Article
Medicine, General & Internal
Raila Aro, Sanna Merilainen, Paivi Sirnio, Juha P. Vayrynen, Vesa-Matti Pohjanen, Karl-Heinz Herzig, Tero T. Rautio, Elisa Makarainen, Reetta Haivala, Kai Klintrup, Markus J. Makinen, Juha Saarnio, Anne Tuomisto
Summary: Sarcopenia and myosteatosis are associated with the inflammatory marker NLR in colorectal cancer patients, but not with mGPS. Patients with serrated CRC may have an increased risk of myosteatosis. However, sarcopenia and myosteatosis are not independent predictors of patient survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yingqi Wang, Andrew Chang, Wei Phin Tan, Joseph J. Fantony, Ajay Gopalakrishna, Gregory J. Barton, Paul E. Wischmeyer, Rajan T. Gupta, Brant A. Inman
Summary: The study aimed to determine the impact of nonmodifiable risk factors, modifiable lifestyle risk factors, or cancer-related factors on body composition changes and sarcopenia in bladder cancer survivors. Results showed that lifestyle factors like diet quality and physical activity are not associated with skeletal muscle mass, suggesting limited impact on sarcopenia.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Oncology
Wei Hong, Ang Li, Yanhong Liu, Xiangjun Xiao, David C. Christiani, Rayjean J. Hung, James McKay, John Field, Christopher Amos, Chao Cheng
Summary: Analysis of whole-exome sequencing data reveals correlations between clonal hematopoiesis and lung cancer risk factors, identifies genetic variants associated with clonal hematopoiesis, and uncovers numerous potential novel clonal hematopoiesis mutations.
Article
Nutrition & Dietetics
Marius Kemper, Isabel Molwitz, Linda Krause, Matthias Reeh, Christoph Burdelski, Stefan Kluge, Jin Yamamura, Jakob R. Izbicki, Geraldine de Heer
Summary: The linear association of computer tomography derived muscle parameters with important clinical outcomes post esophagectomy is unclear, partly due to varying cut-off values for defining sarcopenia. The study results suggest that poor muscle status determined by CT imaging is not sufficient reason to deny a patient an oncologic resection.
CLINICAL NUTRITION
(2021)
Article
Oncology
Marius Kemper, Nathaniel Melling, Linda Krause, Kjell Kuehn, Julia-Kristin Gra, Jakob R. Izbicki, Laura Gerdes, Gerhard Adam, Jin Yamamura, Isabel Molwitz
Summary: This study found that an increase in MRA was associated with fewer postoperative complications, shorter hospital stays, and prolonged survival. No relevant associations were found between SMI and postoperative complications, hospital stays, or survival. Therefore, MRA may be a more reliable tool for identifying high-risk patients with poor muscle status before colorectal surgery.
Article
Geriatrics & Gerontology
Jing-jin Jiang, Si-min Chen, Jing Chen, Li Wu, Jin-ting Ye, Qin Zhang
Summary: This study aimed to investigate the relationship between serum IGF-1 levels and sarcopenia in older individuals. The results showed that serum IGF-1 levels were correlated with ASMI in elderly men but not with grip strength. There was no significant relationship between serum IGF-1 levels and ASMI or grip strength in elderly women. Higher serum IGF-1 levels were associated with a lower prevalence of sarcopenia in elderly men but not in elderly women.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dexin Yang, Yuqin Feng, Haohua Lu, Kelie Chen, Jinming Xu, Peiwei Li, Tianru Wang, Dajing Xia, Yihua Wu
Summary: This study aimed to identify subtypes of genomic variants associated with the efficacy of immune checkpoint inhibitors (ICIs). The results showed that lung cancer patients with KRAS(G12C) mutation combined with TP53 mutation exhibited promising efficacy with ICI therapy. However, classical activating mutations of EGFR had negative effects on the survival outcomes, while USH2A missense mutation was associated with better outcomes.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastien Mule, Ali Serhal, Athena Galletto Pregliasco, Jessica Nguyen, Camila Lopes Vendrami, Edouard Reizine, Guang-Yu Yang, Julien Calderaro, Giuliana Amaddeo, Alain Luciani, Frank H. Miller
Summary: This study evaluated the ability of preoperative MRI to predict the most frequent subtypes of HCC in North American and European patients treated with surgical resection. The results showed that MRI can predict the characteristics of different HCC subtypes, which has important implications for future treatment and management.
