Article
Nutrition & Dietetics
Lila S. Nolan, Angela N. Lewis, Qingqing Gong, James J. Sollome, Olivia N. DeWitt, Robert D. Williams, Misty Good
Summary: Metabolomics analysis of breast milk from mothers of preterm infants revealed significant differences in metabolites related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins, and oxidative stress between mothers of infants with different birth weights. Understanding these differences may provide insights into tailored nutrition and care for preterm newborns in the future.
Article
Nutrition & Dietetics
Karine Redeuil, Antoine Leveques, Jean-Marie Oberson, Sylvie Benet, Emeline Tissot, Karin Longet, Antonio de Castro, Celine Romagny, Lydie Beauport, Celine J. Fischer Fumeaux, Jean-Francois Tolsa, Michael Affolter, Esther Campos Gimenez, Clara L. Garcia-Rodenas, Sagar K. Thakkar
Summary: This study found that some vitamin levels in breast milk for preterm infants may be higher compared to term infants, particularly in the first two weeks postpartum, while carotenoids may have higher concentrations in term milk between weeks 1 and 4 postpartum.
CLINICAL NUTRITION
(2021)
Article
Nursing
Hande Z. Ulus, Merve Yasemin Tekbudak, Jonathan C. Allen
Summary: The research aimed to concentrate human milk in a milk bank setting by precipitating lactose, in order to increase its caloric and protein density while avoiding the side effects of high osmolality. The results showed that lactose and osmolality were significantly reduced in the concentrated milk without significant protein loss. This method could potentially provide a simple and low-cost solution for feeding preterm infants with higher nutrient density and no non-human components.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Pediatrics
Arianna Aceti, Andrea Barbarossa, Teresa Gazzotti, Elisa Zironi, Giampiero Pagliuca, Francesca Vitali, Isadora Beghetti, Luigi Corvaglia
Summary: The exposure of preterm infants to PFASs through HM feeding may exceed reference values for older and healthier infants, requiring further investigation into the risks and ways to reduce exposure through maternal exposure and HM feeding.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
D. Mallardi, C. Tabasso, P. Piemontese, S. Morandi, T. Silvetti, F. Biscarini, P. Cremonesi, B. Castiglioni, V Pica, M. Stuknyte, I De Noni, O. Amato, N. Liotto, F. Mosca, P. Roggero
Summary: The study showed that inoculating PDHM with mother's own milk could restore bacterial growth and personalize the human milk microbiome in PDHM. This personalized effect is beneficial due to the presence of maternal probiotic bacteria in the milk, making PDHM more similar to the mother's own milk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Andrea C. Masi, Nicholas D. Embleton, Christopher A. Lamb, Gregory Young, Claire L. Granger, Julia Najera, Daniel P. Smith, Kristi L. Hoffman, Joseph F. Petrosino, Lars Bode, Janet E. Berrington, Christopher J. Stewart
Summary: Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The study found a significant lower concentration of a specific HMO in the breast milk of infants with NEC compared to controls. Combining HMO and metagenome data accurately classified 87.5% of infants as healthy or having NEC.
Review
Nutrition & Dietetics
Safiyyah Abbas, Amy K. Keir, Maria Makrides, Laura D. Klein, Luke E. Grzeskowiak, Andrew J. McPhee, Alice R. Rumbold
Summary: NEC is a devastating disease affecting preterm infants, and HMOs are emerging as a potential preventive therapy. However, there are challenges in tailoring HMO delivery to preterm infants and further research is needed to understand the benefits and long-term effects of oligosaccharide supplementation.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Felix Castillo, Felix-Joel Castillo-Ferrer, Begona Cordobilla, Joan Carles Domingo
Summary: A single-center study compared the fatty acids profile, particularly DHA levels, in donor human milk and mother's own milk for preterm infants. The study found that DHA levels were significantly lower in donor human milk compared to mother's own milk, potentially providing inadequate supply of DHA for preterm infants.
Article
Nutrition & Dietetics
Noelia Ureta-Velasco, Kristin Keller, Diana Escuder-Vieco, Jose C. E. Serrano, Nadia Raquel Garcia-Lara, Carmen R. Pallas-Alonso
Summary: Preterm infants are at high risk for iodine deficiency, and donor human milk is the preferred feeding option. However, information on the iodine concentration in donor human milk is lacking. This study aimed to evaluate the iodine concentration in donor human milk and assess its adequacy for preterm infants. The results showed that 70% of donor human milk had iodine concentration below the recommended level in this iodine-sufficient population.
Article
Nutrition & Dietetics
Katherine E. Chetta, Joseph L. Alcorn, John E. Baatz, Carol L. Wagner
Summary: Frozen storage is crucial for preserving human milk for critically ill and very preterm infants, while milk pasteurization is essential for donor milk given to this population. Nutrient changes occur in milk due to storage and processing conditions, potentially leading to the presence of bioactive complexes like HAMLET, which may have unknown clinical implications. HAMLET, a protein-lipid complex found in human milk, has specific toxicity to certain cells and can trigger inflammatory pathways with unclear consequences, particularly in immature intestinal tissues. Addressing HAMLET's presence and bioactive role in human milk is important in neonatal research.
Article
Nutrition & Dietetics
Jean-Christophe Roze, Mickael Hartweg, Laure Simon, Helene Billard, Yipu Chen, Sean Austin, Cecile Boscher, Thomas Moyon, Dominique Darmaun, Clara L. Garcia Rodenas, Clair-Yves Boquien
Summary: This study explored the impact of HMOs on growth and neurodevelopment in preterm infants. The findings showed that HMO concentrations decreased with advancing postnatal age. Total HMOs were positively correlated with neonatal length growth. Among Secretor(+) Lewis(+) mothers, LNFP-III was significantly associated with neurodevelopmental scores at 2 years.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Reka A. Vass, Gabriella Kiss, Edward F. Bell, Robert D. Roghair, Attila Miseta, Jozsef Bodis, Simone Funke, Tibor Ertl
Summary: Pituitary hormones like prolactin and luteinizing hormone were found to be higher in breast milk from mothers of preterm infants compared to term infants. Infant formulas have higher total protein content but do not contain detectable levels of pituitary hormones.
Article
Immunology
Patricia Bimboese, Seilesh Kadambari, Sepehr N. Tabrizi, Suzanne M. Garland, Alison Tigg, Rosalind Lau, Colin J. Morley, Nigel Curtis
Summary: Approximately half of preterm or very-low-birth-weight infants exposed to CMV-positive breast milk become infected, with one-fifth developing clinical symptoms. Infected infants have longer hospital stays and more episodes of prolonged neutropenia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Johanna Elizabeth Kemp, Piet Becker, Friedeburg Anna Maria Wenhold
Summary: This study aimed to explore the macronutrient and energy content of human milk from South African mothers of preterm infants. The results showed that the protein content of the milk differed from published data, which has implications for milk fortification practices.
Article
Pediatrics
Rong Lin, Wei Shen, Fan Wu, Jian Mao, Ling Liu, Yanmei Chang, Rong Zhang, Xiuzhen Ye, Yinping Qiu, Li Ma, Rui Cheng, Hui Wu, Dongmei Chen, Zhi Zheng, Xinzhu Lin, Xiaomei Tong
Summary: This study investigated the use of human milk fortifier for very preterm infants in China and the impact of different breast milk enhancement strategies on the infants' complications and nutritional status. The results suggest that adding HMF at an enteral volume of 80-100 ml/kg/day can promote growth and reduce the incidence of extrauterine growth restriction (EUGR) in preterm infants.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
C. H. F. Ferreira, Y. Shifrin, J. Pan, J. Ivanovska, P. J. McNamara, J. Belik
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Gastroenterology & Hepatology
Cristina H. F. Ferreira, Francisco E. Martinez, Gerson C. Crott, Jaques Belik
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Article
Pediatrics
Cristina Helena Ferreira, Fabio Carmona, Francisco Eulogio Martinez
JORNAL DE PEDIATRIA
(2014)
Article
Pediatrics
Walusa Assad Goncalves-Ferri, Cristina Helena Faleiros Ferreira, Laryssa de Carli de Almeida Couto, Thaissa Rodrigues Souza, Thayane de Castro Peres, Fabio Carmona, Davi Casale Aragon, Gerson Crott, Marisa M. Mussi-Pinhata, Jose Simon Camelo Junior, Anelise Roosch, Lourenco Sbragia Neto
Summary: In this study, low technology, mild controlled hypothermia was found to be a feasible, safe, and effective treatment for NEC Modified Bell's Stage II/III. It reduced the need for surgery, bowel perforation, extensive intestinal resection, mortality, and shortened the duration of parenteral nutrition. New approaches like mild controlled hypothermia may provide a promising alternative to conventional treatments for NEC.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Walusa Assad Goncalves-Ferri, Agnes Afrodite Sumarelli Albuquerque, Renata Sayuri Ansai Pereira de Castro, Cristina Helena Faleiros Ferreira, Luis K. Oharomari Jr, Diego Fernando Silva Lessa, Paulo Renata Barbosa Evora
Summary: The authors designed an animal model of neonatal sepsis and analyzed the treatment of neonatal septic shock with Methylene Blue (MB) in a swine model. The study showed that MB improved biomarkers related to septic shock prognosis, although no improvement in blood levels could be detected. This suggests that MB might be a beneficial drug for treating hemodynamic instability in infants.
Article
Pediatrics
Walusa Assad Goncalves-Ferri, Cristina Helena Faleiros Ferreira, Lara Malosso Sgarbi Albuquerque, Julia Belcavelo Contin Silva, Mariel Versiane Caixeta, Fabio Carmona, Cristina Calixto, Davi Casale Aragon, Gerson Crott, Marisa M. Mussi-Pinhata, Anelise Roosch, Lourenco Sbragia
Summary: This study describes the steps and management of applying hypothermia in preterm infants using low technology and presents the safety aspects of the initiative. The results show that controlled hypothermia for preterm infants with NEC is safe when performed through passive methods with incubator servo-control for temperature management.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Pediatrics
Lara Malosso Sgarbi Albuquerque, Cristina Calixto, Gerson Claudio Crott, Julia Belcavelo Contin Silva, Mariel Versiane Caixeta, Cristina Helena Faleiros Ferreira, Thayane de Castro Peres, Lisianne Virginia Pereira Monte Costa, Davi Aragon, Walusa Assad Goncalves-Ferri
PEDIATRIC RESEARCH
(2021)
Meeting Abstract
Pediatrics
Mariel Versiane Caixeta, Julia Belcavelo Contin Silva, Lara Malosso Sgarbi Albuquerque, Lisianne Virginia Pereira Monte Costa, Davi Casale Aragon, Cristina Calixto, Thayanne de Castro Peres, Cristina Helena Faleiros Ferreira, Walusa Assad Goncalves Ferri
PEDIATRIC RESEARCH
(2021)
Meeting Abstract
Pediatrics
Walusa Goncalves-Ferri, Agnes Albuquerque, Sayuri de Castro, Cristina Helena Faleiros Ferreira, Diego Lessa, Paulo Roberto Evora
PEDIATRIC RESEARCH
(2019)
