Synthesis of hydrophilic HYNIC-[1,2,4,5]tetrazine conjugates and their use in antibody pretargeting with 99mTc

Exploring Structural Parameters for Pretargeting Radioligand Optimization

(2017) Jan-Philip Meyer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pretargeted Imaging and Therapy

(2017) Mohamed Altai et al.   JOURNAL OF NUCLEAR MEDICINE

DOTA-tetrazine probes with modified linkers for tumor pretargeting

(2017) Tilman Läppchen et al.   NUCLEAR MEDICINE AND BIOLOGY

Drug Conjugation Affects Pharmacokinetics and Specificity of Kidney-Targeted Peptide Carriers

(2016) Maria Janzer et al.   BIOCONJUGATE CHEMISTRY

Design, Synthesis, and Evaluation of a Low-Molecular-Weight 11C-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry

(2016) Christoph Denk et al.   BIOCONJUGATE CHEMISTRY

99mTc-bioorthogonal click chemistry reagent for in vivo pretargeted imaging

(2016) María Fernanda García et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines

(2016) Abdolreza Yazdani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a novel antibody–tetrazine conjugate for bioorthogonal pretargeting

(2016) Agnese Maggi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives

(2016) Alyssa Vito et al.   PLoS One

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry

(2015) Jan-Philip Meyer et al.   BIOCONJUGATE CHEMISTRY

Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics

(2015) Brian M. Zeglis et al.   MOLECULAR PHARMACEUTICS

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging

(2015) Outi Keinänen et al.   ACS Medicinal Chemistry Letters

Substitution of the Lys Linker with the β-Ala Linker Dramatically Decreased the Renal Uptake of 99mTc-Labeled Arg-X-Asp-Conjugated and X-Ala-Asp-Conjugated α-Melanocyte Stimulating Hormone Peptides

(2014) Adam M. Flook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction

(2014) Raffaella Rossin et al.   MOLECULAR PHARMACEUTICS

Molecular imaging agents for SPECT (and SPECT/CT)

(2013) Gopinath Gnanasegaran et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry

(2013) B. M. Zeglis et al.   JOURNAL OF NUCLEAR MEDICINE

Diels-Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

(2013) R. Rossin et al.   JOURNAL OF NUCLEAR MEDICINE

[99mTc(CO)3]-Radiolabeled Bevacizumab: In vitro and in vivo Evaluation in a Melanoma Model

(2013) Ximena Camacho et al.   ONCOLOGY

Using antibodies to target cancer therapeutics

(2012) David M Goldenberg et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation

(2011) Mark R. Karver et al.   BIOCONJUGATE CHEMISTRY

Antibody-Radionuclide Conjugates for Cancer Therapy: Historical Considerations and New Trends

(2011) M. Steiner et al.   CLINICAL CANCER RESEARCH

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide

(2010) Jianquan Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydrazinonicotinic acid (HYNIC) – Coordination chemistry and applications in radiopharmaceutical chemistry

(2010) Levente K. Meszaros et al.   INORGANICA CHIMICA ACTA

Trifluoroacetyl as a protecting group for HYNIC: stability in the presence of electrophiles and application in the synthesis of 99mTc-radiolabelled peptides

(2010) M. Bashir-Uddin Surfraz et al.   TETRAHEDRON

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition

(2009) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor Accumulation of Radiolabeled Bevacizumab due to Targeting of Cell- and Matrix-Associated VEGF-A Isoforms

(2009) Thamar H. Stollman et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer

(2008) Misara Hamoudeh et al.   ADVANCED DRUG DELIVERY REVIEWS

Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides

(2008) Shuang Liu   ADVANCED DRUG DELIVERY REVIEWS

A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions

(2008) M. Bashir-Uddin Surfraz et al.   DALTON TRANSACTIONS

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging in the era of molecular oncology

(2008) Ralph Weissleder et al.   NATURE