The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand?

Pathway discovery using transcriptomic profiles in adult-onset severe asthma

(2018) Pieter-Paul Hekking et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal phthalate exposure promotes allergic airway inflammation over 2 generations through epigenetic modifications

(2018) Susanne Jahreis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A meta-analysis of genome-wide association studies of asthma in Puerto Ricans

(2017) Qi Yan et al.   EUROPEAN RESPIRATORY JOURNAL

T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED

(2017) Chih-Hsi Scott Kuo et al.   EUROPEAN RESPIRATORY JOURNAL

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma

(2017) Pieter-Paul Hekking et al.   EUROPEAN RESPIRATORY JOURNAL

No evidence of large genetic effects on steroid response in asthma patients

(2017) Michael Mosteller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

(2017) Niloufar Farzan et al.   PHARMACOGENOMICS

The need for precision medicine clinical trials in childhood asthma: rationale and design of the PUFFIN trial

(2017) Susanne JH Vijverberg et al.   PHARMACOGENOMICS

From bench to bedside: Therapeutic potential of interleukin-9 in the treatment of asthma

(2017) Fang Gong et al.   Experimental and Therapeutic Medicine

Treatment response heterogeneity in asthma: the role of genetic variation

(2017) Susanne J. H. Vijverberg et al.   Expert Review of Respiratory Medicine

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

(2016) Bonnie R. Joubert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacogenomics of inhaled corticosteroids and leukotriene modifiers: a systematic review

(2016) N. Farzan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis

(2016) Anand Kumar Andiappan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment

(2016) Steve Turner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution

(2016) Hari K. Somineni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children

(2016) T. Bauer et al.   Molecular Systems Biology

Genome-wide association studies (GWAS) and their importance in asthma

(2015) A. García-Sánchez et al.   ALLERGOLOGIA ET IMMUNOPATHOLOGIA

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts

(2015) Louise Fleming et al.   EUROPEAN RESPIRATORY JOURNAL

Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response

(2015) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity

(2015) Joanne E. Sordillo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation

(2015) Hani Harb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

DNA methylation and childhood asthma in the inner city

(2015) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles

(2015) Helena Persson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic variation in uncontrolled childhood asthma despite ICS treatment

(2015) M Leusink et al.   PHARMACOGENOMICS JOURNAL

Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma

(2015) Y Wang et al.   PHARMACOGENOMICS JOURNAL

The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together: Figure 1

(2015) Adnan Custovic et al.   THORAX

Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

(2015) Rebecca C. Richmond et al.   HUMAN MOLECULAR GENETICS

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma

(2015) Amber Dahlin et al.   PLoS One

Maternal Smoking and DNA Methylation in Newborns: In Utero Effect or Epigenetic Inheritance?

(2014) B. R. Joubert et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genome-wide association study identifies ALLC polymorphisms correlated with FEV1 change by corticosteroid

(2014) Tae-Joon Park et al.   CLINICA CHIMICA ACTA

Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells

(2014) K. M. Hew et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Future clinical implications emerging from recent genome-wide expression studies in asthma

(2014) Jean-Christophe Bérubé et al.   Expert Review of Clinical Immunology

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids

(2014) Heung-Woo Park et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Similarity network fusion for aggregating data types on a genomic scale

(2014) Bo Wang et al.   NATURE METHODS

Modules, networks and systems medicine for understanding disease and aiding diagnosis

(2014) Mika Gustafsson et al.   Genome Medicine

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

(2013) S. Michel et al.   ALLERGY

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration

(2013) Lisa M McShane et al.   BMC Medicine

β-2 Adrenergic receptor gene methylation is associated with decreased asthma severity in inner-city Schoolchildren

(2013) J. M. Gaffin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Application of ’omics technologies to biomarker discovery in inflammatory lung diseases

(2013) Craig E. Wheelock et al.   EUROPEAN RESPIRATORY JOURNAL

Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma

(2013) Anna K. Naumova et al.   HUMAN GENETICS

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

(2013) Andrea Rossnerova et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Arg16 ADRB2 genotype increases the risk of asthma exacerbation in children with a reported use of long-acting β2-agonists: results of the pacman cohort

(2013) Miranda JL Zuurhout et al.   PHARMACOGENOMICS

DNA methylation levels within the CD14 promoter region are lower in placentas of mothers living on a farm

(2012) Gisela G.G. Slaats et al.   ALLERGY

DNA Hypomethylation atALOX12Is Associated with Persistent Wheezing in Childhood

(2012) Eva Morales et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide Association Identifies theTGene as a Novel Asthma Pharmacogenetic Locus

