Article
Surgery
Stijn W. de Jonge, Quirine J. J. Boldingh, Anna H. Koch, Lidewine Daniels, Eefje N. de Vries, Ingrid J. B. Spijkerman, Wim M. Ankum, Gino M. M. J. Kerkhoffs, Marcel G. Dijkgraaf, Markus W. Hollmann, Marja A. Boermeester
Summary: This study aimed to test the hypothesis that the timing of surgical antibiotic prophylaxis affects the risk of surgical site infection, but no significant difference was found within the 60-minute interval before incision. In contrast to earlier studies, this research was unable to replicate differences in SSI risk.
Article
Infectious Diseases
Marco Lollobrigida, Gianluca Pingitore, Luca Lamazza, Giulia Mazzucchi, Giorgio Serafini, Alberto De Biase
Summary: The benefit of antibiotic prophylaxis for most oral surgical procedures is controversial, with substantial agreement found in some clinical scenarios but discordant responses in others. Specific guidelines on antibiotics in dentistry, particularly on antibiotic prophylaxis in oral surgery, are needed to avoid unnecessary prescriptions, as indicated by the heterogeneous responses collected from the survey sample.
Article
Surgery
L. Salm, W. R. Marti, D. J. Stekhoven, C. Kindler, M. Von Strauss, E. Mujagic, W. P. Weber
Summary: Bodyweight and BMI are significantly correlated with SSI rates, with an 80-kg cut-off helping identify high-risk SSI patients. Double-dose AMP can reduce SSI rates in patients weighing 80 kg or more.
Article
Infectious Diseases
Christian de Tymowski, Tarek Sahnoun, Sophie Provenchere, Marylou Para, Nicolas Derre, Pierre Mutuon, Xavier Duval, Nathalie Grall, Bernard Iung, Solen Kerneis, Jean-Christophe Lucet, Philippe Montravers
Summary: The use of vancomycin/gentamicin (VGA) as a second-line prophylaxis for surgical site infection (SSI) seems to be as effective as cephalosporins (CA), although the microbiological etiology differs.
Article
Surgery
Ryan J. Ellis, Brian C. Brajcich, Kimberly A. Bertens, Carlos H. F. Chan, Carlos Fernandez-del Castillo, Paul J. Karanicolas, Shishir K. Maithel, Bradley N. Reames, Sharon M. Weber, Roberto J. Vidri, Henry A. Pitt, Vanessa M. Thompson, Mithat Gonen, Susan K. Seo, Adam C. Yopp, Clifford Y. Y. Ko, Michael I. D'Angelica
Summary: The association between bactibilia and postoperative complications in patients undergoing pancreatoduodenectomy is influenced by perioperative antibiotic prophylaxis. The presence of cefoxitin-resistant organisms in bile cultures is associated with increased risk of surgical site infection and clinically relevant postoperative pancreatic fistula.
Article
Orthopedics
Bryan D. Springer, Larry M. Baddour, Peter B. Lockhart, Martin H. Thornhill
Summary: The study found no significant positive association between invasive dental procedures (IDPs) and late periprosthetic joint infections (LPJIs). Therefore, there is no rationale to administer antibiotic prophylaxis (AP) before IDPs in patients with prosthetic joints, considering the cost and inconvenience of AP, the risk of adverse drug reactions, and the potential for unnecessary use of AP that promotes antibiotic resistance. Dental care should focus on maintaining good oral hygiene rather than recommending AP for IDPs.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Medicine, General & Internal
Rami Sommerstein, Andrew Atkinson, Stefan P. Kuster, Danielle Vuichard-Gysin, Stephan Harbarth, Nicolas Troillet, Andreas F. Widmer
Summary: The study investigated whether double-dose cefuroxime for surgical antimicrobial prophylaxis in patients weighing at least 80 kg was associated with a decreased rate of surgical site infection (SSI). The results showed that double-dose cefuroxime was not consistently associated with a lower SSI rate in this patient population.
Review
Medicine, General & Internal
Jessica L. Seidelman, Christopher R. Mantyh, Deverick J. Anderson
Summary: Surgical site infections occur in 0.5% to 3% of patients undergoing surgery and are associated with longer hospital stays. Measures such as avoiding razors, maintaining normothermia, using chlorhexidine gluconate plus alcohol-based skin preparation, decolonization with intranasal antistaphylococcal agents, controlling perioperative glucose concentrations, and using negative pressure wound therapy can reduce the rate of surgical site infections.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Hiroyuki Nakarai, Koji Yamada, Juichi Tonosu, Hiroaki Abe, Kenichi Watanabe, Yuichi Yoshida, Junichi Ohya, Yusuke Sato, Nobuhiro Hara, Rentaro Okazaki, Seiichi Azuma, Hideki Nakamoto, So Kato, Yasushi Oshima, Sakae Tanaka, Akiro Higashikawa
Summary: In this retrospective study using prospectively collected data, alternative antimicrobial prophylaxis agents were found to increase the risk of reoperation for surgical site infections after spine surgery, particularly in the thoracolumbar surgery group. The study supports the current practice of using first-generation cephalosporins as recommended in multiple guidelines for spine surgery.
