Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao, Huifang Shang
Summary: Patients with early-onset Parkinson's disease (EOPD) have a higher prevalence of suicidal ideation (SI) and depression, with risk factors including depression, non-smoking, and lower education level.
JOURNAL OF NEUROLOGY
(2021)
Review
Nutrition & Dietetics
Damiano Terenzi, Anne-Katrin Muth, Soyoung Q. Park
Summary: This paper reviews the current literature on the relationship between nutritive patterns, inflammatory markers, and the detection of Parkinson's disease (PD). The findings suggest that long-term gut inflammation may contribute to the development of PD, and specific nutritive patterns could improve gut health and reduce the risk of PD.
Article
Clinical Neurology
Pauli Ylikotila, Jussi Sipila, Tiina Alapirtti, Riitta Ahmasalo, Eriko Koshimizu, Satoko Miyatake, Anri Hurme-Niiranen, Ari Siitonen, Hiroshi Doi, Fumiaki Tanaka, Naomichi Matsumoto, Kari Majamaa, Laura Kytovuori
Summary: Recent study found that repeat expansion is a rare cause of early-onset Parkinson's disease. Among a nationwide cohort of Finnish patients, 1.10% had biallelic repeat expansion in the RFC1 gene.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Rana Abu Manneh, Paraskevi P. Chairta, Ellie Mitsi, Maria A. Loizidou, Andrea N. Georgiou, Yiolanda P. Christou, Marios Pantzaris, Eleni Zamba-Papanicolaou, Andreas Hadjisavvas
Summary: Parkinson's Disease (PD) is a complex neurodegenerative disease with unclear etiology. This study aimed to investigate the genetic landscape of early-onset PD (EOPD) in the Greek-Cypriot population and identified several pathogenic variants associated with EOPD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Patricia Krause, Johanna Reimer, Jonathan Kaplan, Friederike Borngraeber, Gerd-Helge Schneider, Katharina Faust, Andrea A. Kuehn
Summary: Subthalamic Deep Brain Stimulation (STN-DBS) is a safe and effective therapy for managing motor symptoms in patients with Parkinson's disease. It can also improve non-motor symptoms and reduce additional neuropsychiatric features, which is important for the management of Early-onset PD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Chunyu Li, Ruwei Ou, Xiaojing Gu, Yanbing Hou, Yongping Chen, Qianqian Wei, Lingyu Zhang, Junyu Lin, Kuncheng Liu, Jingxuan Huang, Xueping Chen, Wei Song, Bi Zhao, Ying Wu, Huifang Shang
Summary: A study analyzed rare variants in the ANXA1 gene in 743 Chinese early-onset Parkinson's disease patients and found six rare missense mutations. However, no significant association was found between these variants and Parkinson's disease, indicating that ANXA1 mutations are rare in early-onset Parkinson's disease in the Asian population.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Fan Zhou, ChangLian Tan, Chendie Song, Min Wang, Jiaying Yuan, Yujing Liu, Sainan Cai, QinRu Liu, Qin Shen, Yuqing Tang, Xu Li, Haiyan Liao
Summary: The study examined the altered functional connectivity of brain networks in Early-Onset Parkinson's Disease (EOPD) and Late-Onset Parkinson's Disease (LOPD) and their relationship to clinical symptoms. Using independent component analysis, the brain networks of EOPD and LOPD were constructed and functional connectivity alterations were observed. EOPD showed increased functional connectivity within the Sensorimotor Network (SMN) and Executive Control Network (ECN), while LOPD demonstrated increased functional connectivity within the ECN and decreased functional connectivity within the Cerebellar Network (CN). Furthermore, LOPD showed increased functional connectivity between the SMN and Default Mode Network (DMN). The study concluded that there are abnormal functional connectivity patterns in EOPD and LOPD, possibly reflecting associated pathological damage or compensation.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Julia M. Lappin, Shane Darke
Summary: Methamphetamine users, typically young adults, are at elevated risk for neurological harms such as stroke and Parkinson's disease which may develop prematurely. Evidence suggests a link between methamphetamine use and increased risk for haemorrhagic stroke and early onset of Parkinson's disease. However, direct evidence of dopaminergic neuron degeneration in methamphetamine users has not been demonstrated.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Efthalia Angelopoulou, Maria Bozi, Athina-Maria Simitsi, Christos Koros, Roubina Antonelou, Nikolaos Papagiannakis, Matina Maniati, Dafni Poula, Maria Stamelou, Demetrios K. Vassilatis, Ioannis Michalopoulos, Styliani Geronikolou, Nikolaos Scarmeas, Leonidas Stefanis
Summary: This study investigated the clinical differences between early-onset Parkinson's disease (EOPD) and mid-and-late-onset Parkinson's disease (MLOPD) in the Greek population. The results showed that EOPD and MLOPD have distinct clinical profiles regarding motor and non-motor symptoms, side of onset, and motor complications.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Summary: The study revealed that fall-related risk factors in patients with early Parkinson's disease (PD) were highly associated with gastrointestinal dysautonomia.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Xiaojing Gu, Yanbing Hou, Yongping Chen, Ruwei Ou, Bei Cao, Qianqian Wei, Lingyu Zhang, Wei Song, Bi Zhao, Ying Wu, Huifang Shang
Summary: A loss-of-function variant in the LIN28A gene was identified in two East Asian EOPD patients, leading to developmental defects and PD-related phenotype that could be rescued. However, further analysis did not support a major causal role for LIN28A in PD.