(2012) Kelan G. Tantisira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Perinatal nicotine exposure induces asthma in second generation offspring

(2012) Virender K Rehan et al.   BMC Medicine

Methylation ofIL-2promoter at birth alters the risk of asthma exacerbations during childhood

(2012) J. A. Curtin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tailored second-line therapy in asthmatic children with the Arg16genotype

(2012) Brian J. Lipworth et al.   CLINICAL SCIENCE

450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy

(2012) Bonnie R. Joubert et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans

(2012) Rachel A. Myers et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment

(2012) Patrick G Holt et al.   NATURE MEDICINE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Prenatal and Passive Smoke Exposure and Incidence of Asthma and Wheeze: Systematic Review and Meta-analysis

(2012) Hannah Burke et al.   PEDIATRICS

Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

(2012) V Berce et al.   PHARMACOGENOMICS JOURNAL

DNA Methylation Profiles of Airway Epithelial Cells and PBMCs from Healthy, Atopic and Asthmatic Children

(2012) Dorota Stefanowicz et al.   PLoS One

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA

(2012) Adaikalavan Ramasamy et al.   PLoS One

FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid-treated asthmatic children

(2011) E. S. Koster et al.   ALLERGY

Predictors of Symptoms Are Different From Predictors of Severe Exacerbations From Asthma in Children

(2011) Ann Chen Wu et al.   CHEST

Genetic and genomic approaches to asthma

(2011) Youming Zhang et al.   CURRENT OPINION IN PULMONARY MEDICINE

Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo

(2011) Anthony Bosco et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Brief History of IL-9

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

Genomic DNA Hypomethylation by Histone Deacetylase Inhibition Implicates DNMT1 Nuclear Dynamics

(2011) M. K. Arzenani et al.   MOLECULAR AND CELLULAR BIOLOGY

Multidimensionality of microarrays: Statistical challenges and (im)possible solutions

(2011) Stefan Michiels et al.   Molecular Oncology

Genomewide Association betweenGLCCI1and Response to Glucocorticoid Therapy in Asthma

(2011) Kelan G. Tantisira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lifestyle and parental allergen sensitization are reflected in the intrauterine environment at gene expression level

(2010) M. Joerink et al.   ALLERGY

Gene–environment interactions in asthma and allergy: the end of the beginning?

(2010) Donata Vercelli   Current Opinion in Allergy and Clinical Immunology

A sequence variant on 17q21 is associated with age at onset and severity of asthma

(2010) Eva Halapi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation?

(2010) Monica Cheng Munthe-Kaas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Editors' Choice

(2010) Donald Y.M. Leung et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chromosome 17q21 SNP and severe asthma

(2010) Aristea Binia et al.   JOURNAL OF HUMAN GENETICS

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Step-up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids

(2010) Robert F. Lemanske et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate

(2010) F Liu et al.   ONCOGENE

Global strategy for the diagnosis and management of asthma in children 5 years and younger

(2010) Soren Erik Pedersen et al.   PEDIATRIC PULMONOLOGY

Prenatal Tobacco Smoke Exposure Affects Global and Gene-specific DNA Methylation

(2009) Carrie V. Breton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Testing significance relative to a fold-change threshold is a TREAT

(2009) D. J. McCarthy et al.   BIOINFORMATICS

Expression profiling of genes related to asthma exacerbations

(2009) T. Aoki et al.   CLINICAL AND EXPERIMENTAL ALLERGY

17q21 variants modify the association between early respiratory infections and asthma

(2009) L. A. M. Smit et al.   EUROPEAN RESPIRATORY JOURNAL

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Adrenergic β2-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol

(2009) Kaninika Basu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children

(2009) L. S. Subrata et al.   JOURNAL OF IMMUNOLOGY

Variants ofDENND1BAssociated with Asthma in Children

(2009) Patrick M.A. Sleiman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Inhaled Corticosteroids in Infants and Preschoolers With Recurrent Wheezing and Asthma: A Systematic Review With Meta-analysis

(2009) J. A. Castro-Rodriguez et al.   PEDIATRICS

5-Lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci

(2009) Kelan G. Tantisira et al.   Pharmacogenetics and Genomics

Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma

(2009) Frederica Perera et al.   PLoS One

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

(2009) F. Schembri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ORMDL3Gene Is Associated with Asthma in Three Ethnically Diverse Populations

(2008) Joshua Galanter et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications

(2008) Roger Tavendale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

ALOX5 promoter genotype and response to montelukast in moderate persistent asthma

(2008) Juan J. Telleria et al.   RESPIRATORY MEDICINE

How corticosteroids control inflammation: Quintiles Prize Lecture 2005

(2006) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY