Review
Chemistry, Multidisciplinary
Jiangyi Luo, Hanwen Yuan, Linxi Mao, Juanjiang Wu, Sai Jiang, Yupei Yang, Yangfen Fu, Leping Liu, Shenghuang Chen, Wei Wang
Summary: Zhishi, the dried young fruit of Citrus aurantium L. or Citrus sinensis Osbeck, is widely used in flavorings, canned food, beverages, and medicines. It has a bidirectional regulating effect on the gastrointestinal tract and its active ingredients have clinical applications as blood pressure boosting and anti-shock drugs. Flavonoids and alkaloids of Zhishi make it potential weight loss and beauty products.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Agricultural Engineering
Peixi Zhu, Mengya Hao, Feng Su, Wenhao Xu, Qihong Zhang, Weike Su, Erwin Adams
Summary: This study employed mechanochemistry for the first time to extract essential oil from Citrus aurantium L. var. amara Engl. It achieved a higher yield and identified more compounds compared to traditional extraction methods. Furthermore, the mechanochemical-assisted extraction caused changes in the material's surface structure.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biology
Jing Chen, Yaliang Shi, Yicheng Zhong, Zhimin Sun, Juan Niu, Yue Wang, Tianxin Chen, Jianhua Chen, Mingbao Luan
Summary: This study focused on the flavonoid biosynthesis in Citrus aurantium L. fruits, showing a gradual decrease in total flavonoid concentration as fruit developed. The main flavonoids shifted from neohesperidin to naringin as the development stage progressed. Key genes related to flavonoid biosynthesis were identified through transcriptome analysis, providing a foundation for understanding the mechanisms underlying flavonoid biosynthesis in Citrus aurantium L. fruits.
Article
Agronomy
Chahinez Oulebsir, Hakima Mefti-Korteby, Zahr-Eddine Djazouli, Bachar Zebib, Othmane Merah
Summary: This study investigated the essential oil composition of sour orange leaves grown in Algeria and determined their antioxidant and anti-inflammatory properties. Results showed that the essential oil contained various volatile compounds and exhibited antioxidant and anti-inflammatory effects.
Review
Biochemistry & Molecular Biology
Sawssan Maksoud, Roula M. Abdel-Massih, Hiba N. Rajha, Nicolas Louka, Farid Chemat, Francisco J. Barba, Esperance Debs
Summary: Citrus genus is a globally important staple crop, with Citrus aurantium L. standing out for its unique characteristics and rich content of active constituents with various health benefits. This paper provides an overview of recent studies on the biological activities and medicinal uses of active constituents in C.aurantium.
Article
Plant Sciences
Xiao-Yi Li, Yun-Fang Hao, Zhan-Xi Hao, Jian-Guo Jiang, Qiang Liu, Qun Shen, Li Liu, Yan-Kui Yi, Chun-Yan Shen
Summary: CHL extracts may suppress lipid accumulation by inhibiting differentiation of 3T3-L1 cells and attenuating metabolic syndromes in HFD-fed mice.
Article
Biochemistry & Molecular Biology
Wei-Feng Cai, Mao-Mao Yan, Zheng Wang, Meng-Ping Jiang, Bing Yan, Chun-Yan Shen
Summary: The alkaloid extracts from the flower of Citrus aurantium L. var. amara Engl. (CAVA) have the potential to regulate lipid metabolism by increasing antioxidant enzyme activity and inhibiting lipid synthesis gene expression.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Dorottya Koncz, Barbara Toth, Muh Akbar Bahar, Orsolya Roza, Dezso Csupor
Summary: This study provides an overview of the safety and efficacy of p-synephrine and evaluates its weight loss effects through a meta-analysis. The findings suggest that prolonged use of synephrine may increase blood pressure, but it does not facilitate weight loss or affect body composition parameters. Further research is needed to confirm its safety and efficacy.
