Journal
ORGANIC LETTERS
Volume 20, Issue 8, Pages 2195-2198Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00523
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Funding
- CAS [XDPB0402, 153D31KYSB20170121]
- SCST [15JC1400402]
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For the biosynthesis of Pip in Huperzia serrata, the mechanistic studies were evaluated. Through a series of biochemical analyses, Pip is biosynthesized through a two-step cascade reaction. Three intermediates possibly exist simultaneously as an equilibrium matter in the first-step reaction catalyzed by HsAld1, while HsSard4 performs as a ketimine reductase and chemoselectively and stereoselectively takes 1,2-dehydropipecolic acid as the preferred substrate in vitro.
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