Review
Oncology
Lucia Gonzalez-Ruiz, Miguel Angel Gonzalez-Moles, Isabel Gonzalez-Ruiz, Isabel Ruiz-Avila, Pablo Ramos-Garcia
Summary: The study focused on the prognostic and clinicopathological significance of cyclin D1 (CD1) overexpression/CCND1 amplification in melanomas. The findings suggest that CCND1/cyclin D1 upregulation is a common molecular oncogenic alteration in melanomas, mainly due to overexpression of the cyclin D1 protein. This upregulation is associated with higher Breslow thickness, which is considered a significant prognostic factor in individual melanoma patients.
Review
Endocrinology & Metabolism
Sarah A. A. Jeffreys, Therese M. M. Becker, Sarah Khan, Patsy Soon, Hans Neubauer, Paul de Souza, Branka Powter
Summary: This review evaluates the prognostic and predictive value of CCND1 amplification in breast cancer. The results show that CCND1 amplification is significantly associated with positive estrogen receptor status, cyclin D1 overexpression, shorter recurrence-free survival (RFS), and overall survival (OS). It is also predictive of reduced RFS and OS in patients treated with endocrine therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Zhigang Yang, Tao Xu, Tao Xie, Liangliang Yang, Guiping Wang, Yang Gao, Gangming Xi, Xiaobiao Zhang
Summary: This study investigated the role of CDC42EP3 in glioma development and its potential downstream mechanism. It was found that CDC42EP3 overexpression was positively correlated with pathological grading and increased the risk of recurrence. Knocking down CDC42EP3 inhibited cell proliferation and migration while promoting apoptosis. The study also suggested that CDC42EP3 might regulate the expression of CCND1. Overall, CDC42EP3 was found to promote glioma progression through targeting CCND1.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yan Liu, Ai Zhang, Ping-Ping Bao, Li Lin, Yina Wang, Haijian Wu, Xiao-Ou Shu, Aiguo Liu, Qiuyin Cai
Summary: The study reveals that miR-374b modulates the malignant behavior of breast cancer cells by negatively regulating CCND1 and TGFA genes, shedding light on the molecular mechanisms of breast cancer progression.
Review
Oncology
Yuwen Jiang, Chenlu Zhang, Ling Lu, Xinfeng Wang, Haiyan Liu, Yijing Jiang, Lemin Hong, Yifan Chen, Hongming Huang, Dan Guo
Summary: This study aimed to evaluate the prognostic significance of Cyclin D1 in multiple myeloma patients. The results showed that overexpression of Cyclin D1 might be a predictive biomarker for patients treated with bortezomib, undergoing autologous stem cell transplantation, or in the relapsed and refractory period.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Biotechnology & Applied Microbiology
Abdul K. Siraj, Sandeep Kumar Parvathareddy, Padmanaban Annaiyappanaidu, Saeeda O. Ahmed, Nabil Siraji, Asma Tulbah, Fouad Al-Dayel, Dahish Ajarim, Khawla S. Al-Kuraya
Summary: The study demonstrated that cyclin D1 over-expression in Middle Eastern breast cancers is associated with favorable prognostic features, serving as an independent predictor of overall survival and recurrence-free survival. Cyclin D1 expression was also found to be associated with phospho-Rb in luminal subtype of breast cancer, predicting luminal A breast cancer independently.
ONCOTARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Heiko Mueller, Wencke Walter, Stephan Hutter, Niroshan Nadarajah, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Summary: Aberrant somatic hypermutation (aSHM) can target proto-oncogenes and drive oncogenesis. In mantle cell lymphoma (MCL), aSHM targets CCND1, leading to the production of mutated proteins in the non-nodal subtype (nnMCL), which increases the likelihood of lymphomagenesis.
CANCER GENE THERAPY
(2022)
Article
Pharmacology & Pharmacy
Ankur Sharma, Xin Liu, Vishal Chandra, Rajani Rai, Doris M. Benbrook, Sukyung Woo
Summary: The study investigated the pharmacodynamic effects of SHetA2 in ovarian cancer models and established a physiologically based pharmacokinetic/pharmacodynamic model. The results showed that oral administration of 60 mg/kg of SHetA2 for 7 days achieved consistent plasma pharmacokinetics and tissue distribution, effectively inhibiting the growth of ovarian cancer cell lines. Cyclin D1 was identified as a potential pharmacodynamic marker for SHetA2.
Article
Oncology
Zhipeng Li, Zeyu Zhu, Yanjun Wang, Ying Wang, Weibing Li, Zhigang Wang, Xinyuan Zhou, Yuhua Bao
Summary: Colon carcinoma is a common cancer with unsatisfactory treatment strategies, especially for advanced cases. Dysregulated miRNAs are believed to impact tumor development, with has-miR-15a-5p found to inhibit proliferation and migration of colon cancer cells by targeting the CCND1 gene. This study suggests that has-miR-15a-5p could serve as a potential molecular target for the diagnosis and treatment of colon cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, General & Internal
Magdalena Marianna Kowalczyk, Magda Baranska, Wojciech Fendler, Edyta M. Borkowska, Jozef Kobos, Maciej Borowiec, Wioletta Pietruszewska
Summary: This study found a correlation between the CCND1 gene polymorphism and the risk of developing precancerous laryngeal lesions and laryngeal cancer. Cyclin D1 expression was also identified as a potential predictive marker for survival time in laryngeal cancer patients.
Article
Surgery
Li Fang, Xiuping Xu, Wenyan Zheng, Lingyun Wu, Haijun Wan
Summary: The expression levels of miR-340 and CCND1 in lung cancer tissues are closely related to the prognosis and clinicopathological characteristics of patients, with miR-340 being downregulated and CCND1 being upregulated in lung cancer tissues.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Article
Oncology
Qiuling Wang, Jingxin Han, Pu Xu, Xinchun Jian, Xieshan Huang, Deyu Liu
Summary: The study identified a novel LncRNA SNHG16/miR-17-5p/CCND1 signaling pathway that plays a crucial role in regulating the pathogenesis of oral squamous cell carcinoma (OSCC) by promoting cell proliferation, migration, and epithelial-mesenchymal transition. Targeting this axis hindered the development of OSCC, providing potential diagnostic and therapeutic biomarkers for clinical use.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Medicine, Research & Experimental
Qian Zhong, Ying Xiong, Chen Ling, Yanping Qian, Xia Zhao, Hanshuo Yang
Summary: miR-20b down-regulates cyclin D1, increases sensitivity of ovarian cancer cells to olaparib, reduces expression of RAD51 and induces cell cycle arrest in G0/G1 phase. Ovarian cancer patients with higher expression of miR-20b have significantly longer progression-free survival.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Li-Li Quan, Jin-Yang Liu, Li-Xia Qu, Hui La, Hai-Li Wang, Xiao-Xia Chen, Na Wang, Zhen-Zhi Wei
Summary: This study analyzed the expression of Cyclin D1 (CCND1) gene in ovarian cancer using the Oncomine database, finding that its high expression is associated with poor prognosis. Cell experiments showed that silencing CCND1 gene expression can reduce ovarian cancer cell proliferation and promote apoptosis.
Review
Dentistry, Oral Surgery & Medicine
Teresa De Porras-Carrique, Pablo Ramos-Garcia, Manuel Aguilar-Diosdado, Saman Warnakulasuriya, Miguel Angel Gonzalez-Moles
Summary: There is a high prevalence and frequent association between OLP and autoimmune disorders, especially thyroid disease and diabetes mellitus.
Review
Biochemistry & Molecular Biology
Miguel Angel Gonzalez-Moles, Carmen Keim-del Pino, Pablo Ramos-Garcia
Summary: Oral lichen planus (OLP) is a chronic inflammatory disease that may be autoimmune in nature and is considered a potentially malignant disorder. The molecular alterations that lead to malignancy in OLP are not well understood, but they may be related to the inflammatory infiltrate and abnormal epithelial response. Further research is needed to support this hypothesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Oncology
Miguel Angel Gonzalez-Moles, Pablo Ramos-Garcia
Review
Dentistry, Oral Surgery & Medicine
Miguel Angel Gonzalez-Moles, Pablo Ramos-Garcia
Summary: This paper discusses the new terminologies and concepts in oral lichen planus (OLP) and analyzes whether it is necessary to accept these new terms. The study found that many of the new terms are not justified. Based on the existing evidence, the paper presents its position on these new terms.
Review
Oncology
Maria Lopez-Ansio, Pablo Ramos-Garcia, Miguel Angel Gonzalez-Moles
Summary: Oral cancer has a high incidence globally, with OSCC being the most common type. Loss of pRb function is associated with improved survival in patients with OSCC. This systematic review and meta-analysis provide evidence-based results supporting this association.
Review
Oncology
Isabel Gonzalez-Ruiz, Pablo Ramos-Garcia, Isabel Ruiz-Avila, Miguel Angel Gonzalez-Moles
Summary: Oral and oropharyngeal cancers have a high worldwide incidence and mortality rate. The poor prognosis is mainly due to late diagnosis in advanced stages, where treatment is not effective. Reducing the delay in diagnosis is crucial to improve patient outcomes.
Review
Biochemistry & Molecular Biology
Jose Luis Civico-Ortega, Isabel Gonzalez-Ruiz, Pablo Ramos-Garcia, David Cruz-Granados, Valerie Samayoa-Descamps, Miguel angel Gonzalez-Moles
Summary: The aim of this systematic review and meta-analysis was to assess the clinicopathological and prognostic significance of epidermal growth factor receptor (EGFR) overexpression in patients with oral squamous cell carcinoma (OSCC). A total of 50 primary-level studies (4631 patients) met the inclusion criteria. The findings support that immunohistochemical assessment of EGFR overexpression may serve as a useful prognostic biomarker for OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Teresa De Porras-Carrique, Pablo Ramos-Garcia, Miguel Angel Gonzalez-Moles
Summary: This study conducted a systematic review and meta-analysis to evaluate the prevalence and association of hypertension in patients with oral lichen planus (OLP). The results showed a high prevalence of hypertension in patients with OLP and a significant association between hypertension and OLP. Healthcare practitioners should be aware of this comorbidity and take appropriate measures when managing OLP.
Review
Medicine, General & Internal
Maria del Mar Roca-Rodriguez, Pablo Ramos-Garcia, Cristina Lopez-Tinoco, Manuel Aguilar-Diosdado
Summary: Cord blood leptin levels were significantly higher in gestational diabetes mellitus (GDM) compared to controls. Subgroup analyses based on continents, analysis technique, and sample source also showed consistent results. Further research is needed to determine the predictive role of cord blood leptin levels in metabolic diseases in GDM mothers and their offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Inmaculada Isorna, Miguel Angel Gonzalez-Moles, Miguel Munoz, Francisco Esteban
Summary: The overexpression of neurokinin-1 receptor (NK-1R) in thyroid cancer cells has been found to be associated with cancer progression. NK-1R antagonists show dose-dependent antitumor effects, inhibiting cancer cell proliferation, inducing apoptosis, and hindering cell migration and angiogenesis. Targeting NK-1R may represent a promising therapeutic approach for thyroid cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Miguel Angel Gonzalez-Moles, Teresa de Porras-Carrique, Pablo Ramos-Garcia
Summary: This study aims to evaluate the association between oral lichen planus (OLP) and hepatic diseases, including hepatocellular carcinoma. The results suggest that OLP patients have a tendency to develop hepatitis B, hepatitis C, cirrhosis, hepatic steatosis, and hepatocellular carcinoma. Therefore, it is important to investigate hepatic disease in OLP patients for early diagnosis and better management.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)
Article
Obstetrics & Gynecology
J. A. Gil-Montoya, T. Rivero-Blanco, X. Leon-Rios, M. Exposito-Ruiz, I Perez-Castillo, M. J. Aguilar-Cordero
Summary: Pregnancy has significant consequences on oral health, particularly for gingival health. This study found that the number of women with periodontal and gingival diseases increased during the late stages of pregnancy compared to early pregnancy. Obesity and poor oral hygiene during early pregnancy were the most influential risk factors for developing periodontal disease.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.