Journal
ORGANIC LETTERS
Volume 20, Issue 5, Pages 1300-1303Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00002
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Funding
- SERB [SB/S1/OC-63/2013]
- CSIR
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The first catalytic enantioselective synthesis of 5,6-dihydro-4H-1,2-oxazines bearing an oxygen-containing quaternary stereogenic center has been developed through iodoetherification of gamma,delta-unsaturated oximes. This operationally straightforward reaction is catalyzed by Cinchona alkaloids-based bifunctional tertiary aminothiourea derivatives and furnishes the products generally in good to excellent yields and with moderate to high enantioselectivities (up to 97:3 er).
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