Article
Gastroenterology & Hepatology
Raaj S. Mehta, Bharati Kochar, Zhen Zhou, Jonathan C. Broder, Paget Chung, Keming Yang, Jessica Lockery, Michelle Fravel, Joanne Ryan, Suzanne Mahady, Suzanne G. Orchard, John J. Mcneil, Anne Murray, Robyn L. Woods, Michael E. Ernst, Andrew T. Chan
Summary: This study investigated the associations of proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) use with dementia and cognitive decline. The study found that long-term use of PPI and H2RA was not associated with incident dementia, cognitive impairment without dementia (CIND), or decline in cognition over time.
Editorial Material
Gastroenterology & Hepatology
Peter Malfertheiner, Christian Schulz, Colin W. Howden
Summary: This article is related to Gong et al papers. To view these articles, visit the website.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung
Summary: This article is related to the papers by Gong et al. To access these articles, visit and.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Critical Care Medicine
Tanja Tran, Deborah Assayag, Pierre Ernst, Samy Suissa
Summary: This study found no association between the use of PPIs and all-cause mortality or respiratory-related hospitalization in patients with IPF, suggesting that PPIs may not be as beneficial in treating IPF as some studies have suggested.
Editorial Material
Oncology
Courtney M. Richman, David A. Leiman
Summary: Proton pump inhibitors (PPIs) are commonly used for digestive diseases, but there is conflicting data on the association between PPI use and gastric cancer risk. A pooled case-control study found that short-term PPI use was associated with increased risk of gastric cancer, but long-term use did not show this association. This study provides reassurance to patients and clinicians that long-term PPI use does not significantly increase gastric cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang
Summary: This study found that the use of proton pump inhibitors (PPIs) is associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly among individuals without indications for medication. However, the use of histamine-2 receptor antagonists (H2RAs) is not related to the risk of ASCVD.
Article
Medicine, General & Internal
Paul M. McKeigue, Sharon Kennedy, Amanda Weir, Jen Bishop, Stuart J. McGurnaghan, David McAllister, Chris Robertson, Rachael Wood, Nazir Lone, Janet Murray, Thomas M. Caparrotta, Alison Smith-Palmer, David Goldberg, Jim McMenamin, Bruce Guthrie, Sharon Hutchinson, Helen M. Colhoun
Summary: Severe COVID-19 is strongly associated with polypharmacy and drugs that have sedation, respiratory depression, or dyskinesia effects. Measures to reduce mortality and morbidity from COVID-19 should focus on reducing overprescribing of these drug classes and limiting inappropriate polypharmacy.
Article
Medicine, General & Internal
Elizabeth T. Jensen, Joe Yi, Wesley Jackson, Rachana Singh, Robert M. Joseph, Karl C. K. Kuban, Michael E. Msall, Lisa Washburn, Rebecca Fry, Andrew M. South, T. Michael O'Shea
Summary: Early acid suppressant use in extremely preterm infants may be associated with poorer neurodevelopmental outcomes, including decreased IQ scores, autism spectrum disorder, and epilepsy.
Article
Public, Environmental & Occupational Health
Johnmary T. Arinze, Maria A. J. de Ridder, Dina Vojinovic, Hanne van Ballegooijen, Emanuil Markov, Talita Duarte-Salles, Peter Rijnbeek, Katia M. C. Verhamme
Summary: This study aimed to investigate the impact of regulatory intervention on the use patterns of ranitidine-containing medicines and their therapeutic alternatives, and to report discernible trends in treatment discontinuation and switching to alternative medications.
Review
Pharmacology & Pharmacy
Marie Bridoux, Nicolas Simon, Anthony Turpin
Summary: Proton pump inhibitors (PPIs) can interact with cancer drugs and may impact the efficacy of cancer treatments. PPIs may have pro-tumor activity by increasing plasma gastrin levels or anti-tumor activity by inhibiting V-ATPases. They may reduce the efficacy of some antineoplastic agents and have indirect interactions with immunotherapies through the microbiome. PPIs also have effects on hypomagnesemia, bone loss, iron deficiencies, and vitamin B12 deficiencies, but may protect the renal system.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Medicine, General & Internal
Ahhyung Choi, Yunha Noh, So-Hee Park, Seung-Ah Choe, Ju-Young Shin
Summary: This cohort study aims to investigate whether the use of proton pump inhibitors during pregnancy is associated with the incidence of preeclampsia.
