Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Article
Dentistry, Oral Surgery & Medicine
Marketa Janovska, Katherine J. Bodiford, Alison J. Bruce, Roy S. Rogers III
Summary: The study found that oral lichen planus and vulvar lichen sclerosus may coexist in patients in their seventies. The most commonly used treatment is topical corticosteroids, and the coexistence of both diseases does not increase the risk of malignancy.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Medicine, General & Internal
Takahiro Yagyuu, Masahiro Isogawa, Kazuhiko Yamamoto, Tsutomu Sugiura, Yumiko Matsusue, Masato Kasahara, Tadaaki Kirita
Summary: This study aims to explore if adding cepharanthine, an herbal extract, can enhance the efficacy of corticosteroid therapy in treating oral lichen planus (OLP). The study will be conducted at three Japanese hospitals, comparing the safety and efficacy of integrated oral cepharanthine and corticosteroid therapy with standard corticosteroid therapy. The primary outcome is the change in pain intensity when drinking room-temperature water.
Article
Dermatology
S. Utz, V. G. A. Suter, S. Cazzaniga, L. Borradori, L. Feldmeyer
Summary: Topical tacrolimus is an effective therapy for oral lichen planus, especially for patients who are unresponsive to potent topical corticosteroids. Adjusting the treatment frequency based on signs of clinical activity and subjective impairment is important, with regular follow-up essential for early detection of potential squamous cell carcinoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Contaldo, R. Grassi, F. Fiori, G. M. Nardi, R. Borgia, A. Romano, R. Serpico, M. Petruzzi
Summary: Oral Lichen planus is an immune-mediated disease with unknown causes that affects the oral mucous. Human papillomavirus infection may be correlated with Oral Lichen Planus.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Review
Biology
Won Jung, Sungil Jang
Summary: Oral lichen planus is a chronic inflammatory disease with an unknown cause. Dysbiosis in the oral microbiome and functional abnormalities in the oral mucosa play important roles in its development.
Article
Oncology
Katharina Theresa Obermeier, Sabina Noreen Wuersching, Paris Liokatis, Wenko Smolka, Philipp Poxleitner, Christin Kleye, Michael Ehrenfeld, Maximilian Kollmuss, Sven Otto
Summary: Oral lichen ruber planus (OLP) is a chronic inflammatory disease of the oral mucosa that can progress to oral squamous cell carcinoma (OSCC) in a small percentage of cases. Surgical treatment, including tumor resection and neck dissection, is recommended. This study examined 103 OLP patients and compared their lymph node metastasis and survival rates with a group of OSCC patients without OLP. The analysis showed that patients with OLP had a significantly lower risk of lymph node metastasis compared to those without OLP.
Review
Medicine, General & Internal
Katharina Boch, Ewan A. Langan, Khalaf Kridin, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber
Summary: Lichen planus is a T cell-mediated disease affecting the skin and mucous membranes, characterized by inflammatory infiltrate and basal layer degeneration. While usually self-limiting, it can cause significant morbidity. Current treatment includes corticosteroids, but new options like Janus kinase inhibitors and biologics may lead to a change in treatment landscape.
FRONTIERS IN MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Ingrida Cema, Jagriti Kakar, Madara Dzudzilo, Modra Murovska
Summary: Oral lichen planus (OLP) is an autoimmune lesion mediated by T cells and activated by an unknown antigen. Epstein-Barr virus (EBV) can act as both an exogenous and an endogenous antigen in the pathogenesis of OLP. In the development of the autoimmune process, factors such as cytokines, chemokines, autoantibodies, self-reactive B and T cells, and dysregulation of antigen-presenting cells play a role.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Immunology
Qionghua Li, Fei Wang, Yujie Shi, Liang Zhong, Shumin Duan, Wenjing Kuang, Na Liu, En Luo, Yu Zhou, Lu Jiang, Hongxia Dan, Xiaobo Luo, Dunfang Zhang, Qianming Chen, Xin Zeng, Taiwen Li
Summary: This study characterized the mucosal immune microenvironment of oral lichen planus (OLP) using single-cell RNA sequencing and immune repertoire sequencing. Activated tissue-resident memory CD8+ T cells were found in OLP tissues, along with clonal expansion of T cell receptor repertoires and BCR clonal expansion. Fibroblasts were identified as potential promoters of immune cell recruitment into connective tissue in OLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunshan Li, Yaodong He, Junwei Xiang, Linfei Feng, Yuanyin Wang, Ran Chen
Summary: Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), play important regulatory roles in eukaryotes by post-transcriptionally inhibiting gene expression. The role and mechanisms of miRNAs in oral lichen planus (OLP) are still unclear, but they show potential as biomarkers for OLP diagnosis and therapeutic targets.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sarinthon Pariyawathee, Ekarat Phattarataratip, Kobkan Thongprasom
CLINICAL ORAL INVESTIGATIONS
(2020)
Editorial Material
Dermatology
K. Thongprasom
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Clery Saad Abboud, Eloiza Helena da Silva Brandao, Karen Roberta Lopes Cunha, Kaline de Sousa Brito, Camila de Barros Gallo, Angela Cristina Molon, Anna Carolina Ratto Tempestini Horliana, Adriana Santos Lino Franco, Kobkan Thongprasom, Maria Fernanda Setubal Destro Rodrigues
Summary: This study evaluated the serum and salivary levels of cytokines in patients with oral lichen planus treated with photobiomodulation and clobetasol propionate. The results showed that IL-1β plays an important role in OLP pathogenesis and is positively correlated with disease severity. Additionally, photobiomodulation did not have a regulatory effect on cytokines.
Letter
Dentistry, Oral Surgery & Medicine
Kobkan Thongprasom, Nawaporn Pengpis, Ekarat Phattarataratip, Lakshman Samaranayake
Article
Dentistry, Oral Surgery & Medicine
Kittiphoj Tikkhanarak, Daras Wangboo, Nichakorn Sookviboonpol, Kobkan Thongprasom
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2019)
