Journal
ORGANIC LETTERS
Volume 20, Issue 12, Pages 3562-3565Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01341
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Funding
- National Natural Science Foundation of China [31270136]
- Natural Science Foundation for Distinguished Young Scholars of Hubei Province of China [2018CFA069]
- Fundamental Research Funds for the Central Universities [2662018PY053]
- Open Project Program of Guangdong Key Laboratory of Marine Materia Medica [LMM2018-4]
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The biosynthetic pathway of diisonitrile chalkophore SF2768 was identified in Streptomyces thioluteus through heterologous expression recently. Isolation and structure elucidation of the N-substituted formamides that coexisted with the diisonitriles implied that a hydration event was involved. In vitro enzymatic assays of an endogenous isonitrile hydratase suggested a rare sequential-hydration of the diisonitriles. Additionally, the results of Cu-CAS assays indicate that both partial and complete hydration led to the loss of the copper-chelating ability of SF2768.
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