Journal
PLACENTA
Volume 69, Issue -, Pages 134-139Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2018.04.011
Keywords
Preeclampsia; Eclampsia; Magnesium; Magnesium salts; Placenta; Human
Funding
- Fondo Nacional de Desarrollo Cientifico y Tecnologico, Chile [FONDECYT 1150377, 3160194]
- Comision Nacional para la Investigacion en Ciencia y Tecnologia (CONICYT)
- Vicerrectorate of Research and School of Medicine, PUC (Chile)
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Preeclampsia is a heterogeneous pregnancy-specific syndrome associated with abnormal trophoblast invasion and endothelial dysfunction. Magnesium (Mg2+) level may be normal or decreased in women with preeclampsia. However, the use of Mg2+ salts, such as Mg2+ sulphate, are useful in reducing the pathophysiological consequences of preeclampsia with severe features and eclampsia. Although the mechanism of action of this Mg2+ salt is not well understood, the available evidence suggests a beneficial effect of Mg2+ for the mother and foetus. The mechanisms include a lower level of soluble fms-like tyrosine kinase 1 and endoglin, blockage of brain N-methyl-D-aspartate receptors, decreased inflammation mediators, activation of nitric oxide synthases, blockage of arginases, and reduced free radicals level. The maintenance of Mg2+ homeostasis in pregnancy is crucial for an appropriate pregnancy progression. Oral Mg2+ salts can be used for this purpose which could result in mitigating the deleterious consequences of this syndrome to the mother, foetus, and newborn.
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