Article
Biochemistry & Molecular Biology
Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Lung cancer metastasis is a major cause of lung cancer-related deaths. This study investigated the potential of cycloartocarpin in inhibiting the metastasis of lung cancer cells. The results showed that non-toxic concentrations of cycloartocarpin effectively suppressed cell migration and attenuated anchorage-independent cell growth. This was accompanied by the inhibition of the EMT process through the suppression of the FAK/AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Huiling Zhou, Qing Guan, Xuyang Hou, Lijun Liu, Li Zhou, Wei Li, Haidan Liu
Summary: Our study reveals that Rictor is highly expressed in NSCLC and regulated transcriptionally, with its interaction with KLF4 affecting the migration and invasion ability of NSCLC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Lingling Zu, Jinling He, Ning Zhou, Jingtong Zeng, Yifang Zhu, Quanying Tang, Xin Jin, Lei Zhang, Song Xu
Summary: This study found that ITGB2 is downregulated in NSCLC, leading to shorter overall survival time for patients. It may inhibit the proliferation and migration of NSCLC cells through regulating EMT signaling.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xiaosu Chen, Yajing Lv, Kejia Xu, Xiaoshuang Wang, Yujia Zhao, Jia Li, Xuan Qin, Yi Shi, Longlong Wang, Antao Chang, Chongbiao Huang, Rong Xiang
Summary: Chemotherapeutic agents, including cisplatin, have been shown to promote tumor metastasis by influencing the stability of beta-catenin through the key gene DCBLD2. The inhibition of DCBLD2 presents a promising treatment option for preventing chemotherapy-induced metastasis.
Article
Oncology
Wen-Hui Hsieh, Shu-Wei Liao, Shun-Ming Chan, Jin-De Hou, Szu-Yuan Wu, Bing-Ying Ho, Kung-Yen Chen, Yu-Ting Tai, Hsu-Wei Fang, Chih-Yuan Fang, Se-Yi Chen, Jui-An Lin
Summary: The effects of clinically relevant concentrations of lidocaine on epithelial-mesenchymal transition (EMT) and associated lung cancer behaviors were investigated. Lidocaine attenuated the inhibitory effect of 5-fluorouracil (5-FU) on cell migration and promoted EMT at clinically relevant concentrations. Lidocaine also induced EMT-associated anoikis resistance in lung cancer cells.
Article
Cell Biology
Yuanyang Lai, Fang Lin, Xuejiao Wang, Jiao Zhang, Jinghua Xia, Ying Sun, Miaomiao Wen, Xiaofei Li, Zhipei Zhang, Jinbo Zhao
Summary: This study found that STYK1 is upregulated in NSCLC and correlated with poor clinical outcomes. STYK1 suppressed FoxO1 functions, thereby promoting metastasis and EMT in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kavya Ramkumar, C. Allison Stewart, Kasey R. Cargill, Carminia M. Della Corte, Qi Wang, Li Shen, Lixia Diao, Robert J. Cardnell, David H. Peng, B. Leticia Rodriguez, You-Hong Fan, John Heymach, Jing Wang, Carl M. Gay, Don L. Gibbons, Lauren A. Byers
Summary: AXL, a TAM family receptor tyrosine kinase, plays a significant role in determining resistance to targeted therapies in NSCLC and other cancers. High levels of AXL and epithelial-to-mesenchymal transition are associated with subsets of treatment-naive and treatment-relapsed NSCLC. Combined inhibition of AXL and ATR significantly decreases cell proliferation of NSCLC and LCNEC cell lines, inducing DNA damage and replication stress.
MOLECULAR CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Article
Biochemistry & Molecular Biology
Kittipong Sanookpan, Nongyao Nonpanya, Boonchoo Sritularak, Pithi Chanvorachote
Summary: The study demonstrated that ovalitenone suppresses EMT via inhibition of the AKT/mTOR signaling pathway and has potential for inhibiting CSC phenotypes. These findings reveal the anti-metastasis potential of the compound and support the development of ovalitenone treatment for lung cancer therapy.
Review
Biochemistry & Molecular Biology
Kalliopi Andrikou, Tania Rossi, Alberto Verlicchi, Ilaria Priano, Paola Cravero, Marco Angelo Burgio, Lucio Crino, Sara Bandini, Paola Ulivi, Angelo Delmonte
Summary: Liquid biopsy, particularly the examination of circulating tumor cells (CTCs), has shown promise as a noninvasive method for detecting cancer-related biomarkers and monitoring treatment response in non-small cell lung cancer (NSCLC) patients. High CTC count has been correlated with poor prognosis, while a decrease in CTC count during treatment may indicate increased sensitivity to therapy. Additionally, molecular characterization of CTCs can provide valuable information on tumor biology and mechanisms of resistance to targeted treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nilu Dhungel, Reneau Youngblood, Min Chu, Jennifer Carroll, Ana-Maria Dragoi
Summary: The tumor microenvironment plays a crucial role in the acquisition of aggressive traits by cancer cells through the initiation of hybrid epithelial/mesenchymal (E/M) states. Direct interaction between lung fibroblasts and small cell lung carcinoma cells induces a transient hybrid EMT phenotype in cancer cells, which is reversed upon disruption of the interaction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Jara Martin, Joan Josep Castellano, Ramon Maria Marrades, Jordi Canals, Nuria Vinolas, Tania Diaz, Laureano Molins, Daniel Martinez, Bing Han, Jorge Moises, Yangyi He, Mariano Monzo, Alfons Navarro
Summary: Circ-10720 regulates EMT, apoptosis, and proliferation in non-small cell lung cancer and acts as a biomarker for relapse.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tsung-Ming Chang, Yao-Chang Chiang, Chiang-Wen Lee, Chieh-Mo Lin, Mei-Ling Fang, Miao-Ching Chi, Ju-Fang Liu, Yu Ru Kou
Summary: This study reveals the function of CXCL14 in promoting EMT and metastasis in lung cancer, with ACKR2 playing a role in this process. These findings can be used as prognostic biomarkers of lung cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)