Article
Pathology
Stephan Ledderose, Severin Rodler, Lennert Eismann, Georg Ledderose, Carola Ledderose
Summary: The degree of stromal tumor-infiltrating lymphocytes (sTILs) can reliably predict survival in patients with muscle-invasive urinary bladder cancer (MIBC).
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Immunology
Zexi He, Jun Gu, Ting Luan, Haihao Li, Charles Li, Zhenjie Chen, Enxiu Luo, Jiansong Wang, Yinglong Huang, Mingxia Ding
Summary: The study demonstrates the importance of the TIL-related model in predicting prognosis, immune status, and immunotherapy response in bladder cancer patients, which can help in screening patients who respond to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Xinyue Li, Jing Yang
Summary: This study investigated the relationship between tumor deposits and clinicopathological characteristics, tumor-infiltrating lymphocytes, and prognosis in gastric cancer. The results showed a significant association between tumor deposits and various characteristics and prognosis of gastric cancer, with patients having more than 4 tumor deposits having a worse prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Chengzeng Yin, Yoshinaga Okugawa, Akira Yamamoto, Takahito Kitajima, Tadanobu Shimura, Mikio Kawamura, Masahiro Tsujiura, Yosiki Okita, Masaki Ohi, Yuji Toiyama
Summary: Tumor-infiltrating immune cells, specifically CD8(+) tumor-infiltrating lymphocytes (TILs) and CD66b(+) tumor-associated neutrophils (TANs), in the invasive margin of colorectal cancer (CRC) have significant prognostic value for predicting survival and disease-free survival. The combined evaluation of TILs and TANs improves the prediction of oncological outcomes. Low tumor infiltration by CD8(+) TILs and CD66b(+) TANs is an independent predictive factor for overall survival and disease-free survival.
Article
Pathology
Meng Zhao, Hui Xing, Jiankun He, Xinran Wang, Yueping Liu
Summary: This study explored the correlation between the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and tumor infiltrating lymphocyte (TIL) before neoadjuvant therapy (NAT) and the prognosis of patients with triple negative breast cancer. The results showed that NLR was negatively correlated with TILs density and positively correlated with FOXP3+ TIL. High NLR, low TIL density, and low CD8+ TIL density were associated with poor prognosis in patients with breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Kosuke Imamura, Yusuke Tomita, Ryo Sato, Tokunori Ikeda, Shinji Iyama, Takayuki Jodai, Misako Takahashi, Akira Takaki, Kimitaka Akaike, Shohei Hamada, Shinya Sakata, Koichi Saruwatari, Sho Saeki, Koei Ikeda, Makoto Suzuki, Takuro Sakagami
Summary: This study found that the infiltration of drebrin-expressing T cells within the tumor cell nest in resectable squamous cell lung cancer patients is associated with short relapse-free survival and overall survival. The in vitro induced drebrin(+) T cells co-express multiple exhaustion-associated molecules. Single-cell RNA-sequencing analysis confirmed that exhausted tumor-infiltrating CD8(+) T cells specifically expressed drebrin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lennert Eismann, Severin Rodler, Alexander Buchner, Gerald Bastian Schulz, Yannic Volz, Robert Bischoff, Benedikt Ebner, Thilo Westhofen, Jozefina Casuscelli, Raphaela Waidelich, Christian Stief, Boris Schlenker, Stephan Ledderose
Summary: This study investigated the impact of tumor-infiltrating lymphocytes (TILs) in squamous cell carcinoma (SCC) of the bladder on patient prognosis. The findings suggest that subsets of TILs can predict overall survival (OS) and progression-free survival (PFS), and may be used to stratify patients with bladder SCC for immunotherapy.
