Article
Hematology
Shrey Kohli, Kunal Kumar Singh, Anubhuti Gupta, Paulina Markmeyer, Franziska Lochmann, Dheerendra Gupta, Rajiv Rana, Ahmed Elwakiel, Hanna Huebner, Matthias Ruebner, Berend Isermann
Summary: The study revealed a unidirectional interaction between placental inflammasome activation and reduced placental TM expression, and demonstrated that soluble TM treatment or placental TM restoration can alleviate PE-like symptoms.
Article
Biochemical Research Methods
Che-Yu Chou, Pinpin Lin, Jongwoon Kim, Shan-Shan Wang, Chia-Chi Wang, Chun-Wei Tung
Summary: In this study, a valid prediction model for ex vivo human placental barrier permeability was developed, which can be used for assessing the toxic effects of chemicals on the fetus.
BMC BIOINFORMATICS
(2022)
Article
Cell Biology
Mark Richards, Sagnik Pal, Elin Sjoberg, Pernilla Martinsson, Lakshmi Venkatraman, Lena Claesson-Welsh
Summary: Endothelial cells exhibit heterogeneous barrier properties at inter-organ and intra-vessel levels, with predetermined leakage sites showing distinct characteristics that may disproportionately impact pathological vascular leakage. Mechanistically, reduced laminin alpha 5 at predetermined sites is associated with decreased VE-cadherin and increased VEGFA-induced VE-cadherin phosphorylation.
Article
Biochemistry & Molecular Biology
Roberta Lugano, Kalyani Vemuri, Stefano Barbera, Maurizio Orlandini, Elisabetta Dejana, Lena Claesson-Welsh, Anna Dimberg
Summary: CD93 regulates the stability of VE-cadherin at endothelial junctions by interacting with VE-cadherin and limiting its phosphorylation and turnover. CD93 deficiency leads to increased phosphorylation of VE-cadherin, displacing it from endothelial cell-cell contacts and disrupting endothelial junctions, resulting in enhanced blood-brain barrier permeability. This mechanism is regulated through the Rho/Rho kinase-dependent pathway.
Article
Biochemistry & Molecular Biology
Qiuling Jie, Fei Sun, Qi Li, Juan Zhu, Yunjian Wei, Huamei Yang, Ping Long, Zhen Wang, Xiaohui Yang, Dan Li, Liping Huang, Yanlin Ma
Summary: The study found that RPL39 is significantly downregulated in early-onset PE placental tissues, and its knockdown can inhibit proliferation, migration, and invasion of trophoblast cells by targeting E-cadherin to affect cell functions.
Article
Biochemistry & Molecular Biology
Pablo Torres-Vergara, Felipe Troncoso, Jesenia Acurio, Ellen Kupka, Lina Bergman, Anna-Karin Wikstro, Carlos Escudero
Summary: Disruption of blood-brain barrier is a central issue in the pathophysiology of acute cerebral complications in women with preeclampsia. The underlying mechanisms are unclear. This study found that plasma from women with preeclampsia increased cell apoptosis and permeability in human brain endothelial cells, possibly through activation of VEGFR2. The different phosphorylation patterns of VEGFR2 suggest that further investigation is needed to determine its specific activation status.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Medicine, General & Internal
Marta Peksa, Alexandra Kamieniecki, Anna Gabrych, Anna Lew-Tusk, Krzysztof Preis, Malgorzata Swiatkowska-Freund
Summary: Pregnancy-induced hypertension and pre-eclampsia are serious complications of pregnancy, and the abnormality of the placental barrier is believed to be involved in their pathogenesis. This study found a correlation between the discontinuity of E-cadherin expression and the development of pre-eclampsia, suggesting that it could be an immunohistochemical marker.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Developmental Biology
Vaishali Kasture, Deepali Sundrani, Karuna Randhir, Girija Wagh, Sadhana Joshi
Summary: This study reveals the association of various apoptotic markers with oxidative stress and placental dimensions in preeclampsia patients.
