The development of a stochastic mathematical model of Alzheimer’s disease to help improve the design of clinical trials of potential treatments

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

(2017) Lori B. Chibnik et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Solanezumab: too late in mild Alzheimer's disease?

(2017) The Lancet Neurology   LANCET NEUROLOGY

A Rare Success against Alzheimer's

(2017) Miia Kivipelto et al.   SCIENTIFIC AMERICAN

Why has therapy development for dementia failed in the last two decades?

(2016) Serge Gauthier et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A simulation system for biomarker evolution in neurodegenerative disease

(2015) Alexandra L. Young et al.   MEDICAL IMAGE ANALYSIS

Fitting the epidemiology and neuropathology of the early stages of Alzheimer’s disease to prevent dementia

(2015) Javier Mar et al.   Alzheimers Research & Therapy

A data-driven model of biomarker changes in sporadic Alzheimer's disease

(2014) Alexandra L. Young et al.   BRAIN

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

(2013) Michael W. Weiner et al.   Alzheimers & Dementia

Alzheimer’s disease: analysis of a mathematical model incorporating the role of prions

(2013) Mohamed Helal et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

Investigating Interventions in Alzheimer's Disease with Computer Simulation Models

(2013) Carole J. Proctor et al.   PLoS One

Modeling the course of Alzheimer's disease to improve clinical trials: symposium report

(2013) René Spiegel et al.   Alzheimers Research & Therapy

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

(2012) Susan M. Landau et al.   ANNALS OF NEUROLOGY

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Comparison of Imaging Biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging

(2012) Jennifer L. Whitwell   ARCHIVES OF NEUROLOGY

Measuring Alzheimer Disease Progression with Transition Probabilities: Estimates from NACC-UDS

(2012) D. Eldon Spackman et al.   Current Alzheimer Research

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Combining patient-level and summary-level data for Alzheimer’s disease modeling and simulation: a beta regression meta-analysis

(2012) James A. Rogers et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease

(2012) Hubert M. Fonteijn et al.   NEUROIMAGE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Longitudinal Change of Biomarkers in Cognitive Decline

(2011) Raymond Y. Lo   ARCHIVES OF NEUROLOGY

Regional Expansion of Hypometabolism in Alzheimer's Disease Follows Amyloid Deposition with Temporal Delay

(2011) Stefan Förster et al.   BIOLOGICAL PSYCHIATRY

A comparison of non-homogeneous Markov regression models with application to Alzheimer's disease progression

(2011) R. A. Hubbard et al.   JOURNAL OF APPLIED STATISTICS

An Improved Model for Disease Progression in Patients From the Alzheimer's Disease Neuroimaging Initiative

(2011) Mahesh N. Samtani et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A multi-state model for the analysis of changes in cognitive scores over a fixed time interval

(2011) Arnold B Mitnitski et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Model-Based Economic Evaluation in Alzheimer's Disease: A Review of the Methods Available to Model Alzheimer's Disease Progression

(2011) Colin Green et al.   VALUE IN HEALTH

Clinical core of the Alzheimer's disease neuroimaging initiative: Progress and plans

(2010) Paul S. Aisen et al.   Alzheimers & Dementia

Disease progression model for cognitive deterioration from Alzheimer's Disease Neuroimaging Initiative database

(2010) Kaori Ito et al.   Alzheimers & Dementia

The potential and limits for clinical trials for early Alzheimer’s disease and some recommendations

(2010) L. S. Schneider   Journal of Nutrition Health & Aging

The clinical use of structural MRI in Alzheimer disease

(2010) Giovanni B. Frisoni et al.   Nature Reviews Neurology

Mathematical Modeling for the Pathogenesis of Alzheimer's Disease

(2010) Ishwar K. Puri et al.   PLoS One

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Clinical Features of Mild Cognitive Impairment Differ in the Research and Tertiary Clinic Settings

(2008) G.A. Jicha et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS