Article
Oncology
Yujin Pan, Deyu Li, Jiuhui Yang, Ning Wang, Erwei Xiao, Lianyuan Tao, Xiangming Ding, Peichun Sun, Dongxiao Li
Summary: This study demonstrates the preferability of portal venous for CTC testing and the association of high PoV M-CTC count with increased risk of metastasis and shorter survival time in resectable PDAC patients. PoV CTC phenotype detection shows potential as a reliable and accurate tool for identifying high-risk PDAC patients for better management strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Nishant Thakur, Muhammad Joan Ailia, Yosep Chong, Ok Ran Shin, Kwangil Yim
Summary: This study evaluated the prognostic significance, clinicopathological value, and relationship with epithelial-mesenchymal transition (EMT) of tumor budding (TB) in lung cancer. The results showed that high-grade TB was significantly associated with poor overall survival (OS) and disease-free survival (DFS), as well as clinicopathological characteristics and EMT markers.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Hongjuan You, Dongchen Yuan, Yanwei Bi, Ning Zhang, Qi Li, Tao Tu, Xiao Wei, Qi Lian, Tong Yu, Delong Kong, Xiaoying Yang, Xiangye Liu, Xiaomei Liu, Fanyun Kong, Kuiyang Zheng, Renxian Tang
Summary: The study indicated that vimentin expression is increased in HBX-positive hepatoma cells and HBV-related HCC tissues, correlated with HBX. HBX enhances vimentin expression through LASP1 mediated signal pathways, contributing to EMT, proliferation, and migration of HCC cells.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Kostas Palamaris, Evangelos Felekouras, Stratigoula Sakellariou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by aggressive behavior and resistance to chemotherapy, with emerging evidence pointing to epithelial to mesenchymal transition (EMT) as a key driver of disease progression and drug resistance. EMT allows cancer cells to transition to a more mesenchymal state, contributing to tumor dissemination and chemoresistance in PDAC.
Article
Cell Biology
Cheng Xiong, Youwei Zhu, Meilin Xue, Yongsheng Jiang, Yiming Zhong, Lingxi Jiang, Minmin Shi, Hao Chen
Summary: This study revealed that TAMs promote PDAC progression through the TGF-beta signaling pathway, and the pro-tumorigenic effects of TAMs or TAM-CM can be abolished by inhibiting the TGF-beta signaling pathway or neutralizing TGF-beta antibody.
Article
Oncology
Julie Dardare, Andrea Witz, Margaux Betz, Aurelie Francois, Morgane Meras, Laureline Lamy, Aurelien Lambert, Stephanie Grandemange, Marie Husson, Marie Rouyer, Jessica Demange, Jean-Louis Merlin, Alexandre Harle, Pauline Gilson
Summary: This study investigates the role of DDB2 in pancreatic ductal adenocarcinoma (PDAC). The results show that lower expression of DDB2 is associated with shorter disease-free survival in PDAC patients. Overexpression of DDB2 can decrease cell migration and invasion, and increase sensitivity to certain chemotherapy drugs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Shaoqiu Zheng, Jing Luo, Shoucheng Xie, Shanming Lu, Qinghua Liu, Huanqin Xiao, Wenjuan Luo, Yanfang Huang, Kun Liu
Summary: Recent evidence suggests that cancer stem cells (CSCs) are the origin of cancers. This study investigated the relationship between tumor buds, which are hypothesized to represent epithelial-mesenchymal transition (EMT)-like CSCs, and EMT and CSC markers in cervical squamous cell carcinoma (CxSCC). The findings indicate that tumor buds in CxSCC may represent EMT-like CSCs in vivo.
