Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Allergy
Tuomas Jartti, Unna Liimatainen, Paraskevi Xepapadaki, Tero Vahlberg, Claus Bachert, Susetta Finotto, Marek L. Kowalski, Anna Sobanska, Heikki Lukkarinen, Maria Pasioti, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G. Papadopoulos
Summary: The study suggests that vitamin D supplementation may have a beneficial effect in combating rhinovirus infection, and that RV infection is closely linked to the severity of preschool asthma and disease progression.
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Sonja Soininen, Aino-Maija Eloranta, Ursula Schwab, Timo A. Lakka
Summary: The purpose of this study was to investigate the intake and sources of vitamin D, as well as the determinants of serum 25-hydroxyvitamin D (S-25(OH)D) in Finnish adolescents. The results showed that most adolescents had vitamin D intake at the recommended level, although a quarter did not meet the recommended intake and almost a third had low levels of S-25(OH)D. The main determinants of S-25(OH)D were vitamin D intake from supplements, consumption of milk products, consumption of meat products, travels to sunny countries, and average daylight time.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Naoko Tsugawa, Mayu Nishino, Akiko Kuwabara, Honami Ogasawara, Maya Kamao, Shunjiro Kobayashi, Junichi Yamamura, Satoshi Higurashi
Summary: The study found that the low vitamin D status in recent lactating mothers may have decreased the concentrations of vitamin D and 25OHD in breast milk, compared to the 1980s. This has important implications for improving the vitamin D status of lactating mothers and infants.
Article
Nutrition & Dietetics
Zhenyu Zhong, Guannan Su, Liping Du, Qingyun Zhou, Fuzhen Li, Wei Chi, Shengyun Liu, Meifen Zhang, Xianbo Zuo, Peizeng Yang
Summary: This study using Mendelian randomization found that genetically increased serum 25-hydroxyvitamin D levels were associated with a higher risk of Behcet's disease, with data from Chinese and Turkish cohorts supporting this conclusion. The contribution to Behcet's disease risk may increase with higher levels of vitamin D.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, Intira Sriprasert, Rachel Danis, Raj Pandian, Harpreet Matharu, Nicole Bender, Melissa Natavio
Summary: This study compared the effects of two combined oral contraceptive formulations on 25(OH)D levels and VDBP levels, revealing different impacts. LNG may have a suppressive effect on VDBP. Further research is needed to understand the influence of hormonal contraceptive formulations on vitamin D status and women's health.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Laura D. F. Cooke, Stefania D'Angelo, Elizabeth M. Curtis, Philip Titcombe, Justin H. Davies, Keith M. Godfrey, Jane K. Cleal, Rohan M. Lewis, Cyrus Cooper, Nicholas C. Harvey
Summary: There is an association between specific single nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism pathway and cord blood 25(OH)D in both mothers and offspring, indicating a potential role of genetic factors in this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Hsin-Ya Tang, Wang-Sheng Ko, Yuan-Horng Yan, Su-Chen Yu, Ya-ling Chiou
Summary: Shift nurses in Taiwan often experience 25(OH)D deficiency, sleep disturbances, depression, and fatigue. However, no significant correlation was found between 25(OH)D levels and mental health.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Simei Wang, Quanmei Xu, Anqi Wang, Fang Yuan, Xiaona Luo, Yilin Wang, Miao Guo, Yuanfeng Zhang, Wenjing Zhang, Xiaobing Ji, Yun Ren, Yucai Chen
Summary: This study found a correlation between 25-hydroxyvitamin D deficiency and tic disorders (TD) in Chinese children, but no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. Additionally, the deficiency of 25-hydroxyvitamin D was most pronounced in children over the age of 9.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Wolfgang Hogler, Katharina Tischlinger, William D. Fraser, Jonathan C. Y. Tang, Suma Uday
Summary: This study examined the impact of maternal socioeconomic status (SES) on newborn vitamin D levels. The results showed that newborns born in the summer had significantly higher vitamin D levels compared to those born in the winter. The study also found that living environment had a significant influence on newborn vitamin D levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Andrew R. Beauchesne, Kelly Copeland Cara, Danielle M. Krobath, Laura Paige Penkert, Shruti P. Shertukde, Danielle S. Cahoon, Belen Prado, Ruogu Li, Qisi Yao, Jing Huang, Tee Reh, Mei Chung
Summary: The results of this systematic review indicate that current evidence does not provide sufficient certainty to support a causal relationship between vitamin D intake and asthma, wheeze, eczema, infectious diseases, or rickets in generally healthy infants and young children. The only evidence that reaches a moderate level of certainty is the effect of daily vitamin D supplementation on increasing blood serum 25(OH)D concentrations. However, there is currently no consensus on the definitions of vitamin D status based on these concentrations.
