Journal
PEDIATRIC RHEUMATOLOGY
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12969-018-0250-0
Keywords
Vitamin D; Childhood arthritis; Juvenile idiopathic arthritis
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Funding
- University of Saskatchewan
- The Jim Pattison Children's Hospital Foundation
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Background: Vitamin D has been implicated in the pathogenesis of autoimmune diseases. While the roles of vitamin D in other autoimmune diseases have been investigated, less is known about the role of vitamin D in chronic childhood arthritis. Main body: This review summarizes and evaluates evidence relating to 25-hydroxyvitamin D (25(OH) D) and chronic childhood arthritis. A scoping literature review was conducted using Ovid Medline, Ovid Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science and Scopus. Further, we geo-mapped the results of the studies to identify the patterns of the association between vitamin D and chronic childhood arthritis across the globe. Of 38 studies reporting 25(OH) D concentrations in childhood chronic arthritis, 32 (84.2%) reported that a significant number of children had suboptimal (< 75 nmol/L) status. Conclusion: The data indicate suboptimal vitamin D status in children with chronic arthritis. Further, the association between low vitamin D and increased arthritis activity follow a north-south geographical gradient.
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