Review
Medicine, Research & Experimental
Dana Elkhalifa, Menatallah Rayan, Ahmed T. Negmeldin, Abdelbary Elhissi, Ashraf Khalil
Summary: Chemically modified mRNA is a promising approach for producing biopharmaceutical agents, with applications in addressing epidemics and treating a variety of chronic diseases, such as metabolic disorders, cancer, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nutrition & Dietetics
Dvya Delilaa Clarence, Keshav Raj Paudel, Bikash Manandhar, Sachin Kumar Singh, Hari Prasad Devkota, Jithendra Panneerselvam, Vivek Gupta, Nitin Chitranshi, Nitin Verma, Sonia Saad, Gaurav Gupta, Philip Michael Hansbro, Brian Gregory Oliver, Thiagarajan Madheswaran, Kamal Dua, Dinesh Kumar Chellappan
Summary: Chronic inflammation of the respiratory tract is a major public health issue that can lead to various chronic respiratory diseases. The conventional drug therapies only address the symptoms, while the combination of nutraceuticals and nanoparticles has gained attention as it can not only improve symptoms, but also has anti-inflammatory and antioxidant properties with fewer adverse effects.
Article
Biochemistry & Molecular Biology
Zhijian Xu, Danrong Shi, Jian-Bao Han, Yun Ling, Xiangrui Jiang, Xiangyun Lu, Chuan Li, Likun Gong, Guangbo Ge, Yani Zhang, Yi Zang, Tian-Zhang Song, Xiao-Li Feng, Ren-Rong Tian, Jia Ji, Miaojin Zhu, Nanping Wu, Chunhui Wu, Zhen Wang, Yechun Xu, Cheng Peng, Min Zheng, Junling Yang, Feifei Du, Junliang Wu, Peipei Wang, Jingshan Shen, Jianliang Zhang, Yong-Tang Zheng, Hangping Yao, Weiliang Zhu
Summary: In this report, we found that nelfinavir, an FDA approved drug for HIV infection, is effective against SARS-CoV-2 and COVID-19. Nelfinavir can inhibit the activity of the main protease of SARS-CoV-2 and has antiviral activity in Vero E6 cells. The results from animal models and clinical study in COVID-19 patients suggest that nelfinavir has the potential to be a highly promising medication with a preventative effect.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Veterinary Sciences
Mahmoud Kandeel, Abdullah I. A. Al-Mubarak
Summary: Camels are carriers of pathogenic viruses and more research is needed to develop effective vaccines and treatments. Due to their ability to carry coronaviruses, camels can be a suitable model for viral vaccine trials.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Mayssa Hachem, Houda Nacir
Summary: This review focuses on the targeted delivery of DHA to the brain in different lipid forms and suggests future research directions. DHA is essential for neural development, learning, and vision, but deficiencies in cerebral DHA levels have been associated with neurodegenerative diseases. Understanding the role of DHA in brain transport and its beneficial effects in healthy conditions and brain disorders is crucial for the prevention and treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Serena Coppola, Laura Carucci, Roberta De Michele, Roberto Berni Canani
Summary: Food allergy is a major chronic condition in the pediatric population, and the dynamic dialogue between the gut microbiome and immune system is deeply regulated in the first 1,000 days of life. Immunonutrition strategies could be crucial for the prevention and treatment of pediatric food allergy.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Bing Han, Chengwei He
Summary: Autophagy is a common mechanism for maintaining cellular homeostasis by degrading proteins, protein aggregates, and organelles, and dysfunction of autophagy is observed in many diseases. Saponins, natural compounds with autophagy-modulating effects, may have therapeutic and preventive effects on autophagy-related diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Manel Dhahri, Mawadda Alghrably, Hamdoon A. Mohammed, Syed Lal Badshah, Noreen Noreen, Fouzi Mouffouk, Saleh Rayyan, Kamal A. Qureshi, Danish Mahmood, Joanna Izabela Lachowicz, Mariusz Jaremko, Abdul-Hamid Emwas
Summary: Neurodegenerative diseases pose a significant public health burden globally, particularly among aging populations. Despite advances in understanding the underlying mechanisms, effective therapeutic strategies are lacking. Natural polysaccharides have shown neuroprotective and therapeutic effects, making them a potential avenue for prevention and treatment of neurodegenerative diseases.
Review
Chemistry, Multidisciplinary
Julian Szymanski, Dominik Szwajgier, Ewa Baranowska-Wojcik
Summary: Beets are a rich source of bioactive compounds such as betalain pigments, phenols, and saponins. These compounds exhibit neuroprotective properties due to their antioxidant activity, anti-inflammatory effects, and ability to lower the activity of acetylcholinesterase. Betanin, the most common pigment in beetroot, has been shown to have antioxidant activity and can protect neurons against peroxidation. Phenolic compounds in beetroots, including gallic, ferulic, and vanillic acids, also have similar protective effects. The administration of betanin has been found to reverse artificially induced neurodegenerative diseases, while vanillic acid has been shown to improve spatial learning ability. Processed beetroot products like juices and jams can be beneficial in preventing and supporting therapy for neurodegenerative diseases like Alzheimer's.