ANNALS OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nguyen N. Nguyen, Muppala N. P. Raju, Briget da Graca, Dapeng Wang, Nada A. Mohamed, Manohar B. Mutnal, Arundhati Rao, Monica Bennett, Matthew Gokingco, Huy Pham, Amin A. Mohammad
Summary: There is an inverse relationship between vitamin D levels and hospital LOS for COVID-19 patients. Vitamin D status is a predictor for severity of outcomes. LC-MS/MS results are useful for assessing the odds of mortality and the need for ventilation during hospitalization.
Review
Nutrition & Dietetics
Allison Daniel, Sara Shama, Samantha Ismail, Celine Bourdon, Alex Kiss, Martha Mwangome, Robert H. J. Bandsma, Deborah L. O'Connor
Summary: The study aimed to understand the relation between maternal BMI and human-milk energy, fat, and total protein. It was found that there was a positive association between maternal BMI and human-milk fat, but no significant association with energy and total protein. The certainty of evidence for human-milk energy was low, while for fat and total protein it was very low.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Pediatrics
Curtis J. D'Hollander, Charles D. G. Keown-Stoneman, Catherine S. Birken, Deborah L. O'Connor, Jonathon L. Maguire
Summary: Early introduction of infant cereal at 4 months compared with 6 months was associated with higher BMI z score, increased obesity risk, similar height-for-age z score, and less favorable eating behavior. Therefore, recommendations for introducing solid food around 6 months of age are supported.
JOURNAL OF PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Alison Mildon, Jane Francis, Stacia Stewart, Bronwyn Underhill, Yi Man Ng, Christina Rousseau, Erica Di Ruggiero, Cindy-Lee Dennis, Deborah L. O'Connor, Daniel W. Sellen
Summary: While 70% of participants continued breastfeeding for 6 months, only 18% practiced exclusive breastfeeding for the full duration. The early use of formula was common in the first three months, and the introduction of solids and non-formula fluids at 5 to 6 months further compromised exclusive breastfeeding rates. Transitions between different categories of breastmilk feeding intensity were common, with 35% making two or more transitions. High levels of breastmilk provision were observed despite low rates of exclusive breastfeeding for 6 months, highlighting the need for nuanced reporting and intervention designs in future studies.
MATERNAL AND CHILD NUTRITION
(2022)
Review
Pediatrics
Megan R. Beggs, Nicole Bando, Sharon Unger, Deborah L. O'Connor
Summary: Infants born preterm or with low birth weight are at higher risk for health complications and neurodevelopmental issues. Nutritional strategies, particularly through fortification of human milk, may improve short-term growth outcomes, but there is still a lack of evidence on long-term neurodevelopmental benefits. Further research is needed to determine the most effective fortification practices and their impact on clinical outcomes.
Article
Nutrition & Dietetics
Kathryn Walton, Meghan McGee, Julie Sato, Nicole Law, Kathryn E. Hopperton, Nicole Bando, Alex Kiss, Sharon L. Unger, Deborah L. O'Connora
Summary: This study compared the dietary patterns and body composition of very low birth weight (VLBW) children with poor social-emotional functioning to those with typical functioning. The results showed that poor social-emotional functioning was positively associated with higher fruit juice intake and energy intake. Children with poor social-emotional functioning were more likely to have a limited food repertoire but less likely to exceed dietary fat recommendations. Overall diet quality and body composition did not differ between the two groups. Diet counselling is important to improve the nutrition of VLBW children and mitigate chronic disease risk.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Food Science & Technology
Michael A. Pitino, Sharon Unger, Alexander Gill, Allison J. McGeer, Alain Doyen, Yves Pouliot, Richard P. Bazinet, Akash Kothari, Tony Mazzulli, Debbie Stone, Deborah L. O'Connor
Summary: This study demonstrates that HPP is effective in inactivating representative enveloped and nonenveloped viruses in human milk, reducing bacterial load, with no adverse effect on macronutrient and energy composition. Therefore, HPP shows great promise in replacing HoP in human milk banking facilities.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Nutrition & Dietetics
Amber J. Mullen, Deborah L. O'Connor, Anthony J. Hanley, Giovanni Piedimonte, Maeve Wallace, Sylvia H. Ley
Summary: The study aimed to identify metabolic and obstetric risk factors for delayed onset of lactogenesis II. Results showed that delayed onset of lactogenesis II was associated with prolonged time to first breast contact postpartum.
