Review
Medicine, General & Internal
Amit Akirov, Hiba Masri-Iraqi, Idit Dotan, Ilan Shimon
Summary: The diagnosis, management, and treatment of acromegaly heavily rely on the levels of serum IGF-1, basal GH, and nadir GH following OGTT. However, these hormone concentrations can be influenced by various factors, leading to discordant levels that may require additional monitoring and data. New standards for GH and IGF-1 provide more accurate tools, but limitations should be considered along with clinical history and imaging studies when evaluating patients with acromegaly.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Stefano Frara, Meliha Melin Uygur, Luigi di Filippo, Mauro Doga, Marco Losa, Simona Santoro, Pietro Mortini, Andrea Giustina
Summary: This study aimed to evaluate the prevalence and determinants of morphometric vertebral fractures (VFs) in patients with recently diagnosed acromegaly. The results showed a higher prevalence of VFs in acromegaly patients compared to controls, and it was found to be associated with GH levels. Therefore, VF assessment should be included in the diagnosis of acromegaly.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Li Li, Liheng Meng, Yuping Liu, Rashi Tamrakar, Xi Yang, Xinghuang Liang, Jia Zhou, Jing Xian, Zhenxing Huang, Yingfen Qin
Summary: Mixed pituitary TSH/GH adenomas are rare adenomas that produce both GH and TSH simultaneously, often associated with acromegaly and thyrotoxicosis. Treatment typically involves somatostatin analogs to regulate hormone levels before surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Malgorzata Rolla, Aleksandra Jawiarczyk-Przybylowska, Jowita Halupczok-Zyla, Marcin Kaluzny, Bogumil M. Konopka, Izabela Bloniecka, Grzegorz Zielinski, Marek Bolanowski
Summary: Acromegaly patients, predominantly female, commonly suffer from complications such as metabolic disorders, cardiovascular diseases, and endocrine disorders. A majority of patients demonstrate a coexistence of cardiac, metabolic, and endocrine disturbances, with a small percentage being disease-free in these main groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Camilla M. Falch, Anne K. Dupont, Nicoleta C. Olarescu, Markus Wiedmann, Daniel Dahlberg, Jens Bollerslev, Jon Berg-Johnsen, Ansgar Heck
Summary: Surgery is necessary for sustained cure of acromegaly. This study aims to estimate the short- and long-term rates of biochemical control after pituitary surgery in acromegaly and identify predictive factors. The findings indicate that the long-term biochemical control rate remains modest in unselected patients with acromegaly.
ACTA NEUROCHIRURGICA
(2023)
Article
Endocrinology & Metabolism
Charlotte Aagaard, Amanda S. Christophersen, Susanne Finnerup, Christian Rosendal, Helga A. Gulisano, Kare S. Ettrup, Peter Vestergaard, Jesper Karmisholt, Eigil Husted Nielsen, Jakob Dal
Summary: This study investigated the prevalence and patient characteristics of acromegaly over time, as well as the impact of treatment changes on disease control. The study found that the prevalence of acromegaly has increased significantly, with a shift towards a milder clinical phenotype. Modern treatment approaches enable individualized treatment and disease control in the majority of patients with acromegaly.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Oncology
Zhengxing Xie, Yan Zhuang, Zongqiang Zhang, Jieping Liu
Summary: This study investigated the prevalence and potential factors associated with cerebral microbleeds (CMBs) in patients with acromegaly. The results showed a higher incidence of CMBs in patients with acromegaly, which may be related to obstructive sleep apnea (OSA) caused by acromegaly. The increase in CMBs could be an important factor contributing to cognitive decline in patients with acromegaly.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Tyler Cardinal, Casey Collet, Michelle Wedemeyer, Peter A. Singer, Martin Weiss, Gabriel Zada, John D. Carmichael
Summary: The study aimed to identify predictive factors for long-term remission of acromegaly after surgical resection of pituitary adenomas. Postoperative GH levels on day 1 and changes in IGF-1 levels postoperatively were found to be useful in predicting hormonal remission. The findings suggest that these factors can help guide clinical follow-up and the need for adjuvant therapy in acromegaly patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Denise Costa, Rosa Lauretta, Valeria Mercuri, Emilia Sbardella, Irene Samperi, Marialuisa Appetecchia, Antonio Bianchi, Antonella Giampietro, Patrizia Gargiulo, Andrea M. Isidori, Maurizio Poggi, Alfredo Pontecorvi, Laura De Marinis
Summary: This study investigated the treatment choices and outcomes for acromegaly patients resistant to first generation somatostatin analogues. The results showed that c-Peg-V and Pasi-Lar were chosen for the treatment of invasive tumors, and partial response to first gen-SSA seemed to be the main determinant for the choice of Pasi-Lar and positively predicted the treatment outcome.
