Solubility of bosentan in {propylene glycol plus water} mixtures at various temperatures: experimental data and mathematical modelling

Solubility measurements were performed for bosentan (BST) in binary mixtures of propylene glycol (PG) and water at atmospheric pressure within the temperature range, T=293.2 - 313.2 K by employing a shake-flask method. Generated solubility data were correlated with Jouyban-Acree-van't Hoff model and the accuracies of the predicted solubilities and model performance were illustrated by mean relative deviations (MRD). Furthermore, the apparent thermodynamic properties of BST dissolving in all the mixed solvents were calculated, and the obtained results show that the dissolution process is endothermic. By using the inverse Kirkwood-Buff integrals, it was observed that BST is preferentially solvated by water in water-rich solvent mixtures and preferentially solvated by PG (as a cosolvent) in the composition range of 0.20 < x(1)<1.00 at 298.2K.