Article
Oncology
Jiazhang Wei, Weiming Deng, Jingjin Weng, Min Li, Guiping Lan, Xiang Li, Linsong Ye, Yongli Wang, Fei Liu, Huashuang Ou, Yunzhong Wei, Wenlin Huang, Sifang Xie, Guohu Dong, Shenhong Qu
Summary: CTC classification allows for a better understanding of cellular phenotypic changes responsible for locoregional invasion and distant metastasis in nasopharyngeal carcinoma (NPC), and predicts clinical outcomes in patients with progressive NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mitsunobu Oba, Yoshitsugu Nakanishi, Tomoko Mitsuhashi, Katsunori Sasaki, Kanako C. Hatanaka, Masako Sasaki, Ayae Nange, Asami Okumura, Mariko Hayashi, Yusuke Yoshida, Takeo Nitta, Takashi Ueno, Toru Yamada, Masato Ono, Shota Kuwabara, Keisuke Okamura, Takahiro Tsuchikawa, Toru Nakamura, Takehiro Noji, Toshimichi Asano, Kimitaka Tanaka, Kiyoshi Takayama, Yutaka Hatanaka, Satoshi Hirano
Summary: This study examined the association between CCR7 expression and clinicopathological features and EMT in EHCC. High-grade CCR7 expression was significantly correlated with aggressive tumor characteristics, low E-cadherin expression, and poor overall survival. Further experiments demonstrated that CCR7 promotes EHCC cell invasion and migration through induction of EMT, which can be inhibited by a CCR7 antagonist. These findings suggest that CCR7 may serve as a potential target for adjuvant therapy in EHCC.
Review
Medicine, General & Internal
Xiu Hu, Wei Chen
Summary: Pancreatic cancer is the seventh leading cause of cancer death worldwide, and most patients develop metastases, leading to poor treatment outcomes. Chemoresistance is closely related to the epithelial-mesenchymal transition (EMT) of PDAC cells, and inhibiting EMT may help develop more effective drugs against PDAC. Further research is needed to understand drug resistance mechanisms and improve patient outcomes.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Oncology
Kohei Okuyama, Keiji Suzuki, Souichi Yanamoto
Summary: This article summarizes the latest research on the relevance of tumor budding (TB) and partial epithelial-mesenchymal transition (p-EMT) as prognostic markers in the tumor microenvironment (TME) of head and neck squamous cell carcinoma (HNSCC). Understanding the mechanism of TB onset and the relationship between p-EMTs may facilitate the development of novel diagnostic and prognostic methods, and targeted therapies for the prevention of invasion and metastasis.
Article
Oncology
Bo Zhou, Jie Xiang, Ming Jin, Xiang Zheng, Guogang Li, Sheng Yan
Summary: The study showed that high vimentin expression with loss of E-cadherin expression in patients with grade 1 and 2 pNETs undergoing resection was correlated with risks of lymph node metastasis, distant metastasis, disease progression, and poor prognosis.
Article
Oncology
Marie-Lucie Racu, Laetitia Lebrun, Andrea Alex Schiavo, Claude Van Campenhout, Sarah De Clercq, Lara Absil, Esmeralda Minguijon Perez, Calliope Maris, Christine Decaestecker, Isabelle Salmon, Nicky D'Haene
Summary: Pancreatic ductal adenocarcinoma (PDAC) has a low survival rate and its incidence is increasing over time. Understanding the molecular mechanisms behind metastasis and chemoresistance in PDAC is crucial, as these are the main causes of death in patients. SMAD4 is deactivated in half of PDAC cases and its loss is associated with worse overall survival and metastasis. SMAD4 is a key transducer in the TGF-beta pathway, which plays a role in epithelial-mesenchymal transition (EMT). EMT is a biological process where epithelial cells lose their characteristics and acquire a more mesenchymal phenotype, leading to increased motility. Recent studies suggest that cells may undergo intermediate states during EMT, known as epithelial-mesenchymal plasticity (EMP), which exhibit enhanced aggressiveness and more efficient metastasis. This review aims to summarize and analyze current knowledge on SMAD4 loss in PDAC patients and investigate its potential role in EMP, in order to better understand its function in PDAC carcinogenesis.
Article
Oncology
Hui Jiang, Yelin Yang, Yuping Qian, Chengwei Shao, Jianping Lu, Yun Bian, Jianming Zheng
Summary: The study revealed a strong and independent association between the tumor budding (TB) score and overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC), with the high TB score group having significantly higher mortality risk.
