Review
Clinical Neurology
Yafei Wen, Bin Jiao, Yafang Zhou
Summary: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with no effective symptomatic or neuroprotective treatment available. Although some cases may benefit from deep brain stimulation (DBS), there is not sufficient evidence proving its efficacy for PSP patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Olivia Samotus, Andrew Parrent, Mandar Jog
Summary: This study found that spinal cord stimulation (SCS) therapy can improve freezing of gait (FOG) and gait symptoms in Richardson's syndrome PSP patients, suggesting early intervention with SCS for dopaminergic-resistant gait should be considered.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marina Picillo, Carlo Ricciardi, Maria Francesca Tepedino, Filomena Abate, Sofia Cuoco, Immacolata Carotenuto, Roberto Erro, Gianluca Ricciardelli, Michela Russo, Mario Cesarelli, Paolo Barone, Marianna Amboni
Summary: This study aimed to describe gait parameters of PSP phenotypes at an early stage and found that Richardson's syndrome had worse cognitive function and gait parameters compared to other PSP phenotypes. The research also showed that computerized gait analysis can differentiate between PSP phenotypes and vPSP and PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
V. S. Witzig, F. Alosaimi, Y. Temel, J. B. Schulz, A. Jahanshahi, S. K. H. Tan
Summary: This study investigated the effects of long-term intermittent bilateral STN-DBS on PPN cholinergic neurons in the MPTP Parkinsonian mouse model. The results showed that STN-DBS improved gait impairments but did not alter the expression or activation of PPN acetylcholine neurons. Therefore, the motor and gait effects of STN-DBS are less likely to be mediated by the STN-PPN connection and PPN cholinergic system.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Viswas Dayal, Ali Rajabian, Marjan Jahanshahi, Iciar Aviles-Olmos, Dorothy Cowie, Amy Peters, Brian Day, Jonathan Hyam, Harith Akram, Patricia Limousin, Marwan Hariz, Ludvic Zrinzo, Thomas Foltynie
Summary: This study summarized the clinical outcomes of 6 PPN-DBS treated patients, finding that unilaterally treated patients did not show significant improvements, while bilaterally treated patients at least had an initial response. Some PD and PSP patients exhibited different responses in FOG.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Article
Clinical Neurology
Marian L. Dale, Austin L. Prewitt, Graham R. Harker, Grace E. McBarron, Martina Mancini
Summary: This study reviewed the methodology of previous balance studies in PSP and discussed the feasibility of objective balance assessment in PSP. Lessons learned and future approaches were highlighted.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Marianna Amboni, Carlo Ricciardi, Marina Picillo, Chiara De Santis, Gianluca Ricciardelli, Filomena Abate, Maria Francesca Tepedino, Giovanni D'Addio, Giuseppe Cesarelli, Giampiero Volpe, Maria Consiglia Calabrese, Mario Cesarelli, Paolo Barone
Summary: Progressive supranuclear palsy (PSP) is a rare and rapidly progressing disease, and this study demonstrates that gait analysis can effectively differentiate early PSP patients from Parkinson's disease (PD) patients, providing speculative clues for rehabilitation strategies.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Blas Couto, Ivan Martinez-Valbuena, Seojin Lee, Isabel Alfradique-Dunham, Richard J. Perrin, Joel S. Perlmutter, Carlos Cruchaga, Ain Kim, Naomi Visanji, Christine Sato, Ekaterina Rogaeva, Anthony E. Lang, Gabor G. Kovacs
Summary: This study reveals a broader range of disease courses in progressive supranuclear palsy (PSP) than previously known. Time to gait dependence and cognitive impairment are proposed as prognostic milestones. Genetic polymorphisms in TRIM11 and SLC2A13 genes are associated with longer disease duration. The study suggests a subtype of PSP with protracted course and explores its relationship with protein misfolding, seeding activity, and propagation.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neuroimaging
Marie-Laure Welter, Alexandre Vasseur, Regine Edragas, Hugo Chaumont, Fanny Pineau, Graziella Mangone, Claire Olivier, Isabelle Leber, Sophie Rivaud-Pechoux, Stephane Lehericy, Cecile Gallea, Lydia Yahia-Cherif, Annie Lannuzel
