Review
Biochemistry & Molecular Biology
Ronni Baran, Daniela Grimm, Manfred Infanger, Markus Wehland
Summary: OSA is a common disease affecting millions worldwide, with CPAP therapy being a common treatment method to prevent complications such as hypertension by improving airway patency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Susanna S. S. Ng, Vincent W. S. Wong, Grace L. H. Wong, Winnie C. W. Chu, Tat-On Chan, Kin-Wang To, Fanny W. S. Ko, Ka-Pang Chan, David S. Hui
Summary: This study aimed to investigate the effects of autoadjusting CPAP versus subtherapeutic CPAP on NAFLD in patients with concomitant OSA, showing no significant differences in primary and secondary endpoints between the two treatment groups. Weight change correlated with changes in intrahepatic triglyceride and CAP, suggesting weight reduction through lifestyle modification may be beneficial for improving NAFLD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Narongkorn Saiphoklang, Kanyada Leelasittikul, Apiwat Pugongchai
Summary: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea patients, and a predictive equation for CPAP in Thai patients was developed in this study, with neck circumference, body mass index, respiratory disturbance index, and lowest pulse oxygen saturation being significant factors in predicting the optimal pressure. The equation accounted for 50% of the variance in optimal pressure, providing insight into tailored CPAP therapy for Thai patients with OSA.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Gonzalo Labarca, Alexia Schmidt, Jorge Dreyse, Jorge Jorquera, Daniel Enos, Gerard Torres, Ferran Barbe
Summary: CPAP therapy can significantly improve blood pressure, especially nighttime blood pressure, in patients with both OSA and RH.
SLEEP MEDICINE REVIEWS
(2021)
Letter
Medicine, General & Internal
Xiaoting Wang, Liying Guan, Changzhen Wu, Yongjun Zhao, Gang Zhao
Summary: This study aimed to investigate the effects of continuous positive airway pressure (CPAP) on hypertension in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to understand the underlying mechanisms. The results showed that CPAP significantly improved clinic, ambulatory, and home blood pressure, and this improvement was correlated with a decrease in biomarkers of inflammation and oxidative stress. In conclusion, CPAP has a significant antihypertensive effect on OSAHS patients, especially nocturnal hypertension, possibly by counteracting inflammation and oxidative stress.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Francois Bughin, Monique Mendelson, Dany Jaffuel, Jean-Louis Pepin, Frederic Gagnadoux, Frederic Goutorbe, Beatriz Abril, Bronia Ayoub, Alexandre Aranda, Khuder Alagha, Pascal Pomies, Francois Roubille, Jacques Mercier, Nicolas Molinari, Yves Dauvilliers, Nelly Heraud, M. Hayot
Summary: This study aims to assess the potential benefits of a telerehabilitation program implemented at continuous positive airway pressure initiation compared to continuous positive airway pressure alone and usual care on symptoms and cardiometabolic risk factors of obstructive sleep apnea syndrome. The study is a 6-months multicenter randomized controlled trial including 180 obese patients with severe obstructive sleep apnea syndrome.
Article
Clinical Neurology
Ayesha Reynor, Nigel McArdle, Bindiya Shenoy, Satvinder S. Dhaliwal, Siobhan C. Rea, Jennifer Walsh, Peter R. Eastwood, Kathleen Maddison, David R. Hillman, Ivan Ling, Brendan T. Keenan, Greg Maislin, Ulysses Magalang, Allan Pack, Diego R. Mazzotti, Chi-Hang Lee, Bhajan Singh
Summary: The study found that only a minority of sleep clinic patients diagnosed with OSA met the eligibility criteria of RCTs involving CPAP therapy, indicating that the findings of such trials may not be applicable to typical sleep clinic OSA patients. The characteristics of OSA populations in RCTs differ significantly from those in sleep clinic settings.
Article
Clinical Neurology
Wan-Ju Cheng, Eysteinn Finnsson, Jon S. Agustsson, Scott A. Sands, Liang-Wen Hang
Summary: Determining endotypes of OSA can have potential implications for precision interventions. The study aimed to assess whether CPAP treatment outcomes differ across endotypic subgroups. Retrospective analysis of data obtained from 225 patients with OSA showed that certain endotypic subgroups had different outcomes in CPAP treatment, including optimal CPAP pressure, improvements in sleep architecture, and CPAP adherence.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Alexandra Lauren Rice, Sakshi Bajaj, Abigail M. Wiedmer, Natalie Jacobson, Aleksandar K. Stanic, Kathleen M. Antony, Mihaela H. Bazalakova
Summary: This study retrospectively analyzed the impact of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA) during pregnancy on hypertensive disorders of pregnancy. The results suggest that CPAP therapy may decrease the occurrence of hypertensive complications in pregnancies complicated by OSA.
SLEEP AND BREATHING
(2023)
Article
Surgery
Yi-Chih Lin, Chun-Tien Chen, Pin-Zhir Chao, Po-Yueh Chen, Wen-Te Liu, Sheng-Teng Tsao, Sheng-Feng Lin, Chyi-Huey Bai
Summary: This study aimed to compare the effectiveness of uvulopalatopharyngoplasty (UPPP) and continuous positive airway pressure (CPAP) in treating obstructive sleep apnea (OSA) and preventing hypertension. The results showed that both UPPP and CPAP treatment groups had a significant preventive effect on hypertension compared to the non-treatment group, with CPAP showing better effectiveness.