Article
Green & Sustainable Science & Technology
Chan-Gonzalez Jorge de Jesus, Castillo Tellez Margarita, Castillo-Tellez Beatriz, Lezama-Zarraga Francisco Roman, Mejia-Perez Gerardo Alberto, Vega-Gomez Carlos Jesahel
Summary: This study investigated the drying of bitter orange leaves using thermal and photovoltaic solar energy. The integrated system showed better performance in color preservation and drying rate compared to a regular solar dryer.
Review
Chemistry, Medicinal
Fiaz Alam, Kinza Mohammadin, Zainab Shafique, Sayyeda Tayyeba Amjad, Mohammad Hassham Hassan bin Asad
Summary: Plants from the Rutaceae family are known for their significant contributions to both food and medicine, particularly through the production of flavonoids. A systematic review conducted up to 2018 revealed a wide range of flavonoids with various bioactivities, such as anticancer, antibacterial, antiviral, analgesic, and antioxidant properties. The isolation and study of these flavonoids from Rutaceae plants could have important implications for future nutraceutical, therapeutic, and pharmaceutical developments.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Seong Beom Jin, Min Ju Kim, Cheol Woo Choi, Suk Man Park, Su Hyun Yun
Summary: This study genetically verified that sour orange plants derived from anther culture were developed from somatic embryos or haploid tissues. The anther culture technique can be used to obtain homozygous diploid and aneuploid citrus plants.
Article
Green & Sustainable Science & Technology
Punitha Nagarajan, Vijayakumar Subramaniyan, Vidhya Elavarasan, Nilavukkarasi Mohandoss, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: This study focuses on the synthesis of aluminium oxide nanoparticles (Al2O3 NPs) using Citrus aurantium peel extract as a green and efficient method. Various characterisation techniques were used to evaluate the morphology of Al2O3 NPs, as well as their antimicrobial and photocatalytic properties. The results showed that the biosynthesised Al2O3 NPs exhibited feasible antimicrobial, anti-proliferative, and photocatalytic activities, making them potential candidates for various applications.
Article
Biochemistry & Molecular Biology
Qixin Zhang, Wenying Song, Guanqi Tao, Qin Li, Lixia Wang, Wenkang Huang, Lijuan Gao, Lai Yin, Yiping Ye
Summary: This study compared the chemical composition of Quzhou Aurantii Fructus (QAF) and Aurantii Fructus (AF) and found that they have similar main components but also identified trace differential compounds that can be used to distinguish between QAF and AF. Additionally, QAF showed a higher antioxidant capacity compared to AF.
Article
Biochemistry & Molecular Biology
Zixiao Jiang, Zhenqing Li, Fengchao Wang, Zhiqin Zhou
Summary: The study revealed that PMFs in sour orange protected mice from radiation-induced injury by maintaining intestinal structure and showing high radio-resistance potential.
Article
Medicine, Legal
George A. Burdock
Summary: The food ingredient Nigella sativa L., also known as black cumin or black caraway, has a long history of use in Middle- and Far-Eastern cultures. The seed and its extracts have been reported as a successful therapeutic agent, with the presence of thymoquinone being attributed to its effectiveness. However, the quantitative analysis of the seed yields variable results, which can be due to various factors. Despite this variability, many studies have shown positive outcomes in toxicity testing and clinical trials. Some allergic reactions have been reported when N. sativa extracts are applied to the skin. Nevertheless, when consumed at historical levels and as traditionally practiced, N. sativa seeds are considered safe.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Sajad Fakhri, Ebrahim Darvish, Fatemeh Narimani, Seyed Zachariah Moradi, Fatemeh Abbaszadeh, Haroon Khan
Summary: Neurodegenerative diseases are increasing globally, making it crucial to uncover the precise pathophysiological mechanisms and develop novel therapeutic strategies. Non-coding RNAs play a pivotal role in these diseases through various mechanisms, such as gene expression modulation, protein translation interference, and alterations in signaling pathways. The study highlights the role of different ncRNAs and investigates how phytochemicals can modulate ncRNAs in neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, epilepsy, depression, and amyotrophic lateral sclerosis.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2023)
