Article
Biochemistry & Molecular Biology
Katharina B. Kuentzel, Ivan Bradic, Zala N. Mihalic, Melanie Korbelius, Silvia Rainer, Anita Pirchheim, Julia Kargl, Dagmar Kratky
Summary: Advanced maternal age and obesity are the main risk factors for gestational diabetes mellitus (GDM). In this study, we investigated the dysregulation of intracellular lipases in pregnancies complicated by maternal high-fat/high-cholesterol (HF/HCD) feeding with and without GDM. The results suggest that dysregulation of placental lipid hydrolysis may contribute to fetal hepatic lipid accumulation and fetal overgrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Xian Li, Xin Zhang, Chenjing Ma, Long Sun, Zhao He, Jin Gan, Weifeng Ding, Xiaoming Chen, Hang Chen, Ying Feng
Summary: This study investigated the effects of orally administered policosanol from insect wax (PIW) on lipid metabolism, and found that PIW could reduce serum lipid levels, improve weight gain, and alleviate liver fat accumulation in rats fed a high-fat diet. These effects may be attributed to gene regulation and antioxidant activity. The findings suggest the potential use of PIW for developing functional foods with lipid-lowering properties.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Prathapan Ayyappan, Tricia D. D. Larsen, Tyler C. T. Gandy, Eli J. J. Louwagie, Michelle L. L. Baack
Summary: Infants exposed to diabetic pregnancy have an increased risk of cardiomyopathy at birth and early onset cardiovascular disease as adults. A rat model study showed that fetal exposure to maternal diabetes results in cardiac disease through fuel-mediated mitochondrial dysfunction, and a maternal high-fat diet exacerbates the risk. The study aimed to determine whether neonatal rat cardiomyocytes can metabolize ketones as an alternative fuel source and found that they can, suggesting a potential protective role of ketones in neonatal cardiomyopathy due to maternal diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Hengxian Qu, Lina Zong, Jian Sang, Jiaojiao Liang, Yunchao Wa, Dawei Chen, Yujun Huang, Xia Chen, Ruixia Gu
Summary: Lactobacillus rhamnosus hsryfm 1301 fermented milk can inhibit fatty acid synthase, reduce excessive fatty acid production, and alleviate fat accumulation, restore the balance of lipid metabolism, and alleviate the inflammatory response in rats. It can also reduce ROS levels through antioxidant effects, alleviate inflammatory responses, and thus alleviate disordered lipid metabolism.
FERMENTATION-BASEL
(2022)
Article
Food Science & Technology
Shishuai Sun, Chunyu Cao, Jibo Li, Qingwei Meng, Baojing Cheng, Baoming Shi, Anshan Shan
Summary: Lycopene plays a vital role in improving immunity, enhancing antioxidant capacity, and regulating fat metabolism. The study found that under a high-fat diet, lycopene can reduce oxidative stress, inflammation, and fat deposition in the placenta, promoting fetal development. Lycopene supplementation decreases levels of IL-17, IL-6, and TNF-alpha, increases expression of Glrx gene and protein, and enhances antioxidant capacity in the placenta.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Thomas A. Aloysius, Veronika Tillander, Matteo Pedrelli, Simon N. Dankel, Rolf K. Berge, Bodil Bjorndal
Summary: Rest raw materials from chicken, such as chicken protein hydrolysate (CPH) and chicken oil (CO), have beneficial effects on health by reducing cholesterol levels and increasing fatty acid oxidation.
Article
Biochemistry & Molecular Biology
Tianle He, Qingyun Chen, Zhidong Yuan, Yulian Yang, Kai Cao, Ju Luo, Guozhong Dong, Xie Peng, Zhenguo Yang
Summary: There is a strong correlation between maternal high-fat diet and fetal-placental development. Maternal high-fat diet can affect fetal growth and placental nutrient transporters through differentially expressed circRNAs.