Review
Endocrinology & Metabolism
Joan Gil, Mireia Jorda, Berta Soldevila, Manel Puig-Domingo
Summary: Epithelial-mesenchymal transition is a dynamic process that plays essential roles in both physiological and pathological processes, particularly in the growth and invasion of pituitary tumors. Studies have shown the association of EMT with resistance to somatostatin receptor ligands in the treatment of acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Fuerweger, Alfred Haidenberger, Paul Windisch, Susanne Fichte, Ralph Lehrke, Carolin Senger, David Kaul, Daniel Ruess, Maximilian Ruge, Christian Schichor, Joerg-Christian Tonn, Guenter Stalla, Alexander Muacevic
Summary: In addition to surgery and medication, robotic radiosurgery is an effective and safe treatment option for growth hormone-secreting tumors of the pituitary gland infiltrating surrounding tissue structures, achieving biochemical disease control or remission in most patients with decreasing hormone levels. The treatment also demonstrates favorable risk and safety profiles.
Review
Endocrinology & Metabolism
Antonio Bianchi, Sabrina Chiloiro, Antonella Giampietro, Simona Gaudino, Rosalinda Calandrelli, Ciro Mazzarella, Carmelo Caldarella, Mario Rigante, Marco Gessi, Liverana Lauretti, Laura De Marinis, Alessandro Olivi, Alfredo Pontecorvi, Francesco Doglietto
Summary: Growth hormone-secreting adenomas exhibit a wide range of behaviors and outcomes, from mild disease to aggressive neoplasms. Treatment for patients who do not respond to surgery or first-generation somatostatin receptor ligands may involve multiple surgical, medical, and radiation treatments. Currently, there are no markers that can predict the prognosis or aggressiveness of acromegaly. A multidisciplinary approach is necessary to tailor treatment for difficult/aggressive cases, including radiation therapy, chemotherapy, and emerging treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Nidan Qiao, Damin Yu, Guoqing Wu, Qilin Zhang, Boyuan Yao, Min He, Hongying Ye, Zhaoyun Zhang, Yongfei Wang, Hanfeng Wu, Yao Zhao, Jinhua Yu
Summary: This study utilized artificial intelligence approaches to analyze pathological images and predict endocrine outcomes in patients with active acromegaly after stereotactic radiosurgery. The model showed strong predictive power and outperformed established prognostic markers.
JOURNAL OF PATHOLOGY
(2022)
Article
Clinical Neurology
Marcus A. Zachariah, Jordan J. Bozer, Santino Cua, Luciano M. Prevedello, Luma M. Ghalib, Douglas A. Hardesty, Ricardo L. Carrau, Lawrence S. Kirschner, Daniel M. Prevedello
Summary: This study aimed to evaluate whether intraoperative GH measurement could predict long-term outcomes for acromegaly adenomectomy. The results showed that the minimum intraoperative GH level could predict long-term outcomes for acromegaly.
OPERATIVE NEUROSURGERY
(2023)
Review
Respiratory System
Fajri Gafar, Roeland E. Wasmann, Helen M. McIlleron, Rob E. Aarnoutse, H. Simon Schaaf, Ben J. Marais, Dipti Agarwal, Sampson Antwi, Nguyen D. Bang, Adrie Bekker, David J. Bell, Chishala Chabala, Louise Choo, Geraint R. Davies, Jeremy N. Day, Rajeshwar Dayal, Paolo Denti, Peter R. Donald, Ephrem Engidawork, Anthony J. Garcia-Prats, Diana Gibb, Stephen M. Graham, Anneke C. Hesseling, Scott K. Heysell, Misgana I. Idris, Sushil K. Kabra, Aarti Kinikar, Agibothu K. Hemanth Kumar, Awewura Kwara, Rakesh Lodha, Cecile Magis-Escurra, Nilza Martinez, Binu S. Mathew, Vidya Mave, Estomih Mduma, Rachel Mlotha-Mitole, Stellah G. Mpagama, Aparna Mukherjee, Heda M. Nataprawira, Charles A. Peloquin, Thomas Pouplin, Geetha Ramachandran, Jaya Ranjalkar, Vandana Roy, Rovina Ruslami, Ira Shah, Yatish Singh, Marieke G. G. Sturkenboom, Elin M. Svensson, Soumya Swaminathan, Urmila Thatte, Stephanie Thee, Tania A. Thomas, Tjokosela Tikiso, Daan J. Touw, Anna Turkova, Thirumurthy Velpandian, Lilly M. Verhagen, Jana L. Winckler, Hongmei Yang, Vycke Yunivita, Katja Taxis, Jasper Stevens, Jan-Willem C. Alffenaar
Summary: This study aims to investigate the pharmacokinetics of first-line anti-TB drugs in children and adolescents globally. The results show that younger age and HIV-positive status are associated with lower AUC(0-24) for all first-line anti-TB drugs, while severe malnutrition is associated with lower AUC(0-24) for isoniazid and pyrazinamide. The determinants of Cmax are generally similar to those of AUC(0-24).