Summary: This study investigates the relationship between gait and balance disorders and brain lesions in Caribbean AP and PSP-RS patients. The results show that both patient groups have severe gait and balance disorders that are mainly related to structural changes in specific brain areas. In Caribbean AP patients, gait disorders are also related to additional changes in cortical brain areas, while in PSP-RS patients, additional white matter changes are involved.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Shinsuke Fujioka, Takashi Morishita, Koichi Takano, Nobutaka Takahashi, Kanako Kurihara, Akihiro Nishida, Takayasu Mishima, Midori Suenaga, Yoichi Matsunaga, Yoshi Tsuboi
Summary: After analyzing and comparing the volumes of the subthalamic nucleus and whole cerebrum in patients with PSP, MSA, PD, and CBS, it was found that the volume of the subthalamic nucleus may be a useful diagnostic marker for PSP to differentiate it from other neurodegenerative parkinsonian disorders.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Yafei Wen, Hui Zhou, Mengwen Xia, Qianqian Liu, Hongzhi Quan, Liangjuan Fang
Summary: Progressive supranuclear palsy (PSP) is an atypical parkinsonism that lacks validated diagnostic biomarkers. Transcranial sonography (TCS) shows promise in diagnosing PSP and differentiating it from Parkinson's disease, with high sensitivity and specificity.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Jong Hyeon Ahn, Junmo Kwon, Ji Hye Won, Kyoungseob Byeon, Jinyoung Youn, Hyunjin Park, Jin Whan Cho
Summary: This study investigated waiting impulsivity in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) and introduced a novel evaluation method. The results showed that the JTG sign is a surrogate marker of waiting impulsivity in PSP-RS patients, enriching the current understanding of waiting impulsivity in PSP patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Irene Sintini, Kenton Kaufman, Hugo Botha, Peter R. Martin, Stacy R. Loushin, Matthew L. Senjem, Robert I. Reid, Christopher G. Schwarz, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell, Farwa Ali
Summary: Progressive supranuclear palsy is a neurodegenerative disorder characterized by tau inclusions and neurodegeneration, commonly presenting with gait impairments and postural instability. Analysis of multimodal imaging biomarkers and laboratory-based measurements can provide valuable insights into the relationship between neurodegeneration and gait/balance abnormalities in this condition.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Mayuko Sakuwa, Tadashi Adachi, Yuki Suzuki, Hiroshi Takigawa, Ritsuko Hanajima
Summary: This study aimed to investigate the relationship between cognitive impairment and PSP-related pathology. The results showed that the total load of tau pretangles/neurofibrillary tangles was higher in the PSP-CI group compared to the PSP-NC group. Additionally, there was a higher burden of tufted astrocytes in the subthalamic nucleus and medial thalamus in the PSP-CI group.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Kaijia Yu, Zhiwei Ren, Yongsheng Hu, Song Guo, Xiaofan Ye, Jianyu Li, Yongjie Li
Summary: This study suggests that caudal PPN low-frequency stimulation can improve postural instability and gait disorders in patients with Parkinson's disease.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Annemarie Vogel, Inga Claus, Sigrid Ahring, Doreen Gruber, Aiden Haghikia, Ulrike Frank, Rainer Dziewas, Georg Ebersbach, Florin Gandor, Tobias Warnecke
Summary: In contrast with patients with PD, patients with dysphagic MSA more frequently present with oral-phase symptoms and a significantly higher intraindividual interswallow variability. A novel Swallowing Disturbance Questionnaire MSA subscore may be a valuable tool to identify patients with MSA with early oropharyngeal dysphagia.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Marlen Schmicker, Inga Menze, Christine Schneider, Marco Taubert, Tino Zaehle, Notger G. Mueller
Summary: The study suggests that transcranial direct current stimulation (tDCS) can enhance transfer effects on working memory (WM), especially in individuals with high WM capacity. However, in individuals with low WM capacity, tDCS may reduce transfer effects on WM. This highlights the importance of adjusting tDCS protocols based on individual differences in WM capacity.
Article
Neurosciences
Thomas Kinateder, Daniela Marinho, Doreen Gruber, Laura Hatzler, Georg Ebersbach, Florin Gandor
Summary: Sexual dysfunctions are common but underreported in Parkinson's disease, with male patients being more affected. Erectile dysfunction and orgasm dysfunction are the most common complaints. SD has negative impacts on partnership and quality of life and should be routinely assessed.