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Food Science & Technology
Shangxin Song, Yulin Gao, Tianlan Xia, Yefei Zhou, Guido J. E. J. Hooiveld, Michael Muller, Chunbao Li
Summary: This study investigated the impact of high or normal dietary chicken protein levels on obesity development in rats fed high-fat diets. The high chicken protein diet significantly reduced body weight gain, adipose tissue mass, and adipocyte size in comparison to the normal diet, without affecting food intake. It also reduced blood insulin and glycosylated serum protein, but had no effect on OGTT and HOMA-IR results. Additionally, the high chicken protein diet downregulated EAT transcriptomics related to lipid biosynthesis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Ling Zhang, Ziwei Wang, Honghua Wu, Ying Gao, Jia Zheng, Junqing Zhang
Summary: Maternal overnutrition can affect fetal growth and increase the risk of obesity and diabetes in offspring. Placental fatty acid metabolism is important in pregnancy and fetal health. Placental fatty acid beta-oxidation (FAO) may regulate the effects of maternal overnutrition on glucose metabolism in offspring through the AMPK signaling pathway.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yue Zhao, Qing-Yu Wang, Lv-Tao Zeng, Jing-Jing Wang, Zhen Liu, Guo-Qing Fan, Jin Li, Jian-Ping Cai
Summary: Long-term consumption of a high-fat, high-fructose diet can lead to pancreatic islet functional decay, which may be a potential mechanism of type 2 diabetes mellitus. This study reveals the structural and transcriptomic changes that occur in the pancreas under the influence of HFHF diet and aging.
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Physiology
Monika Slupecka-Ziemilska, Paulina Grzesiak, Pawel Kowalczyk, Piotr Wychowanski, Jaroslaw Wolinski
Summary: Maternal exposure to a high fat diet during gestation and lactation influences small intestinal growth and maturation in rat pups at 21 days old, leading to changes in body weight, BMI, adiposity, histomorphometry, brush border enzyme activity, and intestinal contractility. Offspring from the maternal HFD group showed upregulated mRNA expression of cyclooxygenase-2, suggesting a programming towards obesity. These results emphasize the significant role of maternal diet preferences in the developmental programming of metabolic diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Petra Bakovic, Maja Kesic, Darko Kolaric, Jasminka Stefulj, Lipa Cicin-Sain
Summary: Maintaining energy balance is vital to prevent obesity and metabolic disorders, and serotonin plays a crucial role in regulating energy homeostasis. Animals with constitutionally low serotonin activity showed increased susceptibility to harmful effects of a high-energy diet, such as weight gain and insulin resistance, while those with constitutionally high serotonin activity appeared to be protected from major metabolic disturbances. These findings suggest that understanding the role of serotonin in metabolically healthy obesity may provide insights into human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Edward C. Dominguez, Art J. Heires, Jacqueline Pavlik, Tricia D. Larsen, Stephanie Guardado, Joseph H. Sisson, Michelle L. Baack, Debra J. Romberger, Tara M. Nordgren
Article
Pediatrics
Neha Kumbhat, Barry Eggleston, Alexis S. Davis, Sara B. DeMauro, Krisa P. Van Meurs, Elizabeth E. Foglia, Satyan Lakshminrusimha, Michele C. Walsh, Kristi L. Watterberg, Myra H. Wyckoff, Abhik Das, Sara C. Handley, Richard A. Polin, Abbot R. Laptook, Martin Keszler, Angelita M. Hensman, Elisa Vieira, Lucille St Pierre, Anna Maria Hibbs, William E. Truog, Eugenia K. Pallotto, Prabhu S. Parimi, Cheri Gauldin, Anne Holmes, Allison Knutson, Lisa Gaetano, Brenda B. Poindexter, Kurt Schibler, Stephanie L. Merhar, Cathy Grisby, Kristin Kirker, C. Michael Cotten, Ronald N. Goldberg, Joanne Finkle, Kimberley A. Fisher, Matthew M. Laughon, Carl L. Bose, Janice