Article
Endocrinology & Metabolism
Lucia B. Palmero, Victor Martinez-Perez, Miriam Tortajada, Guillermo Campoy, Luis J. Fuentes
Summary: This study assessed the effects of progesterone on vigilance tasks and differentiated between exogenous and endogenous components. The results showed that Morning-type females performed better during the mid-luteal phase, while Evening-type females performed worse.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Alan Penzias, Ricardo Azziz, Kristin Bendikson, Tommaso Falcone, Karl Hansen, Micah Hill, William Hurd, Sangita Jindal, Suleena Kalra, Jennifer Mersereau, Catherine Racowsky, Robert Rebar, Richard Reindollar, Anne Steiner, Cigdem Tanrikut, Dale Stovall, Hugh Taylor, Belinda Yauger, Molly Moravek, Steven Young
Summary: Luteal phase deficiency (LPD) is a clinical diagnosis characterized by an abnormal luteal phase length, with potential causes including inadequate progesterone duration, levels, or resistance. LPD may not necessarily cause infertility or recurrent pregnancy loss, and there is controversy surrounding the diagnosis and treatment proposals.
FERTILITY AND STERILITY
(2021)
Review
Nutrition & Dietetics
Maria Karolina Szmidt, Dominika Granda, Dawid Madej, Ewa Sicinska, Joanna Kaluza
Summary: This study aimed to summarize the association between the Mediterranean diet (MD) and women's reproductive health outcomes. Limited available evidence suggests that higher adherence to the MD may be associated with a lower risk of early age menarche and shorter menstrual cycles, but not dysmenorrhea. Studies also showed potential benefits in terms of premenstrual syndrome, sexual health, endometriosis, and pain. For polycystic ovarian syndrome and infertility, the results were unclear but indicated a beneficial trend. Further research is needed to establish the role of the MD in reproductive health maintenance and prevention/treatment of reproductive health diseases in women.
Article
Behavioral Sciences
Jiajia Xie, Yang Lu, Jianhua Li, Weidong Zhang
Summary: This study investigated the neural responses of females to risk stimuli in different menstrual cycle phases using EEG and an economic risk-taking task. The results showed that women in the midluteal phase exhibited a stronger early neural response to high-risk stimuli, indicating a heightened sensitivity to high risk during this phase.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Fangshu Yao, Kepu Chen, Yiyun Zhuang, Xueer Shen, Xiaochun Wang
Summary: The study found that the menstrual cycle can affect women's olfactory function, with better olfactory discrimination performance observed during the mid-luteal phase. Additionally, better olfactory discrimination and worse olfactory threshold in the mid-luteal phase may predict fewer emotional symptoms and lower behavioral impulsivity, respectively.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Eduard Maury-Sintjago, Alejandra Rodriguez-Fernandez, Julio Parra-Flores, Marcela Ruiz-De la Fuente
Summary: The aim of the study was to determine the association between menstrual cycle phase and resting metabolic rate (RMR) as well as dietary intake. The results showed that lean women had increased RMR, caloric intake, and lipid intake during the luteal phase, while women with obesity only had increased carbohydrate intake.
Article
Endocrinology & Metabolism
Darwin A. Guevarra, Courtney C. Louis, Lilianne M. Gloe, Stefanie Russman Block, Deborah A. Kashy, Kelly L. Klump, Jason S. Moser
Summary: The study found increased anhedonic depression in the mid-luteal phase of the menstrual cycle for women, but no significant changes in anxious apprehension and anxious arousal. Additionally, there was a positive association between stress and anxious apprehension as well as anhedonic depression, but not anxious arousal. These associations were not stronger in the mid-luteal phase, providing weak evidence for a window of vulnerability for affective symptoms during this phase.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Behavioral Sciences
Malihe Eskandari Torbaghan, Ali Moghimi, Hamid Reza Kobravi, Masoud Fereidoni, Imanollah Bigdeli
Summary: This study aimed to investigate the effect of estradiol on stress and effect of stress on spatial working memory during the menstrual cycle. The results showed that estradiol levels decreased in the late follicular, luteal, and early follicular phases, while galvanic skin response decreased after stress induction in all three phases. Spatial working memory diminished after stress induction in all three phases, but increased in the late follicular phase. Average power spectrum density in all frequency bands increased after stress induction in the frontal and prefrontal channels. Therefore, stress led to spatial working memory dysfunction, while estradiol improved spatial working memory performance in the late follicular phase.
BRAIN AND BEHAVIOR
(2023)
Review
Nutrition & Dietetics
Rodica Siminiuc, Dinu Turcanu
Summary: Premenstrual syndrome (PMS) is a common disorder for women, with over 200 identified symptoms. The study shows that diet plays a crucial role in managing PMS, although there is a lack of scientific evidence on the actual effect of foods and nutrients. The effectiveness of certain micronutrients and herbal supplements has been demonstrated, but more research is needed to support their use as an effective treatment for PMS.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Christopher Weyh, Karsten Krueger, Peter Peeling, Lindy Castell
Summary: This review emphasizes the essential role of minerals in the optimal functioning of the immune system and inflammation regulation. It highlights the importance of a balanced diet in supplying necessary minerals for immune support, while also cautioning against over-consumption of supplements. Certain at-risk groups should pay attention to ensure they are receiving sufficient supply of key minerals to maintain immune competence and systemic inflammation regulation.