FRONTIERS IN GENETICS
(2021)
Article
Geriatrics & Gerontology
Lin Zhang, Qin Shen, Haiyan Liao, Junli Li, Tianyu Wang, Yuheng Zi, Fan Zhou, Chendie Song, Zhenni Mao, Min Wang, Sainan Cai, Changlian Tan
Summary: This study revealed differences in cortical complexity between patients with left-onset (LPD) and right-onset (RPD) Parkinson's disease (PD), with RPD patients showing decreased complexity in specific regions. The findings suggest asymmetrical motor symptoms influence cortical complexity in early-stage PD, particularly in the banks of the left superior temporal sulcus and left superior temporal gyrus in RPD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Marthe Smedinga, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Bart Post, Edo Richard
Summary: Research on Parkinson's disease (PD) is increasingly focusing on early disease modification and prevention, similar to strategies seen in Alzheimer's disease research. Challenges faced in Alzheimer's prevention trials, including insufficiently robust trial results and trial design flaws, also apply to PD research and need to be addressed for optimal trial design.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Emanuele Camerucci, Cole D. Stang, Mania Hajeb, Pierpaolo Turcano, Aidan F. Mullan, Peter Martin, Owen A. Ross, James H. Bower, Michelle M. Mielke, Rodolfo Savica
Summary: Based on a study of residents in seven counties in Minnesota, early-onset Parkinson's disease (EOPD) occurs between the ages of 40 and 55 with a lower incidence rate, and male patients are more likely to die than female patients.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Chemistry, Analytical
Ilaria Mileti, Alessandro Zampogna, Alessandro Santuz, Francesco Asci, Zaccaria Del Prete, Adamantios Arampatzis, Eduardo Palermo, Antonio Suppa
Article
Biology
Sebastian Bohm, Falk Mersmann, Alessandro Santuz, Adamantios Arampatzis
Summary: The study explored the behavior of the soleus muscle during running and found that improvements in energy cost following increases in plantar flexor strength and Achilles tendon stiffness may be attributed to increased enthalpy efficiency of the operating soleus muscle. The results further suggest that the energy production of the soleus muscle during the lengthening phase of the muscle-tendon unit may play a crucial role in the overall metabolic energy cost of running.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Sport Sciences
Falk Mersmann, Theresa Domroes, Nikolaos Pentidis, Meng-Shiuan Tsai, Sebastian Bohm, Arno Schroll, Adamantios Arampatzis
Summary: This study investigated the effects of evidence-based tendon exercise intervention on high-level patellar tendon strain, micromorphological integrity, and pain in adolescent basketball players. The results suggest that functional high-load tendon exercises may reduce the prevalence of high-level patellar tendon strain and impairments of its micromorphology in adolescent athletes, providing new opportunities for tendinopathy prevention.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Article
Biology
Sebastian Bohm, Falk Mersmann, Alessandro Santuz, Arno Schroll, Adamantios Arampatzis
Summary: The study found that the soleus and vastus lateralis muscles operate under different conditions during running, with the soleus continuously shortening as a work generator and the vastus lateralis contracting near optimal length for force generation. The favorable operating conditions of both muscles are attributed to the effective length and velocity-decoupling of fascicles and muscle-tendon unit.
Article
Chemistry, Analytical
Mohamadreza Kharazi, Christos Theodorakis, Falk Mersmann, Adamantios Arampatzis, Sebastian Bohm
Summary: The study aimed to simplify the measurement of Achilles tendon curvature by reducing the number of markers while maintaining high accuracy. Results showed that using only 30% to 50% of the marker set can maintain high accuracy in determining AT length and strain, which is useful for practical applications.
Article
Chemistry, Analytical
Juri Taborri, Alessandro Santuz, Leon Bruell, Adamantios Arampatzis, Stefano Rossi
Summary: This study investigates the effects of anterior-posterior and medio-lateral perturbations on walking. The findings suggest that anterior-posterior perturbations are more challenging and result in differences in joint angles, range of motion, and inter-joint coordination. Medio-lateral perturbations only affect the ankle joint. These findings can be applied in rehabilitative protocols to reduce the risk of falling.
Article
Multidisciplinary Sciences
Alessandro Santuz, Lars Janshen, Leon Bruell, Victor Munoz-Martel, Juri Taborri, Stefano Rossi, Adamantios Arampatzis
Summary: There is increasing evidence that including sex as a biological variable is crucial for promoting rigorous and reproducible science. However, the literature on the sex-specific characteristics of motor control in human locomotion is limited. In this study, we investigated muscle activation patterns and found sparse sex-specific modulations of motor control. Our results suggest the existence of small but defined sex-specific differences in the way humans control locomotion and that these differences are not fully maintained in older age.