EUROPEAN RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Nadjia Amini, Jolan Dupont, Laurence Lapauw, Laura Vercauteren, Leen Antonio, Terence W. W. O'Neill, Dirk Vanderschueren, Neil Pendleton, Giulia Rastrelli, Mario Maggi, Felipe F. F. Casanueva, Jolanta Slowikowska-Hilczer, Margus Punab, Ilpo T. T. Huhtaniemi, Frederick C. W. Wu, Sabine Verschueren, Jos Tournoy, Evelien Gielen
Summary: This study aimed to investigate the cross-sectional and longitudinal associations between sarcopenia and cognitive performance in middle-aged and older men. The study found that several components of sarcopenia were associated with domain-specific cognitive performance. Longitudinally, baseline and change in subdomains of cognition predicted change in muscle function in specific subgroups.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Rheumatology
Celia Dandache, Cyrille B. Confavreux, Antoine Gavoille, Emmanuel Massy, Lauriane Chambard, Julien Rambaud, Madiane Geye, Marie Brevet, Nicolas Girard, Fabien Subtil, Jean-Baptiste Pialat
Summary: A comparison of muscle mass in cancer patients showed that whole-body densitometry (DEXA) can predict early mortality, while routine cancer follow-up computed tomography (CT) cannot.
Article
Immunology
Shay Ben Shachar, Noam Barda, Sigal Manor, Sapir Israeli, Noa Dagan, Shai Carmi, Ran Balicer, Bracha Zisser, Yoram Louzoun
Summary: HLA haplotypes are not a major risk/protecting factor for SARS-CoV-2 infection or severity among the Israeli population, suggesting a weak association, if any, with limited impact on the pandemic.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jarrett Eshima, Samantha A. O'Connor, Ethan Marschall, Robert Bowser, Christopher L. Plaisier, Barbara S. Smith
Summary: In this study, the postmortem transcriptomes of 208 ALS patients were analyzed to investigate the heterogeneity of ALS pathology. Three distinct molecular subtypes were identified, which showed significant differences in patient survival. These findings suggest the existence of independent disease mechanisms driving the clinical heterogeneity in ALS.
NATURE COMMUNICATIONS
(2023)
Article
Geriatrics & Gerontology
Jolan Dupont, Leen Antonio, Lenore Dedeyne, Terence W. O'Neill, Dirk Vanderschueren, Giulia Rastrelli, Mario Maggi, Gyorgy Bartfai, Felipe F. Casanueva, Aleksander Giwercman, Jolanta Slowikowska-Hilczer, Margus Punab, Ilpo T. Huhtaniemi, Frederick C. W. Wu, Jos Tournoy, Katrien Koppo, Evelien Gielen
Summary: In middle-aged and older men, inflammatory markers hs-CRP and WBC were negatively associated with QoL and PASE scores, while WBC was negatively associated with gait speed and knee strength. However, baseline inflammatory markers (hs-CRP, WBC, and albumin) did not predict functional decline, decline in physical activity, decreased QoL, or incident sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Carla Manuela Crispim Nascimento, Juliana de Fatima Zacarin Cardoso, Isabela Thais Machado de Jesus, Fabiana de Souza Orlandi, Leticia Pimenta Costa-Guarisco, Grace Angelica de Oliveira Gomes, Ariene Angelini Dos Santos Orlandi, Fernando Augusto Vasilceac, Sofia Cristina Iost Pavarini, Karina Gramani-Say, Paula Costa Castro, Aline Cristina Martins Gratao, Marisa Silvana Zazzetta, Marcia Regina Cominetti, Henrique Pott-Junior
Summary: The study found that relative fat mass index is independently associated with sarcopenia, while loss of strength is associated with female sex, lower physical activity, worse nutrition and IL-10/TNF-a ratio. Female sex, insufficiently active lifestyle, and relative fat mass index are identified as key determinants of sarcopenia.
