Article
Oncology
Hui Cheng, Fei Liu, Manqian Zhou, Shang Chen, Haoyan Huang, Yue Liu, Xiaotong Zhao, Qiaonan Zhang, Xinrun Zhou, Zongjin Li, Hong Cai
Summary: The study found that the PGE2 matrix can promote early stage hair follicle development and improve the condition of hair follicle stem cells. In addition, the PGE2 delivery system may be a new strategy for treating hair disorders.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Yohan Choi, Hayce Jeon, Mats Brannstrom, James W. Akin, Thomas E. Curry, Misung Jo
Summary: The study showed an up-regulation of ACE2 expression in human ovulatory follicles after hCG administration, with higher expression in cumulus cells than in granulosa cells. The expression of ACE2 in primary hGLC cultures was increased by hCG and inhibited by RU486 and CORT125281.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Alexander Hedbrant, Ingrid Persson, Ann Erlandsson, Jonny Wijkander
Summary: Green and black tea, and to a lesser extent Rooibos tea, are able to inhibit the formation of PGE2 in human monocytes and mediate their effects by inhibiting the expression of the enzymes responsible for PGE2 formation.
Article
Medicine, Research & Experimental
Filippo Pelizzaro, Maria Piera Kitenge, Romilda Cardin, Alberto Ponzoni, Umberto Cillo, Alessandro Vitale, Gianluca Businello, Giada Munari, Matteo Fassan, Fabio Farinati
Summary: The study revealed the activation of the MAGL/COX-2/PGE2 axis in hepatocellular carcinoma, with circulating PGE2 serving as a potential prognostic biomarker in HCC patients. Elevated levels of circulating PGE2 were associated with significantly shorter overall survival in HCC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Corey S. Moran, Erik Biros, Smriti M. Krishna, Susan K. Morton, Daniel J. Sexton, Jonathan Golledge
Summary: The study showed that neutralization of kallikrein-1 with blocking antibody inhibited AAA development in a mouse model, reduced inflammation, and decreased levels of related proteins and metabolites.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Urology & Nephrology
Henricus A. M. Mutsaers, Rikke Norregaard
Summary: This article summarizes the role of PGE2 in the kidney and focuses on the involvement of the four EP receptors in renal fibrosis.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Anders Blomqvist
Summary: We have recently shown that prostaglandin production in brain endothelial cells is essential for fever generation during systemic immune challenge. In this discussion, I examine the implications of this finding in relation to previous studies and highlight unresolved issues.
DNA AND CELL BIOLOGY
(2023)
Article
Immunology
Wenfei Wang, Yuping Ning, Yejun Wang, Guofang Deng, Simona Pace, Stefanie A. Barth, Christian Menge, Kehong Zhang, Youchao Dai, Yi Cai, Xinchun Chen, Oliver Werz
Summary: This study found that infection of human macrophages by M.tb significantly increases the expression of COX-2 and mPGES-1, leading to the formation of a large amount of PGE(2). However, the anti-inflammatory drug SASP can reduce the expression of COX-2 and the release of PGE(2).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Reproductive Biology
Dominika Wolak, Anna Hrabia
Summary: This study investigated the expression of selected MMPs and their TIMPs in the chicken ovary during a pause in egg laying induced by feed deprivation. The results suggested that the selected MMPs and TIMPs may not be involved in the regulation of the advanced stages of atresia of the largest yellow preovulatory follicles in the chicken ovary.
Article
Biochemistry & Molecular Biology
Piotr Wojcik, Michal Biernacki, Natalia Domian, Neven Zarkovic, Elzbieta Skrzydlewska
Summary: This study evaluated the impact of Celecoxib on apoptosis in keratinocytes, and the results suggested that COX-2 inhibition can attenuate UVB-induced apoptosis, with AEA playing a significant role as an anti-apoptotic agent in this process.
Article
Biochemistry & Molecular Biology
Haiyan Yao, Quanping Guo, Mengran Wang, Rui Wang, Zhaoqing Xu
Summary: A novel class of molecules with a basic structure of pyrazole N-aryl sulfonate was designed and synthesized using a new pyrazole sulfonate synthetic method. Several compounds within this class showed excellent anti-inflammatory and analgesic activities, as well as selective COX-2 inhibitory properties. The LD50 of two compounds in mice were found to be greater than 2000 mg/kg in acute oral toxicity assays conducted in vivo.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi
Summary: MDV infection induces activation of COX-2 and production of PGE2, leading to inhibition of T cell proliferation via EP2 and EP4 receptors on day 21 post infection. Oral administration of the COX-2 inhibitor meloxicam during MDV infection suppresses COX-2 activation and rescues T cell proliferation on day 21 post infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Rosangela Mayer Goncalves, Marina Delgobo, Jonathan Paulo Agnes, Raquel Nascimento das Neves, Marcelo Falchetti, Tuany Casagrande, Ana Paula Vargas Garcia, Thaynan Cunha Vieira, Nauana Somensi, Maciel Alencar Bruxel, Daniel Augusto Gasparin Bueno Mendes, Alex Rafacho, Andre Bafica, Daniel Pens Gelain, Jose Claudio Fonseca Moreira, Geovanni Dantas Cassali, Alexander James Roy Bishop, Alfeu Zanotto-Filho
Summary: Obesity is a major risk factor for breast cancer, especially in post-menopausal women. An obesogenic diet has been shown to promote mammary tissue inflammation and local estrogen production, accelerating mammary tumor formation in a COX-2-dependent manner. Treatment with a COX-2 inhibitor was found to decrease inflammation, estrogen levels, and mammary tumor formation, leading to prolonged animal survival.
Review
Cell Biology
Janice Garcia-Quiroz, Bismarck Vazquez-Almazan, Rocio Garcia-Becerra, Lorenza Diaz, Euclides Avila
Summary: Chronic infection of high-risk human papillomaviruses (HPV) and chronic inflammation are closely associated with the occurrence and progression of various neoplasms, including cervical cancer. This article reviews the general mechanisms of HPV-driven cervical carcinogenesis, as well as the involvement of cyclooxygenase-2 (COX-2)/prostaglandin E-2 (PGE(2)) and downstream effectors in this pathology. The research also highlights the interaction between chronic HPV infection and PGE(2) signaling, which weakens immune response and promotes the development of cervical cancer. Furthermore, the article provides an update on current therapeutic and preventive options for targeting PGE(2)-derived inflammation and HPV infection in cervical cancer, including nonsteroidal anti-inflammatory drugs, prophylactic and therapeutic vaccines, immunomodulators, antivirals, and nanotechnology.
Review
Gastroenterology & Hepatology
Xuan-Ke Ji, Sailaja Vatsalya Madhurapantula, Gui He, Kun-Yan Wang, Chun-Hua Song, Jian-Ying Zhang, Kai-Juan Wang
Summary: Gastric cancer is a leading cause of cancer-related deaths globally, especially in Asia where the incidence is high and the survival rate for advanced cases is low. COX-2 plays a crucial role in inflammatory responses and its genetic variations may affect susceptibility to gastric cancer, calling for further research to explore new therapeutic approaches.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)