Article
Psychology, Experimental
Rena Gatzounis, Sofie De Bruyn, Liselot Van de Velde, Ann Meulders
Summary: The study found that counterconditioning was not more effective than extinction in reducing pain-related fear and its return. There were no group differences in fear reduction between the counterconditioning and extinction groups.
Review
Behavioral Sciences
Kelle E. Nett, Ryan T. LaLumiere
Summary: The rodent infralimbic cortex (IL) is involved in various motivated behaviors, such as associative learning, drug seeking, and natural reward seeking. Evidence suggests that a major function of IL is to facilitate the encoding and updating of contingencies between cues and behaviors to guide subsequent behaviors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Johanna M. Duran, Rodrigo O. Sierra, Karen Corredor, Fernando P. Cardenas
Summary: The study evaluated the effects of cathodal (c-tDCS) and anodal (a-DCS) transcranial direct current stimulation on memory reactivation and extinction in rats. The results showed that c-tDCS and a-tDCS can attenuate mild fear memories, with only c-tDCS preventing fear expression under strong fear learning and fear recovery after reinstatement.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Behavioral Sciences
Sarah C. Tryon, Iris M. Sakamoto, Devin M. Kellis, Kris F. Kaigler, Marlene A. Wilson
Summary: The study found that female rodents display fear behavior repertoires divergent from males during fear extinction. Individual differences in freezing behavior and ultrasonic vocalizations were observed in female rats during fear learning and extinction, particularly during the initial exposure to the testing environment.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Yu Chen, Xiao Lin, Sizhi Ai, Yan Sun, Le Shi, Shiqiu Meng, Lin Lu, Jie Shi
Summary: The study suggests that novelty-facilitated extinction has a superior effect in preventing fear generalization, providing new perspectives for enhancing the effect of exposure therapy.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Dorothee Poehlchen, Marthe Priouret, Miriam S. Kraft, Florian P. Binder, Deniz A. Guersel, Goetz Berberich, Kathrin Koch, Victor Spoormaker
Summary: The study found no significant differences between OCD patients and healthy controls in fear acquisition and extinction tasks, except for a trend towards higher startle amplitudes during extinction in OCD patients. Sensitive measures such as pupillometry and startle responses did not support the assumption of generic impaired extinction learning and memory in OCD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Arash Javanbakht, Lana Ruvolo Grasser, Shantanu Madaboosi, Asadur Chowdury, Israel Liberzon, Vaibhav A. Diwadkar
Summary: The study found that in instructed extinction learning, there was greater activation for the CS+I compared to CS+U, affecting functional connectivity in multiple brain regions. The addition of cognitive instruction was shown to enhance activation of emotion regulation and reappraisal networks during extinction learning.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Alex. H. K. Wong, Jessica C. Lee, Paula Engelke, Andre Pittig
Summary: This study finds that different generalization rules lead to differential outcomes in fear extinction learning. The Linear group shows stronger safety behaviors to the generalization stimuli (GS) during extinction, and exhibits a stronger reduction in the generalization of safety behaviors afterwards. The results demonstrate that identifying individual's generalization rules can predict expectancy violation to the extinction stimulus and strongly violating threat expectancy enhances extinction learning and its generalization.
BEHAVIOUR RESEARCH AND THERAPY
(2023)
Article
Psychology, Clinical
Maya T. Schenker, Sevil Ince, Luke J. Ney, Chia-Ming K. Hsu, Daniel V. Zuj, Amy S. Jordan, Christian L. Nicholas, Kim L. Felmingham
Summary: Sleep plays a crucial role in fear conditioning, extinction learning, and extinction recall. However, subjective sleep measures were not found to be associated with fear conditioning or extinction processes in individuals with PTSD. Exploratory analyses revealed that shorter sleep onset latency and greater sleep efficiency were associated with improved extinction recall in women with higher PTSD symptom severity.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Neurosciences
Yosif Zaki, William Mau, Christine Cincotta, Amy Monasterio, Emma Odom, Emily Doucette, Stephanie L. Grella, Emily Merfeld, Monika Shpokayte, Steve Ramirez
Summary: This study found that fear memories are formed and extinguished through the involvement of the hippocampus and amygdala in mice. During fear relapse, the cells that were active during fear conditioning are re-engaged. Inactivating these cell ensembles disrupts fear expression after relapse, while stimulating them after extinction cannot mimic fear relapse.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Neurosciences
Michael Treanor, Benjamin M. Rosenberg, Michelle G. Craske
Summary: While there is some evidence of deficits in Pavlovian learning in pediatric anxiety disorders, the existing literature faces methodological and theoretical issues. Future research needs to address these issues in order to further elucidate the role of Pavlovian learning in the etiology, maintenance, and treatment of pediatric anxiety disorders.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Behavioral Sciences
Ho Namkung, Kerrie L. Thomas, Jeremy Hall, Akira Sawa
Summary: Studies on fear learning and extinction have greatly advanced our understanding of the neurobiology involved. Animal studies offer causal insights for human brain regions and their functional connectivity, while human studies provide macroscopic insights into animal neural circuits. However, there is room for improvement in translating basic and clinical research on fear learning and extinction.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Khadijah Shanazz, Rachael Dixon-Melvin, Rebecca Nalloor, Riya Thumar, Almira I. Vazdarjanova
Summary: According to animal experiments, there are differences in the expression of fear memories between female and male rats. Female rats tend to express fear memories through active motor responses, which is referred to as "Anxioescapic" behavior strategy. There is no significant difference in fear learning between female and male rats.
Article
Neurosciences
Daniela Schiller
Summary: This commentary describes the evolution, branches, major challenges, and future endeavors in the field of reconsolidation.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Iulia Zoicas, Johannes Kornhuber
Summary: Acid sphingomyelinase (ASM) regulates fear learning and the expression of contextual fear in a sex-specific manner, but does not affect the expression of cued fear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Kean J. Hsu, Jason Shumake, Kayla Caffey, Semeon Risom, Jocelyn Labrada, Jasper A. J. Smits, David M. Schnyer, Christopher G. Beevers
Summary: This study demonstrated that active attention bias modification training (ABMT) was effective in reducing depressive symptoms in individuals with at least moderate negative attentional bias. Sham ABMT did not show significant benefits, and there were no significant differences in other anxiety-related scales.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Behavioral Sciences
Emily N. Hilz, Suzanne M. Lewis, Megan E. Olshavsky, Elizabeth S. Khoury, Andrea C. Gore, Marie H. Monfils, Hongjoo J. Lee
Summary: This research compared male and female rats (both intact and ovariectomized with/without estradiol replacement) on various behavioral tasks, revealing that regardless of estradiol replacement, female rats exhibited higher scores in conditioned orienting response (OR) compared to males. OR score was found to predict attention impairments, with estradiol availability contributing to this relationship in females. Sex differences were not observed in novelty-seeking, attentional set-shifting, or ultrasonic vocalization response to amphetamine, but estradiol replacement did affect the presentation of these behaviors.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Laura A. Agee, Victoria Nemchek, Cassidy A. Malone, Hongjoo J. Lee, Marie-H Monfils
Summary: Cells in the lateral hypothalamic area play a crucial role in various behavioral and cognitive functions. This study investigates the involvement of orexin in the acquisition and recall of socially transmitted food preferences in rats. The findings suggest a potential sex-specific role for the orexin system in balancing feeding behavior with the sleep/wake cycle.
Letter
Clinical Neurology
Sarah D. Black, Victor A. Del Bene, Andrea S. Celka, Barton Guthrie, Roy C. Martin, Joseph Olson, Jason Shumake, Harrison C. Walker
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Maria Dekhtyar, Janelle T. Foret, Sarah Simon, Jason Shumake, Alexandra L. Clark, Andreana P. Haley
Summary: The study examined the clinical utility of the Controlled Oral Word Association Test (COWAT) in predicting Mild Cognitive Impairment (MCI). The results showed that individuals with MCI produced fewer words with higher lexical frequency. Demographics, test version, and diagnosis did not explain the variance in total correct words or lexical frequency. Total correct words were found to be a more important predictor of diagnosis than lexical frequency.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Behavioral Sciences
Emily N. Hilz, Marcelle Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C. Gore, Hongjoo J. Lee
Summary: This study investigates how modulating ovarian hormonal states with hormonal contraceptives affects drug preference and responsivity in female rats. The findings suggest that hormonal contraceptives and natural ovarian hormone levels have similar effects on drug preference and responsivity, providing new insights into the potential impact of hormone-altering contraceptives.
BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Marie-H. Monfils
BIOLOGICAL PSYCHIATRY
(2022)
Review
Behavioral Sciences
Marie-H Monfils, Hongjoo J. Lee, Roberto U. Cofresi, Rueben A. Gonzales
Summary: This article presents a selective review of the collaborations with Dr. Nadia Chaudhri, highlighting her significant contributions to our understanding of Pavlovian alcohol conditioning.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Marie-H Monfils, Michael Domjan
Summary: This article briefly reviews the reasons and mechanisms behind fear, with a focus on the complex behavioral responses of rodents in the face of impending harm and its relevance to treatment interventions.
EMERGING TOPICS IN LIFE SCIENCES
(2022)
Article
Psychiatry
Jasper A. J. Smits, Marie-H Monfils, Michael W. Otto, Michael J. Telch, Jason Shumake, Justin S. Feinstein, Sahib S. Khalsa, Adam R. Cobb, E. Marie Parsons, Laura J. Long, Bryan McSpadden, David Johnson, Alma Greenberg
Summary: This study aims to validate CO2 reactivity as a biomarker for exposure-based therapy non-response. By assessing CO2 reactivity in 600 adults and incorporating it into a multivariate model, the study seeks to predict treatment non-response and validate the mechanistic specificity and predictive utility of the CO2 reactivity biomarker.
Article
Multidisciplinary Sciences
Laura A. Agee, Emily N. Hilz, Dohyun Jun, Victoria Nemchek, Hongjoo J. Lee, Marie-H. Monfils
Summary: This study aimed to investigate the neural mechanisms underlying the recall of socially acquired information. The results showed no differences in the expression of the immediate early gene Arc in the prefrontal regions and ventral CA3 of the hippocampus between control, demonstrator, and observer groups. This suggests that there may be minimal neural restructuring in these areas during the recall of recently socially acquired information or directly acquired fear associations.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
K. A. Smith, M. R. Raskin, M. H. Donovan, V. Raghunath, S. Mansoorshahi, M. J. Telch, J. Shumake, L. J. Noble-Haeusslein, M. H. Monfils
Summary: There is an association between traumatic brain injuries (TBIs) and psychiatric disorders, such as PTSD. Exposure-based therapy is commonly used to treat PTSD, but some individuals do not respond well to this approach. Fear extinction, a key mechanism in exposure-based therapy, can help identify predictors of successful treatment for non-responders.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Laura A. Agee, Miriam E. Ortega, Hongjoo J. Lee, Marie-H. Monfils
Summary: The ability to learn through social observation or instruction is crucial for both humans and animals. In this study, rats were tested on their ability to learn the association between a light stimulus and a hidden or visible reward through observation of a trained demonstrator. The results showed that observation alone was not enough for rats to learn the association, but when paired with a demonstrator, the observers had higher contact with the reward location, especially when the light cue predicted a sucrose reward. Additionally, the behavior of the demonstrator during the observation period had an influence on the corresponding behavior of their observer during later individual training sessions.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Psychology, Biological
Marissa Raskin, Cassidy Malone, Emily N. Hilz, Jasper A. J. Smits, Michael J. Telch, Michael W. Otto, Jason Shumake, Hongjoo J. Lee, Marie-H. Monfils
Summary: Pavlovian conditioning plays a role in maladaptive behaviors in psychiatric disorders. CO2 reactivity can predict fear and appetitive extinction, suggesting it could be used as a transdiagnostic screening tool for exposure therapy.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
Emily N. Hilz, Laura A. Agee, Donyun Jun, Marie-H. Monfils, Hongjoo J. J. Lee
Summary: In this experiment, we found that female rats exhibit stage-dependent renewal of context-dependent extinction behavior during the estrous cycle. Through cellular compartment analysis, we further investigated how the estrous cycle modulates contextual representation at the neuronal level to drive renewal. The results showed that rats in the proestrus stage during extinction training but in a different stage during long-term memory and renewal testing displayed more renewal of conditioned foodcup behavior compared to rats in other estrous cycle groups. Additionally, these rats showed differential expression of Arc mRNA in regions of the prefrontal cortex, amygdala, and hippocampus.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