Bernhardt, Gennie Bose, Cindy Clark, Stephen D. Kicklighter, Ginger Rhodes-Ryan, Donna White, David P. Carlton, Ravi M. Patel, Yvonne Loggins, Colleen Mackie, Diane Bottcher, Andrew A. Bremer, Rosemary D. Higgins, Stephanie Wilson Archer, Gregory M. Sokol, Dianne E. Herron, Jon E. Tyson, Amir M. Khan, Kathleen A. Kennedy, Claudia Pedrozza, Elizabeth Eason, Emily K. Stephens, Georgia E. McDavid, Karen Martin, Donna Hall, Sharon L. Wright, Pablo J. Sanchez, Leif D. Nelin, Sudarshan R. Jadcherla, Patricia Luzader, Erna Clark, Julie Gutentag, Courtney Park, Julie C. Shadd, Melanie Stein, Hallie Baugher, Jacqueline McCool, Marie G. Gantz, Carla M. Bann, Dennis Wallace, Kristin M. Zaterka-Baxter, Jenna Gabrio, David Leblond, Jeanette O'Donnell Auman, David K. Stevenson, Valerie Y. Chock, M. Bethany Ball, Melinda S. Proud, Elizabeth N. Reichert, R. Jordan Williams, Waldemar A. Carlo, Namasivayam Ambalavanan, Monica Collins, Shirley S. Cosby, Tara McNair, Uday Devaskar, Meena Garg, Teresa Chanlaw, Rachel Geller, Edward F. Bell, Tarah T. Colaizy, Dan L. Ellsbury, Michelle L. Baack, Karen J. Johnson, Mendi L. Schmelzel, Jacky R. Walker, Claire A. Goeke, Tracy L. Tud, Chelsey Elenkiwich, Megan M. Henning, Megan Broadbent, Laurie A. Hogden, Jane E. Brumbaugh, Jonathan M. Klein, John M. Dagle, Janell Fuller, Robin K. Ohls, Sandra Sundquist Beauman, Conra Backstrom Lacy, Carol Hartenberger, Mary Hanson, Elizabeth Kuan, Eric C. Eichenwald, Barbara Schmidt, Haresh Kirpalani, Soraya Abbasi, Christine Catts, Aasma S. Chaudhary, Sarvin Ghavam, Toni Mancini, Jonathan Snyder, Carl T. D'Angio, Ronnie Guillet, Anne Marie Reynolds, Holly I. M. Wadkins, Michael G. Sacilowski, Mary Rowan, Rosemary L. Jensen, Deanna Maffett, Diane Prinzing, Ann Marie Scorsone, Kyle Binion, Stephanie Guilford, Constance Orme, Premini Sabaratnam, Daisy Rochez, Emily Li, Jennifer Donato
Summary: This study compared the outcomes of umbilical cord milking and delayed cord clamping in infants born <29 weeks of gestation. It found that delayed cord clamping is preferable as umbilical cord milking was associated with an increase in severe IVH.
JOURNAL OF PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Emily Barrett, Amy Loverin, Haimei Wang, Michelle Carlson, Tricia D. Larsen, Mariana M. Almeida, Jenna Whitman, Michelle L. Baack, Lisa A. Joss-Moore
Summary: The placenta plays a crucial role in fetal lipid acquisition, with PPAR gamma and KMT5A being key factors in placental lipid handling. This study found that KMT5A is present in human and rat placentas, and in rats, uteroplacental insufficiency can increase KMT5A expression and activity, leading to lipid accumulation in the placenta.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Eli J. Louwagie, Tricia D. Larsen, Angela L. Wachal, Tyler C. T. Gandy, Michelle L. Baack
Summary: Offspring born to diabetic or obese mothers have a higher lifetime risk of heart disease. Research has shown that exposure to late-gestational diabetes mellitus (LGDM) or maternal high-fat (HF) diet can lead to mitochondrial dysfunction, impaired cardiomyocyte bioenergetics, and cardiac dysfunction in rat offspring. Findings suggest that mitochondrial dysfunction may play a central role in neonatal cardiomyopathy, with sex-specific differences observed in mitochondria-mediated mechanisms of heart disease development. Therapeutic mitochondrial transfer may have potential limitations, such as inconsistent effects in male and female offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pediatrics
Kaitlyn M. Dorn, Kaitlyn D. Burns, Maija A. R. Trout, D. Isum Ward, KayeLyn J. Wagner, Lauritz R. Meyer, Michelle L. Baack, Rachel L. Rodel
Summary: This case presents a male neonate with severe anemia at birth, confirmed by rWES to have Diamond-Blackfan anemia along with his mother. It emphasizes the importance of fetal surveillance and the clinical utility of rWES in the neonatal intensive care setting.