Article
Neurosciences
Matthias Loehle, Alexander Bremer, Florin Gandor, Jonathan Timpka, Per Odin, Georg Ebersbach, Alexander Storch
Summary: This study compared the validity of motor state quantification between the Parkinson's disease (PD) home diary and direct clinical observation in fluctuating PD patients. The results showed that the home diary inadequately reflects actual motor states compared to direct clinical observation.
NPJ PARKINSONS DISEASE
(2022)
Article
Multidisciplinary Sciences
Benjamin J. Griffiths, Tino Zaehle, Stefan Repplinger, Friedhelm C. Schmitt, Juergen Voges, Simon Hanslmayr, Tobias Staudigl
Summary: The thalamus plays a significant role in animal cognition and its interaction with the prefrontal cortex can predict perceptual performance. However, little is known about thalamic and thalamocortical contributions to human cognition. This study demonstrates that rhythmic activity in the mediodorsal thalamus and prefrontal cortex predicts the perception of near-threshold visual stimuli, challenging the traditional view of the thalamus as a simple relay.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Maria Kuehne, Laura Polotzek, Aiden Haghikia, Tino Zaehle, Janek S. Lobmaier
Summary: This study investigated the influence of facial mimicry on facial emotion recognition. The results showed that the emotional recognition of the control group was affected by facial mimicry manipulation, while Parkinson's disease patients had impairments in their ability to detect emotion changes. Furthermore, the study found that the facial emotion recognition abilities of Parkinson's disease patients were completely unaffected by mimicry manipulation.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study investigated the potential of P50 sensory gating and prepulse inhibition ratios as surrogate markers for cognitive fatigue in people with multiple sclerosis (pwMS). The results showed that P50 sensory gating was correlated with subjective fatigue ratings. This study is the first to demonstrate fatigue-related disruption of sensory gating in pwMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study found that patients with multiple sclerosis (pwMS) show more measurable changes in cognitive fatigability compared to healthy controls. However, these changes in reaction time and brain activity were not associated with subjective fatigue ratings.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Immunology
Stefanie Linnhoff, Lilli Koehler, Aiden Haghikia, Tino Zaehle
Summary: After acute COVID-19 infection, many patients continue to experience symptoms for more than four weeks, known as Long-COVID syndrome. Surprisingly, the severity of Long-COVID symptoms is not linked to the severity of the initial infection. Fatigue is a common and debilitating symptom of Long-COVID, and non-invasive brain stimulation methods show promise in reducing fatigue symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Carin Janz, Jonathan Timpka, Matthias Loehle, Alexander Bremer, Florin Gandor, Georg Ebersbach, Alexander Storch, Per Odin
Summary: The study aimed to investigate the effect of structured training on motor fluctuations in improving agreement between observer and patient assessments and daily motor state times. The results showed that structured training did not significantly improve the agreement between observers and HD ratings or the reliability of daily motor state times.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Neurosciences
Inga Menze, Notger G. Mueller, Tino Zaehle, Marlen Schmicker
Summary: This study compares different electrode montage approaches for transcranial direct current stimulation (tDCS) and finds that frontoparietal network stimulation is superior in improving working memory capacity. The results also highlight the individual variability in the effects of conventional and sham tDCS. This finding contributes to a better understanding of the impact of tDCS on cognitive functions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Stefan Mainka, Maximilian Lauermann, Georg Ebersbach
Summary: Asymmetry of arm swing is a characteristic of normal physiological gait, but patients with Parkinson's disease (PWPD) may experience a one-sided reduction in arm swing as an early symptom. This study compared arm swing differences between healthy subjects (HS) and mildly-to-moderately impaired PWPD at various walking speeds. The results showed that PWPD had reduced arm swing compared to HS during normal, fast, and very fast walking. The coordination of arm swing was also reduced in PWPD during very slow and normal walking. These findings suggest that reduced one-sided arm swing can be an early sign of parkinsonian gait disturbance.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Correction
Clinical Neurology
Stefan Mainka, Maximilian Lauermann, Georg Ebersbach
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Katharina S. Rufener, Christian Wienke, Alena Salanje, Aiden Haghikia, Tino Zaehle
Summary: This study investigates the effects of pairing tones with transcutaneous auricular vagus nerve stimulation (taVNS) on auditory processing. Results show that taVNS can modulate auditory processing in healthy individuals, suggesting potential applications in auditory disorders.
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)