POLG2disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity

Polymerase subunit gamma 2 affects porcine oocyte maturation and subsequent embryonic development

(2015) Seul-Ki Lee et al.   THERIOGENOLOGY

Defects of Mitochondrial DNA Replication

(2014) William C. Copeland   JOURNAL OF CHILD NEUROLOGY

Keeping mtDNA in Shape between Generations

(2014) James B. Stewart et al.   PLoS Genetics

Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity

(2014) William Dott et al.   Redox Biology

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

(2012) Margaret M. Humble et al.   HUMAN MOLECULAR GENETICS

Mechanisms of Protein Sorting in Mitochondria

(2012) D. Stojanovski et al.   Cold Spring Harbor Perspectives in Biology

Biochemical analysis of human POLG2 variants associated with mitochondrial disease

(2011) Matthew J. Young et al.   HUMAN MOLECULAR GENETICS

A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits

(2011) Kate Craig et al.   MITOCHONDRION

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

(2011) T. A. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Mutation in Human Mitochondrial DNA Polymerase Pol γA Affects Both Polymerization and Proofreading Activities of Only the Holoenzyme

(2010) Young-Sam Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations

(2010) Rajesh Kasiviswanathan et al.   METHODS

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

(2009) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations

(2009) Young-Sam Lee et al.   CELL

Mouse models of mitochondrial DNA defects and their relevance for human disease

(2009) Henna Tyynismaa et al.   EMBO REPORTS

Each Monomer of the Dimeric Accessory Protein for Human Mitochondrial DNA Polymerase Has a Distinct Role in Conferring Processivity

(2009) Young-Sam Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

Molecular and clinical genetics of mitochondrial diseases due toPOLGmutations

(2008) Lee-Jun C. Wong et al.   HUMAN MUTATION

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS