Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 16, Issue 14, Pages 2522-2526Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob03198j
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- UGC, New Delhi
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A novel one-pot strategy has been developed for the construction of spiro-isoindolinone-benzosultams through a Ru(ii)-catalyzed sequential C-C and C-N bond formation. This method is highly atom-economical and compatible with a wide range of substituents. This is the first report on the spirocyclization of 3-aryl N-sulfonyl ketimines with aryl isocyanates to produce highly rigid and pharmaceutically relevant spirocycles through a C-H bond activation.
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