Article
Biotechnology & Applied Microbiology
Elena Nikitina, Tatyana Petrova, Alya Sungatullina, Oxana Bondar, Maria Kharina, Polina Mikshina, Elizaveta Gavrilova, Airat Kayumov
Summary: The exopolysaccharides (EPS) produced by LAB in fermented milk improve its stability and viscosity. The properties of EPS depend on the composition and microstructure, which are influenced by different strains of lactobacilli. Fructose and negative-charged uronic acid play a significant role in changing the properties of EPS.
FERMENTATION-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Ozum Ozoglu, Aytekin Uzunoglu, Mehmet Altay Unal, Mehmet Gumustas, Sibel Aysil Ozkan, Mihriban Korukluoglu, Evrim Gunes Altuntas
Summary: This study designed amperometric lactate biosensors based on lactate oxidase immobilization. These biosensors were then used to successfully measure lactate produced by six different morphologically identified presumptive lactic acid bacteria (LAB) in naturally fermented cheese samples. By using electrochemical biosensors, lactate metabolites can be measured quickly and accurately within 3 minutes, without the need for the long working hours required by traditional methods. This is the first study to use a biosensor to measure lactate produced by foodborne LAB in a real sample.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2023)
Review
Biology
Polrat Wilairatana, Wanida Mala, Manas Kotepui, Kwuntida Uthaisar Kotepui
Summary: The study demonstrated significant differences in blood lactate levels between patients with severe malaria and those with uncomplicated malaria, as well as between patients who died from severe malaria and those who survived. Further research is required to explore the prognostic value of blood lactate levels in identifying high-risk patients with severe malaria or at risk of death.
Review
Medicine, Research & Experimental
John M. Macharia, Zsolt Kaposztas, Timea Varjas, Ferenc Budan, Afshin Zand, Imre Bodnar, Raposa L. Bence
Summary: Although the pathophysiology of colorectal cancer (CRC) is complex and not well understood, interactions between risk factors play a crucial role in the development and progression of the disease. The use of lactic acid bacteria (LAB) prebiotics and probiotics to modulate the tumor microenvironment (TME) has become increasingly popular in CRC management. This study aims to investigate the negative effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. More research is needed to ensure that LAB and their lactic acid by-products do not have unintended adverse effects in CRC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Chemical
Muhammad Ikhsan Taipabu, Karthickeyan Viswanathan, Hou-Tsen Chen, Wei Wu
Summary: This study focuses on the design of green solvent production of ethyl lactate, including conventional reactive distillation design and three designs of reactive distillation column (Design-1, Design-2, and Design-3). The binary interaction parameters from three thermodynamic models (UNIQUAC, UNIFAC, NRTL) were validated. Process simulation and economic evaluation were conducted using Aspen Plus. The results showed that Design-1 is the optimal solution, reducing the total capital cost by 57.3% and the total operating cost by 17.5%.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Review
Biochemistry & Molecular Biology
Marek Kieliszek, Katarzyna Pobiega, Kamil Piwowarek, Anna M. Kot
Summary: In recent decades, there has been rapid development in the biotechnological use of lactic acid bacteria (LAB) in the food industry. Their proteolytic enzymes play a crucial role in providing cells with nitrogen compounds for growth, and advancements in enzymology allow for the creation of new enzymes with various applications.
Review
Polymer Science
Cristina Mihaela Nicolescu, Marius Bumbac, Claudia Lavinia Buruleanu, Elena Corina Popescu, Sorina Geanina Stanescu, Andreea Antonia Georgescu, Siramona Maria Toma
Summary: Plants, animals, bacteria, and food waste are intensively researched for their potential use in biopolymer production. Non-biodegradable plastics pose a significant threat to the environment, driving stakeholders to seek legislative and technical solutions for producing biodegradable polymers with improved packaging characteristics. Microorganisms, particularly lactic acid bacteria, are recognized as promising sources for biopolymer production in various industries. This review provides an overview of the characteristics of lactic acid bacteria strains and their potential in biosynthesizing exopolysaccharides, polylactic acid, and polyhydroxyalkanoates. Additionally, the application of these biopolymers in the food industry and packaging is discussed, along with alternative, cost-effective biosynthesis solutions.
Review
Engineering, Chemical
Tianqi Fang, Mengyuan Liu, Zhaozhe Li, Li Xiong, Dongpei Zhang, Kexin Meng, Xiaolei Qu, Guangyu Zhang, Xin Jin, Chaohe Yang
Summary: With increasing regulation on single-use plastics, attention has turned to lactic acid (LA) and alkyl lactates as important monomers for bio-degradable PLA plastic products. This review focuses on the direct thermal conversion of fructose to LA and derivatives, particularly the synergistic effects of metal/metal cations and acid/base catalysts. The findings provide insights for the rational design of catalysts for the production of carboxylic acids from biomass feedstocks.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Electrochemistry
Oleh Smutok, Taras Kavetskyy, Mykhailo Gonchar, Evgeny Katz
Summary: Lactic acid is a common metabolite in all living organisms, existing in L- and D-forms, which have various applications in biotechnology, food, pharmaceuticals, cosmetics, and the production of poly-L-lactate. Both L- and D-lactate are important biomarkers for diseases, indicators of food quality, and markers for assessing athlete training level. Enzymes such as FC b(2) and DLDH have shown high selectivity towards L- and D-stereoisomers of lactate, making them suitable for use in electrochemical biosensors.
Article
Emergency Medicine
Kemal Sener, Banu Arslan, Sultan Ozselcuk, Ramazan Guven
Summary: Lactic acid is the end-product of anaerobic glycolysis and elevated blood lactate levels are associated with poor patient outcomes. While lactic acidosis can be caused by supplementary food intake in pediatric patients, it is uncommon in adult patients due to oral ingestion.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Joanna Ivy Irorita Fugaban, Eun Sung Jung, Svetoslav Dimitrov Todorov, Wilhelm Heinrich Holzapfel
Summary: This study aimed to select and characterize lactic acid bacteria (LAB) with potential antifungal activities. Key metabolites identified were beta-phenyllactic acid, alpha-hydroxyisobutyric acid, 1,3-butanediol, phenethylamine, and benzoic acid. It was found that pH neutralization significantly reduced antifungal activity, and the bioactive compounds were not stable under high temperatures and pressure.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Agriculture, Multidisciplinary
Zhang Yuxiao, Yanyin Guo, Song Xinhua
Summary: Amino acid metabolism plays a crucial role in plant growth, including protein biosynthesis, secondary metabolite biosynthesis, and stress response. However, there are limited studies on the role of amino acids in the postharvest preservation of fruits and vegetables.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Cell Biology
Pravat Kumar Parida, Mauricio Marquez-Palencia, Vidhya Nair, Akash K. Kaushik, Kangsan Kim, Jessica Sudderth, Eduardo Quesada-Diaz, Ambar Cajigas, Vamsidhara Vemireddy, Paula Gonzalez-Ericsson, Melinda E. Sanders, Bret C. Mobley, Kenneth Huffman, Sunati Sahoo, Prasanna Alluri, Cheryl Lewis, Yan Peng, Robert M. Bachoo, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis, Srinivas Malladi
Summary: Metabolic diversity and plasticity within brain-tropic cells play a crucial role in determining the metastatic fitness of HER2+ breast cancer patients. Lactate secretion by aggressive metastatic cells or lactate supplementation inhibits innate immunosurveillance and promotes overt metastasis. Inhibiting lactate metabolism can impede brain metastasis, but some brain metastatic cells adapt and survive through specific metabolic pathways. xCT, an amino acid transporter, is significantly upregulated in brain metastatic cells compared to primary tumors, and targeting xCT can attenuate residual disease and recurrence.
Article
Agriculture, Dairy & Animal Science
Priscilia Y. Heredia-Castro, Ricardo Reyes-Diaz, Miguel Angel Rendon-Rosales, Lilia M. Beltran-Barrientos, Maria J. Torres-Llanez, Maria C. Estrada-Montoya, Adrian Hernandez-Mendoza, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba
Summary: This study isolated and characterized bacteriocins produced by two Lactobacillus fermentum strains from artisanal Mexican Cocido cheese. One of the strains exhibited high antimicrobial activity against various indicator microorganisms, suggesting its potential application as a biopreservative in dairy products.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Chemistry, Medicinal
Jun-Kyu Byun
Summary: Tumor development is affected by circulating metabolites, with elevated levels of lactic acid and low levels of glucose and glutamine. Lactic acid, a major circulating carbon metabolite produced by tumors, regulates energy metabolism and cancer cell signaling pathways. Recent studies have identified the pro-tumorigenic action of lactic acid and propose targeting its metabolism as a therapeutic strategy for anti-cancer therapy.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