CLINICAL NUTRITION
(2021)
Article
Oncology
Jihyun Kim, Sunshin Kim, Seog-Yun Park, Geon Kook Lee, Kun Young Lim, Jin Young Kim, Jung-Ah Hwang, Namhee Yu, Eun Hye Kang, Mihwa Hwang, Bo Ram Song, Charny Park, Ji-Youn Han
Summary: The researchers analyzed the subtypes of small-cell lung cancer (SCLC) and found that ASCL1+, inflammatory, NEUROD1, and POU2F3+ subtypes were associated with RB1/TP53 mutation, CD8+/PD-L1+ T cell infiltration and endothelial-to-mesenchymal transition, neurotransmission process activation, and epithelial-to-mesenchymal transition, respectively. They also found that endothelial-to-mesenchymal transition was common in platinum-resistant SCLC. Through high-throughput screening, they discovered that the BET inhibitor JQ1 was effective against platinum resistance mediated by endothelial-to-mesenchymal transition, suggesting it as a potential novel treatment for overcoming platinum resistance.
Article
Multidisciplinary Sciences
Jong Soo Lee, Young Saing Kim, Eun Young Kim, Wook Jin
Article
Multidisciplinary Sciences
Jun Su Jung, Sung Jin Park, Eun Young Kim, Kyoung-Sae Na, Young Jae Kim, Kwang Gi Kim
Article
Multidisciplinary Sciences
Eun Young Kim, Young Sup Shim, Young Saing Kim, Sang Pyo Lee, Ki Dong Ko, Won-Jun Choi
Article
Cardiac & Cardiovascular Systems
Moojung Kim, Young Jae Kim, Sung Jin Park, Kwang Gi Kim, Pyung Chun Oh, Young Saing Kim, Eun Young Kim
Summary: The study aimed to develop a machine learning model to identify Korean adult CVD patients with low adherence to influenza vaccination, showing comparable performance in classification.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medicine, General & Internal
Eun Young Kim, Myung Jin Chung
Summary: AI technologies have been playing a crucial role in diagnostic imaging for COVID-19 by improving work efficiency, accurate diagnosis of infections, differentiation from other diseases, and assisting radiologists in making clinical decisions. Future research should focus on multi-modality-based models and selecting optimal model architecture for COVID-19 diagnosis and management.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Eun Young Kim, Young Jae Kim, Won-Jun Choi, Ji Soo Jeon, Moon Young Kim, Dong Hyun Oh, Kwang Nam Jin, Young Jun Cho
Summary: The study evaluated the concordance rate between radiologists and a deep-learning algorithm-based decision support system for chest radiography, showing a high concordance rate of 86.8% and a slight increase in reading time with the system's assistance.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyunsuk Yoo, Eun Young Kim, Hyungjin Kim, Ye Ra Choi, Moon Young Kim, Sung Ho Hwang, Young Joong Kim, Young Jun Cho, Kwang Nam Jin
Summary: This study investigates the feasibility of using artificial intelligence (AI) to identify normal chest radiography (CXR) from radiologists' worklists in a health-screening environment. By simulating the exclusion of normal CXR images, the study analyzes the percentage of normal images sorted and abnormal images erroneously removed. The study also compares the diagnostic performance between AI-assisted reading and reading without AI assistance. The results suggest that AI can increase efficiency and reduce the workload of radiologists.
KOREAN JOURNAL OF RADIOLOGY
(2022)