Review
Biochemistry & Molecular Biology
Saikat Mitra, Abdur Rauf, Hriday Sutradhar, Samia Sadaf, Md. Jamal Hossain, Mahfuza Afroz Soma, Talha Bin Emran, Bashir Ahmad, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Muthu Thiruvengadam
Summary: Mitochondria are targeted for pharmacological interventions due to their role in disease manifestations. Natural sources, such as marine and terrestrial compounds, have shown promising benefits in inhibiting mitochondrial disorders. Developing new candidates from these sources is crucial, as therapeutic options are currently limited.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Shahdadi, Maliheh Faryabi, Haroon Khan, Ali Salehi Sardoei, Bahman Fazeli-Nasab, Bey Hing Goh, Khang Wen Goh, Ching Siang Tan
Summary: This study examined the antibacterial effects of Mentha longifolia essential oil and pulegone in edible coatings on the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli in cheese. The results showed that the addition of these compounds significantly reduced bacterial growth during storage. Increasing the concentration of chitosan, M. longifolia, and pulegone in the coatings further decreased the bacterial population, with pulegone exhibiting a stronger effect. Overall, the findings suggest that M. longifolia essential oil and pulegone, combined with alginate and chitosan coatings, have antibacterial effects against S. aureus, L. monocytogenes, and E. coli in cheese.
Article
Pharmacology & Pharmacy
Mustafa M. Kadhim, Andres Alexis Ramirez-Coronel, Abduladheem Turki Jalil, Hayder Abdullah Talib, Jitendra Gupta, Zanko Hassan Jawhar, Marwan Mahmood Saleh, Vijay Pandey, Xi Zhang, Haroon Khan
Summary: Autophagy is a cell death mechanism that degrades toxic agents and aged organelles to maintain cellular homeostasis. The regulation of this pathway by miRNAs plays a vital role in tumor progression and cancer therapy.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Abdur Rauf, Payal B. Joshi, Zubair Ahmad, Hassan A. Hemeg, Ahmed Olatunde, Saima Naz, Nabia Hafeez, Jesus Simal-Gandara
Summary: Edible mushrooms are popular functional foods due to their rich nutritional bioactive constituents that influence cardiovascular function. They are commonly included in dietary interventions for hypertension and other cardiovascular malfunctions as they contain amino acids, dietary fiber, proteins, sterols, vitamins, and minerals. This review focuses on the antihypertensive potential of mushroom bioactive constituents, their mode of action, absorption kinetics, and bioavailability. Essential bioactives such as ergosterol, lovastatin, cordycepin, tocopherols, chitosan, ergothioneine, gamma-aminobutyric acid, quercetin, and eritadenine are described as having hypotensive effects. Safety concerns regarding allergens and limitations of consuming edible mushrooms, including chemical toxins and their metabolites, are highlighted.
PHYTOTHERAPY RESEARCH
(2023)
Review
Chemistry, Medicinal
Seyed Hossein Shahcheraghi, Fateme Salemi, Shlomo Small, Suliman Syed, Farzam Salari, Waqas Alam, Wai San Cheang, Luciano Saso, Haroon Khan
Summary: Oxidative stress refers to the auxiliary damage of natural materials such as nucleic acids, proteins, and lipids by reactive oxygen/nitrogen species in aerobic metabolism. Resveratrol, a natural polyphenol found in red wine and peanuts, is known for its anti-aging properties. Studies have shown that resveratrol can inhibit the destructive effects of inflammation and reactive oxygen radicals. The nuclear erythroid 2-related factor 2 (Nrf2) is a transcription factor with anti-inflammatory and antioxidant properties, involved in enzyme biotransformation and the biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the role of resveratrol in combating oxidative stress and regulating inflammation through the Nrf2 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Applied
Shah Iram Niaz, Muhammad Ali, Muhammad Saleem, Rubina Qaisrani, Kamran Safdar, Malik Muhammad Akram, Abdur Rauf, Maqbool Ahmad, Sanaullah Abbasi, Taghrid S. Alomar, Najla Almasoud, Giovanni Ribaudo
Summary: This study reports the extraction of essential oil from the leaves of Iphiona grantioides and identifies its chemical constituents. The essential oil shows inhibitory effects on bacterial strains and antioxidant activity.
NATURAL PRODUCT RESEARCH
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Multidisciplinary Sciences
Karempudi Venkata Krishna, Jimmantiyur Madhappan Murugan, Haroon Khan, Munusamy Kumar, Veeramani Veeramanikandan, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Karthikeyan Venkatachalam, Paulraj Balaji
Summary: This study examined the antioxidant properties of extracts from eight Pleurotus mushroom species. The methanolic extract of Pleurotus florida showed the highest concentrations of antioxidant compounds and displayed the greatest antioxidant activity. It also exhibited significant antidiabetic effects, surpassing the efficiency of acarbose.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Abdur Rauf, Bassam Oudh Aljohny, Umer Rashid, Yasir Anwar, Zafar Ali Shah, Naveed Muhammad, Anees Ahmed Khalil, Ahood Khalid, Gauhar Rehman
Summary: The isolated compound Ferruginan A from Olea ferruginea bark demonstrated significant anti-inflammatory and antidiabetic effects in vitro. Molecular docking simulations indicated that Ferruginan A may act on multiple molecular targets. ADMET prediction study showed favorable pharmacokinetic properties of the compound.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Review
Food Science & Technology
Baby Gargi, Sakshi Painuli, Prabhakar Semwal, Deependra Pratap Singh, Rohit Sharma, Abdur Rauf, Anees Ahmed Khalil, Ahood Khalid, Hassan A. Hemeg, Polrat Wilairatana
Summary: This study used bibliometric analysis to assess the global research, current trends, and knowledge mapping related to the correlation between olive oil consumption and cardiovascular diseases (CVD). The results showed an increasing trend in the publication count over the past fifty years, indicating the potential emerging research trend of using olive oil for CVD treatment. Collaboration among authors, countries, and organizations is also expected in this research domain.
FOOD SCIENCE & NUTRITION
(2023)
Review
Food Science & Technology
Abdur Rauf, Anees Ahmed Khalil, Samir Awadallah, Shahid Ali Khan, Tareq Abu-Izneid, Muhammad Kamran, Hassan A. Hemeg, Mohammad S. Mubarak, Ahood Khalid, Polrat Wilairatana
Summary: Reactive oxygen species (ROS) are produced under normal physiological conditions and can have beneficial or harmful effects on biological systems. Maintaining proper cellular ROS levels is important for redox homeostasis. Oxidative stress occurs due to an imbalance between ROS production and antioxidant defenses. Sources of ROS include mitochondria, glucose auto-oxidation, and enzymatic pathways. Possible ROS pathways include NF-kappa B, MAPKs, PI3K-Akt, and the Keap1-Nrf2-ARE signaling pathway.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nanoscience & Nanotechnology
Fazle Rabbi, Amna Nisar, Noor Ul Ain Nawaz, Najla Almasoud, Taghrid S. Alomar, Abdur Rauf
Summary: In this study, a novel method was used to synthesize silver nanoparticles, which were characterized by various techniques and found to exhibit antimicrobial activity.
MICRO & NANO LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Tapan Behl, Ankush Kumar, Vishakha, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Shivam Yadav, Summya Rashid, Nemat Ali, Amira Saber Ahmed, Celia Vargas-De-La-Cruz, Simona Gabriela Bungau, Haroon Khan
Summary: Breast cancer is a common and deadly disease with high morbidity and mortality rates. Early detection using biomarkers is crucial for effective treatment and improved survival rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Oncology
Samira Hassani, Fahimeh Ghanbari, Marzieh Lotfi, Waqas Alam, Michael Aschner, Jelena Popovic-Djordjevic, Seyed Hossein Shahcheraghi, Haroon Khan
Summary: This review discusses the potential of gallic acid (GA), a phenolic compound, in cancer treatment and its anti-tumor properties. GA can inhibit cancer progression by targeting different molecular pathways and can be an effective complement to chemotherapy drugs and combat multidrug resistance.