FRONTIERS IN ONCOLOGY
(2021)
Letter
Dermatology
Linda Manaa, Yosra Soua, Nesrine Ben Salah, Manel Njima, Abir Aouam, Syrine Dada, Monia Youssef, Hichem Belhadjali, Jameleddine Zili
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Ahlem Bellalah, Ibtissem Korbi, Seifeddine Ben Hammouda, Asma Achour, Nouha Ben Abdeljelil, Manel Njima, Amira Daldoul, Rim Hadhri, Leila Njim, Abdelfatteh Zakhama
Summary: Histiocytic sarcoma is a rare malignant neoplasm characterized by extranodal presentation and poor clinical course; a case of bifocal and aggressive HS in a 63-year-old man is documented in this report, highlighting the importance of correct diagnosis for treatment and prognostic prediction; collecting additional cases of HS is crucial for further progress in prognosis and guiding treatment decisions.
ANNALS OF MEDICINE AND SURGERY
(2021)
Editorial Material
Surgery
Anis Haddad, Hazem Beji, Youssef Chaker, Houcine Maghrebi, Amin Makni, Wael Rebai, Mohamed Jouini, Montassar Kacem
ANZ JOURNAL OF SURGERY
(2022)
Article
Oncology
Bin Xu, Talia L. Fuchs, Sara Ahmadi, Mohammed Alghamdi, Bayan Alzumaili, Mohamed-Amine Bani, Eric Baudin, Angela Chou, Antonio De Leo, James A. Fagin, Ian Ganly, Anthony Glover, Dana Hartl, Christina Kanaan, Pierre Khneisser, Fedaa Najdawi, Aradhya Nigam, Alex Papachristos, Andrea Repaci, Philip M. Spanheimer, Erica Solaroli, Brian R. Untch, Justine A. Barletta, Giovanni Tallini, Abir Al Ghuzlan, Anthony J. Gill, Ronald A. Ghossein
Summary: This study aimed to establish an internationally recognized grading system for medullary thyroid carcinoma (MTC) to predict adverse outcomes by evaluating mitotic activity, Ki67 proliferative index, and tumor necrosis in MTC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Satoru Yonekura, Safae Terrisse, Carolina Alves Costa Silva, Antoine Lafarge, Valerio Iebba, Gladys Ferrere, Anne-Gaelle Goubet, Jean-Eudes Fahrner, Imran Lahmar, Kousuke Ueda, Gibrail Mansouri, Eugenie Pizzato, Pierre Ly, Marine Mazzenga, Cassandra Thelemaque, Marine Fidelle, Fanny Jaulin, Jerome Cartry, Marc Deloger, Marine Aglave, Nathalie Droin, Paule Opolon, Angelique Puget, Fanny Mann, Michel Neunlist, Anne Bessard, Laetitia Aymeric, Tamara Matysiak-Budnik, Jacques Bosq, Paul Hofman, Connie P. M. Duong, Sophie Ugolini, Valentin Quiniou, Sylvie Berrard, Bernhard Ryffel, Oliver Kepp, Guido Kroemer, Bertrand Routy, Leonardo Lordello, Mohamed-Amine Bani, Nicola Segata, Fjodor Yousef Yengej, Hans Clevers, Jean-Yves Scoazec, Edoardo Pasolli, Lisa Derosa, Laurence Zitvogel
Summary: Malignant processes can cause atrophy of the ileal mucosa, leading to dysbiosis of the microbiome. Blocking beta-adrenergic receptors and reducing gut microbiota can prevent cancer-induced ileopathy and slow tumor growth.