Review
Nutrition & Dietetics
Kathryn Walton, Allison Daniel, Quenby Mahood, Simone Vaz, Nicole Law, Sharon L. Unger, Deborah L. O'Connor
Summary: This article presents a systematic review and meta-analysis on feeding difficulties and eating behaviors among preterm children. The findings suggest that preterm children are more likely to experience oromotor eating difficulties and challenging eating behaviors compared to term-born peers. Additionally, the article highlights the importance of studying the effects of caregiver-child interactions on subsequent diet in order to prevent obesity and diet-related chronic diseases.
ADVANCES IN NUTRITION
(2022)
Article
Chemistry, Applied
Melanie Sergius-Ronot, Michael A. Pitino, Shyam Suwal, Sara Shama, Sharon Unger, Deborah L. O'Connor, Yves Pouliot, Alain Doyen
Summary: This study found that heat treatments had a greater impact on human milk protein concentrate than high hydrostatic pressure treatments, with heat treatment mainly causing aggregation of lactoferrin and alpha-lactalbumin. High hydrostatic pressure treatment had minimal impact on protein structure, indicating its potential as a pasteurization method for HMPC.
Article
Pediatrics
Jessica A. Omand, Xuedi Li, Charles D. G. Keown-Stoneman, Cornelia M. Borkhoff, Eric Duku, Gerald Lebovic, Jonathon L. Maguire, Muhammad M. Mamdani, Patricia C. Parkin, Caroline Reid-Westoby, Janis Randall Simpson, Mark S. Tremblay, Magdalena Janus, Catherine S. Birken
Summary: This study investigates the association between body weight in early childhood and school readiness in young children. Being classified as overweight or with obesity was found to be associated with poor school readiness in year 2 of kindergarten. Early interventions to promote healthy growth before school entry may help promote development and school readiness in young children.
Article
Health Care Sciences & Services
Nadia Minian, Mathangee Lingam, Rahim Moineddin, Kevin E. Thorpe, Scott Veldhuizen, Rosa Dragonetti, Laurie Zawertailo, Valerie H. Taylor, Margaret Hahn, Wayne K. deRuiter, Osnat C. Melamed, Peter Selby
Summary: This study aimed to assess the effects of a clinical decision support system (CDSS) for physical activity and diet on smoking cessation outcomes and to evaluate the implementation of the study. The results showed that the addition of CDSS did not significantly affect smoking cessation rates, exercise minutes, and fruit and vegetable intake. Further research is needed to improve the impact of integrated health promotion interventions on primary care smoking cessation programs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Pediatrics
Arin C. Deveci, Charles D. G. Keown-Stoneman, Jonathon L. Maguire, Deborah L. O'Connor, Laura N. Anderson, Cindy-Lee Dennis, Catherine S. Birken
Summary: This study found an association between maternal preconception BMI and child growth rates and mean zBMI in children aged 0-10 years. The strongest association was observed from 0 to 4 months of age.
Editorial Material
Nutrition & Dietetics
Deborah L. O'Connor
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Alison Mildon, Jane Francis, Stacia Stewart, Bronwyn Underhill, Yi Man Ng, Christina Rousseau, Valerie Tarasuk, Erica Di Ruggiero, Cindy-Lee Dennis, Deborah L. O'Connor, Daniel W. Sellen
Summary: This study aimed to assess the prevalence, severity, and predictors of household food insecurity among vulnerable women accessing the Canada Prenatal Nutrition Program (CPNP), as well as the associations between household food insecurity and breastfeeding practices up to 6 months. The results showed that household food insecurity was highly prevalent among this cohort, affecting almost half of the participants. However, there was no significant association between food insecurity and continued or exclusive breastfeeding.
PUBLIC HEALTH NUTRITION
(2023)
Article
Clinical Neurology
Fahad S. Al-Ajlan, David J. Gladstone, Dongbeom Song, Kevin E. Thorpe, Rick H. Swartz, Kenneth S. Butcher, Martin del Campo, Dar Dowlatshahi, Henrik Gensicke, Gloria Jooyoung Lee, Matthew L. Flaherty, Michael D. Hill, Richard I. Aviv, Andrew M. Demchuk, SPOTLIGHT Investigators
Summary: In the SPOTLIGHT trial, the impact of delays in drug administration on hematoma expansion in acute intracerebral hemorrhage patients was investigated, and it was found that the use of rFVIIa did not significantly reduce hematoma expansion. Future hemostatic trials should aim to minimize the delay between baseline CT and drug administration in order to improve treatment outcomes.