APPLIED SCIENCES-BASEL
(2023)
Review
Food Science & Technology
Yina Huang, Keyu Xing, Liang Qiu, Qinglong Wu, Hua Wei
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder with unknown causes. Tea, with its active ingredients like tea polyphenols, has shown potential benefits for preventing and treating IBD due to its anti-inflammatory and antioxidant properties, opening up possibilities for further research on tea derivatives as novel therapeutic agents for IBD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Jing Cao, Anni Zhou, Zhuoyang Zhou, Hui Liu, Shaohui Jia
Summary: This study reviewed the structure, functions, and localization of GPLD1 in chronic diseases, as well as exercise-mediated regulation of GPLD1, providing a theoretical support for developing GPLD1 as a new therapeutic target for chronic diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nyarai Mungofa, July Johannes Sibanyoni, Mpho Edward Mashau, Daniso Beswa
Summary: Indigenous leafy vegetables (ILVs) are vital for the well-being of people in rural areas of developing countries due to their ability to withstand harsh conditions and provide important nutrients. However, their consumption is low globally and they are associated with unbalanced diets, poverty, and potential toxicity.
Article
Plant Sciences
Xue Bai, Zhigang Bian, Meng Zhang
Summary: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that regulates the body's antioxidant stress response. Phytochemical ingredients have the potential to activate Nrf2 and reduce oxidative stress injury in the treatment of neurodegenerative diseases (NDDs). Further clinical trials are needed to determine the safety and efficacy of Nrf2 activators for NDDs.
Article
Biochemistry & Molecular Biology
Rongrong Yang, Junjun Li, Xiaoguang Xu, Keyi Xu, Junling Shi
Summary: This study demonstrated that Lactobacillus rhamnosus SHA113 and its culture supernatant have significant preventive and therapeutic effects on alcoholic gastric ulcers, mainly through mechanisms such as promoting mucus secretion, enhancing antioxidant capacity, inhibiting inflammation, and promoting ulcer healing.
Review
Chemistry, Multidisciplinary
Mariam Alkhatib, Chantal Fayad, Adnan Badran, Kamar Hamade, Anis Daou, Elias Baydoun, Akram Hijazi
Summary: Pomegranate fruit contains various beneficial ingredients and exhibits antibacterial, anti-inflammatory, antioxidant, and anticancer activities. It has been widely used in different medical systems for the prevention and treatment of diseases related to the respiratory and digestive systems.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Luyao Ma, Zhenghai Sun, Yawen Zeng, Mingcan Luo, Jiazhen Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Agronomy
Zhenghai Sun, Juan Du, Xiaoying Pu, Muhammad Kazim Ali, Xiaomeng Yang, Chengli Duan, Meirong Ren, Xia Li, Yawen Zeng
Review
Cell Biology
Yawen Zeng, Xiaoying Pu, Juan Du, Xiaomeng Yang, Xia Li, Md. Siddikun Nabi Mandal, Tao Yang, Jiazhen Yang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Agronomy
Hafiz Ghulam Muhu-Din Ahmed, Muhammad Sajjad, Yawen Zeng, Muhammad Iqbal, Sultan Habibullah Khan, Aziz Ullah, Malik Nadeem Akhtar
Article
Agronomy
Hafiz Ghulam Muhu-Din Ahmed, Muhammad Nouman Iqbal, Muhammad Arslan Iqbal, Yawen Zeng, Aziz Ullah, Muhammad Iqbal, Humayun Raza, Muhammad Majid Yar, Nadeem Sarwar, Muhammad Imran, Saddam Hussain
Summary: GWAS was conducted in bread wheat using high-density Illumina 90K Infinium SNP array to determine genetic potential for water shortage tolerance. Significant SNPs associated with stomatal frequency, leaf venation and grain yield under water shortage conditions were identified, highlighting the importance of these traits for drought tolerance in wheat.
Review
Food Science & Technology
Yawen Zeng, Muhammad Kazim Ali, Juan Du, Xia Li, Xiaomeng Yang, Jiazhen Yang, Xiaoying Pu, Li'E Yang, Jingan Hong, Bo Mou, Ling Li, Yan Zhou
Summary: Rice with high resistant starch (RS) content is a commonly used functional food that can effectively prevent diabetes and its complications. High-RS rice offers various health benefits and regulates blood glucose levels, metabolic syndrome, and pancreatic function through different mechanisms. However, the type and processing of rice can affect the RS content and glycemic index, so caution is needed in rice selection and consumption.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Yawen Zeng, Jiazhen Yang, Jia Chen, Xiaoying Pu, Xia Li, Xiaomeng Yang, Li'e Yang, Yumei Ding, Mingying Nong, Shibao Zhang, Jinbao He
Summary: This study demonstrates the action mechanism of functional ingredients in adlay for promoting human health. Adlay and its extracts contain a variety of health effects and are rich in antioxidants. These findings provide a scientific basis for the development of adlay as a functional food and as drugs for the treatment of human diseases.