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Immunology
Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Le Cao, Ashley Mansell, Evdokia Dimitriadis
Summary: This study found that IL11 activates the inflammasome and causes inflammation, fibrosis, and hypertension in pregnant mice, resembling early-onset preeclampsia. It also inhibits trophoblast differentiation. Inhibition of inflammasome activity could prevent IL11-induced inflammation and fibrosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ikram Omar Osman, Clemence Garrec, Gabriel Augusto Pires de Souza, Ana Zarubica, Djamal Brahim Belhaouari, Jean-Pierre Baudoin, Hubert Lepidi, Jean-Louis Mege, Bernard Malissen, Bernard La Scola, Christian Albert Devaux
Summary: COVID-19 is the largest pandemic in this century, and it is not only characterized by respiratory damage, but also by gastrointestinal symptoms. This study suggests that SARS-CoV-2 may cause damage to the epithelial barrier of the intestines by disrupting E-cadherin adherens junctions, leading to gastrointestinal symptoms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Environmental Sciences
Basile Jumentier, Claire-Cecile Barrot, Maxime Estavoyer, Jorg Tost, Barbara Heude, Olivier Francois, Johanna Lepeule
Summary: High-dimensional mediation analysis is increasingly used to evaluate the indirect effects of environmental exposures on health outcomes. HDMAX2 is a new method that combines latent factor regression models and max2 tests to effectively analyze the causal role of maternal smoking during pregnancy on birth weight and gestational age. It demonstrated increased power compared to existing approaches and revealed a complex relationship between exposure and birth weight at the epigenome-wide level.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Biochemical Research Methods
Emily J. Geddes, Zhong Li, Paul J. Hergenrother
Summary: Discovering novel broad-spectrum antibiotics has been challenging due to the impermeability of Gram-negative membranes. However, the development of new methodologies and rules has enabled the prediction of compound accumulation in E. coli, offering a new approach for antibiotic discovery.
Article
Cardiac & Cardiovascular Systems
Mengqi Gu, Fengyuan Zhang, Xiaotong Jiang, Pengzheng Chen, Shuting Wan, Qingfeng Lv, Yuan Lu, Qian Zhou, Yanyun Wang, Lei Li
Summary: This study aimed to evaluate the effects of placental exosomes on endothelial cells. The results showed that H/R-exo and PE-exo inhibited the biological functions of endothelial cells and impaired vessel development, potentially leading to vascular disorders in offspring.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ciara N. Murphy, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Natalie J. Hannan, Mary E. Wlodek, Jenny Myers, Jessica F. Briffa, Tania Romano, Alexandra Roddy Mitchell, Carole-Anne Whigham, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Natasha Pritchard, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: SPINT2 is identified as a potential biomarker for placental dysfunction, associated with preterm preeclampsia and intrauterine growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Cell Biology
Liren Wang, Linxi Li, Yanlin Ma, Handan Hu, Qi Li, Yang Yang, Wenbang Liu, Shuming Yin, Wei Li, Bin Fu, Ryo Kurita, Yukio Nakamura, Mingyao Liu, Yongrong Lai, Dali Li
Article
Biochemistry & Molecular Biology
Wei Huang, Weiying Lu, Qi Li, Yu Zhang, Baoguo Xie, Shu Luo, Yunjian Wei, Yanlin Ma, Yuanhua Huang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biotechnology & Applied Microbiology
Juan Zhu, Yunjian Wei, Zhen Wang, Qiuling Jie, Fei Sun, Qi Li, Ping Long, Yuanhua Huang, Yanhong Yu, Yanlin Ma
JOURNAL OF GENE MEDICINE
(2020)
Article
Medicine, General & Internal
Yu Zhang, Zheng Liu, Jian Ou, Ling-Xiao Zhang, Wei-Ying Lu, Qi Li, Yanlin Ma
Article
Cell & Tissue Engineering
Ping Long, Zhen Wang, Huamei Yang, Zheng Liu, Bangyong Wu, Gaobu Zhong, Jingxi Chen, Chao Sun, Fei Wang, Yao Zhou, Fei Sun, Qi Li, Yanlin Ma
STEM CELL RESEARCH
(2020)
Article
Biology
Yu Zhang, Hongyan Liu, Zheng Liu, Ping Long, Xing Zhao, Qi Li, Yuanhua Huang, Yanlin Ma
Summary: A new CryoLogic Vitrification Method (CVM) was developed in this study, loading a small piece of hiPSCs colonies in the vitrification solution to the hook of Fiberplug and immersed directly in a 37 degrees C warming solution for warming. This method achieved high recovery rate and maintained the stemness and differentiation potential of hiPSCs.