Article
Biochemistry & Molecular Biology
Arzu Ulu, Abigail Burr, Art J. Heires, Jacqueline Pavlik, Tricia Larsen, Pedro A. Perez, Carissa Bravo, Nicholas DiPatrizio, Michelle Baack, Debra J. Romberger, Tara M. Nordgren
Summary: Agricultural workers, especially those working in swine confinement facilities, are at higher risk of developing pulmonary diseases due to exposures to fumes, vapors, and organic dust. Chronic exposure to agricultural dust leads to unresolved inflammation, while diet also plays a significant role in inflammation and disease progression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Samuel J. Gentle, Benjamin Carper, Matthew M. Laughon, Erik A. Jensen, Austin Williams, Colm P. Travers, Namasivayam Ambalavanan, Charitharth Lal, Waldemar A. Carlo, Richard A. Polin, Abbot R. Laptook, Martin Keszler, Angelita M. Hensman, Elisa Vieira, Emilee Little, Lucille St Pierre, Michele C. Walsh, Anna Maria Hibbs, Nancy S. Newman, William E. Truog, Eugenia K. Pallotto, Howard W. Kilbride, Cheri Gauldin, Anne Holmes, Kathy Johnson, Prabhu S. Parimi, Lisa Gaetano, Brenda B. Poindexter, Kurt Schibler, Stephanie L. Merhar, Barbara Alexander, Cathy Grisby, Kristin Kirker, C. Michael Cotten, Ronald N. Goldberg, Joanne Finkle, Kimberley A. Fisher, Carl L. Bose, Janice Bernhardt, Gennie Bose, Cindy Clark, Stephen D. Kicklighter, Ginger Rhodes-Ryan, Donna White, David P. Carlton, Barbara J. Stoll, Ravi M. Patel, Yvonne Loggins, Ellen C. Hale, Diane Bottcher, Colleen Mackie, Andrew A. Bremer, Rosemary D. Higgins, Stephanie Wilson Archer, Gregory M. Sokol, Dianne E. Herron, Jeff Joyce, Jon E. Tyson, Amir M. Khan, Kathleen A. Kennedy, Elizabeth Eason, Emily K. Stephens, Georgia E. McDavid, Julie Arldt-McAlister, Katrina Burson, Carmen Garcia, Donna Hall, Karen Martin, Sara C. Martin, Shawna Rodgers, Patti L. Pierce Tate, Sharon L. Wright, Pablo J. Sanchez, Leif D. Nelin, Sudarshan R. Jadcherla, Patricia Luzader, Erna Clark, Christine A. Fortney, Julie Gutentag, Courtney Park, Julie C. Shadd, Melanie Stein, Jennifer L. Grothause, Hallie Baugher, Lina Yosseff-Salameh, Jacqueline McCool, Abhik Das, Marie G. Gantz, Carla M. Bann, Dennis Wallace, Margaret Crawford, Jenna Gabrio, David Leblond, Jeanette O'Donnell Auman, Carolyn M. Petrie Huitema, Kristin M. Zaterka-Baxter, Krisa P. Van Meurs, Valerie Y. Chock, David K. Stevenson, M. Bethany Ball, Melinda S. Proud, Elizabeth N. Reichert, R. Jordan Williams, Monica Collins, Shirley S. Cosby, Tara McNair, Meredith Estes, Kelli Hagood, Uday Devaskar, Meena Garg, Teresa Chanlaw, Rachel Geller, Edward F. Bell, Tarah T. Colaizy, Michelle L. Baack, Dan L. Ellsbury, Jane E. Brumbaugh, Karen J. Johnson, Megan M. Henning, Chelsey Elenkiwich, Claire A. Goeke, Megan Broadbent, Laurie A. Hogden, Jonathan M. Klein, John M. Dagle, Mendi L. Schmelzel, Jacky R. Walker, Donia B. Bass, Tracy L. Tud, Kristi L. Watterberg, Janell Fuller, Robin K. Ohls, Conra Backstrom Lacy, Sandra Sundquist Beauman, Carol Hartenberger, Mary Hanson, Elizabeth Kuan, Eric C. Eichenwald, Barbara Schmidt, Haresh Kirpalani, Sara B. DeMauro, Soraya Abbasi, Christine Catts, Aasma S. Chaudhary, Sarvin Ghavam, Toni Mancini, Jonathan Snyder, Carl T. D'Angio, Ronnie Guillet, Anne Marie Reynolds, Satyan Lakshminrusimha, Alison Kent, Kyle Binion, Melissa Bowman, Jennifer Donato, Stephanie Guilford, Julianne Hunn, Rosemary L. Jensen, Emily Li, Deanna Maffett, Constance Orme, Diane Prinzing, Linda Reubens, Daisy Rochez, Mary Rowan, Premini Sabaratnam, Michael Sacilowski, Ann Marie Scorsone, Holly