Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Junshen He, Zhao Chen, Ting Wen, Liqun Xu, Chunlin Chen, Ping Liu
Summary: This study suggests that IVIM analysis can serve as an important supplement to ultrasound biometry for the noninvasive identification of false positive SGA pregnancies and SGA patients.
Article
Developmental Biology
Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Marta Diaz, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Mariona Jove, Meritxell Martin-Gari, Alexandra Bonmati-Santane, Francis de Zegher, Lourdes Ibanez, Abel Lopez-Bermejo, Judit Bassols
Summary: In this study, differences in placental fatty acid composition and estimated desaturase and elongase activities were observed between appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) infants. Placentas from SGA infants had lower levels of omega-3 fatty acids and higher omega-6/omega-3 ratios, as well as lower elongase and higher desaturase activity compared to AGA infants. Further studies on the omega-3 fatty acid status in SGA infants may be warranted for prenatal interventions.
Article
Developmental Biology
Anna S. Andersen, Kristi B. Anderson, Ditte N. Hansen, Marianne Sinding, Astrid C. Petersen, David A. Peters, Jens B. Frokjaer, Anne Sorensen
Summary: Placental T1 is negatively correlated with gestational age in AGA pregnancies and significantly reduced in SGA pregnancies. However, the predictive performance of placental T1 is weaker than estimated fetal weight in detecting SGA.
Article
Public, Environmental & Occupational Health
Kelly K. Ferguson, Sara Sammallahti, Emma Rosen, Michiel van den Dries, Anjoeka Pronk, Suzanne Spaan, Monica Guxens, Henning Tiemeier, Romy Gaillard, Vincent W. V. Jaddoe
Summary: This study identified three distinct fetal growth trajectories for weight among babies born small for gestational age (SGA). Children who were consistently small from mid-pregnancy had the worst neurodevelopmental outcomes at age 6, showing lower IQ and slightly more ADHD symptoms compared to non-SGA babies. The findings suggest that fetal growth trajectories may help identify SGA babies who are at risk for poor neurodevelopmental outcomes.
Article
Pediatrics
Dan Wu, Jianzheng Zhu, Xiulian Wang, Huiqing Shi, Yanyan Huo, Meiyan Liu, Fanfan Sun, Hongyan Lan, Chong Guo, Honghua Liu, Tingting Li, Lian Jiang, Xiangying Hu, Tianshu Li, Jing Xu, Guoying Yao, Guowei Zhu, Guangjun Yu, Jinjin Chen
Summary: This study found that rapid increase in BMI during early infancy in former SGA newborns leads to a persistent risk of obesity, highlighting the importance of controlling energy intake and closely monitoring BMI changes for optimal management.
FRONTIERS IN PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Shangzhi Xu, Weiming Wang, Qian Li, Li Huang, Xi Chen, Xu Zhang, Xiaoyi Wang, Weizhen Han, Xingwen Hu, Xuefeng Yang, Liping Hao, Guoping Xiong, Nianhong Yang
Summary: This study found that higher Hb concentrations in late pregnancy and less reduction in Hb during pregnancy were associated with an increased risk of SGA in women at low risk of iron deficiency.
Article
Public, Environmental & Occupational Health
Korede K. Yusuf, Deepa Dongarwar, Dania E. Alagili, Sitratullah O. Maiyegun, Hamisu M. Salihu
Summary: This study examined the temporal trends and risk of small for gestational age (SGA) phenotypes among Asian American ethnic groups using population-based retrospective data. The findings showed that NH-Whites had the lowest SGA rates, while all Asian ethnic groups had consistently higher rates. Among the Asian subgroups, Asian Indians had the highest odds of any SGA compared to NH-Whites. The study highlights the importance of recognizing the diversity within the Asian American population for effective health research and interventions.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Chaelin Lee, Seung Mi Lee, Dong Jun Byun, So Yeon Kim, Hugh Kim, Do Yup Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Man Ho Choi
Summary: Increased levels of tetrahydrocortisol and decreased levels of 21-deoxycortisol were observed in pregnant women carrying small-for-gestational-age (SGA) fetuses. The combination of 21-deoxycortisol concentration and two metabolic ratios of cortisol/21-deoxycortisol and tetrahydrocortisol/cortisol can serve as potential biomarkers for predicting SGA in the first trimester.
