Journal
PITUITARY
Volume 21, Issue 2, Pages 130-137Publisher
SPRINGER
DOI: 10.1007/s11102-018-0874-6
Keywords
Non functioning pituitary adenomas; Pathogenesis; Signalling pathway derangements
Categories
Ask authors/readers for more resources
The pathogenesis of non functioning pituitary adenomas (NFPA) is a complex process involving several factors, from molecular to genetic and epigenetic modifications, where tumor suppressor genes, oncogenes, cell cycle derangements have been demonstrated to play an important role. MicroRNAs (miRNAs) have also been identified as possible players in NFPA tumorigenesis and pituitary stem cells have been investigated for their potential role in pituitary tumor initiation. However, a critical role for paracrine signalling has also been highlighted. This review focuses on the current knowledge on the involvement of these factors in NFPA pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available