Article
Oncology
En Wang, Masatsune Shibutani, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Yuki Okazaki, Shinichiro Kashiwagi, Hiroaki Tanaka, Kiyoshi Maeda
Summary: The study investigated the relationship between TIL infiltration and prognosis in patients with colorectal cancer liver metastases, finding that CD8(+)TIL infiltration was significantly associated with recurrence and overall survival. In patients without preoperative chemotherapy, CD8(+)TIL infiltration was significantly associated with recurrence-free survival, with a higher presence of CD8(+)TILs having a better effect on overall survival. However, in the long-term chemotherapy group, the degree of TIL infiltration was not necessarily associated with prognosis.
Article
Immunology
Ming Zheng, Yi-Ming Li, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Jian-Li Jiang, Ping Zhu, Xiang-Min Yang, Juan Tang, Zhi-Nan Chen
Summary: Immunotherapy targeting tumor-infiltrating lymphocytes has shown promising potential as a treatment for various cancers, but its efficacy varies across different cancer types and patients. The distribution of TIL-T and TIL-B cells and their interactions with the tumor microenvironment play a crucial role in determining the clinical outcomes. Understanding the prognostic significance of these factors can have important implications for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Peng Sun, Jiehua He, Xue Chao, Keming Chen, Yuanyuan Xu, Qitao Huang, Jingping Yun, Mei Li, Rongzhen Luo, Jinbo Kuang, Huajia Wang, Haosen Li, Hui Hui, Shuoyu Xu
Summary: This study establishes a computational TIL assessment method using deep learning, providing valuable prognostic information for TNBC patients. A three-tier stratification model combining mTIL and aTIL shows a higher C-index, indicating its potential for improved risk management and decision-making by pathologists.
Article
Immunology
Xiao-Tian Shen, Sun-Zhe Xie, Jing Xu, Lu-Yu Yang, Lun-Xiu Qin
Summary: This study comprehensively analyzed the global NET-associated gene regulatory network and found a close association between NETs and cancer biology. NETs had diverse prognostic impacts among different cancer types, and SPP1 potentially played a key role in NET-related poor outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Meng Zhou, Zicheng Zhang, Siqi Bao, Ping Hou, Congcong Yan, Jianzhong Su, Jie Sun
Summary: A machine learning-based computational framework was used to identify a lncRNA signature of TIL-Bs, named TILBlncSig, which showed potential in distinguishing survival outcomes and was associated with cancer features and immunosuppressive phenotype.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Cell Biology
Rui Yang, Xiaoqi Wang, Chao Ma, Zhihui Zhang, Ni Liu, Xinchun Ma, Yuqing Zhang, Xiuwen Wang, Yanguo Liu
Summary: The study found that neutrophil-associated markers and ratios, such as tumor-associated neutrophils (TANs), neutrophil-to-T cell ratio (NTR), and neutrophil-to-lymphocyte ratio (NLR), can predict the survival of patients with non-small cell lung cancer (NSCLC). These markers are associated with different clinical outcomes, providing new insights into the role of neutrophils in tumor biology and survival prediction.
CELLULAR IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Iman M. M. Talaat, Noha M. M. Elemam, Shroque Zaher, Maha Saber-Ayad
Summary: Colorectal cancer is a prevalent cancer type worldwide, and the immune cells within the tumor microenvironment play a crucial role in its initiation and progression. Immune checkpoint molecules are highlighted as potential targets for immunotherapy in colorectal cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Kathleen Schueler, Daniel Bethmann, Sandy Kaufhold, Carolin Hartung, Kathrin Stueckrath, Tilmann Lantzsch, Christoph Uleer, Volker Hanf, Susanne Peschel, Jutta John, Marleen Poehler, Jorg Buchmann, Karl-Friedrich Buerrig, Edith Weigert, Christoph Thomssen, Eva Johanna Kantelhardt, Martina Vetter
Summary: Tumour-infiltrating lymphocytes (TILs) have prognostic and predictive value for patients with early breast cancer, especially in HER2-positive breast cancer. The distribution of TILs varies among different breast cancer types, and the percentage of TILs is associated with improved prognosis.
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