Review
Immunology
Sebastien Lopes, Lucile Pabst, Anne Dory, Marion Klotz, Benedicte Gourieux, Bruno Michel, Celine Mascaux
Summary: Gut microbiota can influence the effectiveness of immune checkpoint inhibitors (ICIs) in cancer patients. A meta-analysis was conducted to investigate the impact of proton pump inhibitors (PPIs) on ICIs treatment outcomes. The results suggest that concomitant use of PPIs leads to worse outcomes in terms of overall survival (OS) and progression-free survival (PFS) in advanced cancer patients treated with ICIs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Catia Santos-Pereira, Maria T. Andres, Jose F. Fierro, Ligia R. Rodrigues, Manuela Cote-Real
Summary: Lactoferrin, a versatile natural milk-derived protein, has been found to affect proton pumping ATPases and may exhibit proton pump inhibitor-like activity. Understanding the mechanisms and outcomes of this activity is important for developing improved applications of lactoferrin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Medicine, General & Internal
Ingmar F. Rompen, Daniela C. Merz, Karam T. Alhalabi, Rosa Klotz, Eva Kalkum, Thomas M. Pausch, Hendrik Strothmann, Pascal Probst
Summary: This study aimed to provide an evidence-based overview on the best perioperative drug treatment in pancreatic surgery. The analysis showed that somatostatin analogues and glucocorticoids can reduce the incidence of postoperative pancreatic fistula, while there is limited evidence for other drug treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Sun Young Kim, Ji Sung Lee, Junho Kang, Satoshi Morita, Young Suk Park, Junichi Sakamoto, Kei Muro, Rui-Hua Xu, Tae Won Kim
Summary: This study found that there is a significant interaction between the use of proton pump inhibitors (PPIs) and the type of fluoropyrimidines in the treatment of metastatic colorectal cancer, suggesting that fluorouracil may be a more favorable option for PPI users.
Article
Psychology, Developmental
Mette Bliddal, Helene Kildegaard, Lotte Rasmussen, Martin Ernst, Poul Jorgen Jennum, Stine Hasling Mogensen, Anton Pottegard, Rikke Wesselhoeft
Summary: This study provides a detailed description of the use of melatonin in Danish children, adolescents, and young adults from 2012 to 2019. The incidence of melatonin use increased during this period, and a significant proportion of users had concurrent psychopathology. Long-term use of melatonin was most common among the youngest age groups.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Mikkel Hojlund, Larus S. Gudmundsson, Jacob H. Andersen, Leena K. Saastamoinen, Helga Zoega, Svetlana O. Skurtveit, Jonas W. Wastesson, Jesper Hallas, Anton Pottegard
Summary: The use of benzodiazepines and related drugs has decreased in the Nordic countries from 2004 to 2020, with significant differences between countries. Despite warnings, benzodiazepines are still commonly used in the older population.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shirley Wang, Anton Pottegard, William Crown, Peter Arlett, Darren M. Ashcroft, Eric Benchimol, Marc L. Berger, Gracy Crane, Wim Goettsch, Wei Hua, Shaum Kabadi, David M. Kern, Xavier Kurz, Sinead Langan, Takahiro Nonaka, Lucinda Orsini, Susana Perez-Gutthann, Simone Pinheiro, Nicole Pratt, Sebastian Schneeweiss, Massoud Toussi, Rebecca J. Williams
Summary: Problem ambiguity in communication of key study parameters hinders the use of real-world evidence studies in healthcare decision-making. Clear communication about data provenance, design, analysis, and implementation is essential for reproducibility and assessing potential biases.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Endocrinology & Metabolism
Anton Pottegard, Jacob H. Andersen, Jens Sondergaard, Reimar W. Thomsen, Tina Vilsboll
Summary: This study investigates the changes in drug usage patterns for treating type 2 diabetes in Denmark from 2005 to 2021. The results show an increase in new users of non-insulin, glucose-lowering drugs, with a peak in 2011 and a significant increase in 2020-2021. The prevalence of drug use also steadily increased over the years. General practitioners prescribed the majority of glucose-lowering drugs, and there was a notable shift in the type of drugs prescribed.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lars Christian Lund, Patricia Hjorslev Jensen, Anton Pottegard, Morten Andersen, Nicole Pratt, Jesper Hallas
Summary: Using Danish nationwide health registries, researchers identified 70 drug-diabetes associations, of which 27 were previously unknown. These findings are important for understanding the drugs that can cause diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Oncology