Article
Biochemistry & Molecular Biology
Qiuling Jie, Fei Sun, Qi Li, Juan Zhu, Yunjian Wei, Huamei Yang, Ping Long, Zhen Wang, Xiaohui Yang, Dan Li, Liping Huang, Yanlin Ma
Summary: The study found that RPL39 is significantly downregulated in early-onset PE placental tissues, and its knockdown can inhibit proliferation, migration, and invasion of trophoblast cells by targeting E-cadherin to affect cell functions.
Article
Cell Biology
Zhen Wang, Robert J. Schwartz, Jing Liu, Fei Sun, Qi Li, Yanlin Ma
Summary: The study identified that Smyd1 interacts with ASH2L and activates the promoter of Isl1 by trimethylating H3K4, leading to upregulation of Isl1 expression. Additionally, Smyd1 associates with HDAC to repress ANF expression, thus participating in the downregulation of ANF during early heart development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liping Huang, Yanlin Ma, Lu Chen, Jiang Chang, Mei Zhong, Zhijian Wang, Ying Sun, Xia Chen, Fei Sun, Lu Xiao, Jianing Chen, Yingjun Lai, Chuming Yan, Xiaojing Yue
Summary: Preeclampsia is a life-threatening disease in pregnant women associated with mitochondrial-mediated placental oxidative stress. The down-regulation of Rnd3 in primary trophoblasts from PE patients leads to excessive ROS generation, cell apoptosis, and mitochondrial damage. Rnd3 acts as a protective factor in placental mitochondria through the PPARγ-UCP2 signaling pathway.
Article
Cell Biology
Fei Sun, Qiuling Jie, Qi Li, Yunjian Wei, Hong Li, Xiaojing Yue, Yanlin Ma
Summary: The downregulation of TUSC3 in cervical squamous cell carcinoma (CSCC) is associated with increased proliferation and invasion of cancer cells. Knockdown of TUSC3 promotes cell migration and invasion, while increased expression of TUSC3 has the opposite effects. The downregulation of TUSC3 facilitates proliferation and invasion of CSCC cells through activation of the AKT signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Zuxia Mi, Zheng Liu, Yu Zhang, Juan Zhu, Yufei Yao, Yao Zhou, Yuanhua Huang, Qi Li, Yanlin Ma
Summary: The number of blastomeres in day-2 embryos affects the rate of blastocyst formation and clinical pregnancy, with the 4 blastomeres group showing the highest rates in both categories.
REPRODUCTIVE SCIENCES
(2021)
Article
Medical Laboratory Technology
Ping Long, Yuechuan Shi, Fei Sun, Yunjian Wei, Bangyong Wu, Qi Li, Qiuling Jie, Yanlin Ma
Summary: This study successfully generated CV-iPSCs from human primary chorionic villi cells and identified the optimal electroportion conditions. These CV-iPSCs exhibited pluripotency, normal karyotype, and the ability to differentiate into three germ layers. This research provides a novel strategy for investigating the pathogenesis of diseases and gene therapy.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cell Biology
Yao Zhou, Xiaohui Yang, Zheng Liu, Yu Zhang, Huaye Chen, Yongfang Zhang, Yuxin Hu, Yanlin Ma, Qi Li
Summary: The study identified two novel mutations in the FREM2 gene related to the risk of Fraser syndrome, and described a next-generation sequencing-based single nucleotide polymorphism haplotyping method for selecting embryos from patients with Fraser syndrome for in vitro fertilization and embryo transfer treatment. This approach resulted in the successful delivery of a healthy baby without complications.
Meeting Abstract
Peripheral Vascular Disease
Xiaojing Yue, Xiangsheng Yang, Yanlin Ma, Xia Chen, Liping Huang, Yanhong Yu