Article
Multidisciplinary Sciences
Saravana R. K. Murthy, Xiaoqian Cheng, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Jerome Canady
Summary: This study suggests that cold plasma therapy has potential as a treatment for triple-negative breast cancer (TNBC), a subtype of breast cancer with poor prognosis. The gene marker BCL2A1 was found to play a key role in resistance to cold plasma-induced cell death in TNBC, and this resistance can be reversed by combining siRNA or a BCL2A1 antagonist with cold plasma therapy.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Juan Tornin, Borja Gallego, Veronica Rey, Dzohara Murillo, Carmen Huergo, Aida Rodriguez, Cristina Canal, Rene Rodriguez
Summary: This study reveals the potential of Cold Plasma Treated Medium (PTM) in preventing doxorubicin (DX) resistance in osteosarcoma (OS). PTM treatment increases oxidative stress levels in DX-resistant cells and sensitizes them to DX.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Sofia Chanioti, Marianna Giannoglou, Panagiota Stergiou, Dimitris Passaras, Panagiotis Dimitrakellis, George Kokkoris, Evangelos Gogolides, George Katsaros
Summary: The efficacy and applicability of Plasma Activated Ice (PAI) produced by cold atmospheric plasma (CAP) technology on microorganisms and quality characteristics of perishable fresh sea bream fillets were evaluated. PAI application significantly inhibited the growth of microbial load of the fillets and retarded the quality deterioration, leading to an extension of the fillets shelf-life compared to the other disinfectant media. The results proved the efficiency of PAI in extending the shelf-life of perishable foods during storage and transportation.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biology
Sujan Kumar Mondal, Derick Haas, Jie Han, Theresa L. L. Whiteside
Summary: Small extracellular vesicles (sEV) in TNBC patients' plasma promote T cell dysfunction and tumor progression. Tumor cell-derived exosomes (TEX) carrying surface proteins induce apoptosis of CD8(+)T and CD4(+)T cells but spare B and NK cells. TEX entry into T cells induces mitochondrial stress, initiating intrinsic apoptosis, which limits the therapeutic potential of adoptively transferred T cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pradeep Bhartiya, Neha Kaushik, Linh N. Nguyen, Sander Bekeschus, Kai Masur, Klaus-Dieter Weltmann, Nagendra Kumar Kaushik, Eun Ha Choi
Summary: Excessive redox stress is associated with skin pathophysiologic conditions. This study explores the effect of periodic redox stress on fibroblast cells and finds that stress above a certain threshold leads to alterations in cellular processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Tianxu Fang, Xiaona Cao, Bingzheng Shen, Zhitong Chen, Guojun Chen
Summary: In this study, a hydrogel-mediated combination therapy was proposed to enhance the efficacy of immune checkpoint blockade (ICB) for cancer treatment. Cold atmospheric plasma (CAP) was used to induce cancer immunogenic cell death and release tumor-associated antigens, synergistically augmenting the effectiveness of ICB. Injecting CAP into tumor tissues with the Pluronic hydrogel delivery method effectively preserved the reactive oxygen species (ROS) and reactive nitrogen species (RNS) in CAP, which induced immunogenic cell death. This localized combination therapy evoked strong anti-tumor immune responses and inhibited tumor growth and potential metastatic spread.
Article
Oncology
George Sflomos, Nora Schaumann, Matthias Christgen, Henriette Christgen, Stephan Bartels, Hans Kreipe, Laura Battista, Cathrin Brisken
Summary: Invasive lobular carcinoma (ILC) is a common subtype of breast cancer, often diagnosed at advanced stages. Up to 30% of ILC patients experience relapse, posing a treatment challenge. To address this, we have created a new in vivo model for ILC by grafting triple-negative human cancer cells into mice, which accurately recapitulates the different stages of ILC and provides a valuable tool for preclinical studies on TN ILC.
Article
Chemistry, Medicinal
Zhonglei He, Clara Charleton, Robert W. Devine, Mark Kelada, John M. D. Walsh, Gillian E. Conway, Sebnem Gunes, Julie Rose Mae Mondala, Furong Tian, Brijesh Tiwari, Gemma K. Kinsella, Renee Malone, Denis O'Shea, Michael Devereux, Wenxin Wang, Patrick J. Cullen, John C. Stephens, James F. Curtin
Summary: Pyrazolopyrimidinones are core scaffold in many pharmaceutically relevant compounds and have been demonstrated to be efficient in treating several diseases. This study tested the cytotoxic effects of 15 pyrazolopyrimidinones in combination with cold atmospheric plasma (CAP) on glioblastoma U-251MG cell line, and identified two drugs with enhanced cytotoxicity when combined with CAP. These findings suggest the potential of using CAP combined with pyrazolopyrimidinones as a programmable cytotoxic therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Helena Motaln, Nina Recek, Boris Rogelj
Summary: This review examines the potential use of cold atmospheric plasma in medicine, particularly its beneficial effects on tumor reduction in oncology. It discusses the cellular changes and impacts on main cellular processes, such as proliferation, migration, protein degradation, and various forms of cell death, especially in the oncology field of plasma medicine.
Letter
Medicine, General & Internal
Ryan Sun, Lee-Jen Wei
Summary: This article discusses the clinical benefits of pembrolizumab combined with chemotherapy in patients with triple-negative breast cancer. The authors suggest that both hazard values and ratios should be considered when evaluating clinical benefits.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Physics, Multidisciplinary
Yujing Xu, Sansan Peng, Bing Li, Shuai Wang, Hao Zhang, Qiaosong Li, Zhijie Liu, Bo Guo, Dingxin Liu, Dehui Xu
Summary: The study demonstrates that PAL can be safely injected into the bone marrow of New Zealand rabbits without causing significant toxicity, as evidenced by various tests including acute toxicity, organ examination, and blood analysis.
FRONTIERS IN PHYSICS
(2021)
Article
Oncology
Zhen Zhang
Summary: This study identified high expression of POLD2 in TNBC and poor clinical outcomes in patients with high POLD2 expression. Functional and mechanistic studies revealed the involvement of the E2F1-POLD2 axis in TNBC proliferation, suggesting POLD2 as a potential therapeutic target for TNBC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Hsiu-Chuan Wei
Summary: In this study, a mathematical model of triple negative breast cancer (TNBC) with checkpoint inhibitor immunotherapy is proposed. The model explores the interactions between tumor cells, immune cells, PD-1, PD-L1, and ICI, and demonstrates that the immune system can eliminate small tumors but is hindered by PD-L1 expression. Treatment with checkpoint inhibitor can eliminate larger tumors but is limited by intrinsic immune response. Enhancing CTL response improves treatment outcome significantly, suggesting a synergistic effect of combining checkpoint inhibitor and immune booster therapy.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2023)
Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Runze Fan, Xinyi Zhao, Miao Qi, Huaiyan Zhang, Xinying Zhang, Jin Zhang, Qiaosong Li, Dehui Xu
Summary: Plasma-activated solution (PAS) is receiving significant attention in cancer treatment due to its ability to treat deep tumors and be stored. This study investigated the changes in PAS during storage and its impact on its anticancer effect. The plasma-activated medium (PAM) was prepared by treating RPMI 1640 medium with afterglow gas, and it was stored at different temperatures for varying durations. The results showed that PAM exhibited different anticancer effects depending on the storage temperature, with the highest stability observed at -80 degrees C. These findings provide valuable insights into the storage and application of PAM in anticancer therapy.
Article
Chemistry, Physical
Xin Zeng, Shuai Zhang, Xiucui Hu, Cheng Zhang, Kostya (Ken) Ostrikov, Tao Shao
Summary: With the increase in the greenhouse effect and reduction of fossil fuel resources, finding a feasible solution to directly convert power to chemicals using renewable energy is urgent. The power-to-chemicals approach, such as non-thermal plasma, electro-catalysis, and photo-catalysis, has shown great potential in the past two decades. This paper introduces the application of plasma technology in energy conversion, focusing on plasma-enabled ammonia synthesis and analyzing its state-of-the-art, mechanisms, and techno-economics. It emphasizes the importance of the power-to-chemicals approach in reducing carbon emissions and environmental pollution.
FARADAY DISCUSSIONS
(2023)
Article
Chemistry, Multidisciplinary
Amandeep Singh Pannu, Suvankar Sen, Xiaodong (Tony) Wang, Robert Jones, Kostya (Ken) Ostrikov, Prashant Sonar
Summary: Organic-inorganic hybrid lead trihalide perovskites have shown promise in various optoelectronic devices. Red-emitting perovskite-based LEDs have been less developed compared to green and blue ones. This study utilizes red-emitting 2D perovskites and carbon dots to create a stable composite material for red-emitting LEDs with improved performance.
Article
Nanoscience & Nanotechnology
Negar Zebardastan, Jonathan Bradford, Josh Lipton-Duffin, Jennifer MacLeod, Kostya (Ken) Ostrikov, Massimo Tomellini, Nunzio Motta
Summary: Face-to-face annealing is an effective method for obtaining epitaxial graphene with precise control over size, quality, growth rate and thickness.
Article
Physics, Fluids & Plasmas
Kun Liu, Wenqiang Geng, Xiongfeng Zhou, Qingsong Duan, Zhenfeng Zheng, Kostya (Ken) Ostrikov
Summary: Two modes of the atmospheric-pressure plasma discharge, characterized by the dominant O-3 and NO (x) species, were studied using numerical and experimental methods. A global chemical kinetics model was developed to investigate the mode transition mechanisms, and it accurately described the transition. The individual and synergistic effects of discharge energy and gas temperature on species density and the relative contributions of dominant reactions were quantified under increasing discharge voltage conditions.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Darwin Kurniawan, Jacob Mathew, Michael Ryan Rahardja, Hoang-Phuc Pham, Pei-Chun Wong, Neralla Vijayakameswara Rao, Kostya (Ken) Ostrikov, Wei-Hung Chiang
Summary: This study reports the development of smart anticancer drug nanocarriers through plasma engineering technique. The nanocarriers containing chitosan and nitrogen-doped graphene quantum dots can release drugs in a pH-responsive manner and exhibit enhanced toughness. The loaded nanocarriers demonstrate improved drug loading capability and stable release, showing great potential in cancer treatment.
Article
Chemistry, Multidisciplinary
Xin Zeng, Shuai Zhang, Yadi Liu, Xiucui Hu, Kostya Ken Ostrikov, Tao Shao
Summary: To meet global net-zero emission targets, sustainable and low-carbon alternatives are urgently needed for energy-intensive industrial processes like ammonia synthesis. In this study, plasma catalysis is used to achieve renewable-electricity-driven ammonia synthesis under mild conditions. By identifying energy loss pathways and optimizing process parameters, such as pulse voltage and gap distance, high ammonia yields with high energy efficiency and low emission footprint are obtained.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Rusen Zhou, Dejiang Zhou, Baowang Liu, Lanlan Nie, Yubin Xian, Tianqi Zhang, Renwu Zhou, Xinpei Lu, Kostya Ken Ostrikov, Patrick J. Cullen
Summary: The addition of helium can enhance the synthesis of ammonia by modifying the energy transfer mechanism in the plasma, leading to more efficient activation of N2 and production of NH3.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Physical
Tianlai Xia, Yu Yang, Qiang Song, Mingchuan Luo, Mianqi Xue, Kostya (Ken) Ostrikov, Yong Zhao, Fengwang Li
Summary: Recently, electrocatalytic reactions involving oxygen, nitrogen, water, and carbon dioxide have been developed to produce clean energy, fuels, and chemicals. Understanding catalyst structures, active sites, and reaction mechanisms is crucial for improving performance. In this review, we summarize state-of-the-art in situ characterisation techniques used in electrocatalysis, categorizing them into microscopy, spectroscopy, and other techniques. We discuss the capacities and limits of these techniques to guide further advances in the field.
NANOSCALE HORIZONS
(2023)
Article
Physics, Multidisciplinary
Sanjib Sarkar, Jyoti K. Atul, Modhuchandra Laishram, Dandan Zou, Kostya (Ken) Ostrikov
Summary: The Farley-Buneman and Gradient Drift instabilities in a partially ionized dusty electrojet region were investigated using a fluid model. The effects of dissociative electron-ion recombination and dust charge fluctuation on the instabilities were considered. The dispersion relation describing the propagation of electrojet instabilities within the dust ion acoustic range in a magnetized partially ionized dusty plasma was solved numerically and analytically. The results showed that the Gradient Drift instability was unstable at a much longer wavelength compared to the Farley-Buneman instability. The threshold electron drift velocity for Farley-Buneman instability was affected by the charge on dust, with a decrease at lower altitudes and an increase at higher altitudes. Furthermore, the dissociative electron-ion recombination had a stronger damping effect than the dust charge fluctuation on both instabilities.
Article
Chemistry, Multidisciplinary
Haotian Gao, Guoli Wang, Zhongzheng Huang, Lanlan Nie, Dawei Liu, Xinpei Lu, Guangyuan He, Kostya Ken Ostrikov
Summary: Nitrogen fixation is a crucial process for various biological and industrial processes, but it is also a major source of carbon emissions globally. In this study, a novel approach using plasma-activated mist (PAM) is proposed for efficient and sustainable nitrogen fixation. The PAM system generates nitrogen-fixation species through the reaction of air plasma and water mist, and the liquid-phase nitrogen fixation product is dominated by NO3-. This system is applied to deliver nitrogen-based nutrients directly to plant roots using an aeroponic system, leading to significant improvements in plant growth.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Yang Ding, Renxian Qi, Chenglin Wang, Qianqian Wu, Haozhe Zhang, Xiumei Zhang, Liangliang Lin, Zhengyang Cai, Shaoqing Xiao, Xiaofeng Gu, Haiyan Nan
Summary: This research proposes a novel method for creating 1T-2H-1T MoTe2 optoelectronic devices using oxygen mild plasma preparation, which improves the performance of the devices.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Qilei Xu, Qianqian Wu, Chenglin Wang, Xiumei Zhang, Zhengyang Cai, Liangliang Lin, Xiaofeng Gu, Kostya (Ken) Ostrikov, Haiyan Nan, Shaoqing Xiao
Summary: This study employed a two-step KI-assisted confined-space chemical vapor deposition method to prepare multilayer WSe2/SnS2 p-n heterojunctions. The optical characterization and electrical tests revealed clear interfaces and vertical heterostructures, as well as good rectification characteristics and high photoresponse. These performances are likely attributed to the ultra-low dark current generated in the depletion region and the high direct tunneling current during illumination.
Article
Chemistry, Multidisciplinary
Hsiuan Ling Ho, Jung Yen Yang, Chun Hung Lin, Jiann Shieh, Yu Fang Huang, Yi Hong Ho, Tsung Shine Ko, Chiung Chih Hsu, Kostya (Ken) Ostrikov
Summary: The development of reliable and cost-effective molecular detection at the attomolar level on analyte-immobilizing surfaces without lithographic patterning is a challenge in chemical sensing. This study presents a novel approach using plasma etching to produce custom-designed adhesive superhydrophobic silicon nanograss surfaces. These surfaces enable effective immobilization of Ag nanoparticles and R6G target molecules, providing a reliable Raman scattering platform for detecting trace analytes. The study also introduces a plasma-enabled approach for precise interface nanostructuring, potentially leading to unprecedented capabilities in molecular-level sensing technologies.
ADVANCED MATERIALS INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Jinyong Lin, Dong Li, Changhong Li, Ziqi Zhuang, Chengchao Chu, Kostya (Ken) Ostrikov, Erik W. W. Thompson, Gang Liu, Peiyu Wang
Summary: Cancer cells are more susceptible to oxidative stress and nanomaterials-based therapies that generate reactive oxygen species (ROS) have been effective in eliminating cancer cells. These therapies, including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, as well as multi-modal therapies such as combination therapy, have shown significant inhibition of tumor growth. However, the limitations of multi-modal therapy in material preparation and operation protocols hinder its clinical application. Cold atmospheric plasma (CAP), as a reliable source of ROS, light, and electromagnetic fields, provides a simple alternative for implementing multi-modal treatments. Therefore, the emerging field of tumor precision medicine is expected to benefit from these promising multi-modal therapies based on ROS-generating nanomaterials and reactive media like CAPs.
Article
Chemistry, Multidisciplinary
Huilin Zuo, Jing Bai, Chenglin Wang, Junhao Ni, Yang Ding, Bingyu Pan, Zhengyang Cai, Shaoqing Xiao, Xiaofeng Gu, Xiumei Zhang, Haiyan Nan
Summary: We demonstrate a significant enhancement in the photoresponse time of few-layer black phosphorus (BP) by treating it with silver nitrate solution. X-ray photoelectron spectroscopy (XPS) analysis reveals that the presence of Ag+ diminishes the surface activity of BP devices, leading to decreased hysteresis. The adsorption of Ag+ effectively inhibits the oxidation of the BP surface and reduces the concentration of trap states, resulting in improved photodetector performance.
NEW JOURNAL OF CHEMISTRY
(2023)