Article
Pathology
Christina Kanaan, Sophie Cotteret, Pierre Khneisser, Ranya Soufan, Mohamed-Amine Bani, Pascal Burtin, Isabelle Sourrouille, Michel Ducreux, Abir Al Ghuzlan, Jean-Yves Scoazec
Summary: This article reports the first sporadic case of NF1-associated mucosal inflammatory polyp of the colon. The patient had a pathogenic variant of NF1, suggesting the existence of juvenile-like inflammatory polyps associated with NF1 alterations. Testing NF1 in difficult-to-classify gastrointestinal mesenchymal tumors is justified.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Houcine Maghrebi, Hazem Beji, Anis Haddad, Amine Sebai, Samia Safraoui, Maroua Hafi, Asma Laabidi, Mohamed Jouini, Montasser Jamel Kacem
Summary: This study aimed to evaluate the Glasgow-Blatchford Score (GBS) in predicting the need for transfusions, endoscopic or surgical treatments in patients with non-variceal upper gastrointestinal hemorrhage (NVUGIH). The results showed that GBS has high sensitivity and specificity in predicting the need for these treatments.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Ouadi Yacine, Feryel Letaief Ksontini, Ahmed Ben Mahmoud, Houcine Magherbi, Samir Fadhel Fterich, Montasser Kacem
Summary: This case report describes an early recurrence of pancreatic glucagonoma in a 44-year-old female patient who underwent surgical resection. The recurrence was successfully managed with another surgery and pathology confirmed the nature of the lesions. The rarity of glucagonomas highlights the need for further research and guidelines for their treatment.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Surgery
Hazem Beji, Souhaib Atri, Houcine Maghrebi, Anis Haddad, Amin Makni, Montasser Kacem
Summary: This case report highlights the rare complication of haemobilia causing acute cholangitis in a patient who underwent percutaneous cholecystostomy for acute cholecystitis. The importance of injecting physiological saline serum through the drainage catheter is emphasized. Conservative treatment with antibiotics and saline injection is a good option, with ERCP reserved for cases of failure.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Review
Medicine, General & Internal
Houcine Maghrebi, Chaima Yakoubi, Hazem Beji, Feryel Letaief, Sadok Megdich, Amin Makni, Seif Boukriba, Wassim Frikha, Mouna Ayadi, Montasser Kacem
Summary: This article aimed to study the epidemiology, diagnostic difficulties, and therapeutic principles of intra-abdominal cystic lymphangioma (ACL) in adults. A retrospective study of 32 adult patients with ACL was conducted, and the results showed that ACL is rare in adults and the clinical features remain unclear. Diagnosis can only be confirmed by histopathological examination after complete surgical resection. Both open surgery and laparoscopic surgery are feasible options.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Houcine Maghrebi, Asma Zaiem, Hazem Beji, Bedis Jeribi, Anis Hadded, Seif Boukriba, Wassim Frikha, Selim Hamissa, Mohamed Jouini, Montasser Kacem
Summary: The rupture of omental artery aneurysms is highly dangerous, but can be successfully treated with transcatheter arterial embolization (TAE). This case report describes a successful TAE treatment of a spontaneous rupture of a left omental artery aneurysm.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Oncology
Maximiliano Gelli, Christophe Desterke, Mohamed Amine Bani, Valerie Boige, Charles Ferte, Peggy Dartigues, Bastien Job, Geraldine Perkins, Pierre Laurent-Puig, Diane Goere, Jacques R. R. Mathieu, Jerome Cartry, Michel Ducreux, Fanny Jaulin
Summary: This study aims to elucidate the primary tumor transcriptomic signatures associated with distinct metastatic routes in colorectal cancer (CRC). By analyzing the transcriptomic mRNA sequencing, gene set enrichment analyses and immunohistochemistry of primary tumor specimens, we identified a 61-gene signature that distinguishes between liver and peritoneal metastatic routes. The application of this transcriptomic signature could potentially identify new therapeutic targets for stage IV CRC and contribute to individualized follow-up programs in stage II-III CRC.
Article
Medicine, General & Internal
Youssef Chaker, Yacine Ouadi, Ahmed Ben Mahmoud, Anis Haddad, Houcine Magherbi, Montasser Kacem
Summary: This case describes a rare association of caecal volvulus with intestinal malrotation, highlighting the importance of modern technologies like CT scan for accurate preoperative diagnosis and presenting an approach to this uncommon surgical emergency for efficient treatment.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Medicine, General & Internal
Feryel Letaief Ksontini, Salim Khrouf, Selma Kacem, Anis Haddad, Houcine Magherbi, Youssef Chaker, Mouna Ayadi, Zoubair Ben Safta
Summary: Pancreatic metastasis of renal cancer is rare and requires long-term follow-up. Surgery is the best treatment option.
CASE REPORTS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Ahmed Ben Mahmoud, Souhaib Atri, Wael Rebai, Houcine Maghrebi, Amine Makni, Montasser Jameleddine Kacem
Summary: Hydatid disease is a major health problem worldwide, with the liver being the most common location. Acute pancreatitis secondary to a liver hydatid cyst ruptured in the biliary tract is rare. This case was managed with emergency open surgery, but endoscopic treatment may be a less invasive alternative based on literature review.
ANNALS OF MEDICINE AND SURGERY
(2021)