I. M. Wadkins, Ashley Williams, Karen Wynn, Rachel Jones, Myra Wyckoff, Luc P. Brion, Diana M. Vasil, Lijun Chen, Maria M. DeLeon, Frances Eubanks, Lara Pavageau, Pollieanna Sepulveda, Bradley A. Yoder, Mariana Baserga, Stephen D. Minton, Mark J. Sheffield, Carrie A. Rau, Jill Burnett, Brandy Davis, Susan Christensen, Manndi C. Loertscher, Trisha Marchant, Earl Maxson, Kandace McGrath, Jennifer O. Elmont, Melody Parry, Susan T. Schaefer, Kimberlee Weaver-Lewis, Kathryn D. Woodbury, Seetha Shankaran, Girija Natarajan, Sanjay Chawla, Beena G. Sood, Kirsten Childs, Bogdan Panaitescu, Rebecca Bara, John Barks, Mary K. Christensen, Stephanie A. Wiggins, Diane F. White
Summary: This study aimed to determine the association between the duration of noninvasive respiratory support exposure and the development of bronchopulmonary dysplasia (BPD) or death in preterm infants. The findings were inconclusive, and the relationship between the two factors could not be determined.
JOURNAL OF PERINATOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Kyle M. Siemers, Michelle L. Baack
Summary: In this study by Bidne and colleagues, changes in placental lipids and lipid metabolic enzymes were identified in the context of parental obesity, from as early as 4 weeks of gestation. Their assessment of lipid and enzyme content presents a feasible approach to understand the complexities of metabolic pathologies that impact the lifelong health of both parents and children.
Article
Biochemistry & Molecular Biology
Prathapan Ayyappan, Tricia D. D. Larsen, Tyler C. T. Gandy, Eli J. J. Louwagie, Michelle L. L. Baack
Summary: Infants exposed to diabetic pregnancy have an increased risk of cardiomyopathy at birth and early onset cardiovascular disease as adults. A rat model study showed that fetal exposure to maternal diabetes results in cardiac disease through fuel-mediated mitochondrial dysfunction, and a maternal high-fat diet exacerbates the risk. The study aimed to determine whether neonatal rat cardiomyocytes can metabolize ketones as an alternative fuel source and found that they can, suggesting a potential protective role of ketones in neonatal cardiomyopathy due to maternal diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Elizabeth K. Sewell, Seetha Shankaran, Girija Natarajan, Abbot Laptook, Abhik Das, Scott A. McDonald, Shannon Hamrick, Michelle Baack, Matthew Rysavy, Rosemary D. Higgins, Lina Chalak, Ravi Mangal Patel
Summary: The study aimed to examine the heterogeneity in the effect of therapeutic hypothermia by sex in infants with moderate or severe neonatal encephalopathy. The results showed no significant difference in the primary outcome of death or moderate or severe disability between males and females in infants with moderate or severe neonatal encephalopathy treated with therapeutic hypothermia.
PEDIATRIC RESEARCH
(2023)
Review
Andrology
Eli J. Louwagie, Garrett F. L. Quinn, Kristi L. Pond, Keith A. Hansen
Summary: This article discusses novel strategies and targets for male contraception, with two hormonal methods undergoing phase II clinical trials for safety and efficacy. There are also several non-hormonal methods showing strong potential in preclinical stages of development.
BASIC AND CLINICAL ANDROLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Prathapan Ayyappan, Tricia D. Larsen, Tyler C. Gandy, Michelle L. Baack
CIRCULATION RESEARCH
(2022)
Meeting Abstract
Surgery
S. Jacob, M. L. Baack, A. Savinov, P. J. Wettstein
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)