Article
Infectious Diseases
Carlo Vallicelli, Federico Coccolini, Massimo Sartelli, Luca Ansaloni, Simona Bui, Fausto Catena
Summary: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a combined treatment for peritoneal carcinomatosis, but patients are at high risk of infections and complications. Many authors have proposed aggressive screening protocols and vigilant monitoring to minimize and promptly identify infectious complications.
Review
Infectious Diseases
Andrea Polistena, Francesco Paolo Prete, Stefano Avenia, Giuseppe Cavallaro, Giovanna Di Meo, Alessandro Pasculli, Fabio Rondelli, Alessandro Sanguinetti, Lucia Ilaria Sgaramella, Nicola Avenia, Mario Testini, Angela Gurrado
Summary: This systematic review analyzed the impact of antibiotic prophylaxis on postoperative surgical site infection (SSI) rates in thyroid and parathyroid surgery. The meta-analysis of multiple studies found no significant difference in SSI rates between the group receiving antibiotic prophylaxis and the group without preoperative antibiotics. Low-quality evidence supports the similar SSI rates produced by antibiotic prophylaxis in these surgeries compared to the absence of perioperative antibiotics.
Article
Orthopedics
Vera Spatenkova, Ondrej Bradac, Zdenek Jindrisek, Jan Hradil, Daniela Fackova, Milada Halacova
Summary: This study aimed to analyze SSI and its risk factors in patients after thoracic or lumbar spine surgery, finding that only wound complications and warm seasons were significantly associated with SSI development according to multivariate regression analysis. Contrary to the prevailing literature, corticosteroids, diabetes mellitus, or transfusions were not identified as risk factors for SSI development.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Surgery
Josep Badia, Nares Arroyo-Garcia, Ana Vazquez, Alexander Almendral, Aina Gomila-Grange, Domenico Fraccalvieri, David Pares, Ana Abad-Torrent, Marta Pascual, Alejandro Solis-Pena, Mireia Puig-Asensio, Miguel Pera, Francesc Gudiol, Enric Limon, Miquel Pujol
Summary: This study investigated the implementation and outcomes of a nationwide care bundle for colorectal surgery. The results showed that the implementation of the care bundle significantly reduced the rate of surgical site infection.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Immunology
Miranda R. Norvell, Melissa Porter, Madison H. Ricco, Ryan C. Koonce, Craig A. Hogan, Eric Basler, Megan Wong, Meghan N. Jeffres
Summary: This study found that the use of cefazolin as a perioperative antibiotic for infection prophylaxis in patients labeled beta-lactam allergic undergoing total joint arthroplasty is associated with a decreased incidence of postoperative surgical site infections (SSIs) without an increased risk of interoperative hypersensitivity reactions (HSRs).
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Josep M. Badia, Miriam Flores-Yelamos, Ana Vazquez, Nares Arroyo-Garcia, Mireia Puig-Asensio, David Pares, Miguel Pera, Joaquin Lopez-Contreras, Enric Limon, Miquel Pujol
Summary: Oral antibiotic prophylaxis reduced the rates of surgical site infections in elective colorectal surgery and demonstrated a protective effect in multivariate analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Taylor P. Stauffer, Kevin F. Purcell, Christian Pean, Malcolm DeBaun, Michael Bolognesi, Sean Ryan, Danielle Chun, Thorsten Seyler
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Austin F. Smith, Mark A. Frankle, Kevin J. Cronin
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Zachary Aberman, James Germano, Giles R. Scuderi
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Andreas Fontalis, Shanil Hansjee, Dia Eldean Giebaly, Fabio Mancino, Ricci Plastow, Fares S. Haddad
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Nathan Redlich, Daniel Gelvez, Katherine Dong, Matthew Darlow, Jestin Williams, Berje Shammassian, Amit K. Bhandutia
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Jared A. Bell, Nicholas F. James, Benjamin M. Mauck, James H. Calandruccio, William J. Weller
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Sydney M. Hodgeson, Tatsuya Soeno, Simon C. Mears, Jeffrey B. Stambough, C. Lowry Barnes, Benjamin M. Stronach
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Sterling Kramer, Liz Ford, Jed Walsh
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Ian G. Hasegawa, Joshua L. Gary
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)
Article
Orthopedics
Nicholas M. Brown, Nithya Lingampalli, Michael D. Hellman
ORTHOPEDIC CLINICS OF NORTH AMERICA
(2024)