Manon Cairat, Anton Pottegard, Morten Olesen, Laure Dossus, Agnes Fournier, Blanaid Hicks
Summary: The use of antiplatelet drugs, including low-dose aspirin, clopidogrel, and dipyridamole, does not appear to be associated with a reduced risk of breast cancer. However, there may be a potential inverse association between dipyridamole use and breast cancer risk in women under 55 years old.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
J. J. Komen, N. B. Hunt, A. Pottegard, P. Hjemdahl, B. Wettermark, M. Olesen, M. Bennie, T. Mueller, R. Carragher, O. Karlstad, L. J. Kjerpeseth, O. H. Klungel, T. Forslund
Summary: Harmonisation with common protocols and common data models (CDMs) can improve the validity of pharmacoepidemiologic research by reducing database heterogeneity. The case study comparing the safety and effectiveness of stroke prevention therapy before and after the introduction of direct oral anticoagulants (DOACs) found that in most countries, the risk of stroke decreased while the risk of bleeding remained unchanged. However, in Scotland, there was an increase in major bleeding and intracranial hemorrhage.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Medicine, General & Internal
Efe Eworuke, Mayura Shinde, Laura Hou, Michael J. Paterson, Peter Bjodstrup Jensen, Judith C. Maro, Ashish Rai, Daniel Scarnecchia, Dinci Pennap, Daniel Woronow, Rebecca E. Ghosh, Stephen Welburn, Anton Pottegard, Robert W. Platt, Hana Lee, Marie C. Bradley
Summary: This retrospective cohort study examined the usage and switching patterns of valsartan, losartan, and irbesartan in the USA, UK, Canada, and Denmark before and after the recall of valsartan in July 2018. The results showed a significant decline in the usage of valsartan and an increase in switching to other ARBs in the USA, Canada, and Denmark. No change in usage trends was observed in the UK. The recalls of losartan and irbesartan were also associated with increased switching.
Letter
Psychiatry
Mette Bliddal, Rikke Wesselhoeft, Anton Pottegard
Article
Pediatrics
Mette Bliddal, Rikke Wesselhoeft, Katrine Strandberg-Larsen, Martin T. Ernst, Myrna M. Weissman, Jay A. Gingrich, Ardesheer Talati, Anton Pottegard
Summary: This study used Danish population data to examine the association between maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and children outcomes. The results showed that children of mothers who used SSRIs during pregnancy had higher risk of depressive, anxiety, and adjustment disorders, and earlier age of onset of these disorders compared to children of mothers who did not use SSRIs or discontinued SSRIs use before conception. Paternal use of SSRIs in the absence of maternal use during pregnancy and maternal use only after pregnancy were also associated with these outcomes.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Review
Public, Environmental & Occupational Health
Blanaid Hicks, James A. Kaye, Laurent Azoulay, Kasper Bruun Kristensen, Laurel A. Habel, Anton Pottegard
Summary: With the increasing utilization of medications worldwide, there is a growing opportunity and need for robust studies evaluating drug-cancer associations. Using lag times is an important methodology in such studies. This review discusses the reasons for using lag times, the long latency period of cancer, and practical advice for implementing lag periods.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Carina Lundby, Marianne Nielsen, Trine Simonsen, Stine Galsgaard, Maija Bruun Haastrup, Lene Vestergaard Ravn-Nielsen, Anton Pottegard
Summary: Understanding the attitudes and perspectives of older psychiatric patients towards deprescribing is crucial for promoting patient-centered care. This study found that half of the patients had an intrinsic desire to stop taking medication, while the majority were willing to do so on their physician's advice. Concerns about missing out on future benefits and previous negative experiences with deprescribing were also significant factors influencing patient attitudes.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Rheumatology
Melker S. Johansson, Anton Pottegard, Jens Sondergaard, Martin Englund, Dorte T. Gronne, Soren T. Skou, Ewa M. Roos, Jonas B. Thorlund
Summary: The aim of this study was to investigate the utilization patterns of prescribed analgesics before, during, and after an exercise therapy and patient education program among patients with knee or hip osteoarthritis. The study found that the majority of patients had an increase in analgesic use in the year before the intervention, but a decrease during and after the intervention. A small proportion of patients accounted for more than half of the total analgesic dispensed during the study period.
RHEUMATOLOGY INTERNATIONAL
(2023)