Article
Multidisciplinary Sciences
Robin Macchi, Alessandro Santuz, Arnaud Hays, Fabrice Vercruyssen, Adamantios Arampatzis, Avner Bar -Hen, Caroline Nicol
Summary: This study investigates the influence of sex on recovery after running exercise. The results suggest that women may recover earlier in a dynamic multi-joint task and that sex-specific organization of muscle synergies may contribute to their different recovery times.
Article
Chemistry, Analytical
Saru Meena Ramu, Panagiotis Chatzistergos, Nachiappan Chockalingam, Adamantios Arampatzis, Constantinos Maganaris
Summary: Existing approaches for automated tracking of fascicle length and pennation angle have limitations, but this study proposes a new method that quantifies changes in length and angle based on distortion patterns within the fascicle band, without the need for a single fascicle or specific intensity pattern.
Article
Medicine, General & Internal
Goran Radovanovic, Sebastian Bohm, Adamantios Arampatzis, Kirsten Legerlotz
Summary: The study found that patients with Achilles tendinopathy have asymmetries in mechanical, material, and morphological musculoskeletal properties and function. Therapeutic exercise interventions have little effect on these asymmetries, and reducing asymmetry does not necessarily improve tendon health.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Mohamadreza Kharazi, Christos Theodorakis, Falk Mersmann, Sebastian Bohm, Adamantios Arampatzis
Summary: This study enhances our understanding of how different mechanisms in the triceps surae muscles contribute to the increase in mechanical power and work at the ankle joint during different walking speeds. Both the soleus (Sol) and gastrocnemii muscles play a role in the speed-related increase of mechanical work at the ankle joint, but through distinct energetic processes and mechanisms. This knowledge can inform the design of exercise interventions and customized assistance through bioinspired exoskeleton configurations.
Article
Sport Sciences
Theresa Domroes, Kolja Weidlich, Sebastian Bohm, Adamantios Arampatzis, Falk Mersmann
Summary: Imbalances between muscle strength and tendon stiffness may increase the risk of tendon structural impairments and tendinopathy in adolescent athletes. This study found that female athletes had lower muscle strength and patellar tendon stiffness compared to males, with no significant changes over the competitive season. There were no differences in tendon strain and structural integrity fluctuations between sexes.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Multidisciplinary Sciences
Adamantios Arampatzis, Mohamadreza Kharazi, Christos Theodorakis, Falk Mersmann, Sebastian Bohm
Summary: The study aimed to investigate the role of biarticular mechanisms of the gastrocnemius muscles in providing energy for power and work at the ankle joint during running at increasing speeds. The contribution of the monoarticular soleus and the biarticular gastrocnemius muscles to mechanical power and work at the ankle joint was measured, and it was found that although the soleus had a higher contribution, the biarticular mechanisms of the gastrocnemius also played a significant role. Energy transfer between the ankle and knee joints was observed during the stance and push-off phases, with the gastrocnemius muscles accounting for 16% of the total positive ankle joint work. The rate of energy transfer from the knee to ankle joint increased with speed, indicating the involvement of biarticular mechanisms in running.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Geriatrics & Gerontology
Leon Bruell, Natalie Hezel, Adamantios Arampatzis, Michael Schwenk
Summary: This study compared the feasibility and effectiveness of two different balance training methods (PBTtreadmill and PBTstability) in older adults. Both methods were found to be effective in improving balance ability and reducing fall risk in older adults. However, PBTtreadmill showed better results in improving reactive balance, while PBTstability had more wide-ranging effects on balance ability.
Article
Sport Sciences
Adamantios Arampatzis, Gunnar Laube, Arno Schroll, Johannes Frank, Sebastian Bohm, Falk Mersmann
Summary: This study demonstrated the effectiveness of a perturbation-based exercise intervention in preventing chronic non-specific low-back pain in adolescent athletes over one year. The intervention led to a reduction in low-back pain incidence, decreased pain intensity, increased muscle strength, and a reduction in muscle strength imbalances. Specific trunk muscle interventions are necessary for preventing low-back pain in athletes.
TRANSLATIONAL SPORTS MEDICINE
(2021)
Article
Neurosciences
John J. Buchanan, Alberto Cordova
Summary: Research has shown that spontaneous visual coupling supports frequency entrainment, phase attraction, and intermittent interpersonal coordination during the switch from a novision (NV) to vision (V) context among co-actors. The experiments demonstrate that similar self-paced frequencies result from same amplitude movements, while different amplitudes lead to disparate frequencies. In experiment 1, co-actors were instructed to maintain amplitude without explicit instructions for coordination, which limited frequency and phase entrainment in the V context. In experiment 2, co-actors were instructed to maintain amplitude and intentionally coordinate together, resulting in significant frequency modulations and the production of various stable relative phase patterns.
HUMAN MOVEMENT SCIENCE
(2024)