Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy

Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients

(2017) Shujuan Ma et al.   MEDICINE

Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES

(2016) Tracey G. Simon et al.   HEPATOLOGY

PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer

(2015) Hongbing Liu et al.   CANCER LETTERS

Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection

(2015) Yu Xiang et al.   JOURNAL OF VIROLOGY

Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner

(2015) Ting-ting Gao et al.   Virology Journal

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis

(2014) Akimasa Takahashi et al.   Cancer Cell International

TCTP as therapeutic target in cancers

(2014) Julie Acunzo et al.   CANCER TREATMENT REVIEWS

Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer

(2014) M. A. Babcook et al.   MOLECULAR CANCER THERAPEUTICS

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

(2014) Jidong Cheng et al.   PLoS One

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery

(2014) Mihaela Aldea et al.   TUMOR BIOLOGY

Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells

(2014) M A Babcook et al.   Cell Death & Disease

The mTOR pathway in hepatic malignancies

(2013) Mamatha Bhat et al.   HEPATOLOGY

PTEN protein phosphatase activity regulates hepatitis C virus secretion through modulation of cholesterol metabolism

(2013) Marion Peyrou et al.   JOURNAL OF HEPATOLOGY

Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo

(2013) XIANBIN CAI et al.   ONCOLOGY REPORTS

Simvastatin Inhibits Renal Cancer Cell Growth and Metastasis via AKT/mTOR, ERK and JAK2/STAT3 Pathway

(2013) Zhiqing Fang et al.   PLoS One

Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells

(2013) Tomoko Saito et al.   PLoS One

Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma

(2012) Long-Yi Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

Statins Are Associated With a Reduced Risk of Hepatocellular Cancer: A Systematic Review and Meta-analysis

(2012) Siddharth Singh et al.   GASTROENTEROLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hepatitis C Virus Modulates Insulin Signaling Pathway In Vitro Promoting Insulin Resistance

(2012) José A. del Campo et al.   PLoS One

Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development

(2011) Tim Hon Man Chan et al.   HEPATOLOGY

Antidiabetic Drug Metformin Induces Apoptosis in Human MCF Breast Cancer via Targeting ERK Signaling

(2011) Ahmed Malki et al.   ONCOLOGY RESEARCH

Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53

(2010) Seung Bae Rho et al.   FEBS LETTERS

Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR

(2010) Lu Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells

(2010) Soo Kyung Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

TCTP protects from apoptotic cell death by antagonizing bax function

(2008) L Susini et al.   CELL DEATH AND DIFFERENTIATION

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

Targeting Lipid Metabolism in the Treatment of Hepatitis C Virus Infection

(2008) Fumitake Amemiya et al.   JOURNAL OF INFECTIOUS DISEASES