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Endocrinology & Metabolism
Amir H. Zamanipoor Najafabadi, Merel van der Meulen, Ana Luisa Priego Zurita, S. Faisal Ahmed, Wouter R. van Furth, Evangelia Charmandari, Olaf Hiort, Alberto M. Pereira, Mehul Dattani, Diana Vitali, Johan P. de Graaf, Nienke R. Biermasz
Summary: The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to improve healthcare for pituitary adenoma patients in Europe. This study reviewed surgical outcomes of pituitary adenoma patients within Endo-ERN MTG6 reference centers between 2010 and 2019. The study found that the remission rates varied for different types of adenomas, and a majority of centers used endoscopic surgery with the collaboration of ENT surgeons.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Eva M. G. Viho, Jan Kroon, Richard A. Feelders, Rene Houtman, Elisabeth S. R. van den Dungen, Alberto M. Pereira, Hazel J. Hunt, Leo J. Hofland, Onno C. Meijer
Summary: Glucocorticoid stress hormones are essential for physiology and exert numerous actions via binding to the glucocorticoid receptor (GR). Relacorilant is a selective GR antagonist being evaluated for the treatment of endogenous Cushing's syndrome. This study compared the effects of relacorilant and the non-selective antagonist mifepristone, showing that relacorilant has potent antagonistic effects on GR signaling and prevents anti-inflammatory effects of glucocorticoids.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Sjoukje van der Hoek, Niels Jongs, Megumi Oshima, Brendon L. L. Neuen, Jasper Stevens, Vlado Perkovic, Adeera Levin, Kenneth W. W. Mahaffey, Carol Pollock, Tom Greene, David C. C. Wheeler, Meg J. J. Jardine, Hiddo J. L. Heerspink
Summary: In the CREDENCE trial, canagliflozin was found to have a greater impact on eGFR slope in patients with higher baseline HbA1c levels, indicating that patients with poorer glycemic control may benefit more from the drug.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk, Naomi Klarenbeek
Summary: Polymeric drug-releasing vaginal rings are effective for local and systemic drug administration. This study evaluated the pharmacokinetics, safety, and tolerability of a microprocessor-controlled vaginal ring for oxybutynin administration. Results showed that the MedRing device successfully delivered oxybutynin via the intravaginal route and was well tolerated.
Review
Endocrinology & Metabolism
Victoria R. van Trigt, Iris C. M. Pelsma, Nienke R. Biermasz
Summary: This study aims to describe the quality and outcomes of patient-reported outcome (PRO) measures in patients with refractory hormone-producing pituitary adenomas. The results showed that there is a wide variation in the health-related quality of life in refractory patients, and it is not always impaired compared to patients in remission.
