Journal
ORGANIC LETTERS
Volume 20, Issue 15, Pages 4406-4410Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01535
Keywords
-
Categories
Funding
- MEXT, Japan [17H06401, 26102726, 17K19233]
- AMED, Japan
Ask authors/readers for more resources
The highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating property of 2-aminophenol. Unexpectedly, 2-aminophenol in saccharothriolide B was eliminated through a retro-Michael reaction, to yield presaccharothriolide X under physiological conditions. 2-Aminophenol might be developed into a useful protecting group for bioactive small molecules with an alpha,beta-unsaturated ketone.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available