Article
Biochemistry & Molecular Biology
Karen Cortes-Sarabia, Luz del Carmen Alarcon-Romero, Eugenia Flores-Alfaro, Berenice Illades-Aguiar, Amalia Vences-Velazquez, Miguel Angel Mendoza-Catalan, Napoleon Navarro-Tito, Jesus Valdes, Ma Elena Moreno-Godinez, Carlos Ortuno-Pineda
Summary: The study evaluated the expression of REST and RASSF1A in cervical cytological and histological samples, finding a significant decrease in nuclear expression of REST and RASSF1A in patients with high-grade SIL and SCC. These findings may contribute to the diagnosis, prognosis, and post-treatment follow-up of patients with SIL or SCC.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Yongmei Gao, Mengyan Li, Bo Wang, Yuqing Ma
Summary: This study analyzed the expression of Nrf2 and HO-1 in ESCC and precancerous esophageal lesions, and investigated their relationship with ESCC. The study found that overexpression of Nrf2 and HO-1 was associated with poor prognosis in ESCC. Inhibiting the expression of Nrf2 and HO-1 may improve the prognosis of ESCC and increase immune cell infiltration.
Article
Oncology
Nikki B. Thuijs, Willemijn A. M. Schonck, Linde L. J. Klaver, Guus Fons, Marc van Beurden, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: In this exploratory study, biomarker profiles in patients with multiple high-risk HPV-associated vulvar precursor lesions were compared. While the biomarkers generally showed similar expression between lesions, marked differences were occasionally observed, indicating heterogeneity within multifocal lesions. This study contributes to a better understanding of the potential diagnostic, prognostic, and predictive value of biomarkers in patients with multifocal HSIL.
Article
Oncology
Mayumi Saito, Aarthi Rajesh, Carrie Innes, Rachael van der Griend, Peter Fitzgerald, Bryony Simcock, Peter Sykes, Merilyn Hibma
Summary: The progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with Blimp-1 positive cell staining in the lesion and low numbers of infiltrating CD4 cells in the dermal region beneath the lesion.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros
Summary: The study integrates telomere length, genomics, transcriptomics and proteomics in localized prostate cancer, revealing the links between telomere maintenance, disease drivers and clinical outcomes. Shorter tumor telomere lengths are associated with elevated genomic instability and genes involved in cell proliferation and signaling, while longer telomere lengths in non-tumor samples are associated with a lower rate of biochemical relapse.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jie Gao, Ying Meng, Xin Ge, Chen-Xing Hou, Qing-Hai Zhu, Yi-Zhou Wang, Li-Fan Sun, Chen-Xing Wang, Huai-Qi Li, Tianzhu Zhang, Jin-Hai Ye
Summary: This study revealed the expression and function of SATB2 in oral squamous cell carcinoma, showing that high expression of SATB2 is associated with poor prognosis. Overexpression of SATB2 promotes proliferation, migration, invasion, and tumor growth of OSCC cells, and NOX4 is identified as a downstream target of SATB2. This suggests that SATB2 may play a key role in OSCC tumorigenesis and could be a potential target for future therapeutic development.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Fruzsina Kiss, Viktoria Kormos, Eva Szoke, Angela Kecskes, Norbert Toth, Anita Steib, Arpad Szallasi, Balint Scheich, Balazs Gaszner, Jozsef Kun, Gabor Fulop, Krisztina Pohoczky, Zsuzsanna Helyes
Summary: The expression of TRPA1 and TRPV1 is upregulated in oral squamous cell carcinoma (OSCC) and their activation may regulate cancer cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhibin Chen, Jie Xing, Cuiling Zheng, Qianyu Zhu, Pingping He, Donghu Zhou, Xiaojin Li, Yanmeng Li, Saiping Qi, Qin Ouyang, Bei Zhang, Yibin Xie, Jiansong Ren, Bangwei Cao, Shengtao Zhu, Jian Huang
Summary: This study identified CETN2 and POFUT1 autoantibodies as potential diagnostic markers for early ESCC and HGIN using serological proteome analysis and ELISA.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mauricio Rocha Dourado, Amr Elseragy, Bruno Cesar da Costa, Fabio Haach Teo, Gustavo Narvaes Guimaraes, Renato Assis Machado, Maija Risteli, Wafa Wahbi, Clarissa Araujo Gurgel Rocha, Livia Maris Ribeiro Paranaiba, Wilfredo Alejandro Gonzalez-Arriagada, Sabrina Daniela da Silva, Ana Lucia Carrinho Ayroza Rangel, Marcelo Rocha Marques, Carlos Rossa Junior, Tuula Salo, Ricardo D. Coletta
Summary: In this study, the expression and impact of stress induced phosphoprotein 1 (STIP1) in oral squamous cell carcinoma (OSCC) were investigated. It was found that STIP1 was highly expressed in OSCC, and its overexpression was associated with shorter survival and higher risk of recurrence. Knockdown of STIP1 reduced proliferation, migration, and invasion of tumor cells, and decreased the number of metastases in a zebrafish model. Furthermore, STIP1 was inversely expressed with miR-218-5p, and transfection of miR-218-5p mimics decreased STIP1 levels and inhibited tumor cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Su-Wen Zhu, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, De-Run Chen, Shu-Cheng Wan, Zhi-Jun Sun
Summary: This study revealed the overexpression of CD168 in oral squamous cell carcinoma (OSCC) tissues, which was associated with worse patient survival and pathological grade. Additionally, CD168 expression was positively correlated with other marker expression in OSCC.
Article
Oncology
Jingjing Xiao, Ziren Chen, Yinping Xiao, Long Sui, Chao Wang, Qing Cong
Summary: This study investigated the depth of vulvar intraepithelial neoplasia (VIN) and its involvement of skin appendages, providing evidence for laser surgery. The results showed that the thickness of VIN lesions was generally less than or equal to 1 mm, but could reach approximately 3 mm when extending onto hairy areas, leading to the destruction of involved skin appendages.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Jia Chai, Tianqi Xu, Yanru Yang, Yuan Yuan, Junpeng Xu, Jin Liu, Kaijing Wang, Yao Lv, Jialin Chai, Yulin Kang, Ligang Chen, Junhui Qin, Qingge Jia, Mingyang Li
Summary: Esophageal squamous cell carcinoma (ESCC) is a common cancer with poor prognosis. This study found that overexpression of OTX1 is associated with the prognosis and tumorigenesis of ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Nikki B. Thuijs, Marc van Beurden, Annette H. Bruggink, Renske D. M. Steenbergen, Johannes Berkhof, Maaike C. G. Bleeker
Summary: The study found that the risk of vulvar squamous cell carcinoma (VSCC) is considered lower in high-grade squamous intraepithelial lesion (HSIL) compared to differentiated vulvar intraepithelial neoplasia (dVIN), but more research is needed for confirmation. The incidence of high-grade VIN and cumulative VSCC risk is higher in dVIN compared to HSIL, with independent risk factors including type of VIN, age, and presence of lichen sclerosis. Recognition and early identification of patients with high-risk VIN, particularly dVIN, is crucial.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Ana Silva, Monica Costa Cerqueira, Beatriz Rosa, Catarina Sobral, Filipa Pinto-Ribeiro, Marta Freitas Costa, Fatima Baltazar, Julieta Afonso
Summary: Cancer produces energy through accelerated glycolysis, resulting in increased lactate production. The lactate is transported to and from cancer cells by monocarboxylate transporters (MCTs). MCT1 acts as both an importer and an extruder of lactate and has been studied extensively in recent years, being generally associated with aggressive cancer. This systematic review aimed to evaluate the prognostic value of MCT1 immunoexpression in various malignancies. The results showed that MCT1 is a poor prognostic indicator and is associated with decreased survival in sixteen types of cancer. However, MCT1 overexpression was also linked to better outcomes in colorectal cancer, pancreatic ductal adenocarcinoma, and non-small cell lung cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Huochun Yi, Hongbing Duan, Wensheng Shi, Zhengjin Liu, Yali Liu
Summary: DEK protein is overexpressed in ESCC tissues, associated with poor prognosis, and can independently predict the prognosis of ESCC patients.
ARCHIVES OF MEDICAL SCIENCE
(2021)