Review
Medicine, General & Internal
Tessa N. A. Slagboom, Dirk Jan Stenvers, Elsmarieke van de Giessen, Stefan D. D. Roosendaal, Maartje M. L. de Win, Joseph C. J. Bot, Eleonora Aronica, Rene Post, Jantien Hoogmoed, Madeleine L. L. Drent, Alberto M. M. Pereira
Summary: The study provides a structured analysis of the diagnostic accuracy and clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome, as well as the role of multidisciplinary counseling in decision making. It proposes a complementary diagnostic algorithm for both de novo and recurrent or persistent Cushing's disease. The use of molecular imaging modalities is of added and complementary value in the detection of pituitary microadenoma in ACTH-dependent Cushing's syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Oncology
Selinde S. Wind, Manon A. A. Jansen, Melanie Rijsbergen, Michiel J. van Esdonk, Dimitrios Ziagkos, Wing C. Cheng, Tessa van der Kolk, John Korsten, Agnieszka Gruszka, Debora Schmitz-Rohmer, David Bonnel, Raphael Legouffe, Florian Barre, Marcel W. Bekkenk, Ellen R. M. de Haas, Koen D. Quint, Harald Schnidar, Melanie Rolli, Henk Johan Streefkerk, Jacobus Burggraaf, Maarten H. Vermeer, Robert Rissmann
Correction
Endocrinology & Metabolism
Stephan Petersenn, Maria Fleseriu, Felipe F. Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M. K. Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K. Y. Ho, Jurgen Honegger, Adriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Maya Lodish, Dominique Maiter, Hani J. Marcus, Ann McCormack, Mark Molitch, Christopher A. Muir, Sebastian Neggers, Alberto M. Pereira, Rosario Pivonello, Kalmon Post, Gerald Raverot, Roberto Salvatori, Susan L. Samson, Ilan Shimon, Joanna Spencer-Segal, Greisa Vila, John Wass, Shlomo Melmed
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stephan Petersenn, Maria Fleseriu, Felipe F. Casanueva, Andrea Giustina, Nienke Biermasz, Beverly M. K. Biller, Marcello Bronstein, Philippe Chanson, Hidenori Fukuoka, Monica Gadelha, Yona Greenman, Mark Gurnell, Ken K. Y. Ho, Juergen Honegger, Adriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Maya Lodish, Dominique Maiter, Hani J. Marcus, Ann Mccormack, Mark Molitch, Christopher A. Muir, Sebastian Neggers, Alberto M. Pereira, Rosario Pivonello, Kalmon Post, Gerald Raverot, Roberto Salvatori, Susan L. Samson, Ilan Shimon, Joanna Spencer-Segal, Greisa Vila, John Wass, Shlomo Melmed
Summary: This Consensus Statement provides evidence-based graded consensus recommendations and key summary points for clinical practice on the diagnosis and management of prolactinomas. It covers various aspects including epidemiology, pathogenesis, clinical presentation, assessment, imaging strategies, complications, and treatment in special situations. The workshop emphasizes the need for additional therapeutic options to address clinical challenges in treating these patients.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Victoria R. van Trigt, Ingrid M. Zandbergen, Iris C. M. Pelsma, Leontine E. H. Bakker, Marco J. T. Verstegen, Wouter R. van Furth, Nienke R. Biermasz
Summary: Care trajectories for patients with prolactinoma are highly individualized based on patient and tumor characteristics, as well as the assessment of a multidisciplinary team. Most patients receive pharmacological pretreatment and there is wide variation in the timing of referral. Surgery is considered a last-resort treatment, primarily due to dopamine agonist intolerance.
Review
Endocrinology & Metabolism
Violeta Iotova, Camilla Schalin-Jaentti, Charlotte Van Beuzekom, Petra Bruegmann, Manuela Broesamle, Olaf Hiort, Alberto M. Pereira
Summary: The current study assesses the development and impact of the knowledge generation program of the Endo-ERN, specifically focusing on webinars. The study finds that the program has successfully organized a significant number of webinars, engaging a large number of participants and attracting active participation and feedback. The findings highlight the importance and effectiveness of webinars in knowledge sharing and education in the field of rare endocrine conditions.
ENDOCRINE CONNECTIONS
(2023)
Correction
Oncology
Kevin W. Huynh, Eva Coopmans, Amir Zamanipoor Najafabadi, Linda Dirven, Saskia B. Peerdeman, Nienke Biermasz, Marco J. T. A. Verstegen, Wouter C. van Furth, Dutch Meningioma Consortium
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Anne-Sophie C. A. M. Koning, Merel van der Meulen, Daphne Schaap, Djaina D. Satoer, Christiaan H. Vinkers, Elisabeth F. C. van Rossum, Wouter R. van Furth, Alberto M. Pereira, Onno C. Meijer, Olaf M. Dekkers
Summary: The proportion of neuropsychiatric adverse effects in patients using synthetic glucocorticoids is high, with depression and mania being the most significant associations. Awareness of possible psychiatric side effects is essential when starting glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)