDM LP), with dose received during DM and DBT. The results show that CEDM SP results in higher radiation exposure compared with conventional DM and DBT but lower than the Combo mode. The dose administered during the CEDM SP is lower in patients with dense breasts regardless of their size.
ACADEMIC RADIOLOGY
(2022)
Article
Medicine, General & Internal
Maria Lourdes Garza-Rodriguez, Victor Trevino, Antonio Ali Perez-Maya, Hazyadee Frecia Rodriguez-Gutierrez, Moises Gonzalez-Escamilla, Miguel Angel Elizondo-Riojas, Genaro A. Ramirez-Correa, Oscar Vidal-Gutierrez, Carlos Horacio Burciaga-Flores, Diana Cristina Perez-Ibave
Summary: In this study, a novel pathogenic germline variant in the APC gene was identified using NGS. The variant was confirmed in multiple family members and associated with atypical clinical symptoms. This variant is classified as a PVS1 variant according to ACMG guidelines, providing evidence for early surveillance and suitable treatment in patients with the variant.
Article
Biochemistry & Molecular Biology
Maria Lourdes Garza-Rodriguez, Mariel Araceli Oyervides-Munoz, Antonio Ali Perez-Maya, Celia Nohemi Sanchez-Dominguez, Anais Berlanga-Garza, Mauro Antonio-Macedo, Lezmes Dionicio Valdes-Chapa, Diego Vidal-Torres, Oscar Vidal-Gutierrez, Diana Cristina Perez-Ibave, Victor Trevino
Summary: The study found multiple HPV infections in early-stage cervical lesions, with most integration events being unique and breakpoints occurring in various parts of the viral genome. Host genome integration frequencies were high and related to previously reported integration sites in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Diana A. Vela-Vasquez, Ana M. Sifuentes-Rincon, Ivan Delgado-Enciso, Osiris G. Delgado-Enciso, Cynthia Ordaz-Pichardo, Williams Arellano-Vera, Victor Trevino-Alvarado
Summary: This study found that the fatty acid composition of Wagyu-Cross beef significantly impacted lipid metabolism in consumers, compared to commercial beef. The results support redirecting cattle breeding strategies and promoting beef as a healthier protein source.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Biology
Fahimeh Nezhadmoghadam, Jose Tamez-Pena
Summary: This study aims to determine reliable and clinically relevant risk profiles by analyzing risk factors in COVID-19 patients in an unsupervised manner. Through research on patients from the Mexican Open Registry, multiple distinct positive and negative COVID-19 risk profiles were identified, with significant statistical differences between them.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Fahimeh Nezhadmoghadam, Antonio Martinez-Torteya, Victor Trevino, Emmanuel Martinez, Alejandro Santos, Jose Tamez-Pena
Summary: Through consensus clustering, three different latent classes were successfully discovered among MCI subjects, with two potentially representing two different prodromal presentations of Alzheimer's disease.
CURRENT ALZHEIMER RESEARCH
(2021)
Article
Virology
Victor Trevino, Mariel Oyervides, Genaro A. Ramirez-Correa, Lourdes Garza
Summary: Genomic experiments analyzing human papillomaviruses (HPVs) require a carefully selected list of sequences as a reference database to map millions of reads. However, existing sources are organized based on variations in the L1 gene and use complex multiple sequence alignments, complicating the process and leading to per-analysis-defined databases.
ARCHIVES OF VIROLOGY
(2022)
Review
Genetics & Heredity
Sarah G. Ayton, Martina Pavlicova, Carla Daniela Robles-Espinoza, Jose G. Tamez Pena, Victor Trevino
Summary: This study systematically assessed the ability of multiomics cancer subtyping methods to capture cancer prognosis and found that latent-variable subtyping methods better identify clinically prognostic cancer subtypes.
GENETICS IN MEDICINE
(2022)
Article
Clinical Neurology
Jose Tamez-Pena, Peter Rosella, Saara Totterman, Edward Schreyer, Patricia Gonzalez, Arun Venkataraman, Steven P. Meyers
Summary: This study aims to determine and characterize the association between structural MRI and Diffusion Tensor Imaging (DTI) features and mild traumatic brain injuries (mTBI) in student athletes with post-concussive syndrome (PCS). By analyzing the MRI images and extracting radiomic features, a predictive model was built and it was observed that white matter features were strongly associated with brain injury.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biology
Debora Garza-Hernandez, Karol Estrada, Victor Trevino
Summary: This study applied a robust multivariate analysis to predict CD risk and identified LDpred as the best model. By utilizing the important variants yielded by the models, an unnoticed region potentially contributing to CD risk was identified.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Martha Rebeca Canales Fiscal, Victor Trevino, Luis Javier Ramirez Trevino, Rocio Ortiz Lopez, Servando Cardona Huerta, Victor Javier Lara-Diaz, Jose Gerardo Tamez Pena
Summary: This comprehensive study explores the potential role of thermal imaging in remotely detecting respiratory issues related to COVID-19. The results indicate that thermal imaging is not reliable enough for COVID-19 detection and cannot be used as a mass screening tool.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Oncology
Liliana Gomez-Flores-Ramos, Angelica Leticia Barraza-Arellano, Alejandro Mohar, Miguel Trujillo-Martinez, Lizbeth Grimaldo, Rocio Ortiz-Lopez, Victor Trevino
Summary: This study identified breast cancer-associated genes in young, Mexican women through genetic analysis. The results revealed both well-known genes and rarely reported variants in this population. Furthermore, candidate causal genes were successfully assigned to a significant portion of patients, which could contribute to improved diagnosis, treatment, and life expectancy in young women with breast cancer.
Article
Nutrition & Dietetics
Diana A. Vela-Vasquez, Ana M. Sifuentes-Rincon, Ivan Delgado-Enciso, Cynthia Ordaz-Pichardo, Williams Arellano-Vera, Victor Trevino-Alvarado
Summary: This study found that high monounsaturated fat beef can be included in weight-loss programs as it does not affect weight loss and does not have a negative influence on lipid metabolism.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Fahimeh Nezhadmoghadam, Jose Tamez-Pena
Summary: This paper investigates the ability of unsupervised learning methods to identify reproducible disease subtypes, focusing on patients with MCI and their conversion risk to Alzheimer's disease. A novel methodology utilizing consensus clustering successfully identified four distinct subtypes of MCI patients.
2022 9TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS RESEARCH AND APPLICATIONS, ICBRA 2022
(2022)
Meeting Abstract
Psychology, Clinical
P. Gonzalez, P. Rosella, S. Totterman, E. Schreyer, A. Venkataraman, S. Meyers, J. Tamez-Pena
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Plant Sciences
Laura Carmona-Salazar, Rebecca E. Cahoon, Jaime Gasca-Pineda, Ariadna Gonzalez-Solis, Rosario Vera-Estrella, Victor Trevino, Edgar B. Cahoon, Marina Gavilanes-Ruiz
Summary: This study demonstrates that sphingolipid species in different membrane sources vary in concentration, diversity, and predominance, with each membrane containing its own specific assortment based on the proportion of sphingolipid classes and the predominance of individual species.