REPRODUCTIVE SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Allen J. Wilcox, Marianna Cortese, D. Robert McConnaughey, Dag Moster, Olga Basso
Summary: The study found that birthweight percentiles performed poorly in identifying high-risk infants, while gestational age was effective. The results in Norway and the United States were virtually identical, suggesting this trend is robust across populations.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Endocrinology & Metabolism
Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, Veronica Mericq, Robert Rapaport, Abdullah Alherbish, Debora Braslavsky, Evangelia Charmandari, Steven D. Chernausek, Wayne S. Cutfield, Andrew Dauber, Asma Deeb, Wesley J. Goedegebuure, Paul L. Hofman, Elvira Isganatis, Alexander A. Jorge, Christina Kanaka-Gantenbein, Kenichi Kashimada, Vaman Khadilkar, Xiao-Ping Luo, Sarah Mathai, Yuya Nakano, Mabel Yau
Summary: This International Consensus Guideline, developed by experts from 10 pediatric endocrine societies worldwide, provides new insights into the causes and consequences of short stature after SGA birth. It also offers recommendations for accurate diagnosis, early follow-up, and appropriate treatment options. The guideline emphasizes the importance of genetic testing and counseling, as well as promoting a healthy lifestyle for young adults born SGA.
Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Genetics & Heredity
Hwal Rim Jeong, Jae-A Han, Heeji Kim, Hye Jin Lee, Young Suk Shim, Min Jae Kang, Jong Seo Yoon, Seongho Ryu, Il Tae Hwang
Summary: This study investigated the exosomal miRNA signature associated with catch-up growth in small-for-gestational-age (SGA) children. The results showed that SGA children without catch-up growth have a distinct exosomal miRNA expression profile compared with SGA children with catch-up growth and appropriate-for-gestational-age (AGA) children. The study also identified certain miRNAs that may be associated with growth failure in SGA children.
Article
Clinical Neurology
Han Liu, Hong Li, Cheng Li, Lei Chen, Chenjie Zhang, Zhiwei Liu, Yanting Wu, Hefeng Huang
Summary: The study revealed a negative association between maternal sleep quality during pregnancy and birth weight z-scores in female newborns, but not in males. Additionally, poor sleep quality in late pregnancy was identified as a risk factor for low birth weight.
BEHAVIORAL SLEEP MEDICINE
(2021)
Article
Genetics & Heredity
Ziru Jiang, Kexin Zou, Xia Liu, Hangchao Gu, Yicong Meng, Jing Lin, Weihui Shi, Chuanjin Yu, Li Jin, Li Wang, Xinmei Liu, Jianzhong Sheng, Hefeng Huang, Guolian Ding
Summary: As individuals age, the expression of circadian clock genes in human granulosa cells decreases, with a negative correlation between mRNA expression levels and age. Older patients have lower serum anti-Mullerian hormone (AMH) levels, and the circadian rhythm in the ovaries of older mice significantly differs from that in young mice, while the circadian rhythm in the livers of older mice remains relatively consistent with that of young mice.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Correction
Physiology
Yaoyao Tu, Guangyong Zheng, Guolian Ding, Yanting Wu, Ji Xi, Yingzhou Ge, Hangchao Gu, Yingyu Wang, Jianzhong Sheng, Xinmei Liu, Li Jin, Hefeng Huang
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zuwei Yang, Wenzhong Zhou, Chengliang Zhou, Yuzhong Zhou, Xinmei Liu, Guolian Ding, Yulian Hu, Jiexue Pan, Jianzhong Sheng, Li Jin, Hefeng Huang
Summary: This study found that the most prevalent phenotype of PCOS in Chinese women is normo-androgenic PCOS (NA-PCOS), and that there were no significant differences in intrafollicular steroid levels and product/precursor ratios between NA-PCOS and hyperandrogenic PCOS (HA-PCOS) women. However, HA-PCOS women did have significantly higher serum luteinizing hormone and testosterone levels compared to NA-PCOS women.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Correction
Multidisciplinary Sciences
Guolian Ding, Xin Li, Xinguo Hou, Wenjun Zhou, Yingyun Gong, Fuqiang Liu, Yanlin He, Jia Song, Jing Wang, Paul Basil, Wenbo Li, Sichong Qian, Pradip Saha, Jinbang Wang, Chen Cui, Tingting Yang, Kexin Zou, Younghun Han, Christopher I. Amos, Yong Xu, Li Chen, Zheng Sun
Article
Psychiatry
Kexin Zou, Jun Ren, Sisi Luo, Junyu Zhang, Chengliang Zhou, Chengxi Tan, Pingping Lv, Xiao Sun, Jianzhong Sheng, Xinmei Liu, Hefeng Huang, Guolian Ding
Summary: Studies have shown that gestational diabetes mellitus (GDM) may increase the risk of neurological disorders in offspring. Research using a mouse model of diabetes during pregnancy revealed that intrauterine hyperglycemia exposure can lead to memory impairment in subsequent generations through potential epigenetic mechanisms involving neurodevelopment and synaptic plasticity.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Genetics & Heredity
Yuchen Li, Weihong Zeng, Tong Li, Yanyan Guo, Guangyong Zheng, Xiaoying He, Lilian Bai, Guolian Ding, Li Jin, Xinmei Liu
Summary: The study conducted integrative single-cell analyses of thymocytes at different gestational ages, identifying candidate genes regulating T cell receptor lineage selection and characterizing the trajectory of early thymocyte commitment during fetal growth. Comparisons with mouse data revealed both conserved and species-specific transcriptional dynamics, as well as susceptibility genes associated with autoimmune disorders.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Hong Zhu, Si-Si Luo, Yi Cheng, Yi-Shang Yan, Ke-Xin Zou, Guo-Lian Ding, Li Jin, He-Feng Huang
Summary: The study reveals that changes in the fetal pancreatic metabolome may be a significant mechanism for the increasing prevalence of diabetes caused by intrauterine hyperglycemia exposure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Developmental Biology
Ning-Xin Qin, Yi-Ran Zhao, Wei-Hui Shi, Zhi-Yang Zhou, Ke-Xin Zou, Chuan-Jin Yu, Xia Liu, Ze-Han Dong, Yi-Ting Mao, Cheng-Liang Zhou, Jia-Le Yu, Xin-Mei Liu, Jian-Zhong Sheng, Guo-Lian Ding, Wen-Long Zhao, Yan-Ting Wu, He-Feng Huang
Summary: The study revealed that male offspring conceived by IVF-ET and IVF-FET exhibited increased anxiety and depression-like behaviors at 18 months old, which were associated with reduced expression levels of neurotrophins in the brain.
Article
Cell Biology
Si-si Luo, Ke-xin Zou, Hong Zhu, Yi Cheng, Yi-shang Yan, Jian-zhong Sheng, He-feng Huang, Guo-lian Ding
Summary: Growing evidence suggests that gestational diabetes mellitus (GDM) could affect the long-term neurocognitive health of offspring. Using a GDM mouse model, this study found that GDM altered metabolites in fetal brains, which in turn affected DNA methylation and gene regulation involved in cognition, providing a potential mechanism for the adverse neurocognitive effects of GDM in offspring.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yiting Mao, Yiran Zhao, Sisi Luo, Huixi Chen, Xia Liu, Ting Wu, Guolian Ding, Xinmei Liu, Jianzhong Sheng, Yicong Meng, Hefeng Huang
Summary: The study explores the metabolic phenotype of offspring from advanced paternal age and the inherited alterations in sperm, finding that paternal aging can lead to chronic metabolic risks in offspring and that these risks may be mediated through inherited alterations in sperm.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Reproductive Biology
Xin-Yuan Li, Jie-Xue Pan, Hong Zhu, Guo-Lian Ding, He-Feng Huang
Summary: In recent years, there has been an increasing recognition of the developmental origins of diseases. It is suggested that many chronic diseases in adulthood, including diabetes, obesity, cardiovascular disease, and tumors, may develop early on. Germ cells play a crucial role in inheritance, and external influences during their differentiation and development can lead to damage and increase the risk of chronic disease development. This article further explores the concept of gamete and embryo origins of adult diseases, focusing on environmental insults on germ cells.
BIOLOGY OF REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Bin Chen, Ya-Rui Du, Hong Zhu, Mei-Ling Sun, Chao Wang, Yi Cheng, Haiyan Pang, Guolian Ding, Juan Gao, Yajing Tan, Xiaomei Tong, Pingping Lv, Feng Zhou, Qitao Zhan, Zhi-Mei Xu, Li Wang, Donghao Luo, Yinghui Ye, Li Jin, Songying Zhang, Yimin Zhu, Xiaona Lin, Yanting Wu, Luyang Jin, Yin Zhou, Caochong Yan, Jianzhong Sheng, Peter R. Flatt, Guo-Liang Xu, Hefeng Huang
Summary: Pregestational hyperglycemia increases the offspring's vulnerability to glucose intolerance. The insufficient demethylation by oocyte TET3 leads to hypermethylation in the paternal alleles of several insulin secretion genes. There is an environment-sensitive window in oocyte development that confers predisposition to glucose intolerance in the next generation.
Editorial Material
Multidisciplinary Sciences
Guolian Ding, Bin Chen, John R. McCarrey, Hefeng Huang
Review
Endocrinology & Metabolism
S. -s. Luo, H. Zhu, H-f. Huang, G. -l. Ding
Summary: The purpose of this review was to summarize the sex differences in glycolipid metabolic phenotypes in human and animal models after exposure to maternal hyperglycemia, and to provide an overview of the underlying mechanisms. Maternal hyperglycemia increases the risk of glycolipid metabolic disorders in offspring, and metabolic phenotypes exhibit sex differences in response to maternal hyperglycemia, which may be related to gonadal hormones, organic intrinsic differences, placenta, and epigenetic modifications.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