Review
Nutrition & Dietetics
Giuseppe Merra, Annalisa Noce, Giulia Marrone, Marco Cintoni, Maria Grazia Tarsitano, Annunziata Capacci, Antonino De Lorenzo
Summary: Changes in gut microbiota are correlated with health status, with the Mediterranean diet shown to modulate gut microbiota, increase diversity, and potentially prevent the onset of chronic non-communicable degenerative diseases. Additional controlled intervention studies are needed to further understand the correlations between dietary patterns and gut microbiota composition and activity.
Article
Dermatology
C. Gu, Y. Wu, Y. Luo, S. Wang, H. Yin, Y. Gao, C. Wang, X. Yao, W. Li
Summary: This study investigated the efficacy and safety of dupilumab for atopic dermatitis in Chinese patients. The results showed that dupilumab demonstrated favourable efficacy and was well-tolerated in this population.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Geriatrics & Gerontology
Ligia J. Dominguez, Nicola Veronese, Giovanna Di Bella, Claudia Cusumano, Angela Parisi, Federica Tagliaferri, Stefano Ciriminna, Mario Barbagallo
Summary: The current obesity pandemic is a major global public health problem due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the risk of non-communicable chronic diseases associated with obesity. Numerous studies have shown that overweight and obesity are major risk factors for cardiovascular disease and cancer. Research has shifted towards examining the effects of dietary patterns, with the Mediterranean diet showing the most evidence of health benefits. There is evidence confirming the inverse association between adherence to the Mediterranean diet and overweight/obesity.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Lubomira Izakova, Natasa Hlavacova, Daniela Jezova
Summary: The study found that in the early luteal phase of the menstrual cycle, salivary aldosterone concentrations were significantly higher in women with PMS compared to controls, while cortisol concentrations remained unchanged. This suggests that evening aldosterone levels may play an important role in the development of PMS symptoms.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Alexis L. Oldfield, Heidi Vanden Brink, Faith E. Carter, Brittany Y. Jarrett, Marla E. Lujan
Summary: Eumenorrheic women with obesity display evidence of suppressed antral follicle dynamics, including fewer recruitment events, selectable follicles, and anovulatory dominant follicles, as well as lower anti-Mullerian hormone (AMH) concentrations and an increased prevalence of luteal phase defects.
HUMAN REPRODUCTION
(2023)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Kathy Pan, Aaron K. Aragaki, Yvonne Michael, Cynthia A. Thomson, Linda G. Snetselaar, Jean Wactawski-Wende, David O. Garcia, Christina M. Dieli-Conwright, Aladdin H. Shadyab, Nazmus Saquib, Rowan T. Chlebowski
Summary: This study found that women participating in the Women's Health Initiative dietary modification randomized trial had a lower rate of physical inactivity and spent more time in recreational physical activity compared to the control group.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Obstetrics & Gynecology
Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Tzu-Chun Lin, Miranda M. Broadney, Diane L. Putnick, Sonia L. Robinson, Kristen J. Polinski, Jean Wactawski-Wende, Akhgar Ghassabian, Thomas G. O'Connor, Robert E. Gore -Langton, Judy E. Stern, Erin Bell
Summary: The study aimed to evaluate whether children conceived using assisted reproductive technology (ART) or ovulation induction (OI) have greater cardiometabolic risk compared to children conceived without treatment. The results showed that at 9 years of age, children conceived using ART or OI did not have greater cardiometabolic risk compared to children conceived without treatment.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Tarah J. Ballinger, Zora Djuric, Sagar Sardesai, Kathleen M. Hovey, Chris A. Andrews, Theodore M. Brasky, Jian Ting Zhang, Thomas E. Rohan, Nazmus Saquib, Aladdin H. Shadyab, Michael Simon, Jean Wactawski-Wende, Robert Wallace, Ikuko Kato
Summary: This study found that the use of PPI was inversely associated with the risk of colorectal cancer, while the use of H2RA showed no such association. This relationship is consistent with the preclinical data showing the preventive effect of FASN inhibition on colon cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Sonia M. Grandi, Stefanie N. Hinkle, Sunni L. Mumford, Lindsey A. Sjaarda, Katherine L. Grantz, Pauline Mendola, James L. Mills, Anna Z. Pollack, Edwina Yeung, Cuilin Zhang, Enrique F. Schisterman
Summary: This study examined whether giving birth to male infants increases the risk of maternal mortality. The results showed that women who give birth to male infants do not have an increased risk of all-cause and cause-specific mortality, suggesting that giving birth to male infants may not influence the long-term health of women.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Surgery
Elizabeth L. Chou, Mary Pettinger, Bernhard Haring, Matthew A. Allison, Matthew W. Mell, Mark A. Hlatky, Jean Wactawski-Wende, Robert A. Wild, Aladdin H. Shadyab, Robert B. Wallace, Linda G. Snetselaar, Tracy E. Madsen, Matthew J. Eagleton, Mark F. Conrad, Simin Liu
Summary: This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked.
Meeting Abstract
Clinical Neurology
Galit Dunietz, Kerby Shedden, Kara Michels, Ronald Chervin, Xiru Lyu, Joshua Freeman, Ana Baylin, Louise O'Brien, Jean Wactawski-Wende, Enrique Schisterman, Sunni Mumford