FRONTIERS IN SURGERY
(2022)
Article
Peripheral Vascular Disease
Christian Nejm Roderjan, Aline de Hollanda Cavalcanti, Arthur Fernandes Cortez, Bernardo Chedier, Fernanda Oliveira de Carvalho Carlos, Fabio de Souza, Elizabeth Silaid Muxfeldt
Summary: This study found an association between aortic stiffness and the severity of obstructive sleep apnea in patients with resistant hypertension. As the severity of apnea increased, arterial stiffness also increased, particularly in women, patients with true resistant hypertension, and those with adverse nocturnal blood pressure profiles.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Otorhinolaryngology
Mariana Pinheiro Brendim, Carla Rocha Muniz, Thalyta Georgia Vieira Borges, Flavia Rodrigues Ferreira, Elizabeth Silaid Muxfeldt
Summary: This study aimed to describe the prevalence and characteristics of oropharyngeal dysphagia (OD) in hypertensive patients with obstructive sleep apnea (OSA) through Fiberoptic Endoscopic Evaluation of Swallowing (FEES) and assess the sensitivity of the Eating Assessment Tool-10 (EAT-10) for detecting OD in this population. The results showed a high prevalence of dysphagia in this group, and the severity of dysphagia was associated with higher EAT-10 scores.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Rafael B. Azevedo, Debora C. R. Wandermurem, Flavia C. F. Liborio, Maira K. Machado, Natalia M. Ushijima, Ramon S. Narde, Inah Maria D. Pecly, Elizabeth S. Muxfeldt
Summary: Adverse cardiac metabolic profiles, particularly diabetes and obesity, are important risk factors for severe COVID-19. Patients with cardiovascular comorbidities are more likely to experience adverse clinical outcomes and increased severity of the disease.
CURRENT CARDIOLOGY REVIEWS
(2022)
Article
Peripheral Vascular Disease
Bernardo Chedier, Christian N. Roderjan, Aline H. Cavalcanti, Fabio de Souza, Elizabeth S. Muxfeldt
Summary: This study describes the prevalence of obstructive sleep apnea (OSA) and polysomnography (PSG) pattern in patients with refractory hypertension (RfHT). Patients with RfHT have similar OSA prevalence compared to patients with resistant hypertension, but they are younger and have a better sleep pattern.
JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Urology & Nephrology
Cibele Isaac Saad Rodrigues, Rafael Bellotti Azevedo, Elizabeth Silaid Muxfeldt
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Otorhinolaryngology
Thalyta Georgia Vieira Borges, Carla Rocha Muniz, Flavia Rodrigues Ferreira, Mariana Pinheiro Brendim, Elizabeth Silaid Muxfeldt
Summary: This study aims to evaluate the rehabilitation effect of swallowing therapy program on oropharyngeal dysphagia in resistant hypertensive patients with obstructive sleep apnea (OSA), and to explore the association between clinical and anthropometric characteristics and the outcome. The results showed that patients with resistant hypertension and OSA exhibited improved swallowing performance after the therapy program.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Neurosciences
Celmir de Oliveira Vilaca, Fabio de Souza, Kelly Biancardini Gomes Barbato
Summary: This study retrospectively reviewed neurological cases in a Brazilian federal tertiary center and a teaching hospital in orthopedics in Rio de Janeiro, describing the clinical and epidemiological characteristics of neurological disorders. The majority of cases were females and white individuals, with approximately one-third being peripheral neuropathies.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Meeting Abstract
Peripheral Vascular Disease
Elizabeth Silaid Muxfeldt, Bernardo Chedier, Arthur Fernandes Cortez, Victor Margallo, Taissa Lorena Dos Santos
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Bernardo Chedier, Fabio de Souza, Bianca Viegas, Fernanda Oliveira C. Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Camila Bello Nemer, Sofi A. Luz Botelho Lobo, Bianca Zattar de Mello Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Bernardo Chedier, Fabio de Souza, Bianca Viegas, Fernanda Oliveira C. Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Camila Bello Nemer, Sofia Luz Botelho Lobo, Bianca Zattar de Mello Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Carolina de Carvalho Fortes, Bernardo Chedier, Christian Nejm Roderjan, Bianca Viegas, Fernanda O. Carvalho Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Camila Bello Nemer, Marcus Vinicius Serejo Borges V. da Silva, Lucca Hiroshi de Sa Kimura, Sofia Luz Coutinho Botelho Lobo, Bianca Zattar de M. Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Carolina de Carvalho Fortes, Bernardo Chedier, Christian Nejm Roderjan, Bianca Viegas, Fernanda O. Carvalho Carlos, Taissa Lorena dos Santos, Hugo Farah Affonso Alves, Camila Bello Nemer, Marcus Vinicius Serejo Borges V. da Silva, Lucca Hiroshi de Sa Kimura, Sofia Luz Coutinho Botelho Lobo, Bianca Zattar de M. Barreto, Vitor de Melo Nolasco, Joao Gabriell Bezerra da Silva, Joao Gabriel Rega do N. Vallaperde, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Camila Bello Nemer, Bernardo Chedier, Aline de Hollanda Cavalcanti, Christian Nejm Roderjan, Bianca Viegas, Taissa Lorena dos Santos, Joao Carlos Moreno de Azevedo, Hugo Farah Affonso Alves, Lucca Hiroshi de Sa Kimura, Carolina de Carvalho Fortes, Marcus Vinicius Serejo Borges V. da Silva, Sofia Luz Coutinho Botelho Lobo, Fabio de Souza, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Christian Nejm Roderjan, Fabio de Souza, Bernardo Chedier, Aline de Hollanda Cavalcanti, Bianca Viegas, Fernanda Oliveira Carvalho Carlos, Taissa Lorena dos Santos, Joao Carlos Moreno de Azevedo, Carolina de Carvalho Fortes, Bianca Zattar de Jmello Barreto, Vitor de Melo Nolasco, Joao Gabriel do Nascimento Vallaperde, Joao Gabriell Bezerra da Silva, Elizabeth Silaid Muxfeldt
JOURNAL OF